Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (581 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.328, 5-year impact factor: 5.498
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77949904455&partnerID=40&md5=7ea9221a3dbfbb6d01c7b25f02702a40
Keywords: Adenocarcinoma Cells, Anti-Cancer Agents, Anti-Cancer Therapies, Antiapoptotic, C Terminus, Cancer Cells, Cetuximab, Concentration-Dependent, Fluorescein Isothiocyanate, Growth Factor, Human Cancer Cells, In-Vitro, Insulin-Like Growth Factor-1, Mcf-7 Breast Cancer Cells, Mcf-7 Cells, Phosphoinositides, Protective Effects, Protein Kinase C, Pulldown Assays, Resistant Cells, Signaling Systems, Synthetic Peptide, Tyrosine Phosphorylation, Amino Acids, Bioactivity, Cell Death, Organic Acids, Phosphatases, Clone Cells, Phosphoinositide Dependent Protein Kinase 1, Protein Kinase C Zeta, Somatomedin C, Somatomedin C Receptor, 3 Phosphoinositide Dependent Protein Kinase, 3-Phosphoinositide-Dependent Protein Kinase, Monoclonal Antibody, Peptide Fragment, Protein Serine Threonine Kinase, Amino Acid Sequence, Animal Cell, Apoptosis, Article, Cancer Inhibition, Carboxy Terminal Sequence, Cell Clone, Cell Strain Mcf 7, Colon Adenocarcinoma, Controlled Study, Enzyme Activation, Enzyme Substrate, Human Cell, Hydrophobicity, In Vitro Study, Nonhuman, Priority Journal, Protein Phosphorylation, Protein Protein Interaction, Signal Transduction, Cell Survival, Drug Resistance, Metabolism, Mouse, Physiology, Protein Binding, Synthesis, Tumor Cell Line, Antibodies, Neoplasm, Protein-Serine-Threonine Kinases, Igf Type 1,
Affiliations:
*** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale Delle Ricerche (CNR), Università di Napoli Federico II, 80131 Naples, Italy
Dipartimento Delle Scienze Biologiche, Università di Napoli Federico II, 80131 Naples, Italy
Istituto di Biostutture e Bioimmagini del CNR, Università di Napoli Federico II, 80131 Naples, Italy
Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Università di Napoli Federico II, 80131 Naples, Italy
References:
Samani, A.A., Yakar, S., LeRoith, D., Brodt, P., (2007) Endocr. Rev., 28, pp. 20-4
Samani, A.A., Brodt, P., (2001) Surg. Oncol. Clin. N. Am., 10, pp. 289-312
Ryan, P.D., Goss, P.E., (2008) Oncologist, 13, pp. 16-24
LeRoith, D., Helman, L., (2004) Cancer Cell., 5, pp. 201-202
Wu, Y., Cui, K., Miyoshi, K., Hennighausen, L., Green, J.E., Setser, J., LeRoith, D., Yakar, S., (2003) Cancer Res., 63, pp. 4384-4388
Zhang, L., Zhou, W., Velculescu, V.E., Kern, S.E., Hruban, R.H., Hamilton, S.R., Vogelstein, B., Kinzler, K.W., (1997) Science, 276, pp. 1268-1272
Ouban, A., Muraca, P., Yeatman, T., Coppola, D., (2003) Hum. Pathol., 34, pp. 803-808
Pollak, M., (2008) Nat. Rev. Cancer, 8, pp. 915-928
(2009) Nat. Rev. Cancer., 9, p. 224. , Correction
Chitnis, M.M., Yuen, J.S., Protheroe, A.S., Pollak, M., Macaulay, V.M., (2008) Clin. Cancer Res., 14, pp. 6364-6370
