Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria (489 views)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 0925-4439), 2013 Jun; 1830(6): 3767-3775.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.829, 5-year impact factor: 4.554
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84875971013&partnerID=40&md5=cf9baca151845d5d930b0147fae0a8cd
Keywords: Antimicrobial Activity, Binding, Structure, Temporin, Antiinfective Agent, Lipopolysaccharide, Temporin 1b, Temporin 1b G6a, Temporin 1b G6a S11a, Temporin 1b N7a, Temporin 1b P3a, Temporin 1b S11a, Temporin Kkg6a, Unclassified Drug, Antibacterial Activity, Aqueous Solution, Article, Circular Dichroism, Concentration (parameters), Controlled Study, Drug Binding, Drug Conformation, Drug Design, Drug Effect, Escherichia Coli, Fluorescence Analysis, Nonhuman, Nuclear Magnetic Resonance, Priority Journal, Salmonella Typhimurium, Sequence Analysis, Staphylococcus Aureus, Staphylococcus Epidermidis, Structure Activity Relation, Amphibian Proteins, Animals, Anti-Bacterial Agents, Rana Temporaria, Bacteria (microorganisms), Negibacteria, Posibacteria,
Affiliations:
*** IBB - CNR ***
Università di Napoli Federico II, Dipartimento Delle Scienze Biologiche, Via Mezzocannone 16, 80134 Napoli, Italy
Seconda Università Degli Studi di Napoli, Dipartimento di Scienze Ambientali, Via Vivaldi 43, 81100 Caserta, Italy
Istituto di Biostrutture e Bioimmagini (CNR), Via Mezzocannone 16, 80134 Napoli, Italy
Universit di Napoli Federico II, Dipartimento Delle Scienze Biologiche, Via Mezzocannone 16, 80134 Napoli, Italy
Seconda Universit Degli Studi di Napoli, Dipartimento di Scienze Ambientali, Via Vivaldi 43, 81100 Caserta, Italy
References:
Boman, H.G., Peptide antibiotics and their role in innate immunity (1995) Annu. Rev. Immunol., 13, pp. 61-9
Rinaldi, A.C., Antimicrobial peptides from amphibian skin: An expanding scenario (2002) Curr. Opin. Chem. Biol., 6, pp. 799-804
Hoskin, D.W., Ramamoorthy, A., Studies on anticancer activities of antimicrobial peptides (2008) Biochim. Biophys. Acta, 1778, pp. 357-375
Papo, N., Shai, Y., Host defense peptides as new weapons in cancer treatment (2005) Cell. Mol. Life Sci., 62, pp. 784-790
Mor, A., Multifunctional host defense peptides: Antiparasitic activities (2009) FEBS J., 276, pp. 6474-6482
Pereira, H.A., Novel therapies based on cationic antimicrobial peptides (2006) Curr. Pharm. Biotechnol., 7, pp. 229-234
Finlay, B.B., Hancock, R.E., Can innate immunity be enhanced to treat microbial infections? (2004) Nat. Rev. Microbiol., 2, pp. 497-504
Hancock, R.E., Patrzykat, A., Clinical development of cationic antimicrobial peptides: From natural to novel antibiotics (2002) Curr. Drug Targets Infect. Disord., 2, pp. 79-83
Rosenfeld, Y., Shai, Y., Lipopolysaccharide (Endotoxin)-host defense antibacterial peptides interactions: Role in bacterial resistance and prevention of sepsis (2006) Biochim. Biophys. Acta, 1758, pp. 1513-1522
Bhattacharjya, S., Ramamoorthy, A., Multifunctional host defense peptides: Functional and mechanistic insights from NMR structures of potent antimicrobial peptides (2009) FEBS J., 276, pp. 6465-6473
Blondelle, S.E., Lohner, K., Combinatorial libraries: A tool to design antimicrobial and antifungal peptide analogues having lytic specificities for structure-activity relationship studies (2000) Biopolymers, 55, pp. 74-87
Papo, N., Oren, Z., Pag, U., Sahl, H.G., Shai, Y., The consequence of sequence alteration of an amphipathic alpha-helical antimicrobial peptide and its diastereomers (2002) J. Biol. Chem., 277, pp. 33913-33921
Nikaido, H., Prevention of drug access to bacterial targets: Permeability barriers and active efflux (1994) Science (New York, N.Y.), 264, pp. 382-388
Hancock, R.E., Alterations in outer membrane permeability (1984) Annu. Rev. Microbiol., 38, pp. 237-264
Mahalka, A.K., Kinnunen, P.K., Binding of amphipathic alpha-helical antimicrobial peptides to lipid membranes: Lessons from temporins B and L (2009) Biochim. Biophys. Acta, 1788, pp. 1600-1609
Mangoni, M.L., Shai, Y., Temporins and their synergism against Gram-negative bacteria and in lipopolysaccharide detoxification (2009) Biochim. Biophys. Acta, 1788, pp. 1610-1619
Mangoni, M.L., Epand, R.F., Rosenfeld, Y., Peleg, A., Barra, D., Epand, R.M., Shai, Y., Lipopolysaccharide, a key molecule involved in the synergism between temporins in inhibiting bacterial growth and in endotoxin neutralization (2008) J. Biol. Chem., 283, pp. 22907-22917
Romanelli, A., Moggio, L., Montella, R.C., Campiglia, P., Iannaccone, M., Capuano, F., Pedone, C., Capparelli, R., Peptides from Royal Jelly: Studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins (2011) J. Pept. Sci., 17, pp. 348-352
Bradbury, A.F., Smyth, D.G., Peptide amidation (1991) Trends Biochem. Sci., 16, pp. 112-115
Shai, Y., Mode of action of membrane active antimicrobial peptides (2002) Biopolymers, 66, pp. 236-248
Bhunia, A., Ramamoorthy, A., Bhattacharjya, S., Helical hairpin structure of a potent antimicrobial peptide MSI-594 in lipopolysaccharide micelles by NMR spectroscopy (2009) Chemistry, 15, pp. 2036-2040
Zasloff, M., Antimicrobial peptides of multicellular organisms (2002) Nature, 415, pp. 389-395
