Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment (488 views)
Magn Reson Imaging (ISSN: 0730-725x), 2015; 33(6): 725-736.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.98, 5-year impact factor: 2.327
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84930927735&partnerID=40&md5=0a8837c84854801e249138816b61c686
Keywords: Antiangiogenic, Clustering, Dce-Mri, Gd-Complexes, Pharmacokinetic Modeling, Tumor Heterogeneity, Angiogenesis Inhibitor, Angiomotin, Gadocoletic Acid, Unclassified Drug, Animal Experiment, Animal Model, Antiangiogenic Therapy, Article, Breast Cancer, Cluster Analysis, Contrast Enhancement, Controlled Study, Dna Immunization, Drug Response, Dynamic Contrast Enhanced Magnetic Resonance Imaging, Histogram, Mouse, Nonhuman, Nuclear Magnetic Resonance Imaging, Nuclear Magnetic Resonance Scanner, Priority Journal, Contrast Medium, Gadolinium, Bagg Albino Mouse, Breast Neoplasms, Disease Model, Image Enhancement, Procedures, Inbred Balb C,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging (CNR) c/o Molecular Biotechnologies Center, Via Nizza 52, Torino, Italy
Molecular Imaging Center, University of Torino, Via Nizza 52, Torino, Italy
Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, Torino, Italy
Dept. of Computer Science, University College London, Gower Street, London, United Kingdom
Consiglio Nazionale delle Ricerche
Universita degli Studi di Torino
References:
McDonald, D.M., Choyke, P.L., Imaging of angiogenesis: from microscope to clinic (2003) Nat Med, 9, pp. 713-72
Abdelrahim, M., Konduri, S., Basha, R., Philip, P.A., Baker, C.H., Angiogenesis: an update and potential drug approaches (review) (2010) Int J Oncol, 36, pp. 5-18
Baluk, P., Hashizume, H., McDonald, D.M., Cellular abnormalities of blood vessels as targets in cancer (2005) Curr Opin Genet Dev, 15, pp. 102-111
Hylton, N., Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker (2006) J Clin Oncol, 24, pp. 3293-3298
Miyazaki, K., Collins, D.J., Walker-Samuel, S., Taylor, J.N., Padhani, A.R., Leach, M.O., Quantitative mapping of hepatic perfusion index using MR imaging: a potential reproducible tool for assessing tumour response to treatment with the antiangiogenic compound BIBF 1120, a potent triple angiokinase inhibitor (2008) Eur Radiol, 18, pp. 1414-1421
Jonker, D.J., Rosen, L.S., Sawyer, M.B., de Braud, F., Wilding, G., Sweeney, C.J., A phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors (2011) Ann Oncol, 22, pp. 1413-1419
O'Connor, J.P., Jackson, A., Parker, G.J., Roberts, C., Jayson, G.C., Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies (2012) Nat Rev Clin Oncol, 9, pp. 167-177
Lavini, C., de Jonge, M.C., van de Sande, M.G., Tak, P.P., Nederveen, A.J., Maas, M., Pixel-by-pixel analysis of DCE MRI curve patterns and an illustration of its application to the imaging of the musculoskeletal system (2007) Magn Reson Imaging, 25, pp. 604-612
Tofts, P.S., Modeling tracer kinetics in dynamic Gd-DTPA MR imaging (1997) J Magn Reson Imaging, 7, pp. 91-101
Brix, G., Semmler, W., Port, R., Schad, L.R., Layer, G., Lorenz, W.J., Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging (1991) J Comput Assist Tomogr, 15, pp. 621-628
Yankeelov, T.E., Luci, J.J., Lepage, M., Li, R., Debusk, L., Lin, P.C., Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model (2005) Magn Reson Imaging, 23, pp. 519-529
Turetschek, K., Preda, A., Novikov, V., Brasch, R.C., Weinmann, H.J., Wunderbaldinger, P., Tumor microvascular changes in antiangiogenic treatment: assessment by magnetic resonance contrast media of different molecular weights (2004) J Magn Reson Imaging, 20, pp. 138-144
Farace, P., Merigo, F., Fiorini, S., Nicolato, E., Tambalo, S., Daducci, A., DCE-MRI using small-molecular and albumin-binding contrast agents in experimental carcinomas with different stromal content (2011) Eur J Radiol, 78, pp. 52-59
