Effects of sex steroids on bone in women with subclinical or overt endogenous hypercortisolism (372 views)
Eur J Endocrinol (ISSN: 0804-4643), 2007 Sep; 157(3): 359-366.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.239, 5-year impact factor: 3.325
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-35348938146&partnerID=40&md5=8250d74fc9070e9d69a8bff199ca609a
Keywords: Androstenedione, Corticotropin, Estradiol, Follitropin, Hydrocortisone, Luteinizing Hormone, Prasterone Sulfate, Sex Hormone, Testosterone, Adrenal Incidentaloma, Adrenal Tumor, Adult, Aged, Amenorrhea, Androgen Blood Level, Anthropometry, Article, Bone Density, Bone Mineral, Bone Turnover, Case Control Study, Controlled Study, Corticotropin Release, Disease Severity, Dual Energy X Ray Absorptiometry, Estradiol Blood Level, Female, Femur Neck, Follitropin Blood Level, Human, Hydrocortisone Blood Level, Hypercortisolism, Hypophysis Adenoma, Logistic Regression Analysis, Lumbar Spine, Luteinizing Hormone Blood Level, Major Clinical Study, Menstrual Cycle, Prediction, Prevalence, Priority Journal, Quantitative Analysis, Scoring System, Testosterone Blood Level, Urinary Excretion, Vertebra Fracture, Photon, Case-Control Studies, Cross-Sectional Studies, Cushing Syndrome, Dehydroepiandrosterone Sulfate, Follicle Stimulating Hormone, Gonadal Steroid Hormones, Middle Aged, Osteoporosis, Severity Of Illness Index, Spinal Fractures,
Affiliations:
*** IBB - CNR ***
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy. tauchman@unina.it
Department of Orthopedics, Federico II University of Naples, via S Pansini 5, 80131 Naples, Italy
Department of Biomorphological and Functional Sciences, Federico II University of Naples, via S Pansini 5, 80131 Naples, Italy
References:
Van Staa, T.P., Leufkens, H.G.M., Abenhaim, L., Zhang, B., Cooper, C., Use of corticosteroids and risk of fractures (2000) Journal of Bone and Mineral Research, 15, pp. 993-100
Steinbuch, M., Youket, T.E., Cohen, S., Oral glucocorticoid use is associated with an increased risk of fracture (2004) Osteoporosis International, 15, pp. 323-328
Devogelaer, J.P., Goemaere, S., Boonen, S., Body, J.J., Kaufman, J.M., Reginster, J.Y., Rozenberg, S., Boutsen, Y., Evidence-based guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis: A consensus document of the Belgian Bone Club (2006) Osteoporosis International, 17, pp. 8-19
Khanine, V., Fournier, J.J., Requeda, E., Luton, J.F., Simon, F., Crouzet, P., Osteoporotic fractures at presentation of Cushing's disease: Two case reports and literature review (2000) Joint Bone Spine, 67, pp. 341-345
Freehill, A.K., Lenke, L.G., Severe kyphosis secondary to glucocorti-coid-induced osteoporosis in a young adult with Cushing's disease. A case report and literature review (1999) Spine, 24, pp. 189-193
Vestergaard, P., Lindholm, J., Jorgensen, J.O., Hagen, C., Hoeck, H.C., Laurberg, P., Rejnmark, L., Mosekilde, L., Increased risk of osteoporotic fractures in patients with Cushing's syndrome (2002) European Journal of Endocrinology, 146, pp. 51-56
Chiodini, I., Guglielmi, G., Battista, C., Carnevale, V., Torlontano, M., Cammista, M., Trischitta, V., Scillitani, A., Spinal volumetric bone mineral density and vertebral fractures in female patients with adrenal incidentalomas: The effects of subclinical hypercortisolism and gonadal status (2004) Journal of Clinical Endocrinology and Metabolism, 89, pp. 2237-2241
Tauchmanovà, L., Pivonello, R., Di Somma, C., Rossi, R., De Martino, M.C., Camera, L., Klain, M., Colao, A., Bone demineralization and vertebral fractures in patients with endogenous cortisol excess: Role of disease etiology and gonadal status (2006) Journal of Clinical Endocrinology and Metabolism, 91, pp. 1779-1784
Canalis, E., Mechanisms of glucocortlcoid action in bone: Implications for glucocorticoid-induced osteoporosis (1996) Journal of Clinical Endocrinology and Metabolism, 81, pp. 3441-3447
Borelli, A., Leite, M.O., Correa, P.H., jorgetti, V., Marcondes, J.A., Bataiha, J.R., Cintra, A.B., Wajchenberg, B.L., Bone histomorphometry in Cushing's syndrome (1992) Journal of Endocrinological Investigation, 15, pp. 783-787
Reid, I.R., Glueocorticoid effects on bone (1998) Journal of Clinical Endocrinology and Metabolism, 83, pp. 1860-1861
Lukert, B.P., Raisz, L.G., Glucocorticoid-induced osteoporosis: Pathogenesis and management (1990) Annals of Internal Medicine, 112, pp. 352-364
Pereira, R.M., Delany, A.M., Canalis, E., Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture (2001) Bone, 28, pp. 484-490
O'Brien, C.A., Jia, D., Plotkin, L.I., Bellido, T., Powers, C.C., Stewart, S.A., Manolagas, S.C., Weinstein, R.S., Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength (2004) Endocrinology, 145, pp. 1835-1841
Rubin, M.R., Bilezikian, J.P., The role of parathyroid hormone in the pathogenesis of glucocorticoid-induced osteoporosis: A reexamination of the evidence (2002) Journal of Clinical Endocrinology and Metabolism, 87, pp. 4033-4041
Lado-Abeal, J., Rodriguez-Arnao, J., Newell-Price, J.D.C., Perry, L.A., Grossman, A.B., Besser, G.M., Trainer, P.J., Menstrual abnormalities in women with Cushing's disease are correlated with hypercortisolemia rather than raised circulating androgen levels (1998) Journal of Clinical Endocrinology and Metabolism, 83, pp. 3083-3088
Barbetta, L., Dall'Asta, C., Re, T., Colombo, P., Travaglini, P., Ambrosi, B., Androgen secretion in ectopic ACTH syndrome and in Cushing's disease: Modifications before and after surgery (2001) Hormone and Metabolic Research, 33, pp. 596-560
Kaltsas, G.A., Korbonits, M., Isidori, A.M., Webb, J.A.W., Trainer, P.J., Monson, J.P., Besser, G.M., Grossman, A.B., How common are polycystic ovaries and the polycystic ovarian syndrome in women with Cushing's syndrome? (2000) Clinical Endocrinology, 53, pp. 493-500
Fitzpatric, L.A., Glucocorticoid-induced osteoporosis (1994) Osteoporosis, pp. 202-226. , Ed. R Marcus. Boston: Blackwell Scientific
Castelo-Branco, C., Gomez, O., Pons, F., Martinez de Osaba, M.J., Balasch, J., Antoni Vanrell, J., Secreting ovarian tumors may protect women from osteoporosis (2003) Gynecologic Oncology, 88, pp. 149-152
Adami, S., Zamberlan, N., Castello, R., Tosi, F., Gatti, D., Moghetti, P., Effect of hyperandrogenism and menstrual cycle abnormalities on bone mass and bone turnover in young women (1998) Clinical Endocrinology, 48, pp. 169-173
Sipahi, S., Tuzun, S., Ozaras, R., Calis, H.T., Tuzun, F., Karayel, T., Bone mineral density in women with sarcoidosis (2004) Journal of Bone and Mineral Metabolism, 22, pp. 48-52
Karavitaki, N., loannidis, G., Giannakopoulos, F., Mavrokefalos, P., Thalassinos, N., Evaluation of bone mineral density of the peripheral skeleton in pre- and postmenopausal women with newly diagnosed endogenous Cushing's syndrome (2004) Clinical Endocrinology, 60, pp. 264-270
Terzolo, M., Osella, G., Ali, A., Borretta, G., Cesario, F., Paccotti, P., Angeli, A., Subelinical Cushing's syndrome in adrenal incidentaloma (1998) Clinical Endocrinology, 48, pp. 89-97
Rossi, R., Tauchmanovà, L., Luciano, A., Di Martino, M., Battista, C., Del Viscovo, L., Nuzzo, V., Lombardi, G., Subclinical Cushing's syndrome in patients with adrenal incidentaloma. Clinical and biochemical features (2000) Journal of Clinical Endocrinology and Metabolism, 85, pp. 1440-1448
Tsagarakis, S., Vassiliadi, D., Thalassinos, N., Endogenous subclinical hypercortisolism: Diagnostic uncertainties and clinical implications (2006) Journal of Endocrinological Investigation, 29, pp. 471-482
Young Jr., W.F., The incidentally discovered adrenal mass (2007) New England Journal of Medicine, 356, pp. 601-610
Tauchmanovà, L., Rossi, R., Nuzzo, V., del Puente, A., Esposito, A., Pizzi, C., Fonderico, F., Lombardi, G., Bone loss determined by quantitative ultrasonometry correlates with the disease activity in patients with different degree of endogenous glucocorticoid excess due to adrenal mass (2001) European Journal of Endocrinology, 145, pp. 241-247
del Puente, A., Heyse, S.P., Mandes, M.G., Mantova, D., Carpinelli, A., Nutile, G., Oriente, P., Epidemiology of osteoporosis in women in southern Italy (1998) Aging Clinical and Experimental Research, 10, pp. 53-58
Minne, H.W., Leidig, G., Wüster, C., Siromachkostov, L., Baldauf, G., Bickel, R., Sauer, P., Ziegler, R., A newly defined spine deformity index (SDI) to quantitative vertebral crush fractures in patients with osteoporosis (1988) Bone and Mineral, 3, pp. 335-349
Melton, L.J., Kan, S.H., Frye, K.M., Walmer, H.W., O'Fallon, W.M., Riggs, B., Epidemiology of vertebral fractures in women (1989) Americam Journal of Epidemiology, 124, pp. 1000-1011
Minetto, M., Reimondo, G., Osella, G., Ventura, M., Angeli, A., Terzolo, M., Bone loss is more severe in primary adrenal than in pituitary-dependent Cushing's syndrome (2004) Osteoporosis International, 11, pp. 855-861
Ohmori, N., Nomura, K., Ohmori, K., Kato, Y., Itch, T., Takano, K., Osteoporosis is more prevalent in adrenal than in pituitary Cushing's syndrome (2003) Endocrine Journal, 50, pp. 1-7
Libe, R., Dall'Asta, C., Barbetta, L., Baccarelli, A., Beck-Peccoz, P., Ambrosi, B., Long-term follow-up study of patients with adrenal incidentalomas (2002) European Joumal of Endocrinology, 147, pp. 489-494
King, J.A., Wisniewski, A.B., Bankoiwski, B.J., Kato, Y., Itoh, T., Takano, K., Long-term corticosteroid replacement and bone mineral density in adult women with classical congenital adrenal hyperplasia (2006) Journal of Clinical Endocrinology and Metabolism, 91, pp. 865-869
Haden, S.T., Glowacki, J., Hurwitz, S., Rosen, C., LeBoff, M.S., Effects of age on serum dehydroepiandrosterone sulphate, IGF-1, and IL-6 levels in women (2000) Calcified Tissue International, 66, pp. 414-418
Hermus, A.R., Smals, A., Swinkels, L.M., Huysmans, D.A., Pieters, G.F., Sweep, C.F., Corstens, F.H., Kloppenborg, P.W., Bone mineral density and bone turnover before and 3fter cure of Cushing's syndrome (1995) Journal of Clinical Endocrinology and Metabolism, 80, pp. 2859-2865
Canalis, E., Bilezikian, J.P., Angeli, A., Giustina, A., Perspectives on glucocorticoid-induced osteoporosis (2004) Bone, 34, pp. 593-598
Steinbach, M., Youket, T.E., Chen, S., Oral glucocorticoid use is associated with an increase risk of fracture (2004) Osteoporosis International, 15, pp. 323-332
Chiodini, I., Carnevale, V., Tortolano, M., Fusilli, S., Guglielmi, G., Pileri, M., Modoni, S., Scillitani, A., Alteration of bone turnover and bone mass at different skeletal sites due to pure glucocorticoid excess: Study in eumenorrheic patients with Cushing's syndrome (1998) Journal of Clinical Endocrinology and Metabolism, 83, pp. 1863-1867
Sartorio, A., Conti, A., Ferrero, S., Re, T., Passini, E., Ambrosi, B., Evaluation of markers of bone and collagen turnover in patients with active and preclinical Cushing's syndrome and in patients with adrenal incidentaloma (1998) European Journal of Endocrinology, 138, pp. 146-152
Eur J Endocrinol (ISSN: 0804-4643), 2007 Sep; 157(3): 359-366.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.239, 5-year impact factor: 3.325
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-35348938146&partnerID=40&md5=8250d74fc9070e9d69a8bff199ca609a
Keywords: Androstenedione, Corticotropin, Estradiol, Follitropin, Hydrocortisone, Luteinizing Hormone, Prasterone Sulfate, Sex Hormone, Testosterone, Adrenal Incidentaloma, Adrenal Tumor, Adult, Aged, Amenorrhea, Androgen Blood Level, Anthropometry, Article, Bone Density, Bone Mineral, Bone Turnover, Case Control Study, Controlled Study, Corticotropin Release, Disease Severity, Dual Energy X Ray Absorptiometry, Estradiol Blood Level, Female, Femur Neck, Follitropin Blood Level, Human, Hydrocortisone Blood Level, Hypercortisolism, Hypophysis Adenoma, Logistic Regression Analysis, Lumbar Spine, Luteinizing Hormone Blood Level, Major Clinical Study, Menstrual Cycle, Prediction, Prevalence, Priority Journal, Quantitative Analysis, Scoring System, Testosterone Blood Level, Urinary Excretion, Vertebra Fracture, Photon, Case-Control Studies, Cross-Sectional Studies, Cushing Syndrome, Dehydroepiandrosterone Sulfate, Follicle Stimulating Hormone, Gonadal Steroid Hormones, Middle Aged, Osteoporosis, Severity Of Illness Index, Spinal Fractures,
Affiliations:
*** IBB - CNR ***
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy. tauchman@unina.it
Department of Orthopedics, Federico II University of Naples, via S Pansini 5, 80131 Naples, Italy
Department of Biomorphological and Functional Sciences, Federico II University of Naples, via S Pansini 5, 80131 Naples, Italy
References:
Van Staa, T.P., Leufkens, H.G.M., Abenhaim, L., Zhang, B., Cooper, C., Use of corticosteroids and risk of fractures (2000) Journal of Bone and Mineral Research, 15, pp. 993-100
Steinbuch, M., Youket, T.E., Cohen, S., Oral glucocorticoid use is associated with an increased risk of fracture (2004) Osteoporosis International, 15, pp. 323-328
Devogelaer, J.P., Goemaere, S., Boonen, S., Body, J.J., Kaufman, J.M., Reginster, J.Y., Rozenberg, S., Boutsen, Y., Evidence-based guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis: A consensus document of the Belgian Bone Club (2006) Osteoporosis International, 17, pp. 8-19
Khanine, V., Fournier, J.J., Requeda, E., Luton, J.F., Simon, F., Crouzet, P., Osteoporotic fractures at presentation of Cushing's disease: Two case reports and literature review (2000) Joint Bone Spine, 67, pp. 341-345
Freehill, A.K., Lenke, L.G., Severe kyphosis secondary to glucocorti-coid-induced osteoporosis in a young adult with Cushing's disease. A case report and literature review (1999) Spine, 24, pp. 189-193
Vestergaard, P., Lindholm, J., Jorgensen, J.O., Hagen, C., Hoeck, H.C., Laurberg, P., Rejnmark, L., Mosekilde, L., Increased risk of osteoporotic fractures in patients with Cushing's syndrome (2002) European Journal of Endocrinology, 146, pp. 51-56
Chiodini, I., Guglielmi, G., Battista, C., Carnevale, V., Torlontano, M., Cammista, M., Trischitta, V., Scillitani, A., Spinal volumetric bone mineral density and vertebral fractures in female patients with adrenal incidentalomas: The effects of subclinical hypercortisolism and gonadal status (2004) Journal of Clinical Endocrinology and Metabolism, 89, pp. 2237-2241
Tauchmanovà, L., Pivonello, R., Di Somma, C., Rossi, R., De Martino, M.C., Camera, L., Klain, M., Colao, A., Bone demineralization and vertebral fractures in patients with endogenous cortisol excess: Role of disease etiology and gonadal status (2006) Journal of Clinical Endocrinology and Metabolism, 91, pp. 1779-1784
Canalis, E., Mechanisms of glucocortlcoid action in bone: Implications for glucocorticoid-induced osteoporosis (1996) Journal of Clinical Endocrinology and Metabolism, 81, pp. 3441-3447
Borelli, A., Leite, M.O., Correa, P.H., jorgetti, V., Marcondes, J.A., Bataiha, J.R., Cintra, A.B., Wajchenberg, B.L., Bone histomorphometry in Cushing's syndrome (1992) Journal of Endocrinological Investigation, 15, pp. 783-787
Reid, I.R., Glueocorticoid effects on bone (1998) Journal of Clinical Endocrinology and Metabolism, 83, pp. 1860-1861
Lukert, B.P., Raisz, L.G., Glucocorticoid-induced osteoporosis: Pathogenesis and management (1990) Annals of Internal Medicine, 112, pp. 352-364
Pereira, R.M., Delany, A.M., Canalis, E., Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture (2001) Bone, 28, pp. 484-490
O'Brien, C.A., Jia, D., Plotkin, L.I., Bellido, T., Powers, C.C., Stewart, S.A., Manolagas, S.C., Weinstein, R.S., Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength (2004) Endocrinology, 145, pp. 1835-1841
Rubin, M.R., Bilezikian, J.P., The role of parathyroid hormone in the pathogenesis of glucocorticoid-induced osteoporosis: A reexamination of the evidence (2002) Journal of Clinical Endocrinology and Metabolism, 87, pp. 4033-4041
Lado-Abeal, J., Rodriguez-Arnao, J., Newell-Price, J.D.C., Perry, L.A., Grossman, A.B., Besser, G.M., Trainer, P.J., Menstrual abnormalities in women with Cushing's disease are correlated with hypercortisolemia rather than raised circulating androgen levels (1998) Journal of Clinical Endocrinology and Metabolism, 83, pp. 3083-3088
Barbetta, L., Dall'Asta, C., Re, T., Colombo, P., Travaglini, P., Ambrosi, B., Androgen secretion in ectopic ACTH syndrome and in Cushing's disease: Modifications before and after surgery (2001) Hormone and Metabolic Research, 33, pp. 596-560
Kaltsas, G.A., Korbonits, M., Isidori, A.M., Webb, J.A.W., Trainer, P.J., Monson, J.P., Besser, G.M., Grossman, A.B., How common are polycystic ovaries and the polycystic ovarian syndrome in women with Cushing's syndrome? (2000) Clinical Endocrinology, 53, pp. 493-500
Fitzpatric, L.A., Glucocorticoid-induced osteoporosis (1994) Osteoporosis, pp. 202-226. , Ed. R Marcus. Boston: Blackwell Scientific
Castelo-Branco, C., Gomez, O., Pons, F., Martinez de Osaba, M.J., Balasch, J., Antoni Vanrell, J., Secreting ovarian tumors may protect women from osteoporosis (2003) Gynecologic Oncology, 88, pp. 149-152
Adami, S., Zamberlan, N., Castello, R., Tosi, F., Gatti, D., Moghetti, P., Effect of hyperandrogenism and menstrual cycle abnormalities on bone mass and bone turnover in young women (1998) Clinical Endocrinology, 48, pp. 169-173
Sipahi, S., Tuzun, S., Ozaras, R., Calis, H.T., Tuzun, F., Karayel, T., Bone mineral density in women with sarcoidosis (2004) Journal of Bone and Mineral Metabolism, 22, pp. 48-52
Karavitaki, N., loannidis, G., Giannakopoulos, F., Mavrokefalos, P., Thalassinos, N., Evaluation of bone mineral density of the peripheral skeleton in pre- and postmenopausal women with newly diagnosed endogenous Cushing's syndrome (2004) Clinical Endocrinology, 60, pp. 264-270
Terzolo, M., Osella, G., Ali, A., Borretta, G., Cesario, F., Paccotti, P., Angeli, A., Subelinical Cushing's syndrome in adrenal incidentaloma (1998) Clinical Endocrinology, 48, pp. 89-97
Rossi, R., Tauchmanovà, L., Luciano, A., Di Martino, M., Battista, C., Del Viscovo, L., Nuzzo, V., Lombardi, G., Subclinical Cushing's syndrome in patients with adrenal incidentaloma. Clinical and biochemical features (2000) Journal of Clinical Endocrinology and Metabolism, 85, pp. 1440-1448
Tsagarakis, S., Vassiliadi, D., Thalassinos, N., Endogenous subclinical hypercortisolism: Diagnostic uncertainties and clinical implications (2006) Journal of Endocrinological Investigation, 29, pp. 471-482
Young Jr., W.F., The incidentally discovered adrenal mass (2007) New England Journal of Medicine, 356, pp. 601-610
Tauchmanovà, L., Rossi, R., Nuzzo, V., del Puente, A., Esposito, A., Pizzi, C., Fonderico, F., Lombardi, G., Bone loss determined by quantitative ultrasonometry correlates with the disease activity in patients with different degree of endogenous glucocorticoid excess due to adrenal mass (2001) European Journal of Endocrinology, 145, pp. 241-247
del Puente, A., Heyse, S.P., Mandes, M.G., Mantova, D., Carpinelli, A., Nutile, G., Oriente, P., Epidemiology of osteoporosis in women in southern Italy (1998) Aging Clinical and Experimental Research, 10, pp. 53-58
Minne, H.W., Leidig, G., Wüster, C., Siromachkostov, L., Baldauf, G., Bickel, R., Sauer, P., Ziegler, R., A newly defined spine deformity index (SDI) to quantitative vertebral crush fractures in patients with osteoporosis (1988) Bone and Mineral, 3, pp. 335-349
Melton, L.J., Kan, S.H., Frye, K.M., Walmer, H.W., O'Fallon, W.M., Riggs, B., Epidemiology of vertebral fractures in women (1989) Americam Journal of Epidemiology, 124, pp. 1000-1011
Minetto, M., Reimondo, G., Osella, G., Ventura, M., Angeli, A., Terzolo, M., Bone loss is more severe in primary adrenal than in pituitary-dependent Cushing's syndrome (2004) Osteoporosis International, 11, pp. 855-861
Ohmori, N., Nomura, K., Ohmori, K., Kato, Y., Itch, T., Takano, K., Osteoporosis is more prevalent in adrenal than in pituitary Cushing's syndrome (2003) Endocrine Journal, 50, pp. 1-7
Libe, R., Dall'Asta, C., Barbetta, L., Baccarelli, A., Beck-Peccoz, P., Ambrosi, B., Long-term follow-up study of patients with adrenal incidentalomas (2002) European Joumal of Endocrinology, 147, pp. 489-494
King, J.A., Wisniewski, A.B., Bankoiwski, B.J., Kato, Y., Itoh, T., Takano, K., Long-term corticosteroid replacement and bone mineral density in adult women with classical congenital adrenal hyperplasia (2006) Journal of Clinical Endocrinology and Metabolism, 91, pp. 865-869
Haden, S.T., Glowacki, J., Hurwitz, S., Rosen, C., LeBoff, M.S., Effects of age on serum dehydroepiandrosterone sulphate, IGF-1, and IL-6 levels in women (2000) Calcified Tissue International, 66, pp. 414-418
Hermus, A.R., Smals, A., Swinkels, L.M., Huysmans, D.A., Pieters, G.F., Sweep, C.F., Corstens, F.H., Kloppenborg, P.W., Bone mineral density and bone turnover before and 3fter cure of Cushing's syndrome (1995) Journal of Clinical Endocrinology and Metabolism, 80, pp. 2859-2865
Canalis, E., Bilezikian, J.P., Angeli, A., Giustina, A., Perspectives on glucocorticoid-induced osteoporosis (2004) Bone, 34, pp. 593-598
Steinbach, M., Youket, T.E., Chen, S., Oral glucocorticoid use is associated with an increase risk of fracture (2004) Osteoporosis International, 15, pp. 323-332
Chiodini, I., Carnevale, V., Tortolano, M., Fusilli, S., Guglielmi, G., Pileri, M., Modoni, S., Scillitani, A., Alteration of bone turnover and bone mass at different skeletal sites due to pure glucocorticoid excess: Study in eumenorrheic patients with Cushing's syndrome (1998) Journal of Clinical Endocrinology and Metabolism, 83, pp. 1863-1867
Sartorio, A., Conti, A., Ferrero, S., Re, T., Passini, E., Ambrosi, B., Evaluation of markers of bone and collagen turnover in patients with active and preclinical Cushing's syndrome and in patients with adrenal incidentaloma (1998) European Journal of Endocrinology, 138, pp. 146-152
Effects of sex steroids on bone in women with subclinical or overt endogenous hypercortisolism
OBJECTIVE: Glucocorticoid-induced osteoporosis is the most frequent cause of secondary osteoporosis. Nevertheless, limited data are available on bone status in patients with endogenous cortisol excess. This study is aimed at investigating the role of sex steroids and severity of hypercortisolism on bone mineral density (BMD) and prevalence of vertebral fractures in female patients.; DESIGN: Cross-sectional, case-control study.; PATIENTS: Seventy-one consecutive women were enrolled: 36 with overt hypercortisolism (26 with ACTH-secreting pituitary adenoma and 10 with