Rinaldi, A.C., Mangoni, M.L., Rufo, A., Luzi, C., Barra, D., Zhao, H., Kinnunen, P.K., Simmaco, M., Temporin L: Antimicrobial, haemolytic and cytotoxic activities, and effects on membrane permeabilization in lipid vesicles (2002) Biochem. J., 368, pp. 91-100
Conlon, J.M., Al-Ghafari, N., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H., Davidson, C., Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species (2006) Peptides, 27, pp. 1305-1312
Rosenfeld, Y., Barra, D., Simmaco, M., Shai, Y., Mangoni, M.L., A synergism between temporins toward Gram-negative bacteria overcomes resistance imposed by the lipopolysaccharide protective layer (2006) J. Biol. Chem., 281, pp. 28565-28574
Capparelli, R., Romanelli, A., Iannaccone, M., Nocerino, N., Ripa, R., Pensato, S., Pedone, C., Iannelli, D., Synergistic antibacterial and anti-inflammatory activity of temporin A and modified temporin B in vivo (2009) PLoS One, 4, p. 7191
Carotenuto, A., Malfi, S., Saviello, M.R., Campiglia, P., Gomez-Monterrey, I., Mangoni, M.L., Gaddi, L.M., Grieco, P., A different molecular mechanism underlying antimicrobial and hemolytic actions of temporins A and L (2008) J. Med. Chem., 51, pp. 2354-2362
Bhunia, A., Saravanan, R., Mohanram, H., Mangoni, M.L., Bhattacharjya, S., NMR structures and interactions of temporin-1Tl and temporin-1Tb with lipopolysaccharide micelles: Mechanistic insights into outer membrane permeabilization and synergistic activity (2011) J. Biol. Chem., 286, pp. 24394-24406
Grieco, P., Luca, V., Auriemma, L., Carotenuto, A., Saviello, M.R., Campiglia, P., Barra, D., Mangoni, M.L., Alanine scanning analysis and structure-function relationships of the frog-skin antimicrobial peptide temporin-1Ta (2011) J. Pept. Sci., 17, pp. 358-365
Chen, X., Howe, J., Andra, J., Rossle, M., Richter, W., Da Silva, A.P., Krensky, A.M., Brandenburg, K., Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins (2007) Biochim. Biophys. Acta, 1768, pp. 2421-2431
Ananias, M., Yano, T., Serogroups and virulence genotypes of Escherichia coli isolated from patients with sepsis (2008) Braz. J. Med. Biol. Res., 41, pp. 877-883
Hong, Y., Liu, T., Lee, M.D., Hofacre, C.L., Maier, M., White, D.G., Ayers, S., Maurer, J.J., Rapid screening of Salmonella enterica serovars Enteritidis, Hadar, Heidelberg and Typhimurium using a serologically-correlative allelotyping PCR targeting the O and H antigen alleles (2008) BMC Microbiol., 8, p. 178
Pechorsky, A., Nitzan, Y., Lazarovitch, T., Identification of pathogenic bacteria in blood cultures: Comparison between conventional and PCR methods (2009) J. Microbiol. Methods, 78, pp. 325-330
Lee, J., Choi, Y., Woo, E.R., Lee, D.G., Isocryptomerin, a novel membrane-active antifungal compound from Selaginella tamariscina (2009) Biochem. Biophys. Res. Commun., 379, pp. 676-680
Mayer, M., Meyer, B., Characterization of ligand binding by saturation transfer difference NMR spectroscopy (1999) Angew. Chem. Int. Ed., 38, pp. 1784-1788
Bhunia, A., Mohanram, H., Bhattacharjya, S., Lipopolysaccharide bound structures of the active fragments of fowlicidin-1, a cathelicidin family of antimicrobial and antiendotoxic peptide from chicken, determined by transferred nuclear Overhauser effect spectroscopy (2009) Biopolymers, 92, pp. 9-22
Bhunia, A., Domadia, P.N., Bhattacharjya, S., Structural and thermodynamic analyses of the interaction between melittin and lipopolysaccharide (2007) Biochim. Biophys. Acta, 1768, pp. 3282-3291
Herrmann, T., Guntert, P., Wuthrich, K., Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA (2002) J. Mol. Biol., 319, pp. 209-227
Guntert, P., Automated NMR structure calculation with CYANA (2004) Meth. Mol. Biol. (Clifton, N.J.), 278, pp. 353-378
Koradi, R., Billeter, M., Wuthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J. Mol. Graph., 14, pp. 51-55. , (29-32)
Laskowski, R.A., Rullmannn, J.A., MacArthur, M.W., Kaptein, R., Thornton, J.M., AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR (1996) J. Biomol. NMR, 8, pp. 477-486
Wade, D., Silveira, A., Silberring, J., Kuusela, P., Lankinen, H., Temporin antibiotic peptides: A review and derivation of a consensus sequence (2000) Protein Pept. Lett., 7, pp. 349-357
Rosenfeld, Y., Papo, N., Shai, Y., Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action (2006) J. Biol. Chem., 281, pp. 1636-1643
Wuthrich, K., (1986) NMR of Proteins and Nucleic Acids, p. 292. , John Wiley & Sons Inc. New York
Wang, Z., Jones, J.D., Rizo, J., Gierasch, L.M., Membrane-bound conformation of a signal peptide: A transferred nuclear Overhauser effect analysis (1993) Biochemistry, 32, pp. 13991-13999
Galdiero, S., Russo, L., Falanga, A., Cantisani, M., Vitiello, M., Fattorusso, R., Malgieri, G., Isernia, C., Structure and orientation of the gH625-644 membrane interacting region of herpes simplex virus type 1 in a membrane mimetic system (2012) Biochemistry, 51, pp. 3121-3128
Mihajlovic, M., Lazaridis, T., Charge distribution and imperfect amphipathicity affect pore formation by antimicrobial peptides (2012) Biochim. Biophys. Acta, 1818, pp. 1274-1283
Nagaoka, I., Hirota, S., Niyonsaba, F., Hirata, M., Adachi, Y., Tamura, H., Heumann, D., Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells (2001) J. Immunol., 167, pp. 3329-3338
