Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1221 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
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Paper type: Journal Article, Comparative Study, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T, Review,
Impact factor: 24.52, 5-year impact factor: 26.723
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34648836983&partnerID=40&md5=2445a8b7daad027f5269ca9b66d38e90
Keywords: Acetylcarnitine, Amide, Arginine, Arginine Derivative, Bilirubin, Carbonate Dehydratase Ii, Carnosine, Curcumin, Cyclic Amp Responsive Element Binding Protein, Cyclic Gmp Derivative, Doxorubicin, Endothelial Nitric Oxide Synthase, Ferulic Acid, Heat Shock Protein, Heme Oxygenase, Hemoglobin, Hemoglobin Derivative, Imidazoline Derivative, Inducible Nitric Oxide Synthase, N(g) Nitroarginine Methyl Ester, Neuronal Nitric Oxide Synthase, Nitric Oxide Donor, Nitro Derivative, Ornithine Derivative, Protein Kinase B, Quinoxaline Derivative, Sildenafil, Thiol Derivative, Tumor Necrosis Factor, Alzheimer Disease, Antiinflammatory Activity, Antioxidant Activity, Brain Ischemia, Brain Region, Cell Survival, Central Nervous System, Chronic Fatigue Syndrome, Cognition, Cognitive Defect, Concentration (parameters), Dementia, Depression, Diabetic Neuropathy, Enzyme Localization, Fluid Balance, Human, Human Immunodeficiency Virus Infection, Huntington Chorea, Impotence, Multiple Sclerosis, Nerve Cell Necrosis, Nerve Cell Plasticity, Neuromodulation, Neuroprotection, Neurotoxicity, Neurotransmission, Nitrosative Stress, Nitrosylation, Nonhuman, Oxidation Reduction Reaction, Priority Journal, Protein Expression, Protein Family, Protein Secretion, Proteomics, Pulmonary Hypertension, Reperfusion Injury, Reproduction, Review, Signal Transduction, Sleep Waking Cycle, Somnolence, Animals, Neurodegenerative Diseases, Neuroprotective Agents, Neurotoxicity Syndromes, N (g) Nitroarginine Methyl Ester,
Affiliations:
*** IBB - CNR ***
Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy. calabres@unict.it
Institute of Pharmacology, Catholic University School of Medicine, Roma, Italy
Department of Internal Medicine, Catholic University School of Medicine, Roma, Italy
References:
Not available.
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Comparative Study, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T, Review,
Impact factor: 24.52, 5-year impact factor: 26.723
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34648836983&partnerID=40&md5=2445a8b7daad027f5269ca9b66d38e90
Keywords: Acetylcarnitine, Amide, Arginine, Arginine Derivative, Bilirubin, Carbonate Dehydratase Ii, Carnosine, Curcumin, Cyclic Amp Responsive Element Binding Protein, Cyclic Gmp Derivative, Doxorubicin, Endothelial Nitric Oxide Synthase, Ferulic Acid, Heat Shock Protein, Heme Oxygenase, Hemoglobin, Hemoglobin Derivative, Imidazoline Derivative, Inducible Nitric Oxide Synthase, N(g) Nitroarginine Methyl Ester, Neuronal Nitric Oxide Synthase, Nitric Oxide Donor, Nitro Derivative, Ornithine Derivative, Protein Kinase B, Quinoxaline Derivative, Sildenafil, Thiol Derivative, Tumor Necrosis Factor, Alzheimer Disease, Antiinflammatory Activity, Antioxidant Activity, Brain Ischemia, Brain Region, Cell Survival, Central Nervous System, Chronic Fatigue Syndrome, Cognition, Cognitive Defect, Concentration (parameters), Dementia, Depression, Diabetic Neuropathy, Enzyme Localization, Fluid Balance, Human, Human Immunodeficiency Virus Infection, Huntington Chorea, Impotence, Multiple Sclerosis, Nerve Cell Necrosis, Nerve Cell Plasticity, Neuromodulation, Neuroprotection, Neurotoxicity, Neurotransmission, Nitrosative Stress, Nitrosylation, Nonhuman, Oxidation Reduction Reaction, Priority Journal, Protein Expression, Protein Family, Protein Secretion, Proteomics, Pulmonary Hypertension, Reperfusion Injury, Reproduction, Review, Signal Transduction, Sleep Waking Cycle, Somnolence, Animals, Neurodegenerative Diseases, Neuroprotective Agents, Neurotoxicity Syndromes, N (g) Nitroarginine Methyl Ester,
Affiliations:
*** IBB - CNR ***
Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy. calabres@unict.it
Institute of Pharmacology, Catholic University School of Medicine, Roma, Italy
Department of Internal Medicine, Catholic University School of Medicine, Roma, Italy
References:
Not available.
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.
At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
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Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
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View Export to BibTeX Export to EndNote
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Di Fiore A, De Simone G, Menchise V, Pedone C, Casini A, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II (571 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Apr 1; 15(7): 1937-1942.
Impact Factor: 2.478
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Postiglione A, Soricelli A, Cicerano U, Mansi L, De Chiara S, Gallotta G, Schettini G, Salvatore M
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct (469 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic, 1043-6618linking), 1991 Apr; 23(3): 241-246.
Impact Factor: 0.47
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27 Records (25 excluding Abstracts).
Total impact factor: 104.598 (94.969 excluding Abstracts).
Total 5 year impact factor: 104.252 (94.438 excluding Abstracts).
Total impact factor: 104.598 (94.969 excluding Abstracts).
Total 5 year impact factor: 104.252 (94.438 excluding Abstracts).
1221 views. Last view on Monday 14 October 2024, 14:43:52
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