cortisol-secreting adrenal tumor) and 35 with subclinical hypercortisolism due to adrenal incidentalomas. They were compared with 71 matched controls.; METHODS: At diagnosis, we measured serum cortisol, FSH, LH, estradiol, testosterone, androstenedione and DHEAS, and urinary cortisol excretion. BMD was determined by dual energy X-ray absorptiometry at the lumbar spine and femoral neck. Vertebral fractures were investigated by a semiquantitative scoring method.; RESULTS: Between women with overt and subclinical hypercortisolism BMD values and prevalence of any vertebral (69 vs 57%, P = 0.56), clinical (28 vs 11.4%, P = 0.22), and multiple vertebral fractures (36 vs 31%, P = 0.92) did not differ. Among patients with subclinical hypercortisolism, amenorrhoic women had a lower BMD (P = 0.035) and more frequent vertebral fractures (80 vs 40%; P = 0.043) when compared with the eumenorrhoic ones. Among women with overt hypercortisolism, there was no difference in lumbar BMD (P = 0.37) and prevalence of fractures (81 vs 60%; P = 0.26) between those amenorrhoic and eumenorrhoic. By logistic regression analysis, lumbar spine BMD values and cortisol-to-DHEAS ratio were the best predictors of vertebral fractures (P < 0.01).; CONCLUSIONS: Vertebral fractures are very common in women with endogenous cortisol excess, regardless of its severity. The deleterious effects of hypercortisolism on the spine may be partly counterbalanced by DHEAS increase at any degree of cortisol excess, and by preserved menstrual cycles in women with subclinical but not in those with overt hypercortisolism.
OBJECTIVE: Glucocorticoid-induced osteoporosis is the most frequent cause of secondary osteoporosis. Nevertheless, limited data are available on bone status in patients with endogenous cortisol excess. This study is aimed at investigating the role of sex steroids and severity of hypercortisolism on bone mineral density (BMD) and prevalence of vertebral fractures in female patients.; DESIGN: Cross-sectional, case-control study.; PATIENTS: Seventy-one consecutive women were enrolled: 36 with overt hypercortisolism (26 with ACTH-secreting pituitary adenoma and 10 with cortisol-secreting adrenal tumor) and 35 with subclinical hypercortisolism due to adrenal incidentalomas. They were compared with 71 matched controls.; METHODS: At diagnosis, we measured serum cortisol, FSH, LH, estradiol, testosterone, androstenedione and DHEAS, and urinary cortisol excretion. BMD was determined by dual energy X-ray absorptiometry at the lumbar spine and femoral neck. Vertebral fractures were investigated by a semiquantitative scoring method.; RESULTS: Between women with overt and subclinical hypercortisolism BMD values and prevalence of any vertebral (69 vs 57%, P = 0.56), clinical (28 vs 11.4%, P = 0.22), and multiple vertebral fractures (36 vs 31%, P = 0.92) did not differ. Among patients with subclinical hypercortisolism, amenorrhoic women had a lower BMD (P = 0.035) and more frequent vertebral fractures (80 vs 40%; P = 0.043) when compared with the eumenorrhoic ones. Among women with overt hypercortisolism, there was no difference in lumbar BMD (P = 0.37) and prevalence of fractures (81 vs 60%; P = 0.26) between those amenorrhoic and eumenorrhoic. By logistic regression analysis, lumbar spine BMD values and cortisol-to-DHEAS ratio were the best predictors of vertebral fractures (P < 0.01).; CONCLUSIONS: Vertebral fractures are very common in women with endogenous cortisol excess, regardless of its severity. The deleterious effects of hypercortisolism on the spine may be partly counterbalanced by DHEAS increase at any degree of cortisol excess, and by preserved menstrual cycles in women with subclinical but not in those with overt hypercortisolism.
