Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (584 views)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
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Paper type: Journal Article,
Impact factor: 3.159, 5-year impact factor: 2.837
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84878062037&partnerID=40&md5=bf7c5dcaf83c3ee9541f62a51138dead
Keywords: Amyloid Beta Protein [1-42], Cupric Ion, Thioflavine, Zinc Ion, Article, Beta Sheet, Cerebrospinal Fluid, Circular Dichroism, Fluorescence Analysis, Priority Journal, Protein Conformation, Scanning Force Microscopy, Thioflavin T Fluorescence Assay, Amyloid Beta Protein[1-42],
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging of Catania, National Research Council, V. le A. Doria 6, 95125 Catania, Italy
Department of Chemical Science, University of Catania, V. le A. Doria 6, 95125 Catania, Italy
Department of Physics and Chemistry, University of Palermo, V. le delle Scienze Bld 17 - Parco d'Orleans II, 90128 Palermo, Italy
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269-3192, United States
Department of Biophysics, University of Michigan, Ann Arbor, MI 48109-1055, United States
References:
Not available.
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.159, 5-year impact factor: 2.837
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84878062037&partnerID=40&md5=bf7c5dcaf83c3ee9541f62a51138dead
Keywords: Amyloid Beta Protein [1-42], Cupric Ion, Thioflavine, Zinc Ion, Article, Beta Sheet, Cerebrospinal Fluid, Circular Dichroism, Fluorescence Analysis, Priority Journal, Protein Conformation, Scanning Force Microscopy, Thioflavin T Fluorescence Assay, Amyloid Beta Protein[1-42],
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging of Catania, National Research Council, V. le A. Doria 6, 95125 Catania, Italy
Department of Chemical Science, University of Catania, V. le A. Doria 6, 95125 Catania, Italy
Department of Physics and Chemistry, University of Palermo, V. le delle Scienze Bld 17 - Parco d'Orleans II, 90128 Palermo, Italy
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269-3192, United States
Department of Biophysics, University of Michigan, Ann Arbor, MI 48109-1055, United States
References:
Not available.
Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study
Aβ aggregation is a central event in Alzheimer's disease (AD). In vitro evidence indicates that Aβ aggregation and fibrillogenesis are significantly influenced by the employed experimental conditions. Indeed, although it is widely established that metal ions, such as copper and zinc, have significant effects on the Aβ aggregation process, their actual role in Aβ fibrillogenesis is still debated. In this work the effects of a molar excess of zinc(ii) and/or copper(ii) ions on the Aβ42 aggregation process and the morphology of the resultant aggregates have been compared in samples exhibiting different initial conformations. CD spectroscopy, Th-T-induced fluorescence and Scanning Force Microscopy (SFM) measurements indicated that both metal ions accelerate the aggregation process, yet significantly affect the morphology of aggregates. In particular, copper(ii) ions were the most effective in promoting non-fibrillar, amorphous Aβ aggregates. These results further support the hypothesis that an altered distribution of metal ions in neurons might drive alternative Aβ aggregation pathways. © 2013 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
Aβ aggregation is a central event in Alzheimer's disease (AD). In vitro evidence indicates that Aβ aggregation and fibrillogenesis are significantly influenced by the employed experimental conditions. Indeed, although it is widely established that metal ions, such as copper and zinc, have significant effects on the Aβ aggregation process, their actual role in Aβ fibrillogenesis is still debated. In this work the effects of a molar excess of zinc(ii) and/or copper(ii) ions on the Aβ42 aggregation process and the morphology of the resultant aggregates have been compared in samples exhibiting different initial conformations. CD spectroscopy, Th-T-induced fluorescence and Scanning Force Microscopy (SFM) measurements indicated that both metal ions accelerate the aggregation process, yet significantly affect the morphology of aggregates. In particular, copper(ii) ions were the most effective in promoting non-fibrillar, amorphous Aβ aggregates. These results further support the hypothesis that an altered distribution of metal ions in neurons might drive alternative Aβ aggregation pathways. © 2013 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study
| ▼ Relaxometry based MRI brain segmentation |
Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study
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* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (506 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
Impact Factor: 4.429
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Langella E, Improta R, Barone V
* Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: Effect of protonation of histidine residues (569 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2004 Dec; 87(6): 3623-3632.
