DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres(597 views) Calafiore M, Copani A, Deng W
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Keywords: β-Amyloid, Alzheimer, S Disease, Dna Polymerase-β, Neural Stem Cell, Neurogenesis, Neurosphere, Amyloid Beta Protein, Amyloid Beta Protein[1-42], Dna Directed Dna Polymerase Beta, Microtubule Associated Protein 2, Nestin, Animal Cell, Article, Brain Development, Cell Culture, Cell Cycle Arrest, Cell Differentiation, Cell Maturation, Cell Proliferation, Controlled Study, Gene Expression, Gene Silencing, Mouse, Nerve Cell, Nervous System Development, Neuroblast, Nonhuman, Priority Journal, Subventricular Zone, Amyloid Beta-Peptides, Cell Cycle Checkpoints, Cerebral Ventricles, Amyloid Beta-Peptides Metabolism Pharmacology, Cell Cycle Checkpoints Drug Effects Physiology, Cell Proliferation Drug Effects, Cerebral Ventricles Cytology Metabolism, Dna Polymerase Beta Metabolism Pharmacology, Neurogenesis Drug Effects Physiology, Neurons Cytology Drug Effects Metabolism, Amyloid Beta Protein [1-42],
Affiliations: *** IBB - CNR ***
Department of Cell Biology and Human Anatomy, Institute for Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, CA, United States
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
Istituto di Bioimmagini e Biostrutture, CNR, Catania, Italy
References: Bondolfi, L., Calhoun, M., Ermini, F., Kuhn, H.G., Wiederhold, K.H., Walker, L., Staufenbiel, M., Jucker, M., Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice (2002) J Neurosci, 22, pp. 515-52
Calafiore, M., Battaglia, G., Zappalà, A., Trovato-Salinaro, E., Caraci, F., Caruso, M., Vancheri, C., Copani, A., Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid (2006) Neurobiol Aging, 27, pp. 606-613
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., Erratic expression of DNA polymerases by beta-amyloid causes neuronal death (2002) FASEB J, 16, pp. 2006-2008
Copani, A., Hoozemans, J.J., Caraci, F., Calafiore, M., Van Haastert, E.S., Veerhuis, R., Rozemuller, A.J., Nicoletti, F., DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid (2006) J Neurosci, 26, pp. 10949-10957
Copeland, W.C., Chen, M.S., Wang, T.S., Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA (1992) J Biol Chem, 267, pp. 21459-21464
Darzynkiewicz, Z., Bruno, S., Del Bino, G., Gorczyca, W., Hotz, M.A., Lassota, P., Traganos, F., Features of apoptotic cells measured by flow cytometry (1992) Cytometry, 13, pp. 795-808
Donovan, M.H., Yazdani, U., Norris, R.D., Games, D., German, D.C., Eisch, A.J., Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease (2006) J Comp Neurol, 495, pp. 70-83
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., Beta-amyloid monomers are neuroprotective (2009) J Neurosci, 29, pp. 10582-10587
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., Divide and die: cell cycle events as triggers of nerve cell death (2004) J Neurosci, 24, pp. 9232-9239
Jackman, J., O'Connor, P.M., Methods for synchronizing cells at specific stages of the cell cycle (2001) Curr Protoc Cell Biol, , Chapter 8, Unit 8.3
Jin, K., Galvan, V., Xie, L., Mao, X.O., Gorostiza, O.F., Bredesen, D.E., Greenberg, D.A., Enhanced neurogenesis in Alzheimer's disease transgenic PDGF-APP Sw,Ind mice (2004) Proc Natl Acad Sci U S A, 101, pp. 13363-13367
Jin, K., Peel, A.L., Mao, X.O., Xie, L., Cottrell, B.A., Henshall, D.C., Greenberg, D.A., Increased hippocampal neurogenesis in Alzheimer's disease (2004) Proc Natl Acad Sci U S A, 101, pp. 343-347
Lindsten, T., Golden, J.A., Zong, W.X., Minarcik, J., Harris, M.H., Thompson, C.B., The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool (2003) J Neurosci, 23, pp. 11112-11119
López-Toledano, M.A., Shelanski, M.L., Neurogenic effect of beta-amyloid peptide in the development of neural stem cells (2004) J Neurosci, 24, pp. 5439-5444
Moraes, L., de Moraes Mello, L.E., Shimabukuro, M.K., de Castro Batista, C.M., Mendez-Otero, R., Lack of association between PSA-NCAM expression and migration in the rostral migratory stream of a Huntington's disease transgenic mouse model (2009) Neuropathology, 29, pp. 140-147
Morishima, Y., Gotoh, Y., Zieg, J., Barrett, T., Takano, H., Flavell, R., Davis, R.J., Greenberg, M.E., Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand (2001) J Neurosci, 21, pp. 7551-7560
Nowak, R., Woszczynski, M., Siedlecki, J.A., Changes in the DNA polymerase beta gene expression during development of lung, brain, and testis suggest an involvement of the enzyme in DNA recombination (1990) Exp Cell Res, 191, pp. 51-56
Reichenberger, S., Pfeiffer, P., Cloning, purification and characterization of DNA polymerase beta from Xenopus laevis-studies on its potential role in DNA-end joining (1998) Eur J Biochem, 251, pp. 81-90
Sheaff, R., Ilsley, D., Kuchta, R., Mechanism of DNA polymerase alpha inhibition by aphidicolin (1991) Biochemistry, 30, pp. 8590-8597
Sugo, N., Aratani, Y., Nagashima, Y., Kubota, Y., Koyama, H., Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta (2000) EMBO J, 19, pp. 1397-1404
Sugo, N., Niimi, N., Aratani, Y., Takiguchi-Hayashi, K., Koyama, H., p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice (2004) Mol Cell Biol, 24, pp. 9470-9477
Suslov, O.N., Kukekov, V.G., Ignatova, T.N., Steindler, D.A., Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres (2002) Proc Natl Acad Sci U S A, 99, pp. 14506-14511
Ziabreva, I., Perry, E., Perry, R., Minger, S.L., Ekonomou, A., Przyborski, S., Ballard, C., Altered neurogenesis in Alzheimer's disease (2006) J Psychosom Res, 61, pp. 311-316
Copeland, W. C., Chen, M. S., Wang, T. S., Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA (1992) J Biol Chem, 267, pp. 21459-21464
Donovan, M. H., Yazdani, U., Norris, R. D., Games, D., German, D. C., Eisch, A. J., Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease (2006) J Comp Neurol, 495, pp. 70-83
Giuffrida, M. L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., Beta-amyloid monomers are neuroprotective (2009) J Neurosci, 29, pp. 10582-10587
Jin, K., Peel, A. L., Mao, X. O., Xie, L., Cottrell, B. A., Henshall, D. C., Greenberg, D. A., Increased hippocampal neurogenesis in Alzheimer's disease (2004) Proc Natl Acad Sci U S A, 101, pp. 343-347
L pez-Toledano, M. A., Shelanski, M. L., Neurogenic effect of beta-amyloid peptide in the development of neural stem cells (2004) J Neurosci, 24, pp. 5439-5444
Suslov, O. N., Kukekov, V. G., Ignatova, T. N., Steindler, D. A., Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres (2002) Proc Natl Acad Sci U S A, 99, pp. 14506-14511
DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres