Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (805 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.73, 5-year impact factor: 2.749
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84937207623&partnerID=40&md5=5b42687a83402da0b49803f68d34824b
Keywords: Amyloid, Anti-Aggregant Acstivity, Antidepressants, Butyric Acid (pubchem Cid: 264), Neurons, Neuroprotection, Tranylcypromine (pubchem Cid: 19493 Or 26070), Tranylcypromine Acetamide (pubchem Cid: 583384), Anti-Aggregant Activity, Amyloid Beta Protein[1-42], Glial Fibrillary Acidic Protein, Microtubule Associated Protein 2, Tranylcypromine Butyramide, Tranylcypromine Derivative, Unclassified Drug, Alzheimer Disease, Animal Cell, Animal Experiment, Animal Model, Article, Controlled Study, Drug Degradation, Drug Efficacy, Drug Potency, Drug Stability, Drug Synthesis, In Vitro Study, Nerve Cell Necrosis, Nerve Degeneration, Neurotoxicity, Nonhuman, Priority Journal, Protein Aggregation,
Affiliations:
*** IBB - CNR ***
Department of drug Sciences, university of Catania, Catania, Italy; IRCCS Associazione Oasi maria S.S., institute for research on mental Retardation and brain aging, Troina, Italy. Electronic address: Carafil@hotmail.com., National research council, institute of Biostructures and Bioimaging, Catania, Italy., Department of drug Sciences, university of Catania, Catania, Italy., Department of drug Sciences, university of Catania, Catania, Italy; National research council, institute of Biostructures and Bioimaging, Catania, Italy., National research council, institute of Biostructures and Bioimaging, Catania, Italy; PhD Program in Translational Biomedicine, university of Catania., Department of biomedical and Biotechnological Sciences, university of Catania, Catania, Italy.,
References:
Al-Nuaimi, S.K., Mackenzie, E.M., Baker, G.B., Monoamine oxidase inhibitors and neuroprotection: a review (2012) Am. J. Ther., 19, pp. 436-44
Baker, G.B., Sowa, B., Todd, K.G., Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders? (2007) J. Psychiatry Neurosci., 32, pp. 313-315
Ballard, C., Day, S., Sharp, S., Wing, G., Sorensen, S., Neuropsychiatric symptoms in dementia: importance and treatment considerations (2008) Int. Rev. Psychiatry, 20, pp. 396-404
Bar-Am, O., Amit, T., Weinreb, O., Youdim, M.B., Mandel, S., Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation (2010) J. Alzheimers Dis., 21, pp. 361-371
Basile, L., Pappalardo, M., Guccione, S., Milardi, D., Ramsay, R.R., Computational comparison of imidazoline association with the I2 binding site in human monoamine oxidases (2014) J. Chem. Inf. Model., 54, pp. 1200-1207
Baskaran, A., Carvalho, A.F., Mansut, R.B., McIntyre, R.S., Are major depressive disorder and diabetes mellitus amyloidogenic conditions? (2014) CNS Neurol. Disord. Drug Targets, 13, pp. 1667-1676
Binda, C., Milczek, E.M., Bonivento, D., Wang, J., Mattevi, A., Edmondson, D.E., Lights and shadows on monoamine oxidase inhibition in neuroprotective pharmacological therapies (2011) Curr. Top. Med. Chem., 11, pp. 2788-2796
Blackley, H.K., Patel, N., Davies, M.C., Roberts, C.J., Tendler, S.J., Wilkinson, M.J., Williams, P.M., Morphological development of beta(1-40) amyloid fibrils (1999) Exp. Neurol., 158, pp. 437-443
Cai, Z., Monoamine oxidase inhibitors: promising therapeutic agents for Alzheimer's disease (2014) Mol. Med. Rep., 9, pp. 1533-1541
Caraci, F., Copani, A., Nicoletti, F., Drago, F., Depression and Alzheimer's disease: neurobiological links and common pharmacological targets (2010) Eur. J. Pharmacol., 626, pp. 64-71
Caraci, F., Molinaro, G., Battaglia, G., Giuffrida, M.L., Riozzi, B., Traficante, A., Bruno, V., Nicoletti, F., Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (2011) Mol. Pharmacol., 79, pp. 618-626
Caraci, F., Castellano, S., Salomone, S., Drago, F., Bosco, P., Di Nuovo, S., Searching for disease-modifying drugs in AD: can we combine neuropsychological tools with biological markers? (2014) CNS Neurol. Disord. Drug Targets, 13, pp. 173-186
Carradori, S., Petzer, J.P., Novel monoamine oxidase inhibitors: a patent review (2012-2014) (2015) Expert Opin. Ther. Pat., 25, pp. 91-110
Carradori, S., Silvestri, S., New frontiers in selective human MAO-B inhibitors (2015) J. Med. Chem.