Mora, A., Komander, D., Van Aalten, D.M., Alessi, D.R., (2004) Semin. Cell. Dev. Biol., 15, pp. 161-170
Biondi, R.M., Komander, D., Thomas, C.C., Lizcano, J.M., Deak, M., Alessi, D.R., Van Aalten, D.M., (2002) EMBO J., 21, pp. 4219-4228
Biondi, R.M., Cheung, P.C., Casamayor, A., Deak, M., Currie, R.A., Alessi, D.R., (2000) EMBO J., 19, pp. 979-988
Hindie, V., Stroba, A., Zhang, H., Lopez-Garcia, L.A., Idrissova, L., Zeuzem, S., Hirschberg, D., Biondi, R.M., (2009) Nat. Chem. Biol., 5, pp. 758-764
Casamayor, A., Morrice, N.A., Alessi, D.R., (1999) Biochem. J., 342, pp. 287-292
Toker, A., Newton, A.C., (2000) J. Biol. Chem., 275, pp. 8271-8274
Wick, M.J., Ramos, F.J., Chen, H., Quon, M.J., Dong, L.Q., Liu, F., (2003) J. Biol. Chem., 278, pp. 42913-42919
Grillo, S., Grémeaux, T., Casamayor, A., Alessi, D.R., Le Marchand-Brustel, Y., Tanti, J.F., (2000) Eur. J. Biochem., 267, pp. 6642-6649
Park, J., Hill, M.M., Hess, D., Brazil, D.P., Hofsteenge, J., Hemmings, B.A., (2001) J. Biol. Chem., 276, pp. 37459-37471
Fiory, F., Alberobello, A.T., Miele, C., Oriente, F., Esposito, I., Corbo, V., Ruvo, M., Beguinot, F., (2005) Mol. Cell. Biol., 25, pp. 10803-10814
Xie, Z., Zeng, X., Waldman, T., Glazer, R.I., (2003) Cancer Res., 63, pp. 5370-5375
Ahmed, N., Riley, C., Quinn, M.A., (2008) Br. J. Cancer, 98, pp. 1415-1424
Peifer, C., Alessi, D.R., (2009) Biochem. J., 417, pp. e5-7
Riedemann, J., Macaulay, V.M., (2006) Endocr. Relat. Cancer, 13, pp. S33-43
Alessi, D.R., James, S.R., Downes, C.P., Holmes, A.B., Gaffney, P.R., Reese, C.B., Cohen, P., (1997) Curr. Biol., 7, pp. 261-269
Kato, H., Faria, T.N., Stannard, B., Roberts Jr., C.T., LeRoith, D.J., (1993) J. Biol. Chem., 268, pp. 2655-2661
Ciardiello, F., Bianco, R., Caputo, R., Caputo, R., Damiano, V., Troiani, T., Melisi, D., Tortora, G., (2004) Clin. Cancer Res., 10, pp. 784-793
Caruso, M., Miele, C., Formisano, P., Condorelli, G., Bifulco, G., Oliva, A., Auricchio, R., Beguinot, F., (1997) J. Biol. Chem., 272, pp. 7290-7297
Formisano, P., Oriente, F., Miele, C., Caruso, M., Auricchio, R., Vigliotta, G., Condorelli, G., Beguinot, F., (1998) J. Biol. Chem., 273, pp. 13197-13202
Formisano, P., Sohn, K.J., Miele, C., Di Finizio, B., Petruzziello, A., Riccardi, G., Beguinot, L., Beguinot, F., (1993) J. Biol. Chem., 268, pp. 5241-5248
Fields, G.B., Noble, R.L., (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Klip, A., Logan, W.J., Li, G., (1982) Biochim. Biophys. Acta, 687, pp. 265-280
Jones, H.E., Gee, J.M., Hutcheson, I.R., Knowlden, J.M., Barrow, D., Nicholson, R.I., (2006) Endocr. Relat. Cancer, 13, pp. S45-51
Tortora, G., Bianco, R., Daniele, G., Ciardiello, F., McCubrey, J.A., Ricciardi, M.R., Ciuffreda, L., Milella, M., (2007) Drug Resist. Updat., 10, pp. 81-100
Miller, B.S., Yee, D., (2005) Cancer Res., 65, pp. 10123-10127
