Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates(1416 views) Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Mar 26; 24(18): 4729-4735.
Institute of Biostructure and Bioimaging, National Research Council", via Mezzocannone 16, 80134, Naples, Italy., Department of Pharmacy, University of Naples "Federico II", via Mezzocannone 16, 80134, Naples, Italy., Department of Physics, University of Naples "Federico II", via Cintia, Naples, Italy., Analytical Chemistry for the Environment and CeSMA (Centro Servizi Metrologici Avanzati), University of Naples "Federico II", via N. Protopisani, 80146, Naples, Italy., Institute of Crystallography, National Research Council, Via Amendola 126/O, Bari, Italy., University of Milan, via Venezian 21, 20133, Milan, Italy.,
References: Not available.
Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates
The study of molecules that self-assemble through noncovalent
interactions is one of the most attractive topics in supramolecular
chemistry. The use of short peptides or modified nucleotides as building
blocks for the aggregates is particularly intriguing because these are
very easy to synthesize; moreover, subtle changes in the chemical
structure of such building blocks may drastically affect the properties
of the aggregates. The ability of peptide nucleic acids (PNA) to
aggregate has been very little explored, despite its practical
applications. In this work we investigated the self-assembling
properties of a PNA dimer, conjugated at the N-terminus to a
fluorenylmethoxycarbonyl group. This PNA dimer forms nano-aggregates at
low concentration in CHCl
3
/CH
3
OH mixtures. The
aggregates retain very interesting fluorescent properties (high quantum
yield in the visible region with lifetimes on the nanosecond scale),
which make them promising materials for applications in optoelectronics.
Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates