DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T,
Impact factor: 2.974, 5-year impact factor: 3.018
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84855876064&partnerID=40&md5=17d41a5e6defbf9f531176781415a743
Keywords: β-Amyloid, Alzheimer, S Disease, Dna Polymerase-β, Neural Stem Cell, Neurogenesis, Neurosphere, Amyloid Beta Protein, Amyloid Beta Protein[1-42], Dna Directed Dna Polymerase Beta, Microtubule Associated Protein 2, Nestin, Animal Cell, Article, Brain Development, Cell Culture, Cell Cycle Arrest, Cell Differentiation, Cell Maturation, Cell Proliferation, Controlled Study, Gene Expression, Gene Silencing, Mouse, Nerve Cell, Nervous System Development, Neuroblast, Nonhuman, Priority Journal, Subventricular Zone, Amyloid Beta-Peptides, Cell Cycle Checkpoints, Cerebral Ventricles, Amyloid Beta-Peptides Metabolism Pharmacology, Cell Cycle Checkpoints Drug Effects Physiology, Cell Proliferation Drug Effects, Cerebral Ventricles Cytology Metabolism, Dna Polymerase Beta Metabolism Pharmacology, Neurogenesis Drug Effects Physiology, Neurons Cytology Drug Effects Metabolism, Amyloid Beta Protein [1-42],
Affiliations:
*** IBB - CNR ***
Department of Cell Biology and Human Anatomy, Institute for Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, CA, United States
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
Istituto di Bioimmagini e Biostrutture, CNR, Catania, Italy
References:
Bondolfi, L., Calhoun, M., Ermini, F., Kuhn, H.G., Wiederhold, K.H., Walker, L., Staufenbiel, M., Jucker, M., Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice (2002) J Neurosci, 22, pp. 515-52
Calafiore, M., Battaglia, G., Zappalà, A., Trovato-Salinaro, E., Caraci, F., Caruso, M., Vancheri, C., Copani, A., Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid (2006) Neurobiol Aging, 27, pp. 606-613
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., Erratic expression of DNA polymerases by beta-amyloid causes neuronal death (2002) FASEB J, 16, pp. 2006-2008
Copani, A., Hoozemans, J.J., Caraci, F., Calafiore, M., Van Haastert, E.S., Veerhuis, R., Rozemuller, A.J., Nicoletti, F., DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid (2006) J Neurosci, 26, pp. 10949-10957
Copeland, W.C., Chen, M.S., Wang, T.S., Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA (1992) J Biol Chem, 267, pp. 21459-21464
Darzynkiewicz, Z., Bruno, S., Del Bino, G., Gorczyca, W., Hotz, M.A., Lassota, P., Traganos, F., Features of apoptotic cells measured by flow cytometry (1992) Cytometry, 13, pp. 795-808
Donovan, M.H., Yazdani, U., Norris, R.D., Games, D., German, D.C., Eisch, A.J., Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease (2006) J Comp Neurol, 495, pp. 70-83
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., Beta-amyloid monomers are neuroprotective (2009) J Neurosci, 29, pp. 10582-10587
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., Divide and die: cell cycle events as triggers of nerve cell death (2004) J Neurosci, 24, pp. 9232-9239
Jackman, J., O'Connor, P.M., Methods for synchronizing cells at specific stages of the cell cycle (2001) Curr Protoc Cell Biol, , Chapter 8, Unit 8.3
Jin, K., Galvan, V., Xie, L., Mao, X.O., Gorostiza, O.F., Bredesen, D.E., Greenberg, D.A., Enhanced neurogenesis in Alzheimer's disease transgenic PDGF-APP Sw,Ind mice (2004) Proc Natl Acad Sci U S A, 101, pp. 13363-13367
Jin, K., Peel, A.L., Mao, X.O., Xie, L., Cottrell, B.A., Henshall, D.C., Greenberg, D.A., Increased hippocampal neurogenesis in Alzheimer's disease (2004) Proc Natl Acad Sci U S A, 101, pp. 343-347
Lindsten, T., Golden, J.A., Zong, W.X., Minarcik, J., Harris, M.H., Thompson, C.B., The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool (2003) J Neurosci, 23, pp. 11112-11119