Ding, L., Yang, L., Weiss, T.M., Waring, A.J., Lehrer, R.I., Huang, H.W., Interaction of antimicrobial peptides with lipopolysaccharides (2003) Biochemistry, 42, pp. 12251-12259
Epand, R.M., Vogel, H.J., Diversity of antimicrobial peptides and their mechanisms of action (1999) Biochim. Biophys. Acta, 1462, pp. 11-28
Andra, J., Lamata, M., Martinez De Tejada, G., Bartels, R., Koch, M.H., Brandenburg, K., Cyclic antimicrobial peptides based on Limulus anti-lipopolysaccharide factor for neutralization of lipopolysaccharide (2004) Biochem. Pharmacol., 68, pp. 1297-1307
Schuerholz, T., Brandenburg, K., Marx, G., Antimicrobial peptides and their potential application in inflammation and sepsis (2012) Crit. Care, 16, p. 207
Andra, J., Garidel, P., Majerle, A., Jerala, R., Ridge, R., Paus, E., Novitsky, T., Brandenburg, K., Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide (2004) Eur. J. Biochem., 271, pp. 2037-2046
Andra, J., Howe, J., Garidel, P., Rossle, M., Richter, W., Leiva-Leon, J., Moriyon, I., Brandenburg, K., Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: Thermodynamic, biophysical and microbiological analysis (2007) Biochem. J., 406, pp. 297-307
Dathe, M., Wieprecht, T., Structural features of helical antimicrobial peptides: Their potential to modulate activity on model membranes and biological cells (1999) Biochim. Biophys. Acta, 1462, pp. 71-87
Chen, Y., Mant, C.T., Farmer, S.W., Hancock, R.E., Vasil, M.L., Hodges, R.S., Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index (2005) J. Biol. Chem., 280, pp. 12316-12329
Boman, H. G., Peptide antibiotics and their role in innate immunity (1995) Annu. Rev. Immunol., 13, pp. 61-9
Rinaldi, A. C., Antimicrobial peptides from amphibian skin: An expanding scenario (2002) Curr. Opin. Chem. Biol., 6, pp. 799-804
Hoskin, D. W., Ramamoorthy, A., Studies on anticancer activities of antimicrobial peptides (2008) Biochim. Biophys. Acta, 1778, pp. 357-375
Pereira, H. A., Novel therapies based on cationic antimicrobial peptides (2006) Curr. Pharm. Biotechnol., 7, pp. 229-234
Finlay, B. B., Hancock, R. E., Can innate immunity be enhanced to treat microbial infections? (2004) Nat. Rev. Microbiol., 2, pp. 497-504
Hancock, R. E., Patrzykat, A., Clinical development of cationic antimicrobial peptides: From natural to novel antibiotics (2002) Curr. Drug Targets Infect. Disord., 2, pp. 79-83
Blondelle, S. E., Lohner, K., Combinatorial libraries: A tool to design antimicrobial and antifungal peptide analogues having lytic specificities for structure-activity relationship studies (2000) Biopolymers, 55, pp. 74-87
Hancock, R. E., Alterations in outer membrane permeability (1984) Annu. Rev. Microbiol., 38, pp. 237-264
Mahalka, A. K., Kinnunen, P. K., Binding of amphipathic alpha-helical antimicrobial peptides to lipid membranes: Lessons from temporins B and L (2009) Biochim. Biophys. Acta, 1788, pp. 1600-1609
Mangoni, M. L., Shai, Y., Temporins and their synergism against Gram-negative bacteria and in lipopolysaccharide detoxification (2009) Biochim. Biophys. Acta, 1788, pp. 1610-1619
Mangoni, M. L., Epand, R. F., Rosenfeld, Y., Peleg, A., Barra, D., Epand, R. M., Shai, Y., Lipopolysaccharide, a key molecule involved in the synergism between temporins in inhibiting bacterial growth and in endotoxin neutralization (2008) J. Biol. Chem., 283, pp. 22907-22917
Bradbury, A. F., Smyth, D. G., Peptide amidation (1991) Trends Biochem. Sci., 16, pp. 112-115
Rinaldi, A. C., Mangoni, M. L., Rufo, A., Luzi, C., Barra, D., Zhao, H., Kinnunen, P. K., Simmaco, M., Temporin L: Antimicrobial, haemolytic and cytotoxic activities, and effects on membrane permeabilization in lipid vesicles (2002) Biochem. J., 368, pp. 91-100
Conlon, J. M., Al-Ghafari, N., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H., Davidson, C., Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species (2006) Peptides, 27, pp. 1305-1312
Laskowski, R. A., Rullmannn, J. A., MacArthur, M. W., Kaptein, R., Thornton, J. M., AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR (1996) J. Biomol. NMR, 8, pp. 477-486
Epand, R. M., Vogel, H. J., Diversity of antimicrobial peptides and their mechanisms of action (1999) Biochim. Biophys. Acta, 1462, pp. 11-28
Chen, Y., Mant, C. T., Farmer, S. W., Hancock, R. E., Vasil, M. L., Hodges, R. S., Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index (2005) J. Biol. Chem., 280, pp. 12316-12329
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 0925-4439), 2013 Jun; 1830(6): 3767-3775.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.829, 5-year impact factor: 4.554
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84875971013&partnerID=40&md5=cf9baca151845d5d930b0147fae0a8cd
Keywords: Antimicrobial Activity, Binding, Structure, Temporin, Antiinfective Agent, Lipopolysaccharide, Temporin 1b, Temporin 1b G6a, Temporin 1b G6a S11a, Temporin 1b N7a, Temporin 1b P3a, Temporin 1b S11a, Temporin Kkg6a, Unclassified Drug, Antibacterial Activity, Aqueous Solution, Article, Circular Dichroism, Concentration (parameters), Controlled Study, Drug Binding, Drug Conformation, Drug Design, Drug Effect, Escherichia Coli, Fluorescence Analysis, Nonhuman, Nuclear Magnetic Resonance, Priority Journal, Salmonella Typhimurium, Sequence Analysis, Staphylococcus Aureus, Staphylococcus Epidermidis, Structure Activity Relation, Amphibian Proteins, Animals, Anti-Bacterial Agents, Rana Temporaria, Bacteria (microorganisms), Negibacteria, Posibacteria,
