New SPECT and PET dementia tracers (358 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
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Paper type: Journal Article,
Impact factor: 0.155, 5-year impact factor: 0.141
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-61649092986&partnerID=40&md5=3ad44b560876f279b05a3eba3252a243
Keywords: Amyloid Deposit, Dementia, Neurochemical Imaging, Neuroinflammation, Neurotransmission, 3 (2 Azetidinylmethoxy)pyridine F 18, 3 (2 Azetidinylmethoxy)pyridine I 123, 8 Chloro 2, 5 Tetrahydro 3 Methyl 5 Phenyl 1h 3 Benzazepin 7 Ol Hydrogen Maleate C 11, Altanserin F 18, Av 45, Dpa 714, N [(1 Ethyl 2 Pyrrolidinyl)methyl] 3 Iodo 6 Methoxysalicylamide I 123, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl]ethyl] N (2 Pyridyl)cyclohexanecarboxamide C 11, N Sec Butyl 1 (2 Chlorophenyl) N Methyl 3 Isoquinolinecarboxamide C 11, Neurotransmitter, Nicotine C 11, R 91150, Raclopride C 11, Setoperone F 18, Tracer, Unclassified Drug, Vesamicol Derivative, Alzheimer Disease, Cholinergic System, Disease Course, Dopaminergic System, Human, Nerve Degeneration, Neurofilament, Neuroimaging, Neuropathology, Positron Emission Tomography, Serotoninergic System, Short Survey, Single Photon Emission Computer Tomography, 3 (2 Azetidinylmethoxy) Pyridine F 18, 3 (2 Azetidinylmethoxy) Pyridine I 123, N [(1 Ethyl 2 Pyrrolidinyl) Methyl] 3 Iodo 6 Methoxysalicylamide I 123, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl] Ethyl] N (2 Pyridyl) Cyclohexanecarboxamide C 11,
Affiliations:
*** IBB - CNR ***
Inserm U930, université François-Rabelais, 37000 Tours, France
Inserm U930, service de médecine nucléaire in vitro, hôpital Bretonneau, 2, boulevard Tonnellé, 37044 Tours cedex 9, France
Institute of Biostructure and Bioimaging, CNR, 80131 Naples, Italy
References:
Robbins, T.W., Dopamine and cognition (2003) Curr Opin Neurol, 16 (SUPPL.-2), pp. S1-S
Piggott, M.A., Marshall, E.F., Thomas, N., Lloyd, S., Court, J.A., Jaros, E., Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution (1999) Brain, 122, pp. 1449-1468
Huey, E.D., Putnam, K.T., Grafman, J., A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia (2006) Neurology, 66, pp. 17-22
Hendricksen, M., Thomas, A.J., Ferrier, I.N., Ince, P., O'Brien, J.T., Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression (2004) Am J Psychiatry, 161, pp. 1096-1102
Meltzer, C.C., Smith, G., DeKosky, S.T., Pollock, B.G., Mathis, C.A., Moore, R.Y., Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging (1998) Neuropsychopharmacology, 18, pp. 407-430
Kepe, V., Barrio, J.R., Huang, S.C., Ercoli, L., Siddarth, P., Shoghi-Jadid, K., Serotonin 1A receptors in the living brain of Alzheimer's disease patients (2006) Proc Natl Acad Sci U S A, 103, pp. 702-707
Doder, M., Rabiner, E.A., Turjanski, N., Lees, A.J., Brooks, D.J., Tremor in Parkinson's disease and serotonergic dysfunction: an (11)C-WAY100635 PET study (2003) Neurology, 60, pp. 601-605
Franceschi, M., Anchisi, D., Pelati, O., Zuffi, M., Matarrese, M., Moresco, R.M., Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration (2005) Ann Neurol, 57, pp. 216-225
James, M., Fulton, R., Vercoullie, J., Henderson, D., Garreau, L., Chalon, S., DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization (2008) J Nucl Med, 49, pp. 814-822
