Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties (477 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2015; 23(15): 4181-4187.
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Paper type: Journal Article,
Impact factor: 2.923, 5-year impact factor: 2.869
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84937521131&partnerID=40&md5=c7d21eb3e9b0a34eefa1986073fd0681
Keywords: Anti-Infective, Bacteria, Beta-Carbonic Anhydrase, Fungi, Pathogenic Microorganism, Protozoa, Schiff Base, Selective Inhibitor, Sulfonamide, 3 Fluorosulfanilamide, 4 (2 Aminoethyl) Benzenesulfonamide, Aldehyde, Bacterial Enzyme, Carbonate Dehydratase, Carbonate Dehydratase Inhibitor, Fungal Enzyme, Protozoal Protein, Unclassified Drug, Antibacterial Activity, Antifungal Activity, Antiprotozoal Activity, Article, Brucella Suis, Cryptococcus Neoformans, Drug Efficacy, Drug Potency, Drug Selectivity, Drug Structure, Drug Synthesis, Drug Targeting, Enzyme Inhibition, Hydrophilicity, Hydrophobicity, Leishmania Chagasi, Nonhuman, Bacteria (microorganisms), Brucella Melitensis Biovar Suis, Filobasidiella Neoformans, Leishmania Donovani Chagasi,
Affiliations:
*** IBB - CNR ***
Università Degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, Sesto Fiorentino (Florence), Italy
Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, Napoli, Italy
References:
Not available.
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2015; 23(15): 4181-4187.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.923, 5-year impact factor: 2.869
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84937521131&partnerID=40&md5=c7d21eb3e9b0a34eefa1986073fd0681
Keywords: Anti-Infective, Bacteria, Beta-Carbonic Anhydrase, Fungi, Pathogenic Microorganism, Protozoa, Schiff Base, Selective Inhibitor, Sulfonamide, 3 Fluorosulfanilamide, 4 (2 Aminoethyl) Benzenesulfonamide, Aldehyde, Bacterial Enzyme, Carbonate Dehydratase, Carbonate Dehydratase Inhibitor, Fungal Enzyme, Protozoal Protein, Unclassified Drug, Antibacterial Activity, Antifungal Activity, Antiprotozoal Activity, Article, Brucella Suis, Cryptococcus Neoformans, Drug Efficacy, Drug Potency, Drug Selectivity, Drug Structure, Drug Synthesis, Drug Targeting, Enzyme Inhibition, Hydrophilicity, Hydrophobicity, Leishmania Chagasi, Nonhuman, Bacteria (microorganisms), Brucella Melitensis Biovar Suis, Filobasidiella Neoformans, Leishmania Donovani Chagasi,
Affiliations:
*** IBB - CNR ***
Università Degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, Sesto Fiorentino (Florence), Italy
Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, Napoli, Italy
References:
Not available.
Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties
A series of new Schiff bases derived from sulfanilamide, 3-fluorosulfanilamide or 4-(2-aminoethyl)-benzenesulfonamide containing either a hydrophobic or a hydrophilic tail, have been investigated as inhibitors of three β-carbonic anhydrases (CA, EC 4.2.1.1) from three different microorganisms. Their antifungal, antibacterial and antiprotozoan activities have been determined against the pathogenic fungus Cryptococcus neoformans, the bacterial pathogen Brucella suis and the protozoan parasite Leishmania donovani chagasi, responsible for Leishmaniasis. The results of these inhibition studies show that all three enzymes were efficiently inhibited by the Schiff base sulfonamides with KI values in the nanomolar or submicromolar range, depending on the nature of the tail, coming from the aryl/heteroaryl moiety present in the starting aldehyde employed in the synthesis. Furthermore, the compounds hereby investigated revealed high β-CAs selectivity over the ubiquitous, physiologically relevant and off-target human isoforms (CA I and II) and to be more potent as antifungal and antibacterial than as antiprotozoan potential drugs. © 2015 Elsevier Ltd. All rights reserved.