Huang, F., Greer, A., Hurlburt, W., Han, X., Hafezi, R., Wittenberg, G.M., Reeves, K., Carboni, J.M., (2009) Cancer Res., 69, pp. 161-170
Buck, E., Eyzaguirre, A., Rosenfeld-Franklin, M., Thomson, S., Mulvihill, M., Barr, S., Brown, E., Ji, Q.S., (2008) Cancer Res., 68, pp. 8322-8332
Harris, T.K., (2003) IUBMB Life, 55, pp. 117-126
Komander, D., Fairservice, A., Deak, M., Kular, G.S., Prescott, A.R., Peter Downes, C., Safrany, S.T., Van Aalten, D.M., (2004) EMBO J., 23, pp. 3918-3928
Valentinis, B., Baserga, R., (2001) Mol. Pathol., 54, pp. 133-137
Surmacz, E., Sell, C., Swantek, J., Kato, H., Roberts Jr., C.T., LeRoith, D., Baserga, R., (1995) Exp. Cell Res., 218, pp. 370-380
Reiss, K., Yumet, G., Shan, S., Huang, Z., Alnemri, E., Srinivasula, S.M., Wang, J.Y., Baserga, R., (1999) J. Cell. Physiol., 181, pp. 124-135
Hongo, A., Yumet, G., Resnicoff, M., Romano, G., O'Connor, R., Baserga, R., (1998) Cancer Res., 58, pp. 2477-2484
Liu, Y., Lehar, S., Corvi, C., Payne, G., O'Connor, R., (1998) Cancer Res., 58, pp. 570-576
Dunn, S.E., Hardman, R.A., Kari, F.W., Barrett, J.C., (1997) Cancer Res., 57, pp. 2687-2693
Wang, Q., Greene, M.I., (2008) J. Clin. Invest., 118, pp. 2389-2392
Guix, M., Faber, A.C., Wang, S.E., Olivares, M.G., Song, Y., Qu, S., Rinehart, C., Engelman, J.A., (2008) J. Clin. Invest., 118, pp. 2609-2619
Takahari, D., Yamada, Y., Okita, N.T., Honda, T., Hirashima, Y., Matsubara, J., Takashima, A., Shimoda, T., (2009) Oncology, 76, pp. 42-48
Gallego, R., Codony-Servat, J., García-Albéniz, X., Carcereny, E., Longarón, R., Oliveras, A., Tosca, M., Maurel, J., (2009) Endocr. Relat. Cancer, 16, pp. 311-317
Nahta, R., Yuan, L.X., Zhang, B., Kobayashi, R., Esteva, F.J., (2005) Cancer Res., 65, pp. 11118-11128
Barnes, C.J., Ohshiro, K., Rayala, S.K., El-Naggar, A.K., Kumar, R., (2007) Clin. Cancer Res., 13, pp. 4291-4299
Sachdev, D., Singh, R., Fujita-Yamaguchi, Y., Yee, D., (2006) Cancer Res., 66, pp. 2391-2402
Hashimoto, N., Kido, Y., Uchida, T., Asahara, S., Shigeyama, Y., Matsuda, T., Takeda, A., Kasuga, M., (2006) Nat. Genet., 38, pp. 589-593
Duronio, V., (2008) Biochem. J., 415, pp. 333-344
Seynaeve, C.M., Stetler-Stevenson, M., Sebers, S., Kaur, G., Sausville, E.A., Worland, P.J., (1993) Cancer Res., 53, pp. 2081-2086
Kortmansky, J., Shah, M.A., Kaubisch, A., Weyerbacher, A., Yi, S., Tong, W., Sowers, R., Schwartz, G.K., (2005) J. Clin. Oncol., 23, pp. 1875-1884
Jimeno, A., Rudek, M.A., Purcell, T., Laheru, D.A., Messersmith, W.A., Dancey, J., Carducci, M.A., Donehower, R.C., (2008) Cancer Chemother. Pharmacol., 61, pp. 423-433
Hu, Y.P., Patil, S.B., Panasiewicz, M., Li, W., Hauser, J., Humphrey, L.E., Brattain, M.G., (2008) Cancer Res., 68, pp. 8004-8013
Sato, S., Fujita, N., Tsuruo, T., (2004) J. Biol. Chem., 279, pp. 33759-33767
Michel, J.J., Townley, I.K., Dodge-Kafka, K.L., Zhang, F., Kapiloff, M.S., Scott, J.D., (2005) Mol. Cell., 20, pp. 661-672
