Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (401 views)
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.276, 5-year impact factor: 2.057
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-41149129371&partnerID=40&md5=c1e6f4d9b55063a4f064535587674a39
Keywords: Apolipoprotein A-I, Haemoglobin, Haptoglobin, Lecithin-Cholesterol Acyltransferase, Psoriasis Vulgaris, Albumin, Hemoglobin, Phosphatidylcholine Sterol Acyltransferase, Affinity Chromatography, Article, Binding Assay, Clinical Article, Controlled Study, Enzyme Inhibition, Enzyme Linked Immunosorbent Assay, Human, Phenotypic Variation, Polyacrylamide Gel Electrophoresis, Priority Journal, Protein Function, Protein Isolation, Protein Protein Interaction, Protein Purification, Protein Structure, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Phosphatidylcholine-Sterol O-Acyltransferase, Protein Binding,
Affiliations:
*** IBB - CNR ***
Dipartimento delle Scienze Biologiche, Universita di Napoli Federico II, Naples, Italy.
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Naples, Italy
Dipartimento di Patologia Sistematica Naples, Sezione di Dermatologia, Università di Napoli Federico II, via Mezzocannone 8, 80134 Napoli, Italy
References:
Langlois, M.R., Delanghe, J.R., Biological and clinical significance of haptoglobin polymorphism in humans (1996) Clin Chem, 4, pp. 1589-160
Kalmovarian, N., Friedrichs, W.E., O'Brien, H.V., Linehan, L.A., Bowman, B.H., Yang, F., Extrahepatic expression of plasma protein genes during inflammation (1991) Inflammation, 15, pp. 369-379
Baumann, H., Jahreis, G.P., Morella, K.K., Interaction of cytokine-and glucocorticoid-response elements of acute- phase plasma protein genes (1990) J Biol Chem, 265, pp. 22275-22281
Wejman, J.C., Hovsepian, D., Wall, J.S., Hainfeld, J.F., Greer, J., Structure and assembly of haptoglobin polymers by electron microscopy (1984) J Mol Biol, 174, pp. 43-368
Lange, V., Haptoglobin polymorphism - Not only a genetic marker (1992) Anthropol Anz, 50, pp. 281-302
Baseler, M.W., Burrell, R., Purification of haptoglobin and its effects on lymphocyte and alveolar macrophage responses (1983) Inflammation, 7, pp. 387-400
Oh, S.K., Kim, S.H., Walker, J.E., Interference with immune response at the level of generating effectors cells by tumor-associated haptoglobin (1990) J Nat Cancer Inst, 82, pp. 934-940
Oh, S.K., Pavlotski, N., Tauber, A., Specific binding of haptoglobin to human neutrophils and its functional consequences (1990) J Leuk Biol, 47, pp. 142-148
Arredouani, M., Matthijs, P., Van Hoeyveld, E., Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release (2003) Immunology, 108, pp. 144-151
Gutteridge, J.M.C., The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation (1987) Biochim Biophys Acta, 917, pp. 219-223
Spagnuolo, M.S., Cigliano, L., D'Andrea, L.D., Pedone, C., Abrescia, P., Assignment of the binding site for haptoglobin on apolipoprotein A-I (2005) J Biol Chem, 280, pp. 1193-1198
Snellman, O., Sylven, B., Haptoglobin acting as a natural inhibitor of cathepsin B activity (1974) Nature, 216, p. 1033
Frohlander, N., Ljunggren, O., Lerner, U.H., Haptoglobin synergistically potentiates bradykinin and thrombin induced prostaglandin biosynthesis in isolated osteoblasts (1991) Biochem Biophys Res Commun, 178, pp. 343-351
Cid, M.C., Grant, D.S., Hoffman, G.S., Auerbach, R., Fauci, A.S., Kleinman, H.K., Identification of haptoglobin an a angiogenic factor in sera from patients with systemic vasculitis (1993) J Clin Invest, 91, pp. 977-985
Kim, I.K., Lee, J.K., Kim, H.S., Kwon, O.J., Shim, B.S., A novel function of haptoglobin: Haptoglobin-haemoglobin complex induces apoptosis of hepatocarcinoma Hep 3B cells (1995) J Scand Clin Lab Invest, 55, pp. 529-535
Li, P., Gao, X.H., Chen, H.D., Localization of haptoglobin in normal skin and some skin disease (2005) J Int Derm, 44, pp. 280-284
De Kleijin, D.P.V., Smeets, M.B., Kemmeren, P.P., Acute-phase protein haptoglobin is a cell migration factor involved in arterial restructuring (2002) FASEB J, 16, pp. 1123-1125
Thompson, S., Dargan, E., Griffiths, I.D., Kelly, C.A., Tunren, G.A., The glycosylation of haptoglobin in rheumatoid arthritis (1993) Clin Chem Acta, 29, pp. 107-114
Piva, M., Moreno, J.I., Sharpe-Timms, K.L., Glycosylation and over expression of endometriosis-associated peritoneal haptoglobin (2002) Glycoconj J, 19, pp. 33-41