Venneti, S., Lopresti, B., Wiley, C., The peripheral benzodiazepine receptor in microglia: from pathology to imaging (2006) Prog Neurobiol, 80, pp. 308-322
Braak, H., Braak, E., Frequency of stages of Alzheimer-related lesions in different age categories (1997) Neurobiol Aging, 18, pp. 351-357
Villemagne, V.L., Fodero-Tavoletti, M.T., Pike, K.E., Cappai, R., Masters, C.L., Rowe, C.C., The ART of loss: Abeta imaging in the evaluation of Alzheimer's disease and other dementias (2008) Mol Neurobiol., 38, pp. 1-15
Gomperts, S.N., Rentz, D.M., Moran, E., Becker, J.A., Locascio, J.J., Klunk, W.E., Imaging amyloid deposition in Lewy body diseases (2008) Neurology., 71, pp. 903-910
Francis, P.T., Palmer, A.M., Snape, M., Wilcock, G.K., The cholinergic hypothesis of Alzheimer's disease: a review of progress (1999) J Neurol Neurosurg Psychiatry, 66, pp. 137-147
Ruberg, M., Rieger, F., Villageois, A., Bonnet, A.M., Agid, Y., Acetylcholinesterase and butyrylcholinesterase in frontal cortex and cerebrospinal fluid of demented and non-demented patients with Parkinson's disease (1986) Brain Res, 362, pp. 83-91
Perry, E.K., Haroutunian, V., Davis, K.L., Levy, R., Lantos, P., Eagger, S., Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease (1994) Neuroreport, 5, pp. 747-749
Warren, N.M., Piggott, M.A., Perry, E.K., Burn, D.J., Cholinergic systems in progressive supranuclear palsy (2005) Brain, 128, pp. 239-249
Mesulam, M., Siddique, T., Cohen, B., Cholinergic denervation in a pure multi-infarct state: observations on CADASIL (2003) Neurology, 60, pp. 1183-1185
Perry, E., Walker, M., Grace, J., Perry, R., Acetylcholine in mind: a neurotransmitter correlate of consciousness? (1999) Trends Neurosci, 22, pp. 273-280
Mazière, J., Prunier, C., Barret, O., Guyot, M., Hommet, C., Guilloteau, D., In vivo SPECT imaging of vesicular acetylcholine transporter using [123I]-IBVM in early Alzheimer's disease (2008) Neuroimaging, 40, pp. 280-288
Shinotoh, H., Fukushi, K., Nagatsuka, S., Irie, T., Acetylcholinesterase imaging: its use in therapy evaluation and drug design (2004) Curr Pharm Des, 10, pp. 1505-1517
Bottlaender, M., Valette, H., Roumenov, D., Dollé, F., Coulon, C., Ottaviani, M., Biodistribution and radiation dosimetry of 18F-fluoro-A-85380 in healthy volunteers (2003) J Nucl Med, 44, pp. 596-601
(2008) International Conference of Alzheimer Disease, , Avid Radiopharmaceuticals Inc, Chicago
Blin, J., Baron, J.C., Dubois, B., Crouzel, C., Fiorelli, M., Attar-Levy, D., Loss of brain 5-HT2 receptors in Alzheimer's disease. In vivo assessment with positron emission tomography and [18F]setoperone (1993) Brain, 116, pp. 497-510
Braskie, M.N., Klunder, A.D., Hayashi, K.M., Protas, H., Kepe, V., Miller, K.J., Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease (2008) Neurobiol Aging, , 10.1016/j.neurobiolaging.2008.09.012
Cagnin, A., Brooks, D.J., Kennedy, A.M., Gunn, R.N., Myers, R., Turkheimer, F.E., In-vivo measurement of activated microglia in dementia (2001) Lancet, 358, pp. 461-467
Catafau, A.M., Danus, M., Bullich, S., Nucci, G., Llop, J., Abanades, S., Characterization of the SPECT 5-HT2A receptor ligand 123I-R91150 in healthy volunteers: part 2 - ketanserin displacement (2006) J Nucl Med, 47, pp. 929-937