Samani, A. A., Yakar, S., LeRoith, D., Brodt, P., (2007) Endocr. Rev., 28, pp. 20-4
Samani, A. A., Brodt, P., (2001) Surg. Oncol. Clin. N. Am., 10, pp. 289-312
Ryan, P. D., Goss, P. E., (2008) Oncologist, 13, pp. 16-24
(2009) Nat. Rev. Cancer., 9, p. 224. , Correction
Chitnis, M. M., Yuen, J. S., Protheroe, A. S., Pollak, M., Macaulay, V. M., (2008) Clin. Cancer Res., 14, pp. 6364-6370
Biondi, R. M., Komander, D., Thomas, C. C., Lizcano, J. M., Deak, M., Alessi, D. R., Van Aalten, D. M., (2002) EMBO J., 21, pp. 4219-4228
Biondi, R. M., Cheung, P. C., Casamayor, A., Deak, M., Currie, R. A., Alessi, D. R., (2000) EMBO J., 19, pp. 979-988
Wick, M. J., Ramos, F. J., Chen, H., Quon, M. J., Dong, L. Q., Liu, F., (2003) J. Biol. Chem., 278, pp. 42913-42919
Grillo, S., Gr meaux, T., Casamayor, A., Alessi, D. R., Le Marchand-Brustel, Y., Tanti, J. F., (2000) Eur. J. Biochem., 267, pp. 6642-6649
Park, J., Hill, M. M., Hess, D., Brazil, D. P., Hofsteenge, J., Hemmings, B. A., (2001) J. Biol. Chem., 276, pp. 37459-37471
Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., Cohen, P., (1997) Curr. Biol., 7, pp. 261-269
Fields, G. B., Noble, R. L., (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Jones, H. E., Gee, J. M., Hutcheson, I. R., Knowlden, J. M., Barrow, D., Nicholson, R. I., (2006) Endocr. Relat. Cancer, 13, pp. S45-51
Miller, B. S., Yee, D., (2005) Cancer Res., 65, pp. 10123-10127
Harris, T. K., (2003) IUBMB Life, 55, pp. 117-126
Dunn, S. E., Hardman, R. A., Kari, F. W., Barrett, J. C., (1997) Cancer Res., 57, pp. 2687-2693
Barnes, C. J., Ohshiro, K., Rayala, S. K., El-Naggar, A. K., Kumar, R., (2007) Clin. Cancer Res., 13, pp. 4291-4299
Seynaeve, C. M., Stetler-Stevenson, M., Sebers, S., Kaur, G., Sausville, E. A., Worland, P. J., (1993) Cancer Res., 53, pp. 2081-2086
Hu, Y. P., Patil, S. B., Panasiewicz, M., Li, W., Hauser, J., Humphrey, L. E., Brattain, M. G., (2008) Cancer Res., 68, pp. 8004-8013
Michel, J. J., Townley, I. K., Dodge-Kafka, K. L., Zhang, F., Kapiloff, M. S., Scott, J. D., (2005) Mol. Cell., 20, pp. 661-672
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.328, 5-year impact factor: 5.498
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77949904455&partnerID=40&md5=7ea9221a3dbfbb6d01c7b25f02702a40
Keywords: Adenocarcinoma Cells, Anti-Cancer Agents, Anti-Cancer Therapies, Antiapoptotic, C Terminus, Cancer Cells, Cetuximab, Concentration-Dependent, Fluorescein Isothiocyanate, Growth Factor, Human Cancer Cells, In-Vitro, Insulin-Like Growth Factor-1, Mcf-7 Breast Cancer Cells, Mcf-7 Cells, Phosphoinositides, Protective Effects, Protein Kinase C, Pulldown Assays, Resistant Cells, Signaling Systems, Synthetic Peptide, Tyrosine Phosphorylation, Amino Acids, Bioactivity, Cell Death, Organic Acids, Phosphatases, Clone Cells, Phosphoinositide Dependent Protein Kinase 1, Protein Kinase C Zeta, Somatomedin C, Somatomedin