Longmire, M.R., Ogawa, M., Choyke, P.L., Kobayashi, H., Dendrimers as high relaxivity MR contrast agents (2014) Wiley Interdiscip Rev Nanomed Nanobiotechnol, 6, pp. 155-162
Cheng, H.L., Wallis, C., Shou, Z., Farhat, W.A., Quantifying angiogenesis in VEGF-enhanced tissue-engineered bladder constructs by dynamic contrast-enhanced MRI using contrast agents of different molecular weights (2007) J Magn Reson Imaging, 25, pp. 137-145
de Lussanet, Q.G., Langereis, S., Beets-Tan, R.G., van Genderen, M.H., Griffioen, A.W., van Engelshoven, J.M., Dynamic contrast-enhanced MR imaging kinetic parameters and molecular weight of dendritic contrast agents in tumor angiogenesis in mice (2005) Radiology, 235, pp. 65-72
Aime, S., Gianolio, E., Longo, D., Pagliarin, R., Lovazzano, C., Sisti, M., New insights for pursuing high relaxivity MRI agents from modelling the binding interaction of Gd(III) chelates to HSA (2005) Chembiochem, 6, pp. 818-820
Avedano, S., Tei, L., Lombardi, A., Giovenzana, G.B., Aime, S., Longo, D., Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange (2007) Chem Commun (Camb), pp. 4726-4728
Woods, M., Botta, M., Avedano, S., Wang, J., Sherry, A.D., Towards the rational design of MRI contrast agents: a practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange (2005) Dalton Trans, pp. 3829-3837
Laurent, S., Vander Elst, L., Henrotte, V., Muller, R.N., Noncovalent binding of some new lipophilic gadolinium DTPA complexes to human serum albumin. A structure-affinity relationship (2010) Chem Biodivers, 7, pp. 2846-2855
Geninatti-Crich, S., Szabo, I., Alberti, D., Longo, D., Aime, S., MRI of cells and mice at 1 and 7 Tesla with Gd-targeting agents: when the low field is better! (2011) Contrast Media Mol Imaging, 6, pp. 421-425
Padhani, A.R., MRI for assessing antivascular cancer treatments (2003) Br J Radiol, 76 (Spec No. 1), pp. S60-S80
Armitage, P.A., Farrall, A.J., Carpenter, T.K., Doubal, F.N., Wardlaw, J.M., Use of dynamic contrast-enhanced MRI to measure subtle blood-brain barrier abnormalities (2011) Magn Reson Imaging, 29, pp. 305-314
Gillies, R.J., Schornack, P.A., Secomb, T.W., Raghunand, N., Causes and effects of heterogeneous perfusion in tumors (1999) Neoplasia, 1, pp. 197-207
Casanovas, O., Hicklin, D.J., Bergers, G., Hanahan, D., Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors (2005) Cancer Cell, 8, pp. 299-309
O'Connor, J.P., Rose, C.J., Waterton, J.C., Carano, R.A., Parker, G.J., Jackson, A., Imaging intratumor heterogeneity: role in therapy response, resistance, and clinical outcome (2015) Clin Cancer Res, 21, pp. 249-257
Checkley, D., Tessier, J.J., Kendrew, J., Waterton, J.C., Wedge, S.R., Use of dynamic contrast-enhanced MRI to evaluate acute treatment with ZD6474, a VEGF signalling inhibitor, in PC-3 prostate tumours (2003) Br J Cancer, 89, pp. 1889-1895
Galbraith, S.M., Maxwell, R.J., Lodge, M.A., Tozer, G.M., Wilson, J., Taylor, N.J., Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging (2003) J Clin Oncol, 21, pp. 2831-2842
Yankeelov, T.E., Lepage, M., Chakravarthy, A., Broome, E.E., Niermann, K.J., Kelley, M.C., Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results (2007) Magn Reson Imaging, 25, pp. 1-13
Rose, C.J., Mills, S.J., O'Connor, J.P., Buonaccorsi, G.A., Roberts, C., Watson, Y., Quantifying spatial heterogeneity in dynamic contrast-enhanced MRI parameter maps (2009) Magn Reson Med, 62, pp. 488-499
Chang, Y.C., Huang, Y.H., Huang, C.S., Chang, P.K., Chen, J.H., Chang, R.F., Classification of breast mass lesions using model-based analysis of the characteristic kinetic curve derived from fuzzy c-means clustering (2012) Magn Reson Imaging, 30, pp. 312-322
Lavini, C., Verhoeff, J.J., Majoie, C.B., Stalpers, L.J., Richel, D.J., Maas, M., Model-based, semiquantitative and time intensity curve shape analysis of dynamic contrast-enhanced MRI: a comparison in patients undergoing antiangiogenic treatment for recurrent glioma (2011) J Magn Reson Imaging, 34, pp. 1303-1312