Chung, J.K., Plitman, E., Nakajima, S., Chow, T.W., Chakravarty, M.M., Carravagio, F., Gerretsen, P., Graff-Guerrero, A., Lifetime history of depression predicts increased amyloid-β accumulation in patients with mild cognitive impairment (2015) J. Alzheimers Dis., 45, pp. 907-919
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta amyloid causes neuronal death (1999) FASEB J., 13, pp. 2225-2234
De Bona, P., Giuffrida, M.L., Caraci, F., Copani, A., Pignataro, B., Attanasio, F., Cataldo, S., Rizzarelli, E., Design and synthesis of new trehalose-conjugated pentapeptides as inhibitors of Abeta(1-42) fibrillogenesis and toxicity (2009) J. Pept. Sci., 15, pp. 220-228
Desino, K.E., Pignatello, R., Guccione, S., Basile, L., Ansar, S., Michaelis, M.L., Ramsay, R.R., Audus, K.L., TCP-But: a derivative of TCP showing improved blood-brain permeability (2009) Biochem. Pharmacol., 78, pp. 1412-1417
Eleuteri, S., Di Giovanni, S., Rockenstein, E., Mante, M., Adame, A., Trejo, M., Wrasidlo, W., Lashuel, H.A., Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease (2015) Neurobiol. Dis., 74, pp. 144-157
Emilsson, L., Saetre, P., Balciuniene, J., Castensson, A., Cairns, N., Jazin, E.E., Increased monoamine oxidase messenger RNA expression levels in frontal cortex of Alzheimer's disease patients (2002) Neurosci. Lett., 326, pp. 56-60
Giacobini, E., Gold, G., Alzheimer disease therapy - moving from amyloid-β to tau (2013) Nat. Rev. Neurol., 9, pp. 677-686
Gong, Y., Klein, W.L., Alzheimer's disease-affected brain: presence of oligomeric Abeta ligands (ADDLs) suggests a molecular basis for reversible memory loss (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 10417-10422
Hardy, J., The amyloid hypothesis for Alzheimer's disease: a critical reappraisal (2009) J. Neurochem., 110 (4), pp. 1129-1134
Jan, A., Adolfsson, O., Allaman, I., Buccarello, A.L., Magistretti, P.J., Pfeifer, A., Muhs, A., Lashuel, H.A., Aβ42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Aβ42 species (2010) J. Biol. Chem., 286, pp. 8585-8596
Kennedy, B.P., Ziegler, M.G., Alford, M., Hansen, L.A., Thal, L.J., Masliah, E., Early and persistent alterations in prefrontal cortex MAO A and B in Alzheimer's disease (2003) J. Neural. Transm., 110, pp. 789-801
Kessing, L.V., Søndergård, L., Forman, J.L., Andersen, P.K., Antidepressants and dementia (2009) J. Affect. Disord., 117, pp. 24-29
Klein, W.L., Synaptotoxic amyloid-β oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease? (2013) J. Alzheimers Dis., 33 (S1), pp. S49-S65
Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 7951-7955
Nibuya, M., Morinobu, S., Duman, R.S., Regulation of BDNF and trkB mRNA in rat brain by chonic electroconvulsive seizure and antidepressant drug treatments (1995) J. Neurosci., 15, pp. 7539-7547
Nibuya, M., Nestler, E.J., Duman, R.S., Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus (1996) J. Neurosci., 16, pp. 2365-2372
Ownby, R.L., Crocco, E., Acevedo, A., Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis (2006) Arch. Gen. Psychiatry, 63, pp. 530-538
Pennington, P.R., Wei, Z., Rui, L., Doig, J.A., Graham, B., Kuski, K., Gabriel, G.G., Mousseau, D.D., Alzheimer disease-related presenilin-1 variants exert distinct effects on monoamine oxidase - a activity in vitro (2011) J. Neural Transm., 118, pp. 987-995
Pignatello, R., Puleo, A., Guccione, S., Raciti, G., Acquaviva, R., Campisi, A., Ventura, C.A., Puglisi, G., Enhancement of drug affinity for cell membranes by conjugation with lipoamino acids. I. Synthesis and biological evaluation of lipophilic conjugates of tranylcypromine (2005) Eur. J. Med. Chem., 40, pp. 1074-1079
Reitz, C., Brayne, C., Mayeux, R., Epidemiology of Alzheimer disease (2011) Nat. Rev. Neurol., 7, pp. 137-152
Shulman, K.I., Herrmann, N., Walker, S.E., Current place of monoamine oxidase inhibitors in the treatment of depression (2013) CNS Drugs, 27, pp. 789-797