Turner, G.A., Goodarzi, M.T., Thompson, S., Glycosylation of alpha-1-proteinase inhibitor and haptoglobin in ovarian cancer: Evidence for two different mechanisms (1995) Glycoconj J, 12, pp. 211-218
Cigliano, L., Spaguolo, M.S., Abrescia, P., Quantitative variations of the isoforms in haptoglobin 1-2 and 2-2 individual phenotypes (2003) Arch Biochem Biophys, 416, pp. 227-237
Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of the bacteriophage T4 (1970) Nature, 227, pp. 680-685
O'Farrell, P.H., High resolution two-dimensional electrophoresis of proteins (1975) J Biol Chem, 250, pp. 4007-4021
Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal Biochem, 72, pp. 248-252
Urushibara, N., Kumazaki, T., Ishii, S., Hemoglobin-binding site on human haptoglobin. Identification of lysyl residues participating in the binding (1992) J Biol Chem, 267, pp. 13413-13417
Lustbader, J.W., Arcoleo, J.P., Birken, S., Greer, J., Hemoglobin-binding site on haptoglobin probed by selective proteolysis (1983) J Biol Chem, 258, pp. 1227-1234
Porta, A., Cassano, E., Balestrieri, M., Haptoglobin transport into ovarian follicles and its binding to apolipoprotein A-1 (1999) Zygote, 7, pp. 67-77
Chen, C.H., Albers, J.J., Characterization of proteoliposomes containing apoprotein A-I: A new substrate for the measurement of lecithin: Cholesterol acyltransferase activity (1982) J Lipid Res, 23, pp. 680-691
Sparks, D.L., Phillips, M.C., Lund-Katz, S., The charge and structural stability of apolipoprotein A-I in discoidal and spherical recombinant high density lipoproteins particles (1992) J Biol Chem, 267, pp. 25830-25838
Kunitake, S.T., Carilli, C.T., Lau, K., Protter, A.A., Nava-Vigne, J., Kane, J.P., Identification of proteins associated with apolipoprotein A-I containing lipoproteins purified by selected -affinity immunosorption (1994) Biochemistry, 33, pp. 1988-1993
Wassell, J., Haptoglobin: Function and polymorphism (2000) Clin Lab, 46, pp. 547-552
Sadrzadeh, S.M.H., Bozorgmehr, J., Haptoglobin phenotypes in health and disorders (2004) J Am Clin Pathol, 121, pp. 97-104
Zvi, B., Levy, A.P., Haptoglobin phenotypes, which one is better and when? (2006) Clin Lab, 52, pp. 29-35
Balestrieri, M., Cigliano, L., De Simone, M.L., Dale, B., Abrescia, P., Haptoglobin inhibits lecithin-cholesterol acyltransferase in human follicular fluid (2001) Mol Reprod Dev, 59, pp. 186-191
Bamm, V.V., Tsemakhovic, V.A., Shaklai, M., Shaklai, N., Haptoglobin phenotypes differ in their ability to inhibit theme transfer from hemoglobin to LDL (2004) Biochem, 43, pp. 3899-3906
Yerbury, J.J., Rybchyn, M.S., Easterbrook-Smith, S.B., Henriques, C., Wilson, M., The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin (2005) Biochem, 44, pp. 10914-10925
Rocha-Pereira, P., Santos-Silva, A., Rebelo, I., Fiqueireido, A., Quintanilha, A., Teixeira, F., Dislipidemia and oxidative stress in mild and in severe psoriasis as a risk for cardiovascular disease (2001) Clin Chem Acta, 303, pp. 33-39
Neiman, A.L., Shin, D.B., Wang, X., Margolis, D.J., Troxel, A.B., Gelfand, J.M., Prevalence of cardiovascular risk factors in patients with psoriasis (2006) J Am Acad Dermatol, 55, pp. 829-835
Shapiro, J., Cohen, A.D., David, M., The association between psoriasis, diabetes mellitus, and atherosclerosis in Israel: A case control study (2006) J Am Acad Dermatol, , ahead of print
Mallbris, L., Akre, O., Granath, F., Increased risk for cardiovascular mortality in psoriasis inpatients but not in outpatients (2004) J Eur Epidemiol, 19, pp. 225-230
Gelfand, J.M., Neiman, A.L., Shin, D.B., Wang, X., Margolis, D.J., Troxel, A.B., Risk of myocardial infarction in patients with psoriasis (2006) JAMA, 296, pp. 1735-1741
Ludwig, R.J., Herzog, G., Rostock, A., Psoriasis: A possible risk factor for development of coronary artery calcification (2007) J Br Dermatol, 156, pp. 271-276
Markuszeski, L., Bissinger, A., Janusz, I., Narbutt, J., Jedrzejowska, A.S., Zalewska, A., Heart rate and arrhythmia in patients with psoriasis vulgaris (2007) Arch Med Res, 38, pp. 64-69
Wakkee, M., Thio, H.B., Prens, E.P., Sijbrands, E.J., Neumann, H.A., Unfavourable cardiovascular risk profiles in untreated and treated psoriasis patients (2007) Atherosclerosis, 190, pp. 1-9