A series of new Schiff bases derived from sulfanilamide, 3-fluorosulfanilamide or 4-(2-aminoethyl)-benzenesulfonamide containing either a hydrophobic or a hydrophilic tail, have been investigated as inhibitors of three β-carbonic anhydrases (CA, EC 4.2.1.1) from three different microorganisms. Their antifungal, antibacterial and antiprotozoan activities have been determined against the pathogenic fungus Cryptococcus neoformans, the bacterial pathogen Brucella suis and the protozoan parasite Leishmania donovani chagasi, responsible for Leishmaniasis. The results of these inhibition studies show that all three enzymes were efficiently inhibited by the Schiff base sulfonamides with K
Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties
| ▼ Targeting Of Protein-Protein Interactions For Therapeutic Purposes |
Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties
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Impact Factor: 4.6
View Export to BibTeX Export to EndNote
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Impact Factor: 4.673
View Export to BibTeX Export to EndNote
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Impact Factor: 6.205
View Export to BibTeX Export to EndNote
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Impact Factor: 3.06
View Export to BibTeX Export to EndNote
Alterio V, Esposito D, Monti SM, Supuran CT, De Simone G
* Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2, 4, 6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor (584 views)
J Enzym Inhib Med Ch (ISSN: 1475-6374electronic, 1475-6366linking), 2018 Dec; 33(1): 151-157.
Impact Factor: 4.293
View Export to BibTeX Export to EndNote
Monti SM, Meccariello A, Ceruso M, Szafranski K, Slawinski J, Supuran CT
* Inhibition studies of Brucella suis beta-carbonic anhydrases with a series of 4-substituted pyridine-3-sulphonamides (457 views)
J Enzym Inhib Med Ch (ISSN: 1475-6374electronic, 1475-6366linking), 2018 Dec; 33(1): 255-259.
Impact Factor: 2.332
View Export to BibTeX Export to EndNote
Angapelly S, Ramya PVS, Angeli A, Monti SM, Buonanno M, Alvala M, Supuran CT, Arifuddin M
* Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors (315 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017; 25(2): 539-544.
Impact Factor: 2.881
View Export to BibTeX Export to EndNote
Calce E, Mignogna E, Bugatti V, Galdiero M, Vittoria V, De Luca S
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Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2014 Jul; 68: 28-32.
Impact Factor: 2.858
View Export to BibTeX Export to EndNote
Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
* The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (530 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
Impact Factor: 2.385
View Export to BibTeX Export to EndNote
Avitabile C, Capparelli R, Rigano MM, Fulgione A, Barone A, Pedone C, Romanelli A
* Antimicrobial peptides from plants: Stabilization of the γ core of a tomato defensin by intramolecular disulfide bond (1116 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 240-245.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Scudiero O, Galdiero S, Nigro E, Del Vecchio L, Di Noto R, Cantisani M, Colavita I, Galdiero M, Cassiman JJ, Daniele A, Pedone C, Salvatore F
* Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines (704 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2013 Apr; 57(4): 1701-1708.
Impact Factor: 4.451
View Export to BibTeX Export to EndNote
Monti SM, De Simone G, Dathan NA, Ludwig M, Vullo D, Scozzafava A, Capasso C, Supuran CT
* Kinetic And Anion Inhibition Studies Of A Beta-Carbonic Anhydrase (fbica 1) From The C-4 Plant Flaveria Bidentis (506 views)
Bioorg Med Chem Lett (ISSN: 0960-894x), 2013 Mar 15; 23(6): 1626-1630.
Impact Factor: 2.331
View Export to BibTeX Export to EndNote
Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (671 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Romanelli A, Moggio L, Montella RC, Campiglia P, Iannaccone M, Capuano F, Pedone C, Capparelli R
* Peptides from Royal Jelly: studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins (2036 views)
J Pept Sci (ISSN: 1099-1387, 1075-2617, 1075-2617print), 2011 Dec 2; 17(5): 348-352.
Impact Factor: 1.799
View Export to BibTeX Export to EndNote
Scudiero O, Galdiero S, Cantisani M, Di Noto R, Vitiello M, Galdiero M, Naclerio G, Cassiman JJ, Pedone C, Castaldo G, Salvatore F
* Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (821 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
Impact Factor: 4.672
View Export to BibTeX Export to EndNote
Vitale RM, Alterio V, Innocenti A, Winum JY, Monti SM, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis- sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors (515 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2009 Oct 8; 52(19): 5990-5998.
Impact Factor: 4.802
View Export to BibTeX Export to EndNote
Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (386 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Jan 15; 16(2): 437-442.
Impact Factor: 2.538
View Export to BibTeX Export to EndNote
17 Records (17 excluding Abstracts).
Total impact factor: 58.068 (58.068 excluding Abstracts).
Total 5 year impact factor: 53.063 (53.063 excluding Abstracts).
Total impact factor: 58.068 (58.068 excluding Abstracts).
Total 5 year impact factor: 53.063 (53.063 excluding Abstracts).
477 views. Last view on Tuesday 24 September 2024, 14:03:51
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