Cohen, R.M., Carson, R.E., Filbey, F., Szczepanik, J., Sunderland, T., Age and APOE-epsilon4 genotype influence the effect of physostigmine infusion on the in-vivo distribution volume of the muscarinic-2-receptor dependent tracer [18F]FP-TZTP (2006) Synapse, 60, pp. 86-92
Colloby, S.J., Pakrasi, S., Firbank, M.J., Perry, E.K., Piggott, M.A., Owens, J., In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia (2006) Neuroimage, 33, pp. 423-429
Emond, P., Guilloteau, D., Chalon, S., PE2I: a radiopharmaceutical for in vivo exploration of the dopamine transporter (2008) CNS Neurosci Ther, 14, pp. 47-64
Frokjaer, V.G., Pinborg, L.H., Madsen, J., de Nijs, R., Svarer, C., Wagner, A., Evaluation of the serotonin transporter ligand 123I-ADAM for SPECT studies on humans (2008) J Nucl Med., 49, pp. 247-254
Gilman, S., Koeppe, R.A., Little, R., An, H., Junck, L., Giordani, B., Striatal monoamine terminals in Lewy body dementia and Alzheimer's disease (2004) Ann Neurol, 55, pp. 774-780
Hasselbalch, S.G., Madsen, K., Svarer, C., Pinborg, L.H., Holm, S., Paulson, O.B., Reduced 5-HT(2A) receptor binding in patients with mild cognitive impairment (2008) Neurobiol Aging, 29, pp. 1830-1838
Hiroshi, I., Hidehiko, T., Ryosuke, A., Harumasa, T., Tetsuya, S., Normal database of dopaminergic neurotransmission system in human brain measured by positron emission tomography (2008) Neuroimage, 39, pp. 555-565
Kassiou, M., Eberl, S., Meikle, S.R., Birrell, A., Constable, C., Fulham, M.J., In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT (2001) Nucl Med Biol, 28, pp. 165-175
Lundberg, J., Odano, I., Olsson, H., Halldin, C., Farde, L., Quantification of 11C-MADAM binding to the serotonin transporter in the human brain (2005) J Nucl Med, 46, pp. 1505-1515
Mattner, F., Mardon, K., Katsifis, A., Pharmacological evaluation of [123I]-CLINDE: a radioiodinated imidazopyridine-3-acetamide for the study of peripheral benzodiazepine binding sites (PBBS) (2008) Eur J Nucl Med Mol Imaging, 35, pp. 779-789
Nordberg, A., Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications (2001) Biol Psychiatry, 49, pp. 200-210
Nordberg, A., Amyloid plaque imaging in vivo: current achievement and future prospects (2008) Eur J Nucl Med Mol Imaging, 35 (SUPPL.-1), pp. S46-S50
Pakrasi, S., Colloby, S.J., Firbank, M.J., Perry, E.K., Wyper, D.J., Owens, J., Muscarinic acetylcholine receptor status in Alzheimer's disease assessed using (R,R) 123I-QNB SPECT (2007) J Neurol, 254, pp. 907-913
Pinborg, L.H., Ziebell, M., Frøkjaer, V.G., de Nijs, R., Svarer, C., Haugbøl, S., Quantification of 123I-PE2I binding to dopamine transporter with SPECT after bolus and bolus/infusion (2005) J Nucl Med, 46, pp. 1119-1127
Plotkin, M., Amthauer, H., Quill, S., Marzinzik, F., Klostermann, F., Klaffke, S., Imaging of dopamine transporters and D2 receptors in vascular parkinsonism: a report of four cases (2005) J Neural Transm, 112, pp. 1355-1361
Rinne, J.O., Laine, M., Kaasinen, V., Norvasuo-Heilä, M.K., Någren, K., Helenius, H., Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia (2002) Neurology, 58, pp. 1489-1493
Shin, J., Lee, S.Y., Kim, S.H., Kim, Y.B., Cho, S.J., Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease (2008) Neuroimage, 43, pp. 236-244
Tanaka, Y., Meguro, K., Yamaguchi, S., Ishii, H., Watanuki, S., Funaki, Y., Decreased striatal D2 receptor density associated with severe behavioral abnormality in Alzheimer's disease (2003) Ann Nucl Med, 17, pp. 567-573
Truchot, L., Costes, N., Zimmer, L., Laurent, B., Le Bars, D., Thomas-Antérion, C., A distinct [18F]MPPF PET profile in amnestic mild cognitive impairment compared to mild Alzheimer's disease (2008) Neuroimage, 40, pp. 1251-1256
Zijlmans, J., Evans, A., Fontes, F., Katzenschlager, R., Gacinovic, S., Lees, A.J., [123I] FP-CIT spect study in vascular parkinsonism and Parkinson's disease (2007) Mov Disord, 22, pp. 1278-1285
Rowe, C., Ackerman, U., Browne, W., Mulligan, R., Pike, K.L., O'Keefe, G., Imaging of amyloid ß in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism (2008) Lancet, 7, pp. 129-135
Robbins, T. W., Dopamine and cognition (2003) Curr Opin Neurol, 16 (SUPPL. -2), pp. S1-S
Piggott, M. A., Marshall, E. F., Thomas, N., Lloyd, S., Court, J. A., Jaros, E., Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution (1999) Brain, 122, pp. 1449-1468
Huey, E. D., Putnam, K. T., Grafman, J., A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia (2006) Neurology, 66, pp. 17-22
Meltzer, C. C., Smith, G., DeKosky, S. T., Pollock, B. G., Mathis, C. A., Moore, R. Y., Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging (1998) Neuropsychopharmacology, 18, pp. 407-430
Villemagne, V. L., Fodero-Tavoletti, M. T., Pike, K. E., Cappai, R., Masters, C. L., Rowe, C. C., The ART of loss: Abeta imaging in the evaluation of Alzheimer's disease and other dementias (2008) Mol Neurobiol., 38, pp. 1-15
Gomperts, S. N., Rentz, D. M., Moran, E., Becker, J. A., Locascio, J. J., Klunk, W. E., Imaging amyloid deposition in Lewy body diseases (2008) Neurology., 71, pp. 903-910
Francis, P. T., Palmer, A. M., Snape, M., Wilcock, G. K., The cholinergic hypothesis of Alzheimer's disease: a review of progress (1999) J Neurol Neurosurg Psychiatry, 66, pp. 137-147
Perry, E. K., Haroutunian, V., Davis, K. L., Levy, R., Lantos, P., Eagger, S., Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease (1994) Neuroreport, 5, pp. 747-749
Warren, N. M., Piggott, M. A., Perry, E. K., Burn, D. J., Cholinergic systems in progressive supranuclear palsy (2005) Brain, 128, pp. 239-249
Mazi re, J., Prunier, C., Barret, O., Guyot, M., Hommet, C., Guilloteau, D., In vivo SPECT imaging of vesicular acetylcholine transporter using [123I] -IBVM in early Alzheimer's disease (2008) Neuroimaging, 40, pp. 280-288
(2008) International Conference of Alzheimer Disease, , Avid Radiopharmaceuticals Inc, Chicago
Braskie, M. N., Klunder, A. D., Hayashi, K. M., Protas, H., Kepe, V., Miller, K. J., Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease (2008) Neurobiol Aging, , 10. 1016/j. neurobiolaging. 2008. 09. 012
Catafau, A. M., Danus, M., Bullich, S., Nucci, G., Llop, J., Abanades, S., Characterization of the SPECT 5-HT2A receptor ligand 123I-R91150 in healthy volunteers: part 2 - ketanserin displacement (2006) J Nucl Med, 47, pp. 929-937
Cohen, R. M., Carson, R. E., Filbey, F., Szczepanik, J., Sunderland, T., Age and APOE-epsilon4 genotype influence the effect of physostigmine infusion on the in-vivo distribution volume of the muscarinic-2-receptor dependent tracer [18F] FP-TZTP (2006) Synapse, 60, pp. 86-92
Colloby, S. J., Pakrasi, S., Firbank, M. J., Perry, E. K., Piggott, M. A., Owens, J., In vivo SPECT imaging of muscarinic acetylcholine receptors using (R, R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia (2006) Neuroimage, 33, pp. 423-429
Frokjaer, V. G., Pinborg, L. H., Madsen, J., de Nijs, R., Svarer, C., Wagner, A., Evaluation of the serotonin transporter ligand 123I-ADAM for SPECT studies on humans (2008) J Nucl Med., 49, pp. 247-254
Hasselbalch, S. G., Madsen, K., Svarer, C., Pinborg, L. H., Holm, S., Paulson, O. B., Reduced 5-HT (2A) receptor binding in patients with mild cognitive impairment (2008) Neurobiol Aging, 29, pp. 1830-1838
Pinborg, L. H., Ziebell, M., Fr kjaer, V. G., de Nijs, R., Svarer, C., Haugb l, S., Quantification of 123I-PE2I binding to dopamine transporter with SPECT after bolus and bolus/infusion (2005) J Nucl Med, 46, pp. 1119-1127
Rinne, J. O., Laine, M., Kaasinen, V., Norvasuo-Heil, M. K., N gren, K., Helenius, H., Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia (2002) Neurology, 58, pp. 1489-1493
Shin, J., Lee, S. Y., Kim, S. H., Kim, Y. B., Cho, S. J., Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease (2008) Neuroimage, 43, pp. 236-244
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0.155, 5-year impact factor: 0.141
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-61649092986&partnerID=40&md5=3ad44b560876f279b05a3eba3252a243
Keywords: Amyloid Deposit, Dementia, Neurochemical Imaging, Neuroinflammation, Neurotransmission, 3 (2 Azetidinylmethoxy)pyridine F 18, 3 (2 Azetidinylmethoxy)pyridine I 123, 8 Chloro 2, 5 Tetrahydro 3 Methyl 5 Phenyl 1h 3 Benzazepin 7 Ol Hydrogen Maleate C 11, Altanserin F 18, Av 45, Dpa 714, N [(1 Ethyl 2 Pyrrolidinyl)methyl] 3 Iodo 6 Methoxysalicylamide I 123, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl]ethyl] N (2 Pyridyl)cyclohexanecarboxamide C 11, N Sec Butyl 1 (2 Chlorophenyl) N Methyl 3 Isoquinolinecarboxamide C 11, Neurotransmitter, Nicotine C 11, R 91150, Raclopride C 11, Setoperone F 18, Tracer, Unclassified Drug, Vesamicol Derivative, Alzheimer Disease, Cholinergic System, Disease Course, Dopaminergic System, Human, Nerve Degeneration, Neurofilament, Neuroimaging, Neuropathology, Positron Emission Tomography, Serotoninergic System, Short Survey, Single Photon Emission Computer Tomography, 3 (2 Azetidinylmethoxy) Pyridine F 18, 3 (2 Azetidinylmethoxy) Pyridine I 123, N [(1 Ethyl 2 Pyrrolidinyl) Methyl] 3 Iodo 6 Methoxysalicylamide I 123, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl] Ethyl] N (2 Pyridyl) Cyclohexanecarboxamide C 11,
Affiliations:
*** IBB - CNR ***
Inserm U930, université François-Rabelais, 37000 Tours, France
Inserm U930, service de médecine nucléaire in vitro, hôpital Bretonneau, 2, boulevard Tonnellé, 37044 Tours cedex 9, France
Institute of Biostructure and Bioimaging, CNR, 80131 Naples, Italy
References:
Robbins, T.W., Dopamine and cognition (2003) Curr Opin Neurol, 16 (SUPPL.-2), pp. S1-S
Piggott, M.A., Marshall, E.F., Thomas, N., Lloyd, S., Court, J.A., Jaros, E., Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution (1999) Brain, 122, pp. 1449-1468
Huey, E.D., Putnam, K.T., Grafman, J., A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia (2006) Neurology, 66, pp. 17-22
Hendricksen, M., Thomas, A.J., Ferrier, I.N., Ince, P., O'Brien, J.T., Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression (2004) Am J Psychiatry, 161, pp. 1096-1102