López-Toledano, M.A., Shelanski, M.L., Neurogenic effect of beta-amyloid peptide in the development of neural stem cells (2004) J Neurosci, 24, pp. 5439-5444
Moraes, L., de Moraes Mello, L.E., Shimabukuro, M.K., de Castro Batista, C.M., Mendez-Otero, R., Lack of association between PSA-NCAM expression and migration in the rostral migratory stream of a Huntington's disease transgenic mouse model (2009) Neuropathology, 29, pp. 140-147
Morishima, Y., Gotoh, Y., Zieg, J., Barrett, T., Takano, H., Flavell, R., Davis, R.J., Greenberg, M.E., Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand (2001) J Neurosci, 21, pp. 7551-7560
Nowak, R., Woszczynski, M., Siedlecki, J.A., Changes in the DNA polymerase beta gene expression during development of lung, brain, and testis suggest an involvement of the enzyme in DNA recombination (1990) Exp Cell Res, 191, pp. 51-56
Reichenberger, S., Pfeiffer, P., Cloning, purification and characterization of DNA polymerase beta from Xenopus laevis-studies on its potential role in DNA-end joining (1998) Eur J Biochem, 251, pp. 81-90
Sheaff, R., Ilsley, D., Kuchta, R., Mechanism of DNA polymerase alpha inhibition by aphidicolin (1991) Biochemistry, 30, pp. 8590-8597
Sugo, N., Aratani, Y., Nagashima, Y., Kubota, Y., Koyama, H., Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta (2000) EMBO J, 19, pp. 1397-1404
Sugo, N., Niimi, N., Aratani, Y., Takiguchi-Hayashi, K., Koyama, H., p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice (2004) Mol Cell Biol, 24, pp. 9470-9477
Suslov, O.N., Kukekov, V.G., Ignatova, T.N., Steindler, D.A., Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres (2002) Proc Natl Acad Sci U S A, 99, pp. 14506-14511
Ziabreva, I., Perry, E., Perry, R., Minger, S.L., Ekonomou, A., Przyborski, S., Ballard, C., Altered neurogenesis in Alzheimer's disease (2006) J Psychosom Res, 61, pp. 311-316
Copeland, W. C., Chen, M. S., Wang, T. S., Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA (1992) J Biol Chem, 267, pp. 21459-21464
Donovan, M. H., Yazdani, U., Norris, R. D., Games, D., German, D. C., Eisch, A. J., Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease (2006) J Comp Neurol, 495, pp. 70-83
Giuffrida, M. L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., Beta-amyloid monomers are neuroprotective (2009) J Neurosci, 29, pp. 10582-10587
Jin, K., Peel, A. L., Mao, X. O., Xie, L., Cottrell, B. A., Henshall, D. C., Greenberg, D. A., Increased hippocampal neurogenesis in Alzheimer's disease (2004) Proc Natl Acad Sci U S A, 101, pp. 343-347
L pez-Toledano, M. A., Shelanski, M. L., Neurogenic effect of beta-amyloid peptide in the development of neural stem cells (2004) J Neurosci, 24, pp. 5439-5444
Suslov, O. N., Kukekov, V. G., Ignatova, T. N., Steindler, D. A., Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres (2002) Proc Natl Acad Sci U S A, 99, pp. 14506-14511
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T,
Impact factor: 2.974, 5-year impact factor: 3.018
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84855876064&partnerID=40&md5=17d41a5e6defbf9f531176781415a743
Keywords: β-Amyloid, Alzheimer, S Disease, Dna Polymerase-β, Neural Stem Cell, Neurogenesis, Neurosphere, Amyloid Beta Protein, Amyloid Beta Protein[1-42], Dna Directed Dna Polymerase Beta, Microtubule Associated Protein 2, Nestin, Animal Cell, Article, Brain Development, Cell Culture, Cell Cycle Arrest, Cell Differentiation, Cell Maturation, Cell Proliferation, Controlled Study, Gene Expression, Gene Silencing, Mouse, Nerve Cell, Nervous System Development, Neuroblast, Nonhuman, Priority Journal, Subventricular Zone, Amyloid Beta-Peptides, Cell Cycle Checkpoints, Cerebral Ventricles, Amyloid Beta-Peptides Metabolism Pharmacology, Cell Cycle Checkpoints Drug Effects Physiology, Cell Proliferation Drug Effects, Cerebral Ventricles Cytology Metabolism, Dna Polymerase Beta Metabolism Pharmacology, Neurogenesis Drug Effects Physiology, Neurons Cytology Drug Effects Metabolism, Amyloid Beta Protein [1-42],
