Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (595 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.972, 5-year impact factor: 3.819
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84904992419&partnerID=40&md5=c9a7395249ff9b0dd571ca55ae53fb5b
Keywords: Animals, Apoptosis Drug Effects, Bh3 Interacting Domain Death Agonist Protein Toxicity, Cells, Cultured, Glutamic Acid Toxicity, Humans, Membrane Potential, Mitochondrial Drug Effects, Neurons Drug Effects, Neuroprotective Agents Pharmacology, Structure-Activity Relationship, Thiazolidinediones Pharmacology, 4 Thiazolidinedione Derivative, 4 Dimethoxyphenyl)thiazolidine 2, 4 Dione, 4 Dimethylphenyl)thiazolidine 2, 3 (4 Benzylphenyl)thiazolidine 2, 3 (4 Methoxyphenyl)thiazolidine 2, 3 (4 Phenoxyphenyl)thiazolidine 2, 8 Tetrahydronaphthalen 2 Yl)tiazolidine 2, 3 2 Tolylthiazolidine 2, 3 4 Tolylthiazolidine 2, 3 Phenylthiazolidine 2, 3 [4 (methylsulfonyl)phenyl]thiazolidine 2, 5 (2, 4 Dioxothiazolidin 3 Yl) 2 Methylbenzonitrile, Adenosine Triphosphate, Bi 2a1, Bi 6c9, N [3 (2, 4 Dioxothiazolidin 3 Yl)phenyl]acetamide, Protein Bid, Protein Inhibitor, Truncated Protein Bid, Unclassified Drug, [n [4 [(4 Aminophenyl)thio]phenyl] 4 [[(4 Methoxyphenyl)sulfonyl]amino]butanamide], Animal Cell, Animal Experiment, Animal Model, Article, Binding Affinity, Cell Death, Cell Differentiation, Cell Proliferation, Cell Structure, Cell Survival, Cell Viability, Concentration (parameters), Concentration Response, Degenerative Disease, Disorders Of Mitochondrial Functions, Drug Cytotoxicity, Drug Determination, Drug Potency, Drug Screening, Drug Structure, Drug Synthesis, Excitotoxicity, Gene Overexpression, Gene Transfer, Hippocampus, Human Cell, Median Effective Concentration, Mitochondrial Membrane Potential, Mitochondrial Respiration, Mouse, Nerve Cell, Neurotoxicity, Nonhuman, Oxygen Consumption, Plasmid, Priority Journal, Protein Depletion, Structure Activity Relation, 4 Dimethoxyphenyl) Thiazolidine 2, 4 Dimethylphenyl) Thiazolidine 2, 3 (4 Benzylphenyl) Thiazolidine 2, 3 (4 Methoxyphenyl) Thiazolidine 2, 3 (4 Phenoxyphenyl) Thiazolidine 2, 8 Tetrahydronaphthalen 2 Yl) Tiazolidine 2, 3 [4 (methylsulfonyl) Phenyl] Thiazolidine 2, 4 Dioxothiazolidin 3 Yl) Phenyl] Acetamide, [n [4 [(4 Aminophenyl) Thio] Phenyl] 4 [[(4 Methoxyphenyl) Sulfonyl] Amino] Butanamide],
Affiliations:
*** IBB - CNR ***
Institute for Pharmacology and Clinical Pharmacy, Faculty of Pharmacy (S.O., K.E., A.M.D., C.C.) and Institute for Pharmaceutical Chemistry, Faculty of Pharmacy, Philipps University of Marburg, Marburg, Germany (F.C.S., A.L.K., C.W.-G., M.S.)
and Institute of Biostructures and Bioimaging, Naples, Italy (N.D.).
References:
Becattini, B., Culmsee, C., Leone, M., Zhai, D., Zhang, X., Crowell, K.J., Rega, M.F., Plesnila, N., Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid (2006) Proc Natl Acad Sci USA, 103, pp. 12602-1260
Becattini, B., Sareth, S., Zhai, D., Crowell, K.J., Leone, M., Reed, J.C., Pellecchia, M., Targeting apoptosis via chemical design: Inhibition of bid-induced cell death