Meltzer, C.C., Smith, G., DeKosky, S.T., Pollock, B.G., Mathis, C.A., Moore, R.Y., Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging (1998) Neuropsychopharmacology, 18, pp. 407-430
Kepe, V., Barrio, J.R., Huang, S.C., Ercoli, L., Siddarth, P., Shoghi-Jadid, K., Serotonin 1A receptors in the living brain of Alzheimer's disease patients (2006) Proc Natl Acad Sci U S A, 103, pp. 702-707
Doder, M., Rabiner, E.A., Turjanski, N., Lees, A.J., Brooks, D.J., Tremor in Parkinson's disease and serotonergic dysfunction: an (11)C-WAY100635 PET study (2003) Neurology, 60, pp. 601-605
Franceschi, M., Anchisi, D., Pelati, O., Zuffi, M., Matarrese, M., Moresco, R.M., Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration (2005) Ann Neurol, 57, pp. 216-225
James, M., Fulton, R., Vercoullie, J., Henderson, D., Garreau, L., Chalon, S., DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization (2008) J Nucl Med, 49, pp. 814-822
Venneti, S., Lopresti, B., Wiley, C., The peripheral benzodiazepine receptor in microglia: from pathology to imaging (2006) Prog Neurobiol, 80, pp. 308-322
Braak, H., Braak, E., Frequency of stages of Alzheimer-related lesions in different age categories (1997) Neurobiol Aging, 18, pp. 351-357
Villemagne, V.L., Fodero-Tavoletti, M.T., Pike, K.E., Cappai, R., Masters, C.L., Rowe, C.C., The ART of loss: Abeta imaging in the evaluation of Alzheimer's disease and other dementias (2008) Mol Neurobiol., 38, pp. 1-15
Gomperts, S.N., Rentz, D.M., Moran, E., Becker, J.A., Locascio, J.J., Klunk, W.E., Imaging amyloid deposition in Lewy body diseases (2008) Neurology., 71, pp. 903-910
Francis, P.T., Palmer, A.M., Snape, M., Wilcock, G.K., The cholinergic hypothesis of Alzheimer's disease: a review of progress (1999) J Neurol Neurosurg Psychiatry, 66, pp. 137-147
Ruberg, M., Rieger, F., Villageois, A., Bonnet, A.M., Agid, Y., Acetylcholinesterase and butyrylcholinesterase in frontal cortex and cerebrospinal fluid of demented and non-demented patients with Parkinson's disease (1986) Brain Res, 362, pp. 83-91
Perry, E.K., Haroutunian, V., Davis, K.L., Levy, R., Lantos, P., Eagger, S., Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease (1994) Neuroreport, 5, pp. 747-749
Warren, N.M., Piggott, M.A., Perry, E.K., Burn, D.J., Cholinergic systems in progressive supranuclear palsy (2005) Brain, 128, pp. 239-249
Mesulam, M., Siddique, T., Cohen, B., Cholinergic denervation in a pure multi-infarct state: observations on CADASIL (2003) Neurology, 60, pp. 1183-1185
Perry, E., Walker, M., Grace, J., Perry, R., Acetylcholine in mind: a neurotransmitter correlate of consciousness? (1999) Trends Neurosci, 22, pp. 273-280
Mazière, J., Prunier, C., Barret, O., Guyot, M., Hommet, C., Guilloteau, D., In vivo SPECT imaging of vesicular acetylcholine transporter using [123I]-IBVM in early Alzheimer's disease (2008) Neuroimaging, 40, pp. 280-288
Shinotoh, H., Fukushi, K., Nagatsuka, S., Irie, T., Acetylcholinesterase imaging: its use in therapy evaluation and drug design (2004) Curr Pharm Des, 10, pp. 1505-1517
Bottlaender, M., Valette, H., Roumenov, D., Dollé, F., Coulon, C., Ottaviani, M., Biodistribution and radiation dosimetry of 18F-fluoro-A-85380 in healthy volunteers (2003) J Nucl Med, 44, pp. 596-601
(2008) International Conference of Alzheimer Disease, , Avid Radiopharmaceuticals Inc, Chicago