Berry, L.R., Barck, K.H., Go, M.A., Ross, J., Wu, X., Williams, S.P., Quantification of viable tumor microvascular characteristics by multispectral analysis (2008) Magn Reson Med, 60, pp. 64-72
Cavagna, F.M., Lorusso, V., Anelli, P.L., Maggioni, F., de Haen, C., Preclinical profile and clinical potential of gadocoletic acid trisodium salt (B22956/1), a new intravascular contrast medium for MRI (2002) Acad Radiol, 9, pp. S491-S494
Rovero, S., Amici, A., Di Carlo, E., Bei, R., Nanni, P., Quaglino, E., DNA vaccination against rat her-2/Neu p185 more effectively inhibits carcinogenesis than transplantable carcinomas in transgenic BALB/c mice (2000) J Immunol, 165, pp. 5133-5142
Holmgren, L., Ambrosino, E., Birot, O., Tullus, C., Veitonmaki, N., Levchenko, T., A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth (2006) Proc Natl Acad Sci U S A, 103, pp. 9208-9213
Ramachandran, S., Calcagno, C., Mani, V., Robson, P.M., Fayad, Z.A., Registration of dynamic contrast-enhanced MRI of the common carotid artery using a fixed-frame template-based squared-difference method (2014) J Magn Reson Imaging, 39, p. 1017
Brookes, J.A., Redpath, T.W., Gilbert, F.J., Murray, A.D., Staff, R.T., Accuracy of T1 measurement in dynamic contrast-enhanced breast MRI using two- and three-dimensional variable flip angle fast low-angle shot (1999) J Magn Reson Imaging, 9, pp. 163-171
Liimatainen, T., Sierra, A., Hanson, T., Sorce, D.J., Yla-Herttuala, S., Garwood, M., Glioma cell density in a rat gene therapy model gauged by water relaxation rate along a fictitious magnetic field (2012) Magn Reson Med, 67, pp. 269-277
Ertas, G., Gulcur, H.O., Tunaci, M., Improved lesion detection in MR mammography: three-dimensional segmentation, moving voxel sampling, and normalized maximum intensity-time ratio entropy (2007) Acad Radiol, 14, pp. 151-161
Michoux, N., Simoni, P., Tombal, B., Peeters, F., Machiels, J.P., Lecouvet, F., Evaluation of DCE-MRI postprocessing techniques to assess metastatic bone marrow in patients with prostate cancer (2012) Clin Imaging, 36, pp. 308-315
Faul, F., Erdfelder, E., Lang, A.G., Buchner, A., G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences (2007) Behav Res Methods, 39, pp. 175-191
Knopp, M.V., von Tengg-Kobligk, H., Choyke, P.L., Functional magnetic resonance imaging in oncology for diagnosis and therapy monitoring (2003) Mol Cancer Ther, 2, pp. 419-426
Arigoni, M., Barutello, G., Lanzardo, S., Longo, D., Aime, S., Curcio, C., A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors (2012) Angiogenesis, 15, pp. 305-316
Preda, A., Turetschek, K., Daldrup, H., Floyd, E., Novikov, V., Shames, D.M., The choice of region of interest measures in contrast-enhanced magnetic resonance image characterization of experimental breast tumors (2005) Invest Radiol, 40, pp. 349-354
Peng, S.L., Chen, C.F., Liu, H.L., Lui, C.C., Huang, Y.J., Lee, T.H., Analysis of parametric histogram from dynamic contrast-enhanced MRI: application in evaluating brain tumor response to radiotherapy (2013) NMR Biomed, 26, pp. 443-450
Jain, R.K., Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy (2005) Science, 307, pp. 58-62
Ali, M.M., Janic, B., Babajani-Feremi, A., Varma, N.R., Iskander, A.S., Anagli, J., Changes in vascular permeability and expression of different angiogenic factors following anti-angiogenic treatment in rat glioma (2010) PLoS One, 5, p. e8727
Fotinos-Hoyer, A.K., Guermazi, A., Jara, H., Eckstein, F., Ozonoff, A., Khard, H., Assessment of synovitis in the osteoarthritic knee: comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast-enhanced fat-suppressed T1-weighted MRI (2010) Magn Reson Med, 64, pp. 604-609
Raatschen, H.J., Fu, Y., Brasch, R.C., Pietsch, H., Shames, D.M., Yeh, B.M., In vivo monitoring of angiogenesis inhibitory treatment effects by dynamic contrast-enhanced computed tomography in a xenograft tumor model (2009) Invest Radiol, 44, pp. 265-270