Vahlquist, C., Michaelsson, G., Vessby, B., Serum lipoproteins in middle-aged men with psoriasis (1987) Acta Derm Venereol, 67, pp. 12-15
Eckersall, P.D., Conner, J.G., Plasma haptoglobin in cattle exists as polymers in association with albumin (1990) Comp Biochem Physiol B, 96 B, pp. 309-314
Simard, G., Loiseau, D., Girault, A., Perret, B., Reactivity of HDL subfractions towards lecithin-cholesterol acyltransferase. Modulation by their content in free cholesterol (1989) Biochem Biophys Acta, 1005, pp. 245-252
Kaartinen, V., Mononen, I., Hemoglobin binding to deglycosylated haptoglobin (1988) Biochem Biophys Acta, 14, pp. 345-352
Smeets, M.B., Sluijter, J.P.G., Donbners, M.M.P.C., Increased arterial expression of a glysosylated Haptoglobin isoform after balloon dilation (2003) Cardiovasc Res, 58, pp. 689-695
Brinkman-van der Linder, E.C., de Haan, P.F., Havenaar, E.C., Van, D.J.K.W., Inflammation-induced expression of sialyl-Lewis X is not restricted to alpha 1-acid glycoprotein but also occurs to a lesser extent on alpha-1-anthichymotrypsin and haptoblobin (1998) Glycoconj J, 15, pp. 177-182
Goodarzi, M.T., Axford, J.S., Varanasi, S.S., Sialyl Lewis (x) expression on IgG in rheumatoid arthritis and other arthritic conditions: A preliminary study (1998) Glycoconj J, 15, pp. 1149-1154
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.276, 5-year impact factor: 2.057
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-41149129371&partnerID=40&md5=c1e6f4d9b55063a4f064535587674a39
Keywords: Apolipoprotein A-I, Haemoglobin, Haptoglobin, Lecithin-Cholesterol Acyltransferase, Psoriasis Vulgaris, Albumin, Hemoglobin, Phosphatidylcholine Sterol Acyltransferase, Affinity Chromatography, Article, Binding Assay, Clinical Article, Controlled Study, Enzyme Inhibition, Enzyme Linked Immunosorbent Assay, Human, Phenotypic Variation, Polyacrylamide Gel Electrophoresis, Priority Journal, Protein Function, Protein Isolation, Protein Protein Interaction, Protein Purification, Protein Structure, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Phosphatidylcholine-Sterol O-Acyltransferase, Protein Binding,
Affiliations:
*** IBB - CNR ***
Dipartimento delle Scienze Biologiche, Universita di Napoli Federico II, Naples, Italy.
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Naples, Italy
Dipartimento di Patologia Sistematica Naples, Sezione di Dermatologia, Università di Napoli Federico II, via Mezzocannone 8, 80134 Napoli, Italy
References:
Langlois, M.R., Delanghe, J.R., Biological and clinical significance of haptoglobin polymorphism in humans (1996) Clin Chem, 4, pp. 1589-160
Kalmovarian, N., Friedrichs, W.E., O'Brien, H.V., Linehan, L.A., Bowman, B.H., Yang, F., Extrahepatic expression of plasma protein genes during inflammation (1991) Inflammation, 15, pp. 369-379
Baumann, H., Jahreis, G.P., Morella, K.K., Interaction of cytokine-and glucocorticoid-response elements of acute- phase plasma protein genes (1990) J Biol Chem, 265, pp. 22275-22281
Wejman, J.C., Hovsepian, D., Wall, J.S., Hainfeld, J.F., Greer, J., Structure and assembly of haptoglobin polymers by electron microscopy (1984) J Mol Biol, 174, pp. 43-368
Lange, V., Haptoglobin polymorphism - Not only a genetic marker (1992) Anthropol Anz, 50, pp. 281-302
Baseler, M.W., Burrell, R., Purification of haptoglobin and its effects on lymphocyte and alveolar macrophage responses (1983) Inflammation, 7, pp. 387-400
Oh, S.K., Kim, S.H., Walker, J.E., Interference with immune response at the level of generating effectors cells by tumor-associated haptoglobin (1990) J Nat Cancer Inst, 82, pp. 934-940
Oh, S.K., Pavlotski, N., Tauber, A., Specific binding of haptoglobin to human neutrophils and its functional consequences (1990) J Leuk Biol, 47, pp. 142-148
Arredouani, M., Matthijs, P., Van Hoeyveld, E., Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release (2003) Immunology, 108, pp. 144-151
Gutteridge, J.M.C., The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation (1987) Biochim Biophys Acta, 917, pp. 219-223
Spagnuolo, M.S., Cigliano, L., D'Andrea, L.D., Pedone, C., Abrescia, P., Assignment of the binding site for haptoglobin on apolipoprotein A-I (2005) J Biol Chem, 280, pp. 1193-1198
Snellman, O., Sylven, B., Haptoglobin acting as a natural inhibitor of cathepsin B activity (1974) Nature, 216, p. 1033