Song, M.S., Matveychuk, D., MacKenzie, E.M., Duchcherer, M., Mousseau, D.D., Baker, G.B., An update on amine oxidase inhibitors: multifaceted drugs (2013) Prog. Neuropsychopharmacol. Biol. Psychiatry, 44, pp. 118-124
Walsh, D.M., Selkoe, D.J., A beta oligomers - a decade of discovery (2007) J. Neurochem., 101, pp. 1172-1184
Wei, Z., Gabriel, G.G., Rui, L., Cao, X., Pennington, P.R., Chlan-Fourney, J., Nazarali, A.J., Mousseau, D.D., Monoamine oxidase - a physically interacts with presenilin-1(M146V) in the mouse cortex (2012) J. Alzheimers Dis., 28, pp. 403-422
Yáñez, M., Viña, D., Dual inhibitors of monoamine oxidase and cholinesterase for the treatment of Alzheimer disease (2013) Curr. Top. Med. Chem., 13, pp. 1692-1706
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.73, 5-year impact factor: 2.749
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84937207623&partnerID=40&md5=5b42687a83402da0b49803f68d34824b
Keywords: Amyloid, Anti-Aggregant Acstivity, Antidepressants, Butyric Acid (pubchem Cid: 264), Neurons, Neuroprotection, Tranylcypromine (pubchem Cid: 19493 Or 26070), Tranylcypromine Acetamide (pubchem Cid: 583384), Anti-Aggregant Activity, Amyloid Beta Protein[1-42], Glial Fibrillary Acidic Protein, Microtubule Associated Protein 2, Tranylcypromine Butyramide, Tranylcypromine Derivative, Unclassified Drug, Alzheimer Disease, Animal Cell, Animal Experiment, Animal Model, Article, Controlled Study, Drug Degradation, Drug Efficacy, Drug Potency, Drug Stability, Drug Synthesis, In Vitro Study, Nerve Cell Necrosis, Nerve Degeneration, Neurotoxicity, Nonhuman, Priority Journal, Protein Aggregation,
Affiliations:
*** IBB - CNR ***
Department of drug Sciences, university of Catania, Catania, Italy; IRCCS Associazione Oasi maria S.S., institute for research on mental Retardation and brain aging, Troina, Italy. Electronic address: Carafil@hotmail.com., National research council, institute of Biostructures and Bioimaging, Catania, Italy., Department of drug Sciences, university of Catania, Catania, Italy., Department of drug Sciences, university of Catania, Catania, Italy; National research council, institute of Biostructures and Bioimaging, Catania, Italy., National research council, institute of Biostructures and Bioimaging, Catania, Italy; PhD Program in Translational Biomedicine, university of Catania., Department of biomedical and Biotechnological Sciences, university of Catania, Catania, Italy.,
References:
Al-Nuaimi, S.K., Mackenzie, E.M., Baker, G.B., Monoamine oxidase inhibitors and neuroprotection: a review (2012) Am. J. Ther., 19, pp. 436-44
Baker, G.B., Sowa, B., Todd, K.G., Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders? (2007) J. Psychiatry Neurosci., 32, pp. 313-315
Ballard, C., Day, S., Sharp, S., Wing, G., Sorensen, S., Neuropsychiatric symptoms in dementia: importance and treatment considerations (2008) Int. Rev. Psychiatry, 20, pp. 396-404
Bar-Am, O., Amit, T., Weinreb, O., Youdim, M.B., Mandel, S., Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation (2010) J. Alzheimers Dis., 21, pp. 361-371
Basile, L., Pappalardo, M., Guccione, S., Milardi, D., Ramsay, R.R., Computational comparison of imidazoline association with the I2 binding site in human monoamine oxidases (2014) J. Chem. Inf. Model., 54, pp. 1200-1207
Baskaran, A., Carvalho, A.F., Mansut, R.B., McIntyre, R.S., Are major depressive disorder and diabetes mellitus amyloidogenic conditions? (2014) CNS Neurol. Disord. Drug Targets, 13, pp. 1667-1676
Binda, C., Milczek, E.M., Bonivento, D., Wang, J., Mattevi, A., Edmondson, D.E., Lights and shadows on monoamine oxidase inhibition in neuroprotective pharmacological therapies (2011) Curr. Top. Med. Chem., 11, pp. 2788-2796