Wilmes, L.J., Pallavicini, M.G., Fleming, L.M., Gibbs, J., Wang, D., Li, K.L., AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging (2007) Magn Reson Imaging, 25, pp. 319-327
Bandini, S., Curcio, C., Macagno, M., Quaglino, E., Arigoni, M., Lanzardo, S., Early onset and enhanced growth of autochthonous mammary carcinomas in C3-deficient Her2/neu transgenic mice (2013) Oncoimmunology, 2, p. e26137
Magn Reson Imaging (ISSN: 0730-725x), 2015; 33(6): 725-736.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.98, 5-year impact factor: 2.327
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84930927735&partnerID=40&md5=0a8837c84854801e249138816b61c686
Keywords: Antiangiogenic, Clustering, Dce-Mri, Gd-Complexes, Pharmacokinetic Modeling, Tumor Heterogeneity, Angiogenesis Inhibitor, Angiomotin, Gadocoletic Acid, Unclassified Drug, Animal Experiment, Animal Model, Antiangiogenic Therapy, Article, Breast Cancer, Cluster Analysis, Contrast Enhancement, Controlled Study, Dna Immunization, Drug Response, Dynamic Contrast Enhanced Magnetic Resonance Imaging, Histogram, Mouse, Nonhuman, Nuclear Magnetic Resonance Imaging, Nuclear Magnetic Resonance Scanner, Priority Journal, Contrast Medium, Gadolinium, Bagg Albino Mouse, Breast Neoplasms, Disease Model, Image Enhancement, Procedures, Inbred Balb C,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging (CNR) c/o Molecular Biotechnologies Center, Via Nizza 52, Torino, Italy
Molecular Imaging Center, University of Torino, Via Nizza 52, Torino, Italy
Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, Torino, Italy
Dept. of Computer Science, University College London, Gower Street, London, United Kingdom
Consiglio Nazionale delle Ricerche
Universita degli Studi di Torino
References:
McDonald, D.M., Choyke, P.L., Imaging of angiogenesis: from microscope to clinic (2003) Nat Med, 9, pp. 713-72
Abdelrahim, M., Konduri, S., Basha, R., Philip, P.A., Baker, C.H., Angiogenesis: an update and potential drug approaches (review) (2010) Int J Oncol, 36, pp. 5-18
Baluk, P., Hashizume, H., McDonald, D.M., Cellular abnormalities of blood vessels as targets in cancer (2005) Curr Opin Genet Dev, 15, pp. 102-111
Hylton, N., Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker (2006) J Clin Oncol, 24, pp. 3293-3298
Miyazaki, K., Collins, D.J., Walker-Samuel, S., Taylor, J.N., Padhani, A.R., Leach, M.O., Quantitative mapping of hepatic perfusion index using MR imaging: a potential reproducible tool for assessing tumour response to treatment with the antiangiogenic compound BIBF 1120, a potent triple angiokinase inhibitor (2008) Eur Radiol, 18, pp. 1414-1421
Jonker, D.J., Rosen, L.S., Sawyer, M.B., de Braud, F., Wilding, G., Sweeney, C.J., A phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors (2011) Ann Oncol, 22, pp. 1413-1419
O'Connor, J.P., Jackson, A., Parker, G.J., Roberts, C., Jayson, G.C., Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies (2012) Nat Rev Clin Oncol, 9, pp. 167-177
Lavini, C., de Jonge, M.C., van de Sande, M.G., Tak, P.P., Nederveen, A.J., Maas, M., Pixel-by-pixel analysis of DCE MRI curve patterns and an illustration of its application to the imaging of the musculoskeletal system (2007) Magn Reson Imaging, 25, pp. 604-612
Tofts, P.S., Modeling tracer kinetics in dynamic Gd-DTPA MR imaging (1997) J Magn Reson Imaging, 7, pp. 91-101
Brix, G., Semmler, W., Port, R., Schad, L.R., Layer, G., Lorenz, W.J., Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging (1991) J Comput Assist Tomogr, 15, pp. 621-628
Yankeelov, T.E., Luci, J.J., Lepage, M., Li, R., Debusk, L., Lin, P.C., Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model (2005) Magn Reson Imaging, 23, pp. 519-529