Frohlander, N., Ljunggren, O., Lerner, U.H., Haptoglobin synergistically potentiates bradykinin and thrombin induced prostaglandin biosynthesis in isolated osteoblasts (1991) Biochem Biophys Res Commun, 178, pp. 343-351
Cid, M.C., Grant, D.S., Hoffman, G.S., Auerbach, R., Fauci, A.S., Kleinman, H.K., Identification of haptoglobin an a angiogenic factor in sera from patients with systemic vasculitis (1993) J Clin Invest, 91, pp. 977-985
Kim, I.K., Lee, J.K., Kim, H.S., Kwon, O.J., Shim, B.S., A novel function of haptoglobin: Haptoglobin-haemoglobin complex induces apoptosis of hepatocarcinoma Hep 3B cells (1995) J Scand Clin Lab Invest, 55, pp. 529-535
Li, P., Gao, X.H., Chen, H.D., Localization of haptoglobin in normal skin and some skin disease (2005) J Int Derm, 44, pp. 280-284
De Kleijin, D.P.V., Smeets, M.B., Kemmeren, P.P., Acute-phase protein haptoglobin is a cell migration factor involved in arterial restructuring (2002) FASEB J, 16, pp. 1123-1125
Thompson, S., Dargan, E., Griffiths, I.D., Kelly, C.A., Tunren, G.A., The glycosylation of haptoglobin in rheumatoid arthritis (1993) Clin Chem Acta, 29, pp. 107-114
Piva, M., Moreno, J.I., Sharpe-Timms, K.L., Glycosylation and over expression of endometriosis-associated peritoneal haptoglobin (2002) Glycoconj J, 19, pp. 33-41
Turner, G.A., Goodarzi, M.T., Thompson, S., Glycosylation of alpha-1-proteinase inhibitor and haptoglobin in ovarian cancer: Evidence for two different mechanisms (1995) Glycoconj J, 12, pp. 211-218
Cigliano, L., Spaguolo, M.S., Abrescia, P., Quantitative variations of the isoforms in haptoglobin 1-2 and 2-2 individual phenotypes (2003) Arch Biochem Biophys, 416, pp. 227-237
Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of the bacteriophage T4 (1970) Nature, 227, pp. 680-685
O'Farrell, P.H., High resolution two-dimensional electrophoresis of proteins (1975) J Biol Chem, 250, pp. 4007-4021
Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal Biochem, 72, pp. 248-252
Urushibara, N., Kumazaki, T., Ishii, S., Hemoglobin-binding site on human haptoglobin. Identification of lysyl residues participating in the binding (1992) J Biol Chem, 267, pp. 13413-13417
Lustbader, J.W., Arcoleo, J.P., Birken, S., Greer, J., Hemoglobin-binding site on haptoglobin probed by selective proteolysis (1983) J Biol Chem, 258, pp. 1227-1234
Porta, A., Cassano, E., Balestrieri, M., Haptoglobin transport into ovarian follicles and its binding to apolipoprotein A-1 (1999) Zygote, 7, pp. 67-77
Chen, C.H., Albers, J.J., Characterization of proteoliposomes containing apoprotein A-I: A new substrate for the measurement of lecithin: Cholesterol acyltransferase activity (1982) J Lipid Res, 23, pp. 680-691
Sparks, D.L., Phillips, M.C., Lund-Katz, S., The charge and structural stability of apolipoprotein A-I in discoidal and spherical recombinant high density lipoproteins particles (1992) J Biol Chem, 267, pp. 25830-25838
Kunitake, S.T., Carilli, C.T., Lau, K., Protter, A.A., Nava-Vigne, J., Kane, J.P., Identification of proteins associated with apolipoprotein A-I containing lipoproteins purified by selected -affinity immunosorption (1994) Biochemistry, 33, pp. 1988-1993
Wassell, J., Haptoglobin: Function and polymorphism (2000) Clin Lab, 46, pp. 547-552
Sadrzadeh, S.M.H., Bozorgmehr, J., Haptoglobin phenotypes in health and disorders (2004) J Am Clin Pathol, 121, pp. 97-104
Zvi, B., Levy, A.P., Haptoglobin phenotypes, which one is better and when? (2006) Clin Lab, 52, pp. 29-35
Balestrieri, M., Cigliano, L., De Simone, M.L., Dale, B., Abrescia, P., Haptoglobin inhibits lecithin-cholesterol acyltransferase in human follicular fluid (2001) Mol Reprod Dev, 59, pp. 186-191
Bamm, V.V., Tsemakhovic, V.A., Shaklai, M., Shaklai, N., Haptoglobin phenotypes differ in their ability to inhibit theme transfer from hemoglobin to LDL (2004) Biochem, 43, pp. 3899-3906
Yerbury, J.J., Rybchyn, M.S., Easterbrook-Smith, S.B., Henriques, C., Wilson, M., The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin (2005) Biochem, 44, pp. 10914-10925
Rocha-Pereira, P., Santos-Silva, A., Rebelo, I., Fiqueireido, A., Quintanilha, A., Teixeira, F., Dislipidemia and oxidative stress in mild and in severe psoriasis as a risk for cardiovascular disease (2001) Clin Chem Acta, 303, pp. 33-39