Affiliations:
*** IBB - CNR ***
Università di Napoli Federico II, Dipartimento Delle Scienze Biologiche, Via Mezzocannone 16, 80134 Napoli, Italy
Seconda Università Degli Studi di Napoli, Dipartimento di Scienze Ambientali, Via Vivaldi 43, 81100 Caserta, Italy
Istituto di Biostrutture e Bioimmagini (CNR), Via Mezzocannone 16, 80134 Napoli, Italy
Universit di Napoli Federico II, Dipartimento Delle Scienze Biologiche, Via Mezzocannone 16, 80134 Napoli, Italy
Seconda Universit Degli Studi di Napoli, Dipartimento di Scienze Ambientali, Via Vivaldi 43, 81100 Caserta, Italy
References:
Boman, H.G., Peptide antibiotics and their role in innate immunity (1995) Annu. Rev. Immunol., 13, pp. 61-9
Rinaldi, A.C., Antimicrobial peptides from amphibian skin: An expanding scenario (2002) Curr. Opin. Chem. Biol., 6, pp. 799-804
Hoskin, D.W., Ramamoorthy, A., Studies on anticancer activities of antimicrobial peptides (2008) Biochim. Biophys. Acta, 1778, pp. 357-375
Papo, N., Shai, Y., Host defense peptides as new weapons in cancer treatment (2005) Cell. Mol. Life Sci., 62, pp. 784-790
Mor, A., Multifunctional host defense peptides: Antiparasitic activities (2009) FEBS J., 276, pp. 6474-6482
Pereira, H.A., Novel therapies based on cationic antimicrobial peptides (2006) Curr. Pharm. Biotechnol., 7, pp. 229-234
Finlay, B.B., Hancock, R.E., Can innate immunity be enhanced to treat microbial infections? (2004) Nat. Rev. Microbiol., 2, pp. 497-504
Hancock, R.E., Patrzykat, A., Clinical development of cationic antimicrobial peptides: From natural to novel antibiotics (2002) Curr. Drug Targets Infect. Disord., 2, pp. 79-83
Rosenfeld, Y., Shai, Y., Lipopolysaccharide (Endotoxin)-host defense antibacterial peptides interactions: Role in bacterial resistance and prevention of sepsis (2006) Biochim. Biophys. Acta, 1758, pp. 1513-1522
Bhattacharjya, S., Ramamoorthy, A., Multifunctional host defense peptides: Functional and mechanistic insights from NMR structures of potent antimicrobial peptides (2009) FEBS J., 276, pp. 6465-6473
Blondelle, S.E., Lohner, K., Combinatorial libraries: A tool to design antimicrobial and antifungal peptide analogues having lytic specificities for structure-activity relationship studies (2000) Biopolymers, 55, pp. 74-87
Papo, N., Oren, Z., Pag, U., Sahl, H.G., Shai, Y., The consequence of sequence alteration of an amphipathic alpha-helical antimicrobial peptide and its diastereomers (2002) J. Biol. Chem., 277, pp. 33913-33921
Nikaido, H., Prevention of drug access to bacterial targets: Permeability barriers and active efflux (1994) Science (New York, N.Y.), 264, pp. 382-388
Hancock, R.E., Alterations in outer membrane permeability (1984) Annu. Rev. Microbiol., 38, pp. 237-264
Mahalka, A.K., Kinnunen, P.K., Binding of amphipathic alpha-helical antimicrobial peptides to lipid membranes: Lessons from temporins B and L (2009) Biochim. Biophys. Acta, 1788, pp. 1600-1609
Mangoni, M.L., Shai, Y., Temporins and their synergism against Gram-negative bacteria and in lipopolysaccharide detoxification (2009) Biochim. Biophys. Acta, 1788, pp. 1610-1619
Mangoni, M.L., Epand, R.F., Rosenfeld, Y., Peleg, A., Barra, D., Epand, R.M., Shai, Y., Lipopolysaccharide, a key molecule involved in the synergism between temporins in inhibiting bacterial growth and in endotoxin neutralization (2008) J. Biol. Chem., 283, pp. 22907-22917
Romanelli, A., Moggio, L., Montella, R.C., Campiglia, P., Iannaccone, M., Capuano, F., Pedone, C., Capparelli, R., Peptides from Royal Jelly: Studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins (2011) J. Pept. Sci., 17, pp. 348-352
Bradbury, A.F., Smyth, D.G., Peptide amidation (1991) Trends Biochem. Sci., 16, pp. 112-115
Shai, Y., Mode of action of membrane active antimicrobial peptides (2002) Biopolymers, 66, pp. 236-248
Bhunia, A., Ramamoorthy, A., Bhattacharjya, S., Helical hairpin structure of a potent antimicrobial peptide MSI-594 in lipopolysaccharide micelles by NMR spectroscopy (2009) Chemistry, 15, pp. 2036-2040
Zasloff, M., Antimicrobial peptides of multicellular organisms (2002) Nature, 415, pp. 389-395
Rinaldi, A.C., Mangoni, M.L., Rufo, A., Luzi, C., Barra, D., Zhao, H., Kinnunen, P.K., Simmaco, M., Temporin L: Antimicrobial, haemolytic and cytotoxic activities, and effects on membrane permeabilization in lipid vesicles (2002) Biochem. J., 368, pp. 91-100
Conlon, J.M., Al-Ghafari, N., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H., Davidson, C., Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species (2006) Peptides, 27, pp. 1305-1312
Rosenfeld, Y., Barra, D., Simmaco, M., Shai, Y., Mangoni, M.L., A synergism between temporins toward Gram-negative bacteria overcomes resistance imposed by the lipopolysaccharide protective layer (2006) J. Biol. Chem., 281, pp. 28565-28574
Capparelli, R., Romanelli, A., Iannaccone, M., Nocerino, N., Ripa, R., Pensato, S., Pedone, C., Iannelli, D., Synergistic antibacterial and anti-inflammatory activity of temporin A and modified temporin B in vivo (2009) PLoS One, 4, p. 7191