Impact Factor: 4.585
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Merlino A, Vitagliano L, Ceruso MA, Mazzarella L
* Subtle functional collective motions in pancreatic-like ribonucleases: From ribonuclease A to angiogenin (471 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2003 Oct 1; 53(1): 101-110.
Impact Factor: 4.313
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Quarantelli M, Ciarmiello A, Morra VB, Orefice G, Larobina M, Lanzillo R, Schiavone V, Salvatore E, Alfano B, Brunetti A
* Brain tissue volume changes in relapsing-remitting multiple sclerosis: Correlation with lesion load (560 views) (PDF 253 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2003 Feb; 18(2): 360-366.
Impact Factor: 6.192
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (874 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Merlino A, Vitagliano L, Ceruso M, Di Nola A, Mazzarella L
* Global and local motions in ribonuclease A: A molecular dynamics study (527 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002 Nov 15; 65(4): 274-283.
Impact Factor: 2.372
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Quarantelli M, Larobina M, Volpe U, Amati G, Tedeschi E, Ciarmiello A, Brunetti A, Galderisi S, Alfano B
* Stereotaxy-based regional brain volumetry applied to segmented MRI: Validation and results in deficit and nondeficit schizophrenia (626 views) (PDF 235 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2002 Sep; 17(1): 373-384.
Impact Factor: 5.624
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Aloj L, Fatone G, Mainolfi C, Lamagna B, Meomartino L, Potena A, Alfano B, Brunetti A
* Cerebrospinal fluid clearance studies in rabbits (321 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Alfano B, Quarantelli M, Brunetti A, Larobina M, Covelli EM, Tedeschi E, Salvatore M
Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation (808 views) (PDF 616 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1998 Mar; 39(3): 497-499.
Impact Factor: 2.962
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Alfano B, Brunetti A, Covelli EM, Quarantelli M, Panico M, Ciarmiello A, Salvatore M
Unsupervised, automated segmentation of the normal brain using a multispectral relaxometric magnetic resonance approach (773 views) (PDF 710 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1997 Jan; 37(1): 84-93.
Impact Factor: 3.012
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ALFANO B, ARPAIA M, BRUNETTI A, COVELLI E, CASTELLI L, CARACO C, SORICELLI A, TEDESCHI E, SALVATORE M
Automatic segmentation and evaluation of the volume of gray matter, white matter and cerebrospinal fluid by MRI (370 views)
Neuroradiology 1994, 1994; N/D: N/D-N/D.
Impact Factor: 0
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* Diphenylalanine Motif Drives Self-Assembling in Hybrid PNA-Peptide Conjugates (46 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2021 Oct 13; 27(57): 14307-14316.
Impact Factor: 5.236
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Megna R, Alfano B, Lanzillo R, Costabile T, Comerci M, Vacca G, Carotenuto A, Moccia M, Servillo G, Prinster A, Brescia Morra V, Quarantelli M
* Brain tissue volumes and relaxation rates in multiple sclerosis: implications for cognitive impairment (351 views) (PDF 35 views)
J Neurol (ISSN: 1432-1459electronic, 0340-5354linking, 0340-5354print), 2019 Feb; 266(2): 361-368.
Impact Factor: 3.853
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Pontillo G, Cocozza S, Brunetti A, Brescia Morra V, Riccio E, Russo C, Sacca F, Tedeschi E, Pisani A, Quarantelli M
* Reduced Intracranial Volume in Fabry Disease: Evidence of Abnormal Neurodevelopment? (359 views)
Front Neurol (ISSN: 1664-2295linking, 1664-2295print), 2018 Aug 17; 9(AUG): 672-672.
Impact Factor: 3.508
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Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (468 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2018 Jun; 31(6): e3920-N/D.
Impact Factor: 2.872
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Lanzillo R, Quarantelli M, Pozzilli C, Trojano M, Amato MP, Marrosu MG, Francia A, Florio C, Orefice G, Tedeschi G, Bellantonio P, Annunziata P, Grimaldi LM, Comerci M, Brunetti A, Bonavita V, Alfano B, Marini S, Brescia Morra V
* No evidence for an effect on brain atrophy rate of atorvastatin add-on to interferon β1b therapy in relapsing-remitting multiple sclerosis (the ARIANNA study) (589 views) (PDF 33 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2016 Aug; 22(9): 1163-1173.