Neiman, A.L., Shin, D.B., Wang, X., Margolis, D.J., Troxel, A.B., Gelfand, J.M., Prevalence of cardiovascular risk factors in patients with psoriasis (2006) J Am Acad Dermatol, 55, pp. 829-835
Shapiro, J., Cohen, A.D., David, M., The association between psoriasis, diabetes mellitus, and atherosclerosis in Israel: A case control study (2006) J Am Acad Dermatol, , ahead of print
Mallbris, L., Akre, O., Granath, F., Increased risk for cardiovascular mortality in psoriasis inpatients but not in outpatients (2004) J Eur Epidemiol, 19, pp. 225-230
Gelfand, J.M., Neiman, A.L., Shin, D.B., Wang, X., Margolis, D.J., Troxel, A.B., Risk of myocardial infarction in patients with psoriasis (2006) JAMA, 296, pp. 1735-1741
Ludwig, R.J., Herzog, G., Rostock, A., Psoriasis: A possible risk factor for development of coronary artery calcification (2007) J Br Dermatol, 156, pp. 271-276
Markuszeski, L., Bissinger, A., Janusz, I., Narbutt, J., Jedrzejowska, A.S., Zalewska, A., Heart rate and arrhythmia in patients with psoriasis vulgaris (2007) Arch Med Res, 38, pp. 64-69
Wakkee, M., Thio, H.B., Prens, E.P., Sijbrands, E.J., Neumann, H.A., Unfavourable cardiovascular risk profiles in untreated and treated psoriasis patients (2007) Atherosclerosis, 190, pp. 1-9
Vahlquist, C., Michaelsson, G., Vessby, B., Serum lipoproteins in middle-aged men with psoriasis (1987) Acta Derm Venereol, 67, pp. 12-15
Eckersall, P.D., Conner, J.G., Plasma haptoglobin in cattle exists as polymers in association with albumin (1990) Comp Biochem Physiol B, 96 B, pp. 309-314
Simard, G., Loiseau, D., Girault, A., Perret, B., Reactivity of HDL subfractions towards lecithin-cholesterol acyltransferase. Modulation by their content in free cholesterol (1989) Biochem Biophys Acta, 1005, pp. 245-252
Kaartinen, V., Mononen, I., Hemoglobin binding to deglycosylated haptoglobin (1988) Biochem Biophys Acta, 14, pp. 345-352
Smeets, M.B., Sluijter, J.P.G., Donbners, M.M.P.C., Increased arterial expression of a glysosylated Haptoglobin isoform after balloon dilation (2003) Cardiovasc Res, 58, pp. 689-695
Brinkman-van der Linder, E.C., de Haan, P.F., Havenaar, E.C., Van, D.J.K.W., Inflammation-induced expression of sialyl-Lewis X is not restricted to alpha 1-acid glycoprotein but also occurs to a lesser extent on alpha-1-anthichymotrypsin and haptoblobin (1998) Glycoconj J, 15, pp. 177-182
Goodarzi, M.T., Axford, J.S., Varanasi, S.S., Sialyl Lewis (x) expression on IgG in rheumatoid arthritis and other arthritic conditions: A preliminary study (1998) Glycoconj J, 15, pp. 1149-1154
Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity
OBJECTIVE: The aim of this work was to assess whether psoriasis is associated with phenotype prevalence and altered activity of haptoglobin (Hpt).; BACKGROUND: Hpt is a plasma acute-phase glycoprotein, displaying in humans three phenotypes. Phenotype prevalence or structure modification of Hpt was associated with several diseases. The Hpt main function is to bind and carry to the liver free haemoglobin for degradation and iron recycling. Hpt was recently found able to bind the apolipoprotein A-I (ApoA-I), thus impairing its stimulation on the activity of the enzyme lecithin-cholesterol acyl-transferase (LCAT).; STUDY DESIGN: Hpt was isolated from patients with psoriasis vulgaris, and its activity in haemoglobin or ApoA-I binding and LCAT inhibition was compared with that of normal protein.; METHODS: Two affinity chromatography steps, the first using resin-coupled haemoglobin and the second anti-Hpt antibodies, were used to purify Hpt. The protein phenotype was assessed by electrophoresis. Binding experiments were performed by Enzyme-linked immunosorbent assay with stationary haemoglobin or ApoA-I, Hpt in solution and anti-Hpt antibodies for detection of bound Hpt. Standard LCAT assays were carried out in the presence of Hpt purified from patients or healthy subjects.; RESULTS: Phenotype prevalence of Hpt in psoriasis was not found. After affinity chromatography by haemoglobin, albumin and ApoA-I were routinely found heavily contaminating only Hpt from normal subjects. Isolated Hpt from patients had lower activity than normal protein in both haemoglobin binding and LCAT inhibition.; CONCLUSIONS: In psoriasis, Hpt displays some structure modification(s), which might be associated with the protein function in the disease.