Turetschek, K., Preda, A., Novikov, V., Brasch, R.C., Weinmann, H.J., Wunderbaldinger, P., Tumor microvascular changes in antiangiogenic treatment: assessment by magnetic resonance contrast media of different molecular weights (2004) J Magn Reson Imaging, 20, pp. 138-144
Farace, P., Merigo, F., Fiorini, S., Nicolato, E., Tambalo, S., Daducci, A., DCE-MRI using small-molecular and albumin-binding contrast agents in experimental carcinomas with different stromal content (2011) Eur J Radiol, 78, pp. 52-59
Longmire, M.R., Ogawa, M., Choyke, P.L., Kobayashi, H., Dendrimers as high relaxivity MR contrast agents (2014) Wiley Interdiscip Rev Nanomed Nanobiotechnol, 6, pp. 155-162
Cheng, H.L., Wallis, C., Shou, Z., Farhat, W.A., Quantifying angiogenesis in VEGF-enhanced tissue-engineered bladder constructs by dynamic contrast-enhanced MRI using contrast agents of different molecular weights (2007) J Magn Reson Imaging, 25, pp. 137-145
de Lussanet, Q.G., Langereis, S., Beets-Tan, R.G., van Genderen, M.H., Griffioen, A.W., van Engelshoven, J.M., Dynamic contrast-enhanced MR imaging kinetic parameters and molecular weight of dendritic contrast agents in tumor angiogenesis in mice (2005) Radiology, 235, pp. 65-72
Aime, S., Gianolio, E., Longo, D., Pagliarin, R., Lovazzano, C., Sisti, M., New insights for pursuing high relaxivity MRI agents from modelling the binding interaction of Gd(III) chelates to HSA (2005) Chembiochem, 6, pp. 818-820
Avedano, S., Tei, L., Lombardi, A., Giovenzana, G.B., Aime, S., Longo, D., Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange (2007) Chem Commun (Camb), pp. 4726-4728
Woods, M., Botta, M., Avedano, S., Wang, J., Sherry, A.D., Towards the rational design of MRI contrast agents: a practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange (2005) Dalton Trans, pp. 3829-3837
Laurent, S., Vander Elst, L., Henrotte, V., Muller, R.N., Noncovalent binding of some new lipophilic gadolinium DTPA complexes to human serum albumin. A structure-affinity relationship (2010) Chem Biodivers, 7, pp. 2846-2855
Geninatti-Crich, S., Szabo, I., Alberti, D., Longo, D., Aime, S., MRI of cells and mice at 1 and 7 Tesla with Gd-targeting agents: when the low field is better! (2011) Contrast Media Mol Imaging, 6, pp. 421-425
Padhani, A.R., MRI for assessing antivascular cancer treatments (2003) Br J Radiol, 76 (Spec No. 1), pp. S60-S80
Armitage, P.A., Farrall, A.J., Carpenter, T.K., Doubal, F.N., Wardlaw, J.M., Use of dynamic contrast-enhanced MRI to measure subtle blood-brain barrier abnormalities (2011) Magn Reson Imaging, 29, pp. 305-314
Gillies, R.J., Schornack, P.A., Secomb, T.W., Raghunand, N., Causes and effects of heterogeneous perfusion in tumors (1999) Neoplasia, 1, pp. 197-207
Casanovas, O., Hicklin, D.J., Bergers, G., Hanahan, D., Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors (2005) Cancer Cell, 8, pp. 299-309
O'Connor, J.P., Rose, C.J., Waterton, J.C., Carano, R.A., Parker, G.J., Jackson, A., Imaging intratumor heterogeneity: role in therapy response, resistance, and clinical outcome (2015) Clin Cancer Res, 21, pp. 249-257
Checkley, D., Tessier, J.J., Kendrew, J., Waterton, J.C., Wedge, S.R., Use of dynamic contrast-enhanced MRI to evaluate acute treatment with ZD6474, a VEGF signalling inhibitor, in PC-3 prostate tumours (2003) Br J Cancer, 89, pp. 1889-1895
Galbraith, S.M., Maxwell, R.J., Lodge, M.A., Tozer, G.M., Wilson, J., Taylor, N.J., Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging (2003) J Clin Oncol, 21, pp. 2831-2842
Yankeelov, T.E., Lepage, M., Chakravarthy, A., Broome, E.E., Niermann, K.J., Kelley, M.C., Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results (2007) Magn Reson Imaging, 25, pp. 1-13
Rose, C.J., Mills, S.J., O'Connor, J.P., Buonaccorsi, G.A., Roberts, C., Watson, Y., Quantifying spatial heterogeneity in dynamic contrast-enhanced MRI parameter maps (2009) Magn Reson Med, 62, pp. 488-499