C Receptor, 3 Phosphoinositide Dependent Protein Kinase, 3-Phosphoinositide-Dependent Protein Kinase, Monoclonal Antibody, Peptide Fragment, Protein Serine Threonine Kinase, Amino Acid Sequence, Animal Cell, Apoptosis, Article, Cancer Inhibition, Carboxy Terminal Sequence, Cell Clone, Cell Strain Mcf 7, Colon Adenocarcinoma, Controlled Study, Enzyme Activation, Enzyme Substrate, Human Cell, Hydrophobicity, In Vitro Study, Nonhuman, Priority Journal, Protein Phosphorylation, Protein Protein Interaction, Signal Transduction, Cell Survival, Drug Resistance, Metabolism, Mouse, Physiology, Protein Binding, Synthesis, Tumor Cell Line, Antibodies, Neoplasm, Protein-Serine-Threonine Kinases, Igf Type 1,
Affiliations:
*** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale Delle Ricerche (CNR), Università di Napoli Federico II, 80131 Naples, Italy
Dipartimento Delle Scienze Biologiche, Università di Napoli Federico II, 80131 Naples, Italy
Istituto di Biostutture e Bioimmagini del CNR, Università di Napoli Federico II, 80131 Naples, Italy
Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Università di Napoli Federico II, 80131 Naples, Italy
References:
Samani, A.A., Yakar, S., LeRoith, D., Brodt, P., (2007) Endocr. Rev., 28, pp. 20-4
Samani, A.A., Brodt, P., (2001) Surg. Oncol. Clin. N. Am., 10, pp. 289-312
Ryan, P.D., Goss, P.E., (2008) Oncologist, 13, pp. 16-24
LeRoith, D., Helman, L., (2004) Cancer Cell., 5, pp. 201-202
Wu, Y., Cui, K., Miyoshi, K., Hennighausen, L., Green, J.E., Setser, J., LeRoith, D., Yakar, S., (2003) Cancer Res., 63, pp. 4384-4388
Zhang, L., Zhou, W., Velculescu, V.E., Kern, S.E., Hruban, R.H., Hamilton, S.R., Vogelstein, B., Kinzler, K.W., (1997) Science, 276, pp. 1268-1272
Ouban, A., Muraca, P., Yeatman, T., Coppola, D., (2003) Hum. Pathol., 34, pp. 803-808
Pollak, M., (2008) Nat. Rev. Cancer, 8, pp. 915-928
(2009) Nat. Rev. Cancer., 9, p. 224. , Correction
Chitnis, M.M., Yuen, J.S., Protheroe, A.S., Pollak, M., Macaulay, V.M., (2008) Clin. Cancer Res., 14, pp. 6364-6370
Mora, A., Komander, D., Van Aalten, D.M., Alessi, D.R., (2004) Semin. Cell. Dev. Biol., 15, pp. 161-170
Biondi, R.M., Komander, D., Thomas, C.C., Lizcano, J.M., Deak, M., Alessi, D.R., Van Aalten, D.M., (2002) EMBO J., 21, pp. 4219-4228
Biondi, R.M., Cheung, P.C., Casamayor, A., Deak, M., Currie, R.A., Alessi, D.R., (2000) EMBO J., 19, pp. 979-988
Hindie, V., Stroba, A., Zhang, H., Lopez-Garcia, L.A., Idrissova, L., Zeuzem, S., Hirschberg, D., Biondi, R.M., (2009) Nat. Chem. Biol., 5, pp. 758-764
Casamayor, A., Morrice, N.A., Alessi, D.R., (1999) Biochem. J., 342, pp. 287-292
Toker, A., Newton, A.C., (2000) J. Biol. Chem., 275, pp. 8271-8274
Wick, M.J., Ramos, F.J., Chen, H., Quon, M.J., Dong, L.Q., Liu, F., (2003) J. Biol. Chem., 278, pp. 42913-42919
Grillo, S., Grémeaux, T., Casamayor, A., Alessi, D.R., Le Marchand-Brustel, Y., Tanti, J.F., (2000) Eur. J. Biochem., 267, pp. 6642-6649