OBJECTIVE: The aim of this work was to assess whether psoriasis is associated with phenotype prevalence and altered activity of haptoglobin (Hpt).; BACKGROUND: Hpt is a plasma acute-phase glycoprotein, displaying in humans three phenotypes. Phenotype prevalence or structure modification of Hpt was associated with several diseases. The Hpt main function is to bind and carry to the liver free haemoglobin for degradation and iron recycling. Hpt was recently found able to bind the apolipoprotein A-I (ApoA-I), thus impairing its stimulation on the activity of the enzyme lecithin-cholesterol acyl-transferase (LCAT).; STUDY DESIGN: Hpt was isolated from patients with psoriasis vulgaris, and its activity in haemoglobin or ApoA-I binding and LCAT inhibition was compared with that of normal protein.; METHODS: Two affinity chromatography steps, the first using resin-coupled haemoglobin and the second anti-Hpt antibodies, were used to purify Hpt. The protein phenotype was assessed by electrophoresis. Binding experiments were performed by Enzyme-linked immunosorbent assay with stationary haemoglobin or ApoA-I, Hpt in solution and anti-Hpt antibodies for detection of bound Hpt. Standard LCAT assays were carried out in the presence of Hpt purified from patients or healthy subjects.; RESULTS: Phenotype prevalence of Hpt in psoriasis was not found. After affinity chromatography by haemoglobin, albumin and ApoA-I were routinely found heavily contaminating only Hpt from normal subjects. Isolated Hpt from patients had lower activity than normal protein in both haemoglobin binding and LCAT inhibition.; CONCLUSIONS: In psoriasis, Hpt displays some structure modification(s), which might be associated with the protein function in the disease.
Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity
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Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity
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Merlino A, Fuchs MR, Pica A, Balsamo A, Dworkowski FSN, Pompidor G, Mazzarella L, Vergara A
* Selective X-ray-induced NO photodissociation in haemoglobin crystals: evidence from a Raman-assisted crystallographic study (339 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Jan; 69: 137-140.
Impact Factor: 7.232
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Coppola D, Abbruzzetti S, Nicoletti F, Merlino A, Gambacurta A, Giordano D, Howes BD, De Sanctis G, Vitagliano L, Bruno S, di Prisco G, Mazzarella L, Smulevich G, Coletta M, Viappiani C, Vergara A, Verde C
* ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus (343 views)
Molecular Biosystems (ISSN: 1742-206x), 2012 Oct 30; 8(12): 3295-3304.
Impact Factor: 3.35
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Risitano AM, Imbriaco M, Marando L, Seneca E, Soscia E, Malcovati L, Iori AP, Pane F, Notaro R, Matarazzo M
* From perpetual haemosiderinuria to possible iron overload: iron redistribution in paroxysmal nocturnal haemoglobinuria patients on eculizumab by magnetic resonance imaging (359 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2012 Sep; 158(3): 415-418.
Impact Factor: 4.942
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Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (386 views)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Impact Factor: 3.891
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Monti DM(1), Di Gaetano S, Del Giudice R, Giangrande C, Amoresano A, Monti M, Arciello A, Piccoli R
* Apolipoprotein A-I amyloidogenic variant L174S, expressed and isolated from stably transfected mammalian cells, is associated with fatty acids (324 views)
Amyloid (ISSN: 1350-6129), 2012 Mar; 19(1): 21-27.
Impact Factor: 4.436
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Raimondi S, Guglielmi F, Giorgetti S, Di Gaetano S, Arciello A, Monti DM, Relini A, Nichino D, Doglia SM, Natalello A, Pucci P, Mangione P, Obici L, Merlini G, Stoppini M, Robustelli P, Tartaglia GG, Vendruscolo M, Dobson CM, Piccoli R, Bellotti V
* Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I (459 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2011 Apr 1; 407(3): 465-476.
Impact Factor: 4.001
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Merlino A, Vitagliano L, Balsamo A, Nicoletti FP, Howes BD, Giordano D, Coppola D, Di Prisco G, Verde C, Smulevich G, Mazzarella L, Vergara A
* Crystallization, preliminary X-ray diffraction studies and Raman microscopy of the major haemoglobin from the sub-Antarctic fish Eleginops maclovinus in the carbomonoxy form (317 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2010 Nov; 66: 1536-1540.