Carotenuto, A., Malfi, S., Saviello, M.R., Campiglia, P., Gomez-Monterrey, I., Mangoni, M.L., Gaddi, L.M., Grieco, P., A different molecular mechanism underlying antimicrobial and hemolytic actions of temporins A and L (2008) J. Med. Chem., 51, pp. 2354-2362
Bhunia, A., Saravanan, R., Mohanram, H., Mangoni, M.L., Bhattacharjya, S., NMR structures and interactions of temporin-1Tl and temporin-1Tb with lipopolysaccharide micelles: Mechanistic insights into outer membrane permeabilization and synergistic activity (2011) J. Biol. Chem., 286, pp. 24394-24406
Grieco, P., Luca, V., Auriemma, L., Carotenuto, A., Saviello, M.R., Campiglia, P., Barra, D., Mangoni, M.L., Alanine scanning analysis and structure-function relationships of the frog-skin antimicrobial peptide temporin-1Ta (2011) J. Pept. Sci., 17, pp. 358-365
Chen, X., Howe, J., Andra, J., Rossle, M., Richter, W., Da Silva, A.P., Krensky, A.M., Brandenburg, K., Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins (2007) Biochim. Biophys. Acta, 1768, pp. 2421-2431
Ananias, M., Yano, T., Serogroups and virulence genotypes of Escherichia coli isolated from patients with sepsis (2008) Braz. J. Med. Biol. Res., 41, pp. 877-883
Hong, Y., Liu, T., Lee, M.D., Hofacre, C.L., Maier, M., White, D.G., Ayers, S., Maurer, J.J., Rapid screening of Salmonella enterica serovars Enteritidis, Hadar, Heidelberg and Typhimurium using a serologically-correlative allelotyping PCR targeting the O and H antigen alleles (2008) BMC Microbiol., 8, p. 178
Pechorsky, A., Nitzan, Y., Lazarovitch, T., Identification of pathogenic bacteria in blood cultures: Comparison between conventional and PCR methods (2009) J. Microbiol. Methods, 78, pp. 325-330
Lee, J., Choi, Y., Woo, E.R., Lee, D.G., Isocryptomerin, a novel membrane-active antifungal compound from Selaginella tamariscina (2009) Biochem. Biophys. Res. Commun., 379, pp. 676-680
Mayer, M., Meyer, B., Characterization of ligand binding by saturation transfer difference NMR spectroscopy (1999) Angew. Chem. Int. Ed., 38, pp. 1784-1788
Bhunia, A., Mohanram, H., Bhattacharjya, S., Lipopolysaccharide bound structures of the active fragments of fowlicidin-1, a cathelicidin family of antimicrobial and antiendotoxic peptide from chicken, determined by transferred nuclear Overhauser effect spectroscopy (2009) Biopolymers, 92, pp. 9-22
Bhunia, A., Domadia, P.N., Bhattacharjya, S., Structural and thermodynamic analyses of the interaction between melittin and lipopolysaccharide (2007) Biochim. Biophys. Acta, 1768, pp. 3282-3291
Herrmann, T., Guntert, P., Wuthrich, K., Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA (2002) J. Mol. Biol., 319, pp. 209-227
Guntert, P., Automated NMR structure calculation with CYANA (2004) Meth. Mol. Biol. (Clifton, N.J.), 278, pp. 353-378
Koradi, R., Billeter, M., Wuthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J. Mol. Graph., 14, pp. 51-55. , (29-32)
Laskowski, R.A., Rullmannn, J.A., MacArthur, M.W., Kaptein, R., Thornton, J.M., AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR (1996) J. Biomol. NMR, 8, pp. 477-486
Wade, D., Silveira, A., Silberring, J., Kuusela, P., Lankinen, H., Temporin antibiotic peptides: A review and derivation of a consensus sequence (2000) Protein Pept. Lett., 7, pp. 349-357
Rosenfeld, Y., Papo, N., Shai, Y., Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action (2006) J. Biol. Chem., 281, pp. 1636-1643
Wuthrich, K., (1986) NMR of Proteins and Nucleic Acids, p. 292. , John Wiley & Sons Inc. New York
Wang, Z., Jones, J.D., Rizo, J., Gierasch, L.M., Membrane-bound conformation of a signal peptide: A transferred nuclear Overhauser effect analysis (1993) Biochemistry, 32, pp. 13991-13999
Galdiero, S., Russo, L., Falanga, A., Cantisani, M., Vitiello, M., Fattorusso, R., Malgieri, G., Isernia, C., Structure and orientation of the gH625-644 membrane interacting region of herpes simplex virus type 1 in a membrane mimetic system (2012) Biochemistry, 51, pp. 3121-3128
Mihajlovic, M., Lazaridis, T., Charge distribution and imperfect amphipathicity affect pore formation by antimicrobial peptides (2012) Biochim. Biophys. Acta, 1818, pp. 1274-1283
Nagaoka, I., Hirota, S., Niyonsaba, F., Hirata, M., Adachi, Y., Tamura, H., Heumann, D., Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells (2001) J. Immunol., 167, pp. 3329-3338
Ding, L., Yang, L., Weiss, T.M., Waring, A.J., Lehrer, R.I., Huang, H.W., Interaction of antimicrobial peptides with lipopolysaccharides (2003) Biochemistry, 42, pp. 12251-12259
Epand, R.M., Vogel, H.J., Diversity of antimicrobial peptides and their mechanisms of action (1999) Biochim. Biophys. Acta, 1462, pp. 11-28
Andra, J., Lamata, M., Martinez De Tejada, G., Bartels, R., Koch, M.H., Brandenburg, K., Cyclic antimicrobial peptides based on Limulus anti-lipopolysaccharide factor for neutralization of lipopolysaccharide (2004) Biochem. Pharmacol., 68, pp. 1297-1307
Schuerholz, T., Brandenburg, K., Marx, G., Antimicrobial peptides and their potential application in inflammation and sepsis (2012) Crit. Care, 16, p. 207
Andra, J., Garidel, P., Majerle, A., Jerala, R., Ridge, R., Paus, E., Novitsky, T., Brandenburg, K., Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide (2004) Eur. J. Biochem., 271, pp. 2037-2046