Blackley, H.K., Patel, N., Davies, M.C., Roberts, C.J., Tendler, S.J., Wilkinson, M.J., Williams, P.M., Morphological development of beta(1-40) amyloid fibrils (1999) Exp. Neurol., 158, pp. 437-443
Cai, Z., Monoamine oxidase inhibitors: promising therapeutic agents for Alzheimer's disease (2014) Mol. Med. Rep., 9, pp. 1533-1541
Caraci, F., Copani, A., Nicoletti, F., Drago, F., Depression and Alzheimer's disease: neurobiological links and common pharmacological targets (2010) Eur. J. Pharmacol., 626, pp. 64-71
Caraci, F., Molinaro, G., Battaglia, G., Giuffrida, M.L., Riozzi, B., Traficante, A., Bruno, V., Nicoletti, F., Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (2011) Mol. Pharmacol., 79, pp. 618-626
Caraci, F., Castellano, S., Salomone, S., Drago, F., Bosco, P., Di Nuovo, S., Searching for disease-modifying drugs in AD: can we combine neuropsychological tools with biological markers? (2014) CNS Neurol. Disord. Drug Targets, 13, pp. 173-186
Carradori, S., Petzer, J.P., Novel monoamine oxidase inhibitors: a patent review (2012-2014) (2015) Expert Opin. Ther. Pat., 25, pp. 91-110
Carradori, S., Silvestri, S., New frontiers in selective human MAO-B inhibitors (2015) J. Med. Chem.
Chung, J.K., Plitman, E., Nakajima, S., Chow, T.W., Chakravarty, M.M., Carravagio, F., Gerretsen, P., Graff-Guerrero, A., Lifetime history of depression predicts increased amyloid-β accumulation in patients with mild cognitive impairment (2015) J. Alzheimers Dis., 45, pp. 907-919
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta amyloid causes neuronal death (1999) FASEB J., 13, pp. 2225-2234
De Bona, P., Giuffrida, M.L., Caraci, F., Copani, A., Pignataro, B., Attanasio, F., Cataldo, S., Rizzarelli, E., Design and synthesis of new trehalose-conjugated pentapeptides as inhibitors of Abeta(1-42) fibrillogenesis and toxicity (2009) J. Pept. Sci., 15, pp. 220-228
Desino, K.E., Pignatello, R., Guccione, S., Basile, L., Ansar, S., Michaelis, M.L., Ramsay, R.R., Audus, K.L., TCP-But: a derivative of TCP showing improved blood-brain permeability (2009) Biochem. Pharmacol., 78, pp. 1412-1417
Eleuteri, S., Di Giovanni, S., Rockenstein, E., Mante, M., Adame, A., Trejo, M., Wrasidlo, W., Lashuel, H.A., Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease (2015) Neurobiol. Dis., 74, pp. 144-157
Emilsson, L., Saetre, P., Balciuniene, J., Castensson, A., Cairns, N., Jazin, E.E., Increased monoamine oxidase messenger RNA expression levels in frontal cortex of Alzheimer's disease patients (2002) Neurosci. Lett., 326, pp. 56-60
Giacobini, E., Gold, G., Alzheimer disease therapy - moving from amyloid-β to tau (2013) Nat. Rev. Neurol., 9, pp. 677-686
Gong, Y., Klein, W.L., Alzheimer's disease-affected brain: presence of oligomeric Abeta ligands (ADDLs) suggests a molecular basis for reversible memory loss (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 10417-10422
Hardy, J., The amyloid hypothesis for Alzheimer's disease: a critical reappraisal (2009) J. Neurochem., 110 (4), pp. 1129-1134
Jan, A., Adolfsson, O., Allaman, I., Buccarello, A.L., Magistretti, P.J., Pfeifer, A., Muhs, A., Lashuel, H.A., Aβ42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Aβ42 species (2010) J. Biol. Chem., 286, pp. 8585-8596
Kennedy, B.P., Ziegler, M.G., Alford, M., Hansen, L.A., Thal, L.J., Masliah, E., Early and persistent alterations in prefrontal cortex MAO A and B in Alzheimer's disease (2003) J. Neural. Transm., 110, pp. 789-801
Kessing, L.V., Søndergård, L., Forman, J.L., Andersen, P.K., Antidepressants and dementia (2009) J. Affect. Disord., 117, pp. 24-29
Klein, W.L., Synaptotoxic amyloid-β oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease? (2013) J. Alzheimers Dis., 33 (S1), pp. S49-S65
Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 7951-7955