Park, J., Hill, M.M., Hess, D., Brazil, D.P., Hofsteenge, J., Hemmings, B.A., (2001) J. Biol. Chem., 276, pp. 37459-37471
Fiory, F., Alberobello, A.T., Miele, C., Oriente, F., Esposito, I., Corbo, V., Ruvo, M., Beguinot, F., (2005) Mol. Cell. Biol., 25, pp. 10803-10814
Xie, Z., Zeng, X., Waldman, T., Glazer, R.I., (2003) Cancer Res., 63, pp. 5370-5375
Ahmed, N., Riley, C., Quinn, M.A., (2008) Br. J. Cancer, 98, pp. 1415-1424
Peifer, C., Alessi, D.R., (2009) Biochem. J., 417, pp. e5-7
Riedemann, J., Macaulay, V.M., (2006) Endocr. Relat. Cancer, 13, pp. S33-43
Alessi, D.R., James, S.R., Downes, C.P., Holmes, A.B., Gaffney, P.R., Reese, C.B., Cohen, P., (1997) Curr. Biol., 7, pp. 261-269
Kato, H., Faria, T.N., Stannard, B., Roberts Jr., C.T., LeRoith, D.J., (1993) J. Biol. Chem., 268, pp. 2655-2661
Ciardiello, F., Bianco, R., Caputo, R., Caputo, R., Damiano, V., Troiani, T., Melisi, D., Tortora, G., (2004) Clin. Cancer Res., 10, pp. 784-793
Caruso, M., Miele, C., Formisano, P., Condorelli, G., Bifulco, G., Oliva, A., Auricchio, R., Beguinot, F., (1997) J. Biol. Chem., 272, pp. 7290-7297
Formisano, P., Oriente, F., Miele, C., Caruso, M., Auricchio, R., Vigliotta, G., Condorelli, G., Beguinot, F., (1998) J. Biol. Chem., 273, pp. 13197-13202
Formisano, P., Sohn, K.J., Miele, C., Di Finizio, B., Petruzziello, A., Riccardi, G., Beguinot, L., Beguinot, F., (1993) J. Biol. Chem., 268, pp. 5241-5248
Fields, G.B., Noble, R.L., (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Klip, A., Logan, W.J., Li, G., (1982) Biochim. Biophys. Acta, 687, pp. 265-280
Jones, H.E., Gee, J.M., Hutcheson, I.R., Knowlden, J.M., Barrow, D., Nicholson, R.I., (2006) Endocr. Relat. Cancer, 13, pp. S45-51
Tortora, G., Bianco, R., Daniele, G., Ciardiello, F., McCubrey, J.A., Ricciardi, M.R., Ciuffreda, L., Milella, M., (2007) Drug Resist. Updat., 10, pp. 81-100
Miller, B.S., Yee, D., (2005) Cancer Res., 65, pp. 10123-10127
Huang, F., Greer, A., Hurlburt, W., Han, X., Hafezi, R., Wittenberg, G.M., Reeves, K., Carboni, J.M., (2009) Cancer Res., 69, pp. 161-170
Buck, E., Eyzaguirre, A., Rosenfeld-Franklin, M., Thomson, S., Mulvihill, M., Barr, S., Brown, E., Ji, Q.S., (2008) Cancer Res., 68, pp. 8322-8332
Harris, T.K., (2003) IUBMB Life, 55, pp. 117-126
Komander, D., Fairservice, A., Deak, M., Kular, G.S., Prescott, A.R., Peter Downes, C., Safrany, S.T., Van Aalten, D.M., (2004) EMBO J., 23, pp. 3918-3928
Valentinis, B., Baserga, R., (2001) Mol. Pathol., 54, pp. 133-137
Surmacz, E., Sell, C., Swantek, J., Kato, H., Roberts Jr., C.T., LeRoith, D., Baserga, R., (1995) Exp. Cell Res., 218, pp. 370-380
Reiss, K., Yumet, G., Shan, S., Huang, Z., Alnemri, E., Srinivasula, S.M., Wang, J.Y., Baserga, R., (1999) J. Cell. Physiol., 181, pp. 124-135
Hongo, A., Yumet, G., Resnicoff, M., Romano, G., O'Connor, R., Baserga, R., (1998) Cancer Res., 58, pp. 2477-2484