Andra, J., Howe, J., Garidel, P., Rossle, M., Richter, W., Leiva-Leon, J., Moriyon, I., Brandenburg, K., Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: Thermodynamic, biophysical and microbiological analysis (2007) Biochem. J., 406, pp. 297-307
Dathe, M., Wieprecht, T., Structural features of helical antimicrobial peptides: Their potential to modulate activity on model membranes and biological cells (1999) Biochim. Biophys. Acta, 1462, pp. 71-87
Chen, Y., Mant, C.T., Farmer, S.W., Hancock, R.E., Vasil, M.L., Hodges, R.S., Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index (2005) J. Biol. Chem., 280, pp. 12316-12329
Boman, H. G., Peptide antibiotics and their role in innate immunity (1995) Annu. Rev. Immunol., 13, pp. 61-9
Rinaldi, A. C., Antimicrobial peptides from amphibian skin: An expanding scenario (2002) Curr. Opin. Chem. Biol., 6, pp. 799-804
Hoskin, D. W., Ramamoorthy, A., Studies on anticancer activities of antimicrobial peptides (2008) Biochim. Biophys. Acta, 1778, pp. 357-375
Pereira, H. A., Novel therapies based on cationic antimicrobial peptides (2006) Curr. Pharm. Biotechnol., 7, pp. 229-234
Finlay, B. B., Hancock, R. E., Can innate immunity be enhanced to treat microbial infections? (2004) Nat. Rev. Microbiol., 2, pp. 497-504
Hancock, R. E., Patrzykat, A., Clinical development of cationic antimicrobial peptides: From natural to novel antibiotics (2002) Curr. Drug Targets Infect. Disord., 2, pp. 79-83
Blondelle, S. E., Lohner, K., Combinatorial libraries: A tool to design antimicrobial and antifungal peptide analogues having lytic specificities for structure-activity relationship studies (2000) Biopolymers, 55, pp. 74-87
Hancock, R. E., Alterations in outer membrane permeability (1984) Annu. Rev. Microbiol., 38, pp. 237-264
Mahalka, A. K., Kinnunen, P. K., Binding of amphipathic alpha-helical antimicrobial peptides to lipid membranes: Lessons from temporins B and L (2009) Biochim. Biophys. Acta, 1788, pp. 1600-1609
Mangoni, M. L., Shai, Y., Temporins and their synergism against Gram-negative bacteria and in lipopolysaccharide detoxification (2009) Biochim. Biophys. Acta, 1788, pp. 1610-1619
Mangoni, M. L., Epand, R. F., Rosenfeld, Y., Peleg, A., Barra, D., Epand, R. M., Shai, Y., Lipopolysaccharide, a key molecule involved in the synergism between temporins in inhibiting bacterial growth and in endotoxin neutralization (2008) J. Biol. Chem., 283, pp. 22907-22917
Bradbury, A. F., Smyth, D. G., Peptide amidation (1991) Trends Biochem. Sci., 16, pp. 112-115
Rinaldi, A. C., Mangoni, M. L., Rufo, A., Luzi, C., Barra, D., Zhao, H., Kinnunen, P. K., Simmaco, M., Temporin L: Antimicrobial, haemolytic and cytotoxic activities, and effects on membrane permeabilization in lipid vesicles (2002) Biochem. J., 368, pp. 91-100
Conlon, J. M., Al-Ghafari, N., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H., Davidson, C., Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species (2006) Peptides, 27, pp. 1305-1312
Laskowski, R. A., Rullmannn, J. A., MacArthur, M. W., Kaptein, R., Thornton, J. M., AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR (1996) J. Biomol. NMR, 8, pp. 477-486
Epand, R. M., Vogel, H. J., Diversity of antimicrobial peptides and their mechanisms of action (1999) Biochim. Biophys. Acta, 1462, pp. 11-28
Chen, Y., Mant, C. T., Farmer, S. W., Hancock, R. E., Vasil, M. L., Hodges, R. S., Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index (2005) J. Biol. Chem., 280, pp. 12316-12329
Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria
Background: Temporins are small antimicrobial peptides secreted by the Rana temporaria showing mainly activity against Gram-positive bacteria. However, different members of the temporin family, such as Temporin B, act in synergy also against Gram-negative bacteria. With the aim to develop a peptide with a wide spectrum of antimicrobial activity we designed and analyzed a series of Temporin B analogs. Methods: Peptides were initially obtained by Ala scanning on Temporin B sequence; antimicrobial activity tests allowed to identify the TB_G6A sequence, which was further optimized by increasing the peptide positive charge (TB_KKG6A). Interactions of this active peptide with the LPS of E. coli were investigated by CD, fluorescence and NMR. Results: TB_KKG6A is active against Gram-positive and Gram-negative bacteria at low concentrations. The peptide strongly interacts with the LPS of Gram-negative bacteria and folds upon interaction into a kinked helix. Conclusion: Our results show that it is possible to widen the activity spectrum of an antimicrobial peptide by subtle changes of the primary structure. TB_KKG6A, having a simple composition, a broad spectrum of antimicrobial activity and a very low hemolytic activity, is a promising candidate for the design of novel antimicrobial peptides. General significance: The activity of antimicrobial peptides is strongly related to the ability of the peptide to interact and break the bacterial membrane. Our studies on TB_KKG6A indicate that efficient interactions with LPS can be achieved when the peptide is not perfectly amphipathic, since this feature seems to help the toroidal pore formation process. (C) 2013 Elsevier B.V. All rights reserved.