Impact Factor: 0.563
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (396 views)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin Binds The Anti-Atherogenic Protein Apolipoprotein E: Impairment Of The Apolipoprotein E Stimulation On Both The Enzyme Lecithin-Cholesterol Acyl-Transferase Activity And The Cholesterol Uptake By Hepatocytes (274 views)
Febs J, 2009; 276: 6158-6171.
Impact Factor: 3.986
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Cigliano L, D'Andrea LD, Maresca B, Serino M, Carlucci A, Salvatore A, Spagnuolo MS, Scigliuolo G, Pedone C, Abrescia P
* Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin (393 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 2008 Nov; 389(11): 1421-1426.
Impact Factor: 3.035
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Vergara A, Verde C, Di Prisco G, Mazzarella L
* Bis-histidyl Ferric Adducts in Tetrameric Haemoglobins (187 views)
Protein Reviews, 2008; 9: N/D-N/D.
Impact Factor: 0
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (407 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Tarantino G, Gentile A, Capone D, Basile V, Tarantino M, Di Minno MN, Cuocolo A, Conca P
* Does protracted antiviral therapy impact on HCV-related liver cirrhosis progression? (312 views)
World J Gastroentero (ISSN: 1007-9327, 2219-2840, 1007-9327linking), 2007 Sep 28; 13(36): 4903-4908.
Impact Factor: 2.433
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Verde C, Vergara A, Giordano D, Mazzarella L, Di Prisco G
* The Root effect - a structural and evolutionary perspective (250 views)
Antarctic Science (ISSN: 0954-1020), 2007 Jun; 19(2): 271-278.
Impact Factor: 1.265
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Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (479 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* Liganded and unliganded forms of Antarctic fish haemoglobins in polyethylene glycol: crystallization of an R-state haemichrome intermediate (392 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2001 Sep; 57: 1144-1146.
Impact Factor: 2.124
View Export to BibTeX Export to EndNote
Mazzarella L, D'Avino R, Di Prisco G, Savino C, Vitagliano L, Moody P, Zagari A
Crystal structure of Trematomus newnesi haemoglobin re-opens the Root effect question (388 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Apr 16; 287(5): 897-906.
Impact Factor: 5.501
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* Cell milieu significantly affects the fate of AApoAI amyloidogenic variants: predestination or serendipity? (403 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2017 Nov 23; 1862(3): 377-384.
Impact Factor: 4.28
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Merlino A, Vergara A, Vitagliano L
* Comments on Structural studies of haemoglobin from pisces species shortfin mako shark (Isurus oxyrinchus) at 1. 9 angstrom resolution by P. Ramesh et al. (2013). J. Synchrotron Rad. 20, 843-847 (282 views)
J Synchrotron Radiat (ISSN: 0909-0495), 2014 Jul; 21: N/D-N/D.
Impact Factor: 2.794
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Mazzarella L, Merlino A, Vitagliano L, Verde C, Di Prisco G, Peisach J, Vergara A
* Structural modifications induced by the switch from an endogenous bis-histidyl to an exogenous cyanomet hexa-coordination in a tetrameric haemoglobin (287 views)
Rsc Adv (ISSN: 2046-2069), 2014; 4(49): 25852-25856.
Impact Factor: 3.84
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Cigliano L, De Rosa L, Diana D, Di Stasi R, Spagnuolo MS, Maresca B, Fattorusso R, D'Andrea LD
* Structure and biological activity of a conformational constrained apolipoprotein A-I-derived helical peptide targeting the protein haptoglobin (401 views)
Rsc Adv (ISSN: 2046-2069), 2014; 4(93): 51353-51361.
Impact Factor: 3.84
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Spagnuolo MS, Di Stasi R, De Rosa L, Maresca B, Cigliano L, D'Andrea LD
* Analysis of the haptoglobin binding region on the apolipoprotein A-I-derived P2a peptide (376 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 220-226.
Impact Factor: 1.862
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Merlino A, Fuchs MR, Pica A, Balsamo A, Dworkowski FSN, Pompidor G, Mazzarella L, Vergara A
* Selective X-ray-induced NO photodissociation in haemoglobin crystals: evidence from a Raman-assisted crystallographic study (339 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Jan; 69: 137-140.
Impact Factor: 7.232
View Export to BibTeX Export to EndNote
Coppola D, Abbruzzetti S, Nicoletti F, Merlino A, Gambacurta A, Giordano D, Howes BD, De Sanctis G, Vitagliano L, Bruno S, di Prisco G, Mazzarella L, Smulevich G, Coletta M, Viappiani C, Vergara A, Verde C
* ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus (343 views)
Molecular Biosystems (ISSN: 1742-206x), 2012 Oct 30; 8(12): 3295-3304.