Chang, Y.C., Huang, Y.H., Huang, C.S., Chang, P.K., Chen, J.H., Chang, R.F., Classification of breast mass lesions using model-based analysis of the characteristic kinetic curve derived from fuzzy c-means clustering (2012) Magn Reson Imaging, 30, pp. 312-322
Lavini, C., Verhoeff, J.J., Majoie, C.B., Stalpers, L.J., Richel, D.J., Maas, M., Model-based, semiquantitative and time intensity curve shape analysis of dynamic contrast-enhanced MRI: a comparison in patients undergoing antiangiogenic treatment for recurrent glioma (2011) J Magn Reson Imaging, 34, pp. 1303-1312
Berry, L.R., Barck, K.H., Go, M.A., Ross, J., Wu, X., Williams, S.P., Quantification of viable tumor microvascular characteristics by multispectral analysis (2008) Magn Reson Med, 60, pp. 64-72
Cavagna, F.M., Lorusso, V., Anelli, P.L., Maggioni, F., de Haen, C., Preclinical profile and clinical potential of gadocoletic acid trisodium salt (B22956/1), a new intravascular contrast medium for MRI (2002) Acad Radiol, 9, pp. S491-S494
Rovero, S., Amici, A., Di Carlo, E., Bei, R., Nanni, P., Quaglino, E., DNA vaccination against rat her-2/Neu p185 more effectively inhibits carcinogenesis than transplantable carcinomas in transgenic BALB/c mice (2000) J Immunol, 165, pp. 5133-5142
Holmgren, L., Ambrosino, E., Birot, O., Tullus, C., Veitonmaki, N., Levchenko, T., A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth (2006) Proc Natl Acad Sci U S A, 103, pp. 9208-9213
Ramachandran, S., Calcagno, C., Mani, V., Robson, P.M., Fayad, Z.A., Registration of dynamic contrast-enhanced MRI of the common carotid artery using a fixed-frame template-based squared-difference method (2014) J Magn Reson Imaging, 39, p. 1017
Brookes, J.A., Redpath, T.W., Gilbert, F.J., Murray, A.D., Staff, R.T., Accuracy of T1 measurement in dynamic contrast-enhanced breast MRI using two- and three-dimensional variable flip angle fast low-angle shot (1999) J Magn Reson Imaging, 9, pp. 163-171
Liimatainen, T., Sierra, A., Hanson, T., Sorce, D.J., Yla-Herttuala, S., Garwood, M., Glioma cell density in a rat gene therapy model gauged by water relaxation rate along a fictitious magnetic field (2012) Magn Reson Med, 67, pp. 269-277
Ertas, G., Gulcur, H.O., Tunaci, M., Improved lesion detection in MR mammography: three-dimensional segmentation, moving voxel sampling, and normalized maximum intensity-time ratio entropy (2007) Acad Radiol, 14, pp. 151-161
Michoux, N., Simoni, P., Tombal, B., Peeters, F., Machiels, J.P., Lecouvet, F., Evaluation of DCE-MRI postprocessing techniques to assess metastatic bone marrow in patients with prostate cancer (2012) Clin Imaging, 36, pp. 308-315
Faul, F., Erdfelder, E., Lang, A.G., Buchner, A., G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences (2007) Behav Res Methods, 39, pp. 175-191
Knopp, M.V., von Tengg-Kobligk, H., Choyke, P.L., Functional magnetic resonance imaging in oncology for diagnosis and therapy monitoring (2003) Mol Cancer Ther, 2, pp. 419-426
Arigoni, M., Barutello, G., Lanzardo, S., Longo, D., Aime, S., Curcio, C., A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors (2012) Angiogenesis, 15, pp. 305-316
Preda, A., Turetschek, K., Daldrup, H., Floyd, E., Novikov, V., Shames, D.M., The choice of region of interest measures in contrast-enhanced magnetic resonance image characterization of experimental breast tumors (2005) Invest Radiol, 40, pp. 349-354
Peng, S.L., Chen, C.F., Liu, H.L., Lui, C.C., Huang, Y.J., Lee, T.H., Analysis of parametric histogram from dynamic contrast-enhanced MRI: application in evaluating brain tumor response to radiotherapy (2013) NMR Biomed, 26, pp. 443-450
Jain, R.K., Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy (2005) Science, 307, pp. 58-62
Ali, M.M., Janic, B., Babajani-Feremi, A., Varma, N.R., Iskander, A.S., Anagli, J., Changes in vascular permeability and expression of different angiogenic factors following anti-angiogenic treatment in rat glioma (2010) PLoS One, 5, p. e8727