Background: Temporins are small antimicrobial peptides secreted by the Rana temporaria showing mainly activity against Gram-positive bacteria. However, different members of the temporin family, such as Temporin B, act in synergy also against Gram-negative bacteria. With the aim to develop a peptide with a wide spectrum of antimicrobial activity we designed and analyzed a series of Temporin B analogs. Methods: Peptides were initially obtained by Ala scanning on Temporin B sequence; antimicrobial activity tests allowed to identify the TB_G6A sequence, which was further optimized by increasing the peptide positive charge (TB_KKG6A). Interactions of this active peptide with the LPS of E. coli were investigated by CD, fluorescence and NMR. Results: TB_KKG6A is active against Gram-positive and Gram-negative bacteria at low concentrations. The peptide strongly interacts with the LPS of Gram-negative bacteria and folds upon interaction into a kinked helix. Conclusion: Our results show that it is possible to widen the activity spectrum of an antimicrobial peptide by subtle changes of the primary structure. TB_KKG6A, having a simple composition, a broad spectrum of antimicrobial activity and a very low hemolytic activity, is a promising candidate for the design of novel antimicrobial peptides. General significance: The activity of antimicrobial peptides is strongly related to the ability of the peptide to interact and break the bacterial membrane. Our studies on TB_KKG6A indicate that efficient interactions with LPS can be achieved when the peptide is not perfectly amphipathic, since this feature seems to help the toroidal pore formation process. (C) 2013 Elsevier B.V. All rights reserved.
Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria
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Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (441 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (465 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
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Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (387 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (547 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (760 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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* Effect of Acylation on the Antimicrobial Activity of Temporin B Analogues (411 views)
Chemmedchem (ISSN: 1860-7179linking, 1860-7187electronic), 2018 Aug 10; 13(15): 1549-1554.
Impact Factor: 3.009
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Dennehy R, RomanoM, Ruggiero A, Mohamed YF, Dignam SL, Mujica Troncoso C, Callaghan M, Valvano MA, Berisio R, Mcclean S
* The Burkholderia cenocepacia peptidoglycan-associated lipoprotein is involved in epithelial cell attachment and elicitation of inflammation (294 views)
Cell Microbiol (ISSN: 1462-5814), 2017 May; 19(5): e12691-e12691.
Impact Factor: 4.41
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Tremonte P, Pannella G, Succi M, Tipaldi L, Sturchio M, Coppola R, Luongo D, Sorrentino E
* Antimicrobial activity of Lactobacillus plantarum strains isolated from different environments: a preliminary study (277 views) (PDF 186 views)
International Food Research Journal, 2017 Apr; 24(2): 852-859.
Impact Factor: 0
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Pane K, Sgambati V, Zanfardino A, Smaldone G, Cafaro V, Angrisano T, Pedone E, Di Gaetano S, Capasso D, Haney EF, Izzo V, Varcamonti M, Notomista E, Hancock RE, Di Donato A, Pizzo E
* A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells (427 views)
Febs J (ISSN: 1742-464x), 2016; N/D: N/D-N/D.
Impact Factor: 3.902
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Scudiero O, Nigro E, Cantisani M, Colavita I, Leone M, Mercurio FA, Galdiero M, Pessi A, Daniele A, Salvatore F, Galdiero S
* Design and activity of a cyclic mini-beta-defensin analog: a novel antimicrobial tool (299 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2015 Oct 15; 10: 6523-6539.
Impact Factor: 4.32
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Galdiero S, Falanga A, Berisio R, Grieco P, Morelli G, Galdiero M
* Antimicrobial peptides as an opportunity against bacterial diseases (761 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 Mar 11; 22(14): 1665-1677.
Impact Factor: 3.455
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Molinaro A, Holst O, Lorenzo FD, Callaghan M, Nurisso A, D'Errico G, Zamyatina A, Peri F, Berisio R, Jerala R, Jiménez-Barbero J, Silipo A, Martín-Santamarí S
* Chemistry of lipid a: At the heart of innate immunity (1576 views) (PDF 306 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 7; 21(2): 500-519.
Impact Factor: 5.771
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Speciale I, Paciello I, Fazio LL, Sturiale L, Palmigiano A, Lanzetta R, Parrilli M, Garozzo D, Lemaitre B, Bernardini ML, Molinaro A, De Castro C
* Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties (396 views)
Carbohyd Res (ISSN: 0008-6215, 0008-6215linking), 2015; 412: 20-27.
Impact Factor: 1.817
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Kim JK, Son DW, Kim C-H, Cho JH, Marchetti R, Silipo A, Sturiale L, Park HY, Huh YR, Nakayama H, Fukatsu T, Molinaro A, Lee BL
* Insect gut symbiont susceptibility to host antimicrobial peptides caused by alteration of the bacterial cell envelope (958 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2015; 290(34): 21042-21053.
Impact Factor: 4.258
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Galdiero E, Maselli V, Falanga A, Gesuele R, Galdiero S, Fulgione D, Guida M
* Integrated analysis of the ecotoxicological and genotoxic effects of the antimicrobial peptide melittin on Daphnia magna and Pseudokirchneriella subcapitata (615 views)
Environ Pollut (ISSN: 0269-7491), 2015; 203: 145-152.
Impact Factor: 4.839
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Di Lorenzo F, Silipo A, Bianconi I, Lore' NI, Scamporrino A, Sturiale L, Garozzo D, Lanzetta R, Parrilli M, Bragonzi A, Molinaro A
* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (367 views)
Mol Immunol (ISSN: 0161-5890), 2015; 63(2): 166-175.