Liu, Y., Lehar, S., Corvi, C., Payne, G., O'Connor, R., (1998) Cancer Res., 58, pp. 570-576
Dunn, S.E., Hardman, R.A., Kari, F.W., Barrett, J.C., (1997) Cancer Res., 57, pp. 2687-2693
Wang, Q., Greene, M.I., (2008) J. Clin. Invest., 118, pp. 2389-2392
Guix, M., Faber, A.C., Wang, S.E., Olivares, M.G., Song, Y., Qu, S., Rinehart, C., Engelman, J.A., (2008) J. Clin. Invest., 118, pp. 2609-2619
Takahari, D., Yamada, Y., Okita, N.T., Honda, T., Hirashima, Y., Matsubara, J., Takashima, A., Shimoda, T., (2009) Oncology, 76, pp. 42-48
Gallego, R., Codony-Servat, J., García-Albéniz, X., Carcereny, E., Longarón, R., Oliveras, A., Tosca, M., Maurel, J., (2009) Endocr. Relat. Cancer, 16, pp. 311-317
Nahta, R., Yuan, L.X., Zhang, B., Kobayashi, R., Esteva, F.J., (2005) Cancer Res., 65, pp. 11118-11128
Barnes, C.J., Ohshiro, K., Rayala, S.K., El-Naggar, A.K., Kumar, R., (2007) Clin. Cancer Res., 13, pp. 4291-4299
Sachdev, D., Singh, R., Fujita-Yamaguchi, Y., Yee, D., (2006) Cancer Res., 66, pp. 2391-2402
Hashimoto, N., Kido, Y., Uchida, T., Asahara, S., Shigeyama, Y., Matsuda, T., Takeda, A., Kasuga, M., (2006) Nat. Genet., 38, pp. 589-593
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Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death
Insulin-like growth factor-1 (IGF-1) signaling system exerts a broad antiapoptotic function and plays a crucial role in resistance to anticancer therapies. Exposure of MCF-7 breast cancer cells to IGF-1 rapidly and transiently induced tyrosine phosphorylation and activation of phosphoinositide-dependent kinase-1 (PDK1). This was paralleled by Akt/protein kinase B and protein kinase C-zeta phosphorylation, at Thr(308) and Thr(410), respectively. IGF-1 treatment also enhanced PDK1 interaction with IGF-1 receptor (IGF-1R) in intact MCF-7 cells. Pulldown assays revealed that PDK1 bound IGF-1R in vitro and that the region encompassing amino acids 51-359 of PDK1 was necessary for the interaction. Synthetic peptides corresponding to IGF-1R C terminus amino acids 1295-1337 (C43) and to PDK1 amino acids 114-141 reduced in vitro IGF-1R/PDK1 interaction in a concentration-dependent manner. Loading of fluoresceinated-C43 (fluorescein isothiocyanate (FITC)-C43) into MCF-7 cells significantly reduced IGF-1R/PDK1 interaction and phosphorylation of PDK1 substrates. Moreover, FITC-C43 intracellular loading reverted the protective effect of IGF-1 on growth factor deprivation-induced cell death. Finally, the inhibition of IGF-1R/PDK1 interaction and signaling by FITC-C43 was accompanied by 2-fold enhanced killing capacity of cetuximab in human GEO colon adenocarcinoma cells and was sufficient to restore cell death in cetuximab-resistant cell clones. Thus, disruption of PDK1 interaction with IGF-1R reduces IGF-1 survival effects in cancer cells and may enhance cell death by anticancer agents.