Affiliations:
*** IBB - CNR ***
Department of Cell Biology and Human Anatomy, Institute for Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, CA, United States
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
Istituto di Bioimmagini e Biostrutture, CNR, Catania, Italy
References:
Bondolfi, L., Calhoun, M., Ermini, F., Kuhn, H.G., Wiederhold, K.H., Walker, L., Staufenbiel, M., Jucker, M., Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice (2002) J Neurosci, 22, pp. 515-52
Calafiore, M., Battaglia, G., Zappalà, A., Trovato-Salinaro, E., Caraci, F., Caruso, M., Vancheri, C., Copani, A., Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid (2006) Neurobiol Aging, 27, pp. 606-613
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., Erratic expression of DNA polymerases by beta-amyloid causes neuronal death (2002) FASEB J, 16, pp. 2006-2008
Copani, A., Hoozemans, J.J., Caraci, F., Calafiore, M., Van Haastert, E.S., Veerhuis, R., Rozemuller, A.J., Nicoletti, F., DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid (2006) J Neurosci, 26, pp. 10949-10957
Copeland, W.C., Chen, M.S., Wang, T.S., Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA (1992) J Biol Chem, 267, pp. 21459-21464
Darzynkiewicz, Z., Bruno, S., Del Bino, G., Gorczyca, W., Hotz, M.A., Lassota, P., Traganos, F., Features of apoptotic cells measured by flow cytometry (1992) Cytometry, 13, pp. 795-808
Donovan, M.H., Yazdani, U., Norris, R.D., Games, D., German, D.C., Eisch, A.J., Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease (2006) J Comp Neurol, 495, pp. 70-83
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., Beta-amyloid monomers are neuroprotective (2009) J Neurosci, 29, pp. 10582-10587
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., Divide and die: cell cycle events as triggers of nerve cell death (2004) J Neurosci, 24, pp. 9232-9239
Jackman, J., O'Connor, P.M., Methods for synchronizing cells at specific stages of the cell cycle (2001) Curr Protoc Cell Biol, , Chapter 8, Unit 8.3
Jin, K., Galvan, V., Xie, L., Mao, X.O., Gorostiza, O.F., Bredesen, D.E., Greenberg, D.A., Enhanced neurogenesis in Alzheimer's disease transgenic PDGF-APP Sw,Ind mice (2004) Proc Natl Acad Sci U S A, 101, pp. 13363-13367
Jin, K., Peel, A.L., Mao, X.O., Xie, L., Cottrell, B.A., Henshall, D.C., Greenberg, D.A., Increased hippocampal neurogenesis in Alzheimer's disease (2004) Proc Natl Acad Sci U S A, 101, pp. 343-347
Lindsten, T., Golden, J.A., Zong, W.X., Minarcik, J., Harris, M.H., Thompson, C.B., The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool (2003) J Neurosci, 23, pp. 11112-11119
López-Toledano, M.A., Shelanski, M.L., Neurogenic effect of beta-amyloid peptide in the development of neural stem cells (2004) J Neurosci, 24, pp. 5439-5444
Moraes, L., de Moraes Mello, L.E., Shimabukuro, M.K., de Castro Batista, C.M., Mendez-Otero, R., Lack of association between PSA-NCAM expression and migration in the rostral migratory stream of a Huntington's disease transgenic mouse model (2009) Neuropathology, 29, pp. 140-147
Morishima, Y., Gotoh, Y., Zieg, J., Barrett, T., Takano, H., Flavell, R., Davis, R.J., Greenberg, M.E., Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand (2001) J Neurosci, 21, pp. 7551-7560
Nowak, R., Woszczynski, M., Siedlecki, J.A., Changes in the DNA polymerase beta gene expression during development of lung, brain, and testis suggest an involvement of the enzyme in DNA recombination (1990) Exp Cell Res, 191, pp. 51-56