Impact Factor: 4.84
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (710 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
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Patti F, De Stefano M, Lavorgna L, Messina S, Chisari CG, Ippolito D, Lanzillo R, Vacchiano V, Realmuto S, Valentino P, Coniglio G, Buccafusca M, Paolicelli D, D'Ambrosio A, Montella P, Morra VB, Savettieri G, Alfano B, Gallo A, Simone I, Viterbo R, Zappia M, Bonavita S, Tedeschi G
* Lesion load may predict long-term cognitive dysfunction in multiple sclerosis patients (641 views)
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Impact Factor: 3.057
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (569 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
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Sinopoli A, Magri A, Milardi D, Pappalardo M, Pucci P, Flagiello A, Titman JJ, Nicoletti VG, Caruso G, Pappalardo G, GrassoG
* The role of copper(II) in the aggregation of human amylin (625 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014 Oct; 6(10): 1841-1852.
Impact Factor: 3.585
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De Simone R, Ranieri A, Montella S, Cappabianca P, Quarantelli M, Esposito F, Cardillo G, Bonavita V
* Intracranial pressure in unresponsive chronic migraine (588 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 0340-5354print), 2014 Jul; 261(7): 1365-1373.
Impact Factor: 3.377
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Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (1434 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014 Jun 23; 81: 442-455.
Impact Factor: 3.447
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (866 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
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GrassoG, Magrì A, Bellia F, Pietropaolo A, La Mendola D, Rizzarelli E
* The Copper (ii) And Zinc (ii) Coordination Mode Of Hexxh And Hxxeh Motif In Small Peptides: The Role Of Carboxylate Location And Hydrogen Bonding Network (601 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Jan; 130(1): 92-102.
Impact Factor: 3.444
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Bellia F, Oliveri V, Rizzarelli E, Vecchio G
* New derivative of carnosine for nanoparticle assemblies (539 views)
Eur J Med Chem (ISSN: 1768-3254, 0223-5234, 1768-3254electronic), 2013 Dec; 70: 225-232.
Impact Factor: 3.432
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Dubbioso R, Pappata S, Quarantelli M, D'Arco F, Manganelli F, Esposito M, Santoro L
* Atypical Clinical And Radiological Presentation Of Cryptococcal Choroid Plexitis In An Immunocompetent Woman (432 views)
J Neurol Sci (ISSN: 1878-5883, 0022-510x, 0022-510xlinking), 2013 Nov 15; 334(1-2): 180-182.
Impact Factor: 1.453
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (741 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
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De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L
* The Intrinsic Stability Of The Human Prion Beta-Sheet Region Investigated By Molecular Dynamics (830 views)
Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.
Impact Factor: 2.983
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Ferraro F, Marano E, Petruzzi J, Tedeschi E, Santulli L, Elefante A
* Spontaneous intracranial hypotension and epidural blood patch: A report involving seven cases (422 views)
Anaesth Intensive Care (ISSN: 0310-057x), 2013 May; 41(3): 393-396.
Impact Factor: 1.47
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (1099 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M
* Peptide inhibitors against herpes simplex virus infections (1467 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Mar; 19(3): 148-158.
Impact Factor: 1.862
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Roviello GN, Mottola A, Musumeci D, Bucci EM, Pedone C
* Synthesis and aggregation properties of a novel enzymatically resistant nucleoamino acid (554 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Oct; 43(4): 1465-1470.
Impact Factor: 3.914
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Stanzione F, De Simone A, Esposito L, Vitagliano L
* Dynamical Properties of Steric Zipper Polymorphs Formed by a IAPP-Derived Peptide (532 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Sep; 19(8): 846-851.
Impact Factor: 1.994
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Jószai V, Turi I, Kállay C, Pappalardo G, Di Natale G, Rizzarelli E, Sóvágó I
* Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein (544 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jul; 112: 17-24.
Impact Factor: 3.197
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Elefante A, Peca C, Del Basso DCM, Russo C, Formicola F, Mariniello G, Brunetti A, Maiuri F
* Symptomatic spinal cord metastasis from cerebral oligodendroglioma (536 views)
Neurol Sci (ISSN: 1590-1874, 1590-3478, 1590-1874linking), 2012 Jun; 33(3): 609-613.