Insulin-like growth factor-1 (IGF-1) signaling system exerts a broad antiapoptotic function and plays a crucial role in resistance to anticancer therapies. Exposure of MCF-7 breast cancer cells to IGF-1 rapidly and transiently induced tyrosine phosphorylation and activation of phosphoinositide-dependent kinase-1 (PDK1). This was paralleled by Akt/protein kinase B and protein kinase C-zeta phosphorylation, at Thr(308) and Thr(410), respectively. IGF-1 treatment also enhanced PDK1 interaction with IGF-1 receptor (IGF-1R) in intact MCF-7 cells. Pulldown assays revealed that PDK1 bound IGF-1R in vitro and that the region encompassing amino acids 51-359 of PDK1 was necessary for the interaction. Synthetic peptides corresponding to IGF-1R C terminus amino acids 1295-1337 (C43) and to PDK1 amino acids 114-141 reduced in vitro IGF-1R/PDK1 interaction in a concentration-dependent manner. Loading of fluoresceinated-C43 (fluorescein isothiocyanate (FITC)-C43) into MCF-7 cells significantly reduced IGF-1R/PDK1 interaction and phosphorylation of PDK1 substrates. Moreover, FITC-C43 intracellular loading reverted the protective effect of IGF-1 on growth factor deprivation-induced cell death. Finally, the inhibition of IGF-1R/PDK1 interaction and signaling by FITC-C43 was accompanied by 2-fold enhanced killing capacity of cetuximab in human GEO colon adenocarcinoma cells and was sufficient to restore cell death in cetuximab-resistant cell clones. Thus, disruption of PDK1 interaction with IGF-1R reduces IGF-1 survival effects in cancer cells and may enhance cell death by anticancer agents.
Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death
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Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (202 views)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Impact Factor: 0
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Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (478 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
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Roviello GN, Musumeci D, Roviello V, Pirtskhalava M, Egoyan A, Mirtskhulava M
* Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure (380 views)
Beilstein J Nanotech (ISSN: 2190-4286), 2015; 6(1): 1338-1347.
Impact Factor: 2.778
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Travaglia A, Arena G, Fattorusso R, Isernia C, La Mendola D, Malgieri G, Nicoletti VG, Rizzarelli E
* The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor (499 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Mar 21; 17(13): 3726-3738.
Impact Factor: 5.925
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* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (202 views)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (478 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, Roviello V, Pirtskhalava M, Egoyan A, Mirtskhulava M
* Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure (380 views)
Beilstein J Nanotech (ISSN: 2190-4286), 2015; 6(1): 1338-1347.
Impact Factor: 2.778
View Export to BibTeX Export to EndNote
Travaglia A, Arena G, Fattorusso R, Isernia C, La Mendola D, Malgieri G, Nicoletti VG, Rizzarelli E
* The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor (499 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Mar 21; 17(13): 3726-3738.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
4 Records (4 excluding Abstracts).
Total impact factor: 12.772 (12.772 excluding Abstracts).
Total 5 year impact factor: 12.922 (12.922 excluding Abstracts).
Total impact factor: 12.772 (12.772 excluding Abstracts).
Total 5 year impact factor: 12.922 (12.922 excluding Abstracts).
581 views. Last view on Saturday 13 May 2023, 4:18:07
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