Fotinos-Hoyer, A.K., Guermazi, A., Jara, H., Eckstein, F., Ozonoff, A., Khard, H., Assessment of synovitis in the osteoarthritic knee: comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast-enhanced fat-suppressed T1-weighted MRI (2010) Magn Reson Med, 64, pp. 604-609
Raatschen, H.J., Fu, Y., Brasch, R.C., Pietsch, H., Shames, D.M., Yeh, B.M., In vivo monitoring of angiogenesis inhibitory treatment effects by dynamic contrast-enhanced computed tomography in a xenograft tumor model (2009) Invest Radiol, 44, pp. 265-270
Wilmes, L.J., Pallavicini, M.G., Fleming, L.M., Gibbs, J., Wang, D., Li, K.L., AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging (2007) Magn Reson Imaging, 25, pp. 319-327
Bandini, S., Curcio, C., Macagno, M., Quaglino, E., Arigoni, M., Lanzardo, S., Early onset and enhanced growth of autochthonous mammary carcinomas in C3-deficient Her2/neu transgenic mice (2013) Oncoimmunology, 2, p. e26137
Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment
Purpose: The objective of this study was to compare a clustering approach to conventional analysis methods for assessing changes in pharmacokinetic parameters obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) during antiangiogenic treatment in a breast cancer model. Materials and methods: BALB/c mice bearing established transplantable her2+ tumors were treated with a DNA-based antiangiogenic vaccine or with an empty plasmid (untreated group). DCE-MRI was carried out by administering a dose of 0.05mmol/kg of Gadocoletic acid trisodium salt, a Gd-based blood pool contrast agent (CA) at 1T. Changes in pharmacokinetic estimates (Ktrans and vp ) in a nine-day interval were compared between treated and untreated groups on a voxel-by-voxel analysis. The tumor response to therapy was assessed by a clustering approach and compared with conventional summary statistics, with sub-regions analysis and with histogram analysis. Results: Both the Ktrans and vp estimates, following blood-pool CA injection, showed marked and spatial heterogeneous changes with antiangiogenic treatment. Averaged values for the whole tumor region, as well as from the rim/core sub-regions analysis were unable to assess the antiangiogenic response. Histogram analysis resulted in significant changes only in the vp estimates (p<0.05). The proposed clustering approach depicted marked changes in both the Ktrans and vp estimates, with significant spatial heterogeneity in vp maps in response to treatment (p<0.05), provided that DCE-MRI data are properly clustered in three or four sub-regions. Conclusions: This study demonstrated the value of cluster analysis applied to pharmacokinetic DCE-MRI parametric maps for assessing tumor response to antiangiogenic therapy.
Purpose: The objective of this study was to compare a clustering approach to conventional analysis methods for assessing changes in pharmacokinetic parameters obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) during antiangiogenic treatment in a breast cancer model. Materials and methods: BALB/c mice bearing established transplantable her2+ tumors were treated with a DNA-based antiangiogenic vaccine or with an empty plasmid (untreated group). DCE-MRI was carried out by administering a dose of 0.05mmol/kg of Gadocoletic acid trisodium salt, a Gd-based blood pool contrast agent (CA) at 1T. Changes in pharmacokinetic estimates (Ktrans and v
Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment
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Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment
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Conte C, Moret F, Esposito D, Dal Poggetto G, Avitabile C, Ungaro F, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Biodegradable nanoparticles exposing a short anti-FLT1 peptide as antiangiogenic platform to complement docetaxel anticancer activity (215 views)
Mater Sci Eng C Mater Biol Appl (ISSN: 0928-4931linking), 2019 Sep; 102: 876-886.