Impact Factor: 3.375
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Malgieri G, Avitabile C, Palmieri M, D'Andrea LD, Isernia C, Romanelli A, Fattorusso R
* Structural basis of a temporin 1b analogue antimicrobial activity against gram negative bacteria determined by CD and NMR techniques in cellular environment (583 views)
Acs Chem Biol (ISSN: 1554-8929), 2015; 10(4): 965-969.
Impact Factor: 5.09
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Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S
* Structural insights into and activity analysis of the antimicrobial peptide myxinidin (686 views)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2014 Sep; 58(9): 5280-5290.
Impact Factor: 4.476
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Calce E, Mignogna E, Bugatti V, Galdiero M, Vittoria V, De Luca S
* Pectin functionalized with natural fatty acids as antimicrobial agent (391 views)
Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2014 Jul; 68: 28-32.
Impact Factor: 2.858
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Avitabile C, D'Andrea LD, Romanelli A
* Circular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells (591 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2014 Mar 12; 4: 4293-4293.
Impact Factor: 5.578
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Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (559 views)
Pharmacol Ther (ISSN: 0163-7258, 0163-7258linking), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
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Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (761 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
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D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G
* Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis (456 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Feb; 97(1): 114-120.
Impact Factor: 2.963
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Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
* Copper promotes TFF1-mediated Helicobacter pylori colonization (634 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Nov 13; 8(11): e79455-e79455.
Impact Factor: 3.534
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Cantisani M, Leone M, Mignogna E, Kampanaraki K, Falanga A, Morelli G, Galdiero M, Galdiero S
* Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish (728 views)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2013 Nov; 57(11): 5665-5673.
Impact Factor: 4.451
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (1094 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
* Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis (402 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Sep; 69(Pt9): 1697-1706.
Impact Factor: 7.232
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Avitabile C, Capparelli R, Rigano MM, Fulgione A, Barone A, Pedone C, Romanelli A
* Antimicrobial peptides from plants: Stabilization of the γ core of a tomato defensin by intramolecular disulfide bond (850 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 240-245.
Impact Factor: 1.862
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Scudiero O, Galdiero S, Nigro E, Del Vecchio L, Di Noto R, Cantisani M, Colavita I, Galdiero M, Cassiman JJ, Daniele A, Pedone C, Salvatore F
* Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines (554 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2013 Apr; 57(4): 1701-1708.
Impact Factor: 4.451
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (425 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (428 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (556 views)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (554 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (666 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
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Simonetti O, Cirioni O, Ghiselli R, Goteri G, Orlando F, Monfregola L, De Luca S, Zizzi A, Silvestri C, Veglia G, Giacometti A, Guerrieri M, Offidani A, Scaloni A
* Antimicrobial properties of distinctin in an experimental model of MRSA-infected wounds (510 views)
Eur J Clin Microbiol Infect Dis (ISSN: 0934-9723), 2012 Nov; 31(11): 3047-3055.
Impact Factor: 3.024
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Berisio R
* Editorial: cell processes in bacterial diseases (409 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
Impact Factor: 1.994
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De Simone G
* Editorial: Zinc Metallo-Enzymes As Target For Drug Design (443 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
Impact Factor: 4.07
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Romanelli A, Moggio L, Montella RC, Campiglia P, Iannaccone M, Capuano F, Pedone C, Capparelli R
* Peptides from Royal Jelly: studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins (1516 views)
J Pept Sci (ISSN: 1099-1387, 1075-2617, 1075-2617print), 2011 Dec 2; 17(5): 348-352.
Impact Factor: 1.799
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Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (481 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Scudiero O, Galdiero S, Cantisani M, Di Noto R, Vitiello M, Galdiero M, Naclerio G, Cassiman JJ, Pedone C, Castaldo G, Salvatore F
* Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (626 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
Impact Factor: 4.672
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Scudiero O, Galdiero S, Cantisani M, Di Noto R, Galdiero M, D'Isanto M, Naclerio G, Pedone C, Castaldo G, Salvatore F
* Synthetic Analogs Of Human Beta-Defensins Display A More Effective Antimicrobial Activity Than Wild-Type Peptides (393 views)
Antimicrob Agents Chemother, 2010; 54: 2312-2322.
Impact Factor: 3.445
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Capparelli R, Romanelli A, Iannaccone M, Nocerino N, Ripa R, Pensato S, Pedone C, Iannelli D
* Synergistic antibacterial and anti-inflammatory activity of temporin A and modified temporin B in vivo (452 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 28; 4(9): e7191-e7191.
Impact Factor: 4.351
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (435 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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Cirioni O, Ghiselli R, Orlando F, Silvestri C, De Luca S, Salzano AM, Mocchegiani F, Saba V, Scalise G, Scaloni A, Giacometti A
* Efficacy of the amphibian peptide distinctin in a neutropenic mouse model of staphylococcal sepsis (315 views)
Critical Care Medicine (ISSN: 0090-3493), 2008 Sep; 36(9): 2629-2633.
Impact Factor: 6.594
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Dalla Serra M, Cirioni O, Vitale RM, Renzone G, Coraiola M, Giacometti A, Potrich C, Baroni E, Guella G, Sanseverino M, De Luca S, Scalise G, Amodeo P, Scaloni A
* Structural features of distinctin affecting peptide biological and biochemical properties (616 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 29; 47(30): 7888-7899.
Impact Factor: 3.379
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (668 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (441 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (465 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
View Export to BibTeX Export to EndNote
Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (387 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (547 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
View Export to BibTeX Export to EndNote
Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (760 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
View Export to BibTeX Export to EndNote
48 Records (47 excluding Abstracts).
Total impact factor: 182.138 (177.787 excluding Abstracts).
Total 5 year impact factor: 191.069 (186.686 excluding Abstracts).
Total impact factor: 182.138 (177.787 excluding Abstracts).
Total 5 year impact factor: 191.069 (186.686 excluding Abstracts).
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