Nibuya, M., Morinobu, S., Duman, R.S., Regulation of BDNF and trkB mRNA in rat brain by chonic electroconvulsive seizure and antidepressant drug treatments (1995) J. Neurosci., 15, pp. 7539-7547
Nibuya, M., Nestler, E.J., Duman, R.S., Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus (1996) J. Neurosci., 16, pp. 2365-2372
Ownby, R.L., Crocco, E., Acevedo, A., Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis (2006) Arch. Gen. Psychiatry, 63, pp. 530-538
Pennington, P.R., Wei, Z., Rui, L., Doig, J.A., Graham, B., Kuski, K., Gabriel, G.G., Mousseau, D.D., Alzheimer disease-related presenilin-1 variants exert distinct effects on monoamine oxidase - a activity in vitro (2011) J. Neural Transm., 118, pp. 987-995
Pignatello, R., Puleo, A., Guccione, S., Raciti, G., Acquaviva, R., Campisi, A., Ventura, C.A., Puglisi, G., Enhancement of drug affinity for cell membranes by conjugation with lipoamino acids. I. Synthesis and biological evaluation of lipophilic conjugates of tranylcypromine (2005) Eur. J. Med. Chem., 40, pp. 1074-1079
Reitz, C., Brayne, C., Mayeux, R., Epidemiology of Alzheimer disease (2011) Nat. Rev. Neurol., 7, pp. 137-152
Shulman, K.I., Herrmann, N., Walker, S.E., Current place of monoamine oxidase inhibitors in the treatment of depression (2013) CNS Drugs, 27, pp. 789-797
Song, M.S., Matveychuk, D., MacKenzie, E.M., Duchcherer, M., Mousseau, D.D., Baker, G.B., An update on amine oxidase inhibitors: multifaceted drugs (2013) Prog. Neuropsychopharmacol. Biol. Psychiatry, 44, pp. 118-124
Walsh, D.M., Selkoe, D.J., A beta oligomers - a decade of discovery (2007) J. Neurochem., 101, pp. 1172-1184
Wei, Z., Gabriel, G.G., Rui, L., Cao, X., Pennington, P.R., Chlan-Fourney, J., Nazarali, A.J., Mousseau, D.D., Monoamine oxidase - a physically interacts with presenilin-1(M146V) in the mouse cortex (2012) J. Alzheimers Dis., 28, pp. 403-422
Yáñez, M., Viña, D., Dual inhibitors of monoamine oxidase and cholinesterase for the treatment of Alzheimer disease (2013) Curr. Top. Med. Chem., 13, pp. 1692-1706
Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity
Abstract Monoamine oxidase (MAO) enzymes play a central role in the pathogenesis of Alzheimer's disease (AD) and MAO inhibitors (MAOIs) are antidepressant drugs currently studied for their neuroprotective properties in neurodegenerative disorders. In the present work MAOIs such as tranylcypromine [trans-(+)-2-phenylcyclopropanamine, TCP] and its amide derivatives, TCP butyramide (TCP-But) and TCP acetamide (TCP-Ac), were tested for their ability to protect cortical neurons challenged with synthetic amyloid-β (Aβ)-(1-42) oligomers (100 nM) for 48 h. TCP significantly prevented Aβ-induced neuronal death in a concentration-dependent fashion and was maximally protective only at 10 μM. TCP-But was maximally protective in mixed neuronal cultures at 1 μM, a lower concentration compared to TCP, whereas the new derivative, TCP-Ac, was more efficacious than TCP and TCP-But and significantly protected cortical neurons against Aβ toxicity at nanomolar concentrations (100 nM). Experiments carried out with the Thioflavin-T (Th-T) fluorescence assay for fibril formation showed that TCP and its amide derivatives influenced the early events of the Aβ aggregation process in a concentration-dependent manner. TCP-Ac was more effective than TCP-But and TCP in slowing down the Aβ(1-42) aggregates formation through a lengthening at the lag phase. In our experimental model co-incubation of Aβ(1-42) oligomers with TCP-Ac was able to almost completely prevent Aβ-induced neurodegeneration. These results suggest that inhibition of Aβ oligomer-mediated aggregation significantly contributes to the overall neuroprotective activity of TCP-Ac and also raise the possibility that TCP, and in particular the new compound TCP-Ac, might represent new pharmacological tools to yield neuroprotection in AD. © 2015 Elsevier B.V.