Impact Factor: 3.35
View Export to BibTeX Export to EndNote
Risitano AM, Imbriaco M, Marando L, Seneca E, Soscia E, Malcovati L, Iori AP, Pane F, Notaro R, Matarazzo M
* From perpetual haemosiderinuria to possible iron overload: iron redistribution in paroxysmal nocturnal haemoglobinuria patients on eculizumab by magnetic resonance imaging (359 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2012 Sep; 158(3): 415-418.
Impact Factor: 4.942
View Export to BibTeX Export to EndNote
Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (386 views)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Impact Factor: 3.891
View Export to BibTeX Export to EndNote
Monti DM(1), Di Gaetano S, Del Giudice R, Giangrande C, Amoresano A, Monti M, Arciello A, Piccoli R
* Apolipoprotein A-I amyloidogenic variant L174S, expressed and isolated from stably transfected mammalian cells, is associated with fatty acids (324 views)
Amyloid (ISSN: 1350-6129), 2012 Mar; 19(1): 21-27.
Impact Factor: 4.436
View Export to BibTeX Export to EndNote
Raimondi S, Guglielmi F, Giorgetti S, Di Gaetano S, Arciello A, Monti DM, Relini A, Nichino D, Doglia SM, Natalello A, Pucci P, Mangione P, Obici L, Merlini G, Stoppini M, Robustelli P, Tartaglia GG, Vendruscolo M, Dobson CM, Piccoli R, Bellotti V
* Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I (459 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2011 Apr 1; 407(3): 465-476.
Impact Factor: 4.001
View Export to BibTeX Export to EndNote
Merlino A, Vitagliano L, Balsamo A, Nicoletti FP, Howes BD, Giordano D, Coppola D, Di Prisco G, Verde C, Smulevich G, Mazzarella L, Vergara A
* Crystallization, preliminary X-ray diffraction studies and Raman microscopy of the major haemoglobin from the sub-Antarctic fish Eleginops maclovinus in the carbomonoxy form (317 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2010 Nov; 66: 1536-1540.
Impact Factor: 0.563
View Export to BibTeX Export to EndNote
Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (396 views)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
View Export to BibTeX Export to EndNote
Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin Binds The Anti-Atherogenic Protein Apolipoprotein E: Impairment Of The Apolipoprotein E Stimulation On Both The Enzyme Lecithin-Cholesterol Acyl-Transferase Activity And The Cholesterol Uptake By Hepatocytes (274 views)
Febs J, 2009; 276: 6158-6171.
Impact Factor: 3.986
View Export to BibTeX Export to EndNote
Cigliano L, D'Andrea LD, Maresca B, Serino M, Carlucci A, Salvatore A, Spagnuolo MS, Scigliuolo G, Pedone C, Abrescia P
* Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin (393 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 2008 Nov; 389(11): 1421-1426.
Impact Factor: 3.035
View Export to BibTeX Export to EndNote
Vergara A, Verde C, Di Prisco G, Mazzarella L
* Bis-histidyl Ferric Adducts in Tetrameric Haemoglobins (187 views)
Protein Reviews, 2008; 9: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (407 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
View Export to BibTeX Export to EndNote
Tarantino G, Gentile A, Capone D, Basile V, Tarantino M, Di Minno MN, Cuocolo A, Conca P
* Does protracted antiviral therapy impact on HCV-related liver cirrhosis progression? (312 views)
World J Gastroentero (ISSN: 1007-9327, 2219-2840, 1007-9327linking), 2007 Sep 28; 13(36): 4903-4908.
Impact Factor: 2.433
View Export to BibTeX Export to EndNote
Verde C, Vergara A, Giordano D, Mazzarella L, Di Prisco G
* The Root effect - a structural and evolutionary perspective (250 views)
Antarctic Science (ISSN: 0954-1020), 2007 Jun; 19(2): 271-278.
Impact Factor: 1.265
View Export to BibTeX Export to EndNote
Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (479 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* Liganded and unliganded forms of Antarctic fish haemoglobins in polyethylene glycol: crystallization of an R-state haemichrome intermediate (392 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2001 Sep; 57: 1144-1146.
Impact Factor: 2.124
View Export to BibTeX Export to EndNote
Mazzarella L, D'Avino R, Di Prisco G, Savino C, Vitagliano L, Moody P, Zagari A
Crystal structure of Trematomus newnesi haemoglobin re-opens the Root effect question (388 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Apr 16; 287(5): 897-906.
Impact Factor: 5.501
View Export to BibTeX Export to EndNote
22 Records (20 excluding Abstracts).
Total impact factor: 75.639 (72.845 excluding Abstracts).
Total 5 year impact factor: 82.681 (80.014 excluding Abstracts).
Total impact factor: 75.639 (72.845 excluding Abstracts).
Total 5 year impact factor: 82.681 (80.014 excluding Abstracts).
401 views. Last view on Tuesday 07 March 2023, 22:34:55
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