Impact Factor: 1.412
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (701 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Castellano I, Merlino A
* γ-glutamyltranspeptidases: Sequence, structure, biochemical properties, and biotechnological applications (474 views)
Cell Mol Life Sci (ISSN: 1420-682x), 2012; 69(20): 3381-3394.
Impact Factor: 5.615
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Dinacci D, Tessitore A, Russo AA, De Bonis ML, Lavorgna L, Picconi O, Sacco R, Bonavita S, Gallo A, Servillo G, Marcuccio L, Comerci M, Galletti P, Alfano B, Tedeschi G
* BDNF Val66Met polymorphism and brain volumes in multiple sclerosis (510 views) (PDF 258 views)
Neurol Sci (ISSN: 1590-1874, 1590-3478, 1590-1874linking), 2011 Feb; 32(1): 117-123.
Impact Factor: 1.315
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Pedone E, Limauro D, D'Ambrosio K, De Simone G, Bartolucci S
* Multiple catalytically active thioredoxin folds: a winning strategy for many functions (989 views)
Cell Mol Life Sci Cellular And Molecular Life Sciences (ISSN: 1420-682x), 2010 Nov; 67(22): 3797-3814.
Impact Factor: 7.047
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Turi I, Kállay C, Szikszai D, Pappalardo G, Di Natale G, De Bona P, Rizzarelli E, Sóvágó I
* Nickel(II) complexes of the multihistidine peptide fragments of human prion protein (557 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2010 Sep; 104(8): 885-891.
Impact Factor: 3.317
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Sciacca MFM, Pappalardo M, Attanasio F, Milardi D, La Rosa C, Grasso DM
* Are fibril growth and membrane damage linked processes? An experimental and computational study of IAPP(12-18) and IAPP(21-27) peptides (494 views)
New J Chem (ISSN: 1144-0546), 2010; 34(2): 200-207.
Impact Factor: 2.631
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Vitagliano L, Stanzione F, De Simone A, Esposito L
* Dynamics and Stability of Amyloid-Like Steric Zipper Assemblies with Hydrophobic Dry Interfaces (923 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1161-1171.
Impact Factor: 2.605
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Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (667 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
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Palladino P, Ronga L, Benedetti E, Rossi F, Ragone R
* Peptide Fragment Approach to Prion Misfolding: The Alpha-2 Domain (499 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2009 Sep; 15(3): 165-176.
Impact Factor: 0.869
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (539 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (806 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (543 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
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Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R
* Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis (763 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009 Jan 9; 385(1): 153-162.
Impact Factor: 3.871
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Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (811 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
Impact Factor: 2.648
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (513 views)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
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Di Natale G, Damante CA, Nagy Z, Osz K, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) binding to two novel histidine-containing model hexapeptides: evidence for a metal ion driven turn conformation (521 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2008 Nov; 102(11): 2012-2019.
Impact Factor: 3.133
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Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
* Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein α2-helical 180-195 segment and comparison with full-length α2-helix-derived peptides (517 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008; 14(10): 1096-1102.
Impact Factor: 1.654
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Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G
* Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (488 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Impact Factor: 2.301
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Ronga L, Langella E, Palladino P, Marasco D, Tizzano B, Saviano M, Pedone C, Improta R, Ruvo M
* Does Tetracycline Bind Helix 2 Of Prion? An Integrated Spectroscopical And Computational Study Of The Interaction Between The Antibiotic And Alpha Helix 2 Human Prion Protein Fragments (733 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Feb 15; 66(3): 707-715.
Impact Factor: 3.354
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (568 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (610 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 83-90.
Impact Factor: 3.259
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (525 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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Crisma M, Saviano M, Moretto A, Broxterman QB, Kaptein B, Toniolo C
* Peptide α/310-helix dimorphism in the crystal state (497 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2007; 129(50): 15471-15473.
Impact Factor: 7.885
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Ronga L, Palladino P, Tizzano B, Marasco D, Benedetti E, Ragone R, Rossi F
* Effect of salts on the structural behavior of hPrP α2-helix-derived analogues: The counterion perspective (566 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 790-795.