Reichenberger, S., Pfeiffer, P., Cloning, purification and characterization of DNA polymerase beta from Xenopus laevis-studies on its potential role in DNA-end joining (1998) Eur J Biochem, 251, pp. 81-90
Sheaff, R., Ilsley, D., Kuchta, R., Mechanism of DNA polymerase alpha inhibition by aphidicolin (1991) Biochemistry, 30, pp. 8590-8597
Sugo, N., Aratani, Y., Nagashima, Y., Kubota, Y., Koyama, H., Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta (2000) EMBO J, 19, pp. 1397-1404
Sugo, N., Niimi, N., Aratani, Y., Takiguchi-Hayashi, K., Koyama, H., p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice (2004) Mol Cell Biol, 24, pp. 9470-9477
Suslov, O.N., Kukekov, V.G., Ignatova, T.N., Steindler, D.A., Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres (2002) Proc Natl Acad Sci U S A, 99, pp. 14506-14511
Ziabreva, I., Perry, E., Perry, R., Minger, S.L., Ekonomou, A., Przyborski, S., Ballard, C., Altered neurogenesis in Alzheimer's disease (2006) J Psychosom Res, 61, pp. 311-316
Copeland, W. C., Chen, M. S., Wang, T. S., Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA (1992) J Biol Chem, 267, pp. 21459-21464
Donovan, M. H., Yazdani, U., Norris, R. D., Games, D., German, D. C., Eisch, A. J., Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease (2006) J Comp Neurol, 495, pp. 70-83
Giuffrida, M. L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., Beta-amyloid monomers are neuroprotective (2009) J Neurosci, 29, pp. 10582-10587
Jin, K., Peel, A. L., Mao, X. O., Xie, L., Cottrell, B. A., Henshall, D. C., Greenberg, D. A., Increased hippocampal neurogenesis in Alzheimer's disease (2004) Proc Natl Acad Sci U S A, 101, pp. 343-347
L pez-Toledano, M. A., Shelanski, M. L., Neurogenic effect of beta-amyloid peptide in the development of neural stem cells (2004) J Neurosci, 24, pp. 5439-5444
Suslov, O. N., Kukekov, V. G., Ignatova, T. N., Steindler, D. A., Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres (2002) Proc Natl Acad Sci U S A, 99, pp. 14506-14511
DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres
β-Amyloid protein (Aβ) is thought to be responsible for neuronal apoptosis in Alzheimer's disease (AD). Paradoxically, Aβ can also promote neurogenesis, both in vitro and in vivo, by inducing neural progenitor cells (NPCs) to differentiate into neurons. However, the mechanisms of Aβ-induced neurogenesis are unknown. Here we examined the role of DNA polymerase-β (DNA pol-β), a DNA repair enzyme that is required for proper neurogenesis during brain development and is also responsible for Aβ-induced neuronal apoptosis. In neurospheres obtained from the adult mouse subventricular zone (SVZ), the knockdown of DNA pol-β or its pharmacological blockade showed that the enzyme functioned both to repress proliferation of early nestin + progenitor cells and to promote the maturation of TuJ-1 + neuronal cells. In neurospheres challenged with oligomers of synthetic Aβ 42, the expression levels of DNA pol-β were rapidly increased. DNA pol-β knockdown prevented the Aβ 42-promoted differentiation of nestin + progenitor cells into nestin +/Dlx-2 + neuroblasts. Moreover, when neurospheres were seeded to allow full differentiation of their elements, blockade of DNA pol-β prevented Aβ 42-induced differentiation of progenitors into MAP-2 + neurons. Thus, our data demonstrate that Aβ 42 arrests the proliferation of a subpopulation of nestin + cells via the induction of DNA pol-β, thereby allowing for their differentiation toward the neuronal lineage. Our findings reveal a novel role of DNA pol-β in Aβ 42-induced neurogenesis and identify DNA pol-β as a key mechanistic link between the neurogenic effect of Aβ 42 on NPCs and the proapoptotic effect of Aβ 42 on mature neurons. © 2011 Wiley Periodicals, Inc.
β-Amyloid protein (Aβ) is thought to be responsible for neuronal apoptosis in Alzheimer's disease (AD). Paradoxically, Aβ can also promote neurogenesis, both in vitro and in vivo, by inducing neural progenitor cells (NPCs) to differentiate into neurons. However, the mechanisms of Aβ-induced neurogenesis are unknown. Here we examined the role of DNA polymerase-β (DNA pol-β), a DNA repair enzyme that is required for proper neurogenesis during brain development and is also responsible for Aβ-induced neuronal apoptosis. In neurospheres obtained from the adult mouse subventricular zone (SVZ), the knockdown of DNA pol-β or its pharmacological blockade showed that the enzyme functioned both to repress proliferation of early nestin + progenitor cells and to promote the maturation of TuJ-1 + neuronal cells. In neurospheres challenged with oligomers of synthetic Aβ 42, the expression levels of DNA pol-β were rapidly increased. DNA pol-β knockdown prevented the Aβ 42-promoted differentiation of nestin + progenitor cells into nestin +/Dlx-2 + neuroblasts. Moreover, when neurospheres were seeded to allow full differentiation of their elements, blockade of DNA pol-β prevented Aβ 42-induced differentiation of progenitors into MAP-2 + neurons. Thus, our data demonstrate that Aβ 42 arrests the proliferation of a subpopulation of nestin + cells via the induction of DNA pol-β, thereby allowing for their differentiation toward the neuronal lineage. Our findings reveal a novel role of DNA pol-β in Aβ 42-induced neurogenesis and identify DNA pol-β as a key mechanistic link between the neurogenic effect of Aβ 42 on NPCs and the proapoptotic effect of Aβ 42 on mature neurons. © 2011 Wiley Periodicals, Inc.
DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres
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DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres
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Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (552 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (145 views)
Chem Biol Interact (ISSN: 0009-2797linking), 2021 Jan 25; 334: 109300-109301.
Impact Factor: 5.192
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Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (641 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
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Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (528 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
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Colucci-D'Amato L, Cicatiello AE, Reccia MG, Volpicelli F, Severino V, Russo R, Sandomenico A, Doti N, D'Esposito V, Formisano P, Chambery A
* A targeted secretome profiling by multiplexed immunoassay revealed that secreted chemokine ligand 2 (MCP-1/CCL2) affects neural differentiation in mesencephalic neural progenitor cells (588 views)
Proteomics (ISSN: 1615-9853), 2015 Feb; 15(4): 714-724.
Impact Factor: 4.079
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1516 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (688 views)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (490 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (501 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (629 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (555 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (552 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
View Export to BibTeX Export to EndNote
18 Records (18 excluding Abstracts).
Total impact factor: 83.434 (83.434 excluding Abstracts).
Total 5 year impact factor: 84.007 (84.007 excluding Abstracts).
Total impact factor: 83.434 (83.434 excluding Abstracts).
Total 5 year impact factor: 84.007 (84.007 excluding Abstracts).
597 views. Last view on Thursday 23 March 2023, 7:03:30
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