Blin, J., Baron, J.C., Dubois, B., Crouzel, C., Fiorelli, M., Attar-Levy, D., Loss of brain 5-HT2 receptors in Alzheimer's disease. In vivo assessment with positron emission tomography and [18F]setoperone (1993) Brain, 116, pp. 497-510
Braskie, M.N., Klunder, A.D., Hayashi, K.M., Protas, H., Kepe, V., Miller, K.J., Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease (2008) Neurobiol Aging, , 10.1016/j.neurobiolaging.2008.09.012
Cagnin, A., Brooks, D.J., Kennedy, A.M., Gunn, R.N., Myers, R., Turkheimer, F.E., In-vivo measurement of activated microglia in dementia (2001) Lancet, 358, pp. 461-467
Catafau, A.M., Danus, M., Bullich, S., Nucci, G., Llop, J., Abanades, S., Characterization of the SPECT 5-HT2A receptor ligand 123I-R91150 in healthy volunteers: part 2 - ketanserin displacement (2006) J Nucl Med, 47, pp. 929-937
Cohen, R.M., Carson, R.E., Filbey, F., Szczepanik, J., Sunderland, T., Age and APOE-epsilon4 genotype influence the effect of physostigmine infusion on the in-vivo distribution volume of the muscarinic-2-receptor dependent tracer [18F]FP-TZTP (2006) Synapse, 60, pp. 86-92
Colloby, S.J., Pakrasi, S., Firbank, M.J., Perry, E.K., Piggott, M.A., Owens, J., In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia (2006) Neuroimage, 33, pp. 423-429
Emond, P., Guilloteau, D., Chalon, S., PE2I: a radiopharmaceutical for in vivo exploration of the dopamine transporter (2008) CNS Neurosci Ther, 14, pp. 47-64
Frokjaer, V.G., Pinborg, L.H., Madsen, J., de Nijs, R., Svarer, C., Wagner, A., Evaluation of the serotonin transporter ligand 123I-ADAM for SPECT studies on humans (2008) J Nucl Med., 49, pp. 247-254
Gilman, S., Koeppe, R.A., Little, R., An, H., Junck, L., Giordani, B., Striatal monoamine terminals in Lewy body dementia and Alzheimer's disease (2004) Ann Neurol, 55, pp. 774-780
Hasselbalch, S.G., Madsen, K., Svarer, C., Pinborg, L.H., Holm, S., Paulson, O.B., Reduced 5-HT(2A) receptor binding in patients with mild cognitive impairment (2008) Neurobiol Aging, 29, pp. 1830-1838
Hiroshi, I., Hidehiko, T., Ryosuke, A., Harumasa, T., Tetsuya, S., Normal database of dopaminergic neurotransmission system in human brain measured by positron emission tomography (2008) Neuroimage, 39, pp. 555-565
Kassiou, M., Eberl, S., Meikle, S.R., Birrell, A., Constable, C., Fulham, M.J., In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT (2001) Nucl Med Biol, 28, pp. 165-175
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Rinne, J. O., Laine, M., Kaasinen, V., Norvasuo-Heil, M. K., N gren, K., Helenius, H., Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia (2002) Neurology, 58, pp. 1489-1493
Shin, J., Lee, S. Y., Kim, S. H., Kim, Y. B., Cho, S. J., Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease (2008) Neuroimage, 43, pp. 236-244
New SPECT and PET dementia tracers