Abstract Monoamine oxidase (MAO) enzymes play a central role in the pathogenesis of Alzheimer's disease (AD) and MAO inhibitors (MAOIs) are antidepressant drugs currently studied for their neuroprotective properties in neurodegenerative disorders. In the present work MAOIs such as tranylcypromine [trans-(+)-2-phenylcyclopropanamine, TCP] and its amide derivatives, TCP butyramide (TCP-But) and TCP acetamide (TCP-Ac), were tested for their ability to protect cortical neurons challenged with synthetic amyloid-β (Aβ)-(1-42) oligomers (100 nM) for 48 h. TCP significantly prevented Aβ-induced neuronal death in a concentration-dependent fashion and was maximally protective only at 10 μM. TCP-But was maximally protective in mixed neuronal cultures at 1 μM, a lower concentration compared to TCP, whereas the new derivative, TCP-Ac, was more efficacious than TCP and TCP-But and significantly protected cortical neurons against Aβ toxicity at nanomolar concentrations (100 nM). Experiments carried out with the Thioflavin-T (Th-T) fluorescence assay for fibril formation showed that TCP and its amide derivatives influenced the early events of the Aβ aggregation process in a concentration-dependent manner. TCP-Ac was more effective than TCP-But and TCP in slowing down the Aβ(1-42) aggregates formation through a lengthening at the lag phase. In our experimental model co-incubation of Aβ(1-42) oligomers with TCP-Ac was able to almost completely prevent Aβ-induced neurodegeneration. These results suggest that inhibition of Aβ oligomer-mediated aggregation significantly contributes to the overall neuroprotective activity of TCP-Ac and also raise the possibility that TCP, and in particular the new compound TCP-Ac, might represent new pharmacological tools to yield neuroprotection in AD. © 2015 Elsevier B.V.
Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity
No results. |
Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity
Other filter: ([btitle,keywords] "Anti-Aggregant Acsti ...
Pepe G, Calce E, Verdoliva V, Saviano M, Maglione V, Di Pardo A, De Luca S
* Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders (60 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Nov 23; 21(22): N/D-N/D.
Impact Factor: 4.556
View Export to BibTeX Export to EndNote
Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (412 views)
Front Mol Neurosci (ISSN: 1662-5099, 1662-5099linking, 1662-5099electronic), 2018 Nov 13; 11: 414-414.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (853 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
View Export to BibTeX Export to EndNote
Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (544 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
View Export to BibTeX Export to EndNote
Sciacca MFM, Romanucci V, Zarrelli A, Monaco I, Lolicato F, Spinella N, Galati C, Grasso G, D'Urso L, Romeo M, Diomede L, Salmona M, Bongiorno C, Di Fabio G, La Rosa C, Milardi D
* Inhibition of Abeta Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry (401 views) (PDF 194 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2017 Jun 09; N/D: N/D-N/D.
Impact Factor: 4.211
View Export to BibTeX Export to EndNote
Copani A
* The underexplored question of beta-amyloid monomers (299 views)
Eur J Pharmacol (ISSN: 0014-2999), 2017 May 31; N/D: N/D-N/D.