Impact Factor: 5.08
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Garello F, Pagoto A, Arena F, Buffo A, Blasi F, Alberti D, Terreno E
* MRI visualization of neuroinflammation using VCAM-1 targeted paramagnetic micelles (231 views)
Nanomedicine (ISSN: 1549-9634, 1549-9642), 2017 Nov 8; N/D: N/D-N/D.
Impact Factor: 6.5
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Longo DL, Stefania R, Callari C, De Rose F, Rolle R, Conti L, Consolino L, Arena F, Aime S
* Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy (229 views)
Adv Healthc Mater (ISSN: 2192-2640, 2192-2640linking), 2016 Oct 26; N/D: N/D-N/D.
Impact Factor: 5.11
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Delli Castelli D, Ferrauto G, Di Gregorio E, Terreno E, Aime S
* Sensitive MRI detection of internalized T contrast agents using magnetization transfer contrast (247 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2015 Oct 16; N/D: N/D-N/D.
Impact Factor: 2.983
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Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (470 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (554 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (559 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (511 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (421 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1177 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (615 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (464 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
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Rendina D, Mossetti G, Soscia E, Sirignano C, Insabato L, Viceconti R, Ignarra R, Salvatore M, Nunziata V
* Giant cell tumor and Paget's disease of bone in one family: geographic clustering (360 views)
Clinical Orthopaedics And Related Research (ISSN: 0009-921x), 2004 Apr; (421): 218-224.
Impact Factor: 1.403
View Export to BibTeX Export to EndNote
* Biodegradable nanoparticles exposing a short anti-FLT1 peptide as antiangiogenic platform to complement docetaxel anticancer activity (215 views)
Mater Sci Eng C Mater Biol Appl (ISSN: 0928-4931linking), 2019 Sep; 102: 876-886.
Impact Factor: 5.08
View Export to BibTeX Export to EndNote
Garello F, Pagoto A, Arena F, Buffo A, Blasi F, Alberti D, Terreno E
* MRI visualization of neuroinflammation using VCAM-1 targeted paramagnetic micelles (231 views)
Nanomedicine (ISSN: 1549-9634, 1549-9642), 2017 Nov 8; N/D: N/D-N/D.
Impact Factor: 6.5
View Export to BibTeX Export to EndNote
Longo DL, Stefania R, Callari C, De Rose F, Rolle R, Conti L, Consolino L, Arena F, Aime S
* Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy (229 views)
Adv Healthc Mater (ISSN: 2192-2640, 2192-2640linking), 2016 Oct 26; N/D: N/D-N/D.
Impact Factor: 5.11
View Export to BibTeX Export to EndNote
Delli Castelli D, Ferrauto G, Di Gregorio E, Terreno E, Aime S
* Sensitive MRI detection of internalized T contrast agents using magnetization transfer contrast (247 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2015 Oct 16; N/D: N/D-N/D.
Impact Factor: 2.983
View Export to BibTeX Export to EndNote
Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (470 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (554 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (559 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
View Export to BibTeX Export to EndNote
Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (511 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (421 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
View Export to BibTeX Export to EndNote
Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1177 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
View Export to BibTeX Export to EndNote
Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (615 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (464 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
View Export to BibTeX Export to EndNote
Rendina D, Mossetti G, Soscia E, Sirignano C, Insabato L, Viceconti R, Ignarra R, Salvatore M, Nunziata V
* Giant cell tumor and Paget's disease of bone in one family: geographic clustering (360 views)
Clinical Orthopaedics And Related Research (ISSN: 0009-921x), 2004 Apr; (421): 218-224.
Impact Factor: 1.403
View Export to BibTeX Export to EndNote
13 Records (12 excluding Abstracts).
Total impact factor: 61.69 (58.707 excluding Abstracts).
Total 5 year impact factor: 62.25 (58.878 excluding Abstracts).
Total impact factor: 61.69 (58.707 excluding Abstracts).
Total 5 year impact factor: 62.25 (58.878 excluding Abstracts).
488 views. Last view on Saturday 14 January 2023, 15:36:22
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