Single photon emission tomography (SPECT) and positron emission tomography (PET) are techniques to study in vivo neurotransmitter systems, neuroinflammation and amyloid deposits in normal human brain and in dementia. These methods used to explore the integrity of dopaminergic, cholinergic and serotonergic systems in Alzheimer's disease and in other dementias allowed to understand how the neurotransmission was modified in these disorders. Progress in the understanding of pathophysiological and clinical signs of dementia requires an evolution of the radioligands used to carry out an increasingly early and differential diagnosis in addition to monitoring the progression of disease and the effects of therapies. New emerging radiotracers for neuroinflammation or amyloid deposits are essential. In this article, new SPECT and PET tracers are presented. © 2009 Elsevier Masson SAS. All rights reserved.
Single photon emission tomography (SPECT) and positron emission tomography (PET) are techniques to study in vivo neurotransmitter systems, neuroinflammation and amyloid deposits in normal human brain and in dementia. These methods used to explore the integrity of dopaminergic, cholinergic and serotonergic systems in Alzheimer's disease and in other dementias allowed to understand how the neurotransmission was modified in these disorders. Progress in the understanding of pathophysiological and clinical signs of dementia requires an evolution of the radioligands used to carry out an increasingly early and differential diagnosis in addition to monitoring the progression of disease and the effects of therapies. New emerging radiotracers for neuroinflammation or amyloid deposits are essential. In this article, new SPECT and PET tracers are presented. © 2009 Elsevier Masson SAS. All rights reserved.
New SPECT and PET dementia tracers
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New SPECT and PET dementia tracers
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 2.429
View Export to BibTeX Export to EndNote
Quarantelli M
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Clin Transl Imaging (ISSN: 2281-5872print, 2281-5872linking), 2015; 3: 475-489.
Impact Factor: 0
View Export to BibTeX Export to EndNote
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J Cereb Blood Flow Metab (ISSN: 0271-678x, 1559-7016electronic), 2012 Jul; 32(7): 1393-1415.
Impact Factor: 5.398
View Export to BibTeX Export to EndNote
Cervenka S, Varrone A, Fransen E, Halldin C, Farde L
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View Export to BibTeX Export to EndNote
Darcourt J, Booij J, Tatsch K, Varrone A, Borght TV, Kapucu OL, Nagren K, Nobili F, Walker Z, Van Laere K
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Impact Factor: 5.036
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
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Impact Factor: 7.581
View Export to BibTeX Export to EndNote
Pappata S, Salvatore E, Postiglione A
* In vivo imaging of neurotransmission and brain receptors in dementia (813 views) (PDF 259 views)
J Neuroimaging (ISSN: 1051-2284, 1051-2284linking), 2008 Apr; 18(2): 111-124.
Impact Factor: 1.811
View Export to BibTeX Export to EndNote
Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (991 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
View Export to BibTeX Export to EndNote
17 Records (17 excluding Abstracts).
Total impact factor: 110.122 (110.122 excluding Abstracts).
Total 5 year impact factor: 77.588 (77.588 excluding Abstracts).
Total impact factor: 110.122 (110.122 excluding Abstracts).
Total 5 year impact factor: 77.588 (77.588 excluding Abstracts).
358 views. Last view on Friday 03 February 2023, 16:22:57
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