Impact Factor: 1.801
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Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (972 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
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Quarantelli M, Lanzillo R, Del Vecchio W, Mollica C, Prinster A, Iadicicco L, Iodice V, Santoro L, Salvatore M
* Modifications of brain tissue volumes in facioscapulohumeral dystrophy (789 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2006 Sep; 32(3): 1237-1242.
Impact Factor: 5.559
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Merlino A, Esposito L, Vitagliano L
* Polyglutamine Repeats And Beta-Helix Structure: Molecular Dynamics Study (742 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jun 1; 63(4): 918-927.
Impact Factor: 3.73
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (876 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Tizzano B, Palladino P, De Capua A, Marasco D, Rossi F, Benedetti E, Pedone C, Ragone R, Ruvo M
* The Human Prion Protein Alpha2 Helix: A Thermodynamic Study Of Its Conformational Preferences (771 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2005 Apr 1; 59(1): 72-79.
Impact Factor: 4.684
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Merlino A, Ceruso MA, Vitagliano L, Mazzarella L
* Open interface and large quaternary structure movements in 3D domain swapped proteins: Insights from molecular dynamics simulations of the C-terminal swapped dimer of ribonuclease (736 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2005 Mar; 88(3): 2003-2012.
Impact Factor: 4.507
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Merlino A, Graziano G, Mazzarella L
* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (506 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
Impact Factor: 4.429
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Langella E, Improta R, Barone V
* Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: Effect of protonation of histidine residues (569 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2004 Dec; 87(6): 3623-3632.
Impact Factor: 4.585
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Merlino A, Vitagliano L, Ceruso MA, Mazzarella L
* Subtle functional collective motions in pancreatic-like ribonucleases: From ribonuclease A to angiogenin (471 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2003 Oct 1; 53(1): 101-110.
Impact Factor: 4.313
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Quarantelli M, Ciarmiello A, Morra VB, Orefice G, Larobina M, Lanzillo R, Schiavone V, Salvatore E, Alfano B, Brunetti A
* Brain tissue volume changes in relapsing-remitting multiple sclerosis: Correlation with lesion load (560 views) (PDF 253 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2003 Feb; 18(2): 360-366.
Impact Factor: 6.192
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (874 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Merlino A, Vitagliano L, Ceruso M, Di Nola A, Mazzarella L
* Global and local motions in ribonuclease A: A molecular dynamics study (527 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002 Nov 15; 65(4): 274-283.
Impact Factor: 2.372
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Quarantelli M, Larobina M, Volpe U, Amati G, Tedeschi E, Ciarmiello A, Brunetti A, Galderisi S, Alfano B
* Stereotaxy-based regional brain volumetry applied to segmented MRI: Validation and results in deficit and nondeficit schizophrenia (626 views) (PDF 235 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2002 Sep; 17(1): 373-384.
Impact Factor: 5.624
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Aloj L, Fatone G, Mainolfi C, Lamagna B, Meomartino L, Potena A, Alfano B, Brunetti A
* Cerebrospinal fluid clearance studies in rabbits (321 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Alfano B, Quarantelli M, Brunetti A, Larobina M, Covelli EM, Tedeschi E, Salvatore M
Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation (808 views) (PDF 616 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1998 Mar; 39(3): 497-499.
Impact Factor: 2.962
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Alfano B, Brunetti A, Covelli EM, Quarantelli M, Panico M, Ciarmiello A, Salvatore M
Unsupervised, automated segmentation of the normal brain using a multispectral relaxometric magnetic resonance approach (773 views) (PDF 710 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1997 Jan; 37(1): 84-93.
Impact Factor: 3.012
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ALFANO B, ARPAIA M, BRUNETTI A, COVELLI E, CASTELLI L, CARACO C, SORICELLI A, TEDESCHI E, SALVATORE M
Automatic segmentation and evaluation of the volume of gray matter, white matter and cerebrospinal fluid by MRI (370 views)
Neuroradiology 1994, 1994; N/D: N/D-N/D.
Impact Factor: 0
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65 Records (62 excluding Abstracts).
Total impact factor: 230.335 (222.52 excluding Abstracts).
Total 5 year impact factor: 236.559 (227.448 excluding Abstracts).
Total impact factor: 230.335 (222.52 excluding Abstracts).
Total 5 year impact factor: 236.559 (227.448 excluding Abstracts).
584 views. Last view on Tuesday 08 October 2024, 6:02:29
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