Impact Factor: 3.04
View Export to BibTeX Export to EndNote
D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (745 views)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (291 views) (PDF 202 views)
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Impact Factor: 4.418
View Export to BibTeX Export to EndNote
Pignataro G, Ziaco B, Tortiglione A, Gala R, Cuomo O, Vinciguerra A, Lapi D, Mastantuono T, Anzilotti S, D'Andrea LD, Pedone C, Di Renzo G, Annunziato L, Cataldi M
* Neuroprotective Effect of VEGF-Mimetic Peptide QK in Experimental Brain Ischemia Induced in Rat by Middle Cerebral Artery Occlusion (286 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2015 Sep 16; 6(9): 1517-1525.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
Travaglia A, Pietropaolo A, Di Martino R, Nicoletti VG, La Mendola D, Calissano P, Rizzarelli E
* A Small Linear Peptide Encompassing the NGF N-Terminus Partly Mimics the Biological Activities of the Entire Neurotrophin in PC12 Cells (338 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic, 1948-7193linking), 2015; 6(8): 1379-1392.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (565 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (647 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (4498 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
View Export to BibTeX Export to EndNote
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (900 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (491 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (460 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
View Export to BibTeX Export to EndNote
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (681 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1106 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1479 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1387 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
View Export to BibTeX Export to EndNote
Gustavsson T, Banyasz A, Sarkar N, Markovitsi D, Improta R
* Statin: New life for an old drug (365 views)
Pharmacol Res Academic Press, 2008 Jun 23; 350(1-3): 1-2.
Impact Factor: 3.976
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1004 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
View Export to BibTeX Export to EndNote
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (668 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (444 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
* Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders (60 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Nov 23; 21(22): N/D-N/D.
Impact Factor: 4.556
View Export to BibTeX Export to EndNote
Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (412 views)
Front Mol Neurosci (ISSN: 1662-5099, 1662-5099linking, 1662-5099electronic), 2018 Nov 13; 11: 414-414.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (853 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
View Export to BibTeX Export to EndNote
Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (544 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
View Export to BibTeX Export to EndNote
Sciacca MFM, Romanucci V, Zarrelli A, Monaco I, Lolicato F, Spinella N, Galati C, Grasso G, D'Urso L, Romeo M, Diomede L, Salmona M, Bongiorno C, Di Fabio G, La Rosa C, Milardi D
* Inhibition of Abeta Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry (401 views) (PDF 194 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2017 Jun 09; N/D: N/D-N/D.
Impact Factor: 4.211
View Export to BibTeX Export to EndNote
Copani A
* The underexplored question of beta-amyloid monomers (299 views)
Eur J Pharmacol (ISSN: 0014-2999), 2017 May 31; N/D: N/D-N/D.
Impact Factor: 3.04
View Export to BibTeX Export to EndNote
D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (745 views)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (291 views) (PDF 202 views)
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Impact Factor: 4.418
View Export to BibTeX Export to EndNote
Pignataro G, Ziaco B, Tortiglione A, Gala R, Cuomo O, Vinciguerra A, Lapi D, Mastantuono T, Anzilotti S, D'Andrea LD, Pedone C, Di Renzo G, Annunziato L, Cataldi M
* Neuroprotective Effect of VEGF-Mimetic Peptide QK in Experimental Brain Ischemia Induced in Rat by Middle Cerebral Artery Occlusion (286 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2015 Sep 16; 6(9): 1517-1525.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
Travaglia A, Pietropaolo A, Di Martino R, Nicoletti VG, La Mendola D, Calissano P, Rizzarelli E
* A Small Linear Peptide Encompassing the NGF N-Terminus Partly Mimics the Biological Activities of the Entire Neurotrophin in PC12 Cells (338 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic, 1948-7193linking), 2015; 6(8): 1379-1392.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (565 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (647 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (4498 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
View Export to BibTeX Export to EndNote
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (900 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (491 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (460 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
View Export to BibTeX Export to EndNote
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (681 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1106 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1479 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1387 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
View Export to BibTeX Export to EndNote
Gustavsson T, Banyasz A, Sarkar N, Markovitsi D, Improta R
* Statin: New life for an old drug (365 views)
Pharmacol Res Academic Press, 2008 Jun 23; 350(1-3): 1-2.
Impact Factor: 3.976
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1004 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
View Export to BibTeX Export to EndNote
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (668 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (444 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
32 Records (31 excluding Abstracts).
Total impact factor: 159.442 (154.428 excluding Abstracts).
Total 5 year impact factor: 154.183 (148.892 excluding Abstracts).
Total impact factor: 159.442 (154.428 excluding Abstracts).
Total 5 year impact factor: 154.183 (148.892 excluding Abstracts).
805 views. Last view on Saturday 20 May 2023, 22:27:03
ibb.cnr.it