Effects of sex steroids on bone in women with subclinical or overt endogenous hypercortisolism
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Effects of sex steroids on bone in women with subclinical or overt endogenous hypercortisolism
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Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E
* Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity (487 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015 Jan; 142: 39-46.
Impact Factor: 3.205
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De Leva MF, Varrone A, Filla A, Quarantelli M, Bilo L, Piscitelli V, Salvatore E, Ammendola S, Striano S, De Michele G, Bonavita V, Pappata S
* Neuroimaging follow-up in a case of Rasmussen's encephalitis with dyskinesias (362 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2007 Oct 31; 22(14): 2117-2121.
Impact Factor: 3.207
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Tauchmanovà L, Pivonello R, Di Somma C, Rossi R, De Martino MC, Camera L, Klain M, Salvatore M, Lombardi G, Colao A
* Bone demineralization and vertebral fractures in endogenous cortisol excess: Role of disease etiology and gonadal status (506 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2006 May; 91(5): 1779-1784.
Impact Factor: 5.799
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Tauchmanovà L, Colao A, Marzano LA, Sparano L, Camera L, Rossi A, Palmieri G, Marzano E, Salvatore M, Pettinato G, Lombardi G, Rossi R
* Andrenocortical carcinomas: Twelve-year prospective experience (296 views)
World J Surg (ISSN: 0364-2313), 2004 Sep; 28(9): 896-903.
Impact Factor: 1.952
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Di Somma C, Pivonello R, Loche S, Faggiano A, Klain M, Salvatore M, Lombardi G, Colao A
* Effect of 2 years of cortisol normalization on the impaired bone mass and turnover in adolescent and adult patients with Cushing's disease: A prospective study (510 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Mar; 58(3): 302-308.
Impact Factor: 2.767
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (426 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
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Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (442 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
* Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity (487 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015 Jan; 142: 39-46.
Impact Factor: 3.205
View Export to BibTeX Export to EndNote
De Leva MF, Varrone A, Filla A, Quarantelli M, Bilo L, Piscitelli V, Salvatore E, Ammendola S, Striano S, De Michele G, Bonavita V, Pappata S
* Neuroimaging follow-up in a case of Rasmussen's encephalitis with dyskinesias (362 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2007 Oct 31; 22(14): 2117-2121.
Impact Factor: 3.207
View Export to BibTeX Export to EndNote
Tauchmanovà L, Pivonello R, Di Somma C, Rossi R, De Martino MC, Camera L, Klain M, Salvatore M, Lombardi G, Colao A
* Bone demineralization and vertebral fractures in endogenous cortisol excess: Role of disease etiology and gonadal status (506 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2006 May; 91(5): 1779-1784.
Impact Factor: 5.799
View Export to BibTeX Export to EndNote
Tauchmanovà L, Colao A, Marzano LA, Sparano L, Camera L, Rossi A, Palmieri G, Marzano E, Salvatore M, Pettinato G, Lombardi G, Rossi R
* Andrenocortical carcinomas: Twelve-year prospective experience (296 views)
World J Surg (ISSN: 0364-2313), 2004 Sep; 28(9): 896-903.
Impact Factor: 1.952
View Export to BibTeX Export to EndNote
Di Somma C, Pivonello R, Loche S, Faggiano A, Klain M, Salvatore M, Lombardi G, Colao A
* Effect of 2 years of cortisol normalization on the impaired bone mass and turnover in adolescent and adult patients with Cushing's disease: A prospective study (510 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Mar; 58(3): 302-308.
Impact Factor: 2.767
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (426 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (442 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
7 Records (7 excluding Abstracts).
Total impact factor: 31.161 (31.161 excluding Abstracts).
Total 5 year impact factor: 28.172 (28.172 excluding Abstracts).
Total impact factor: 31.161 (31.161 excluding Abstracts).
Total 5 year impact factor: 28.172 (28.172 excluding Abstracts).
372 views. Last view on Thursday 11 May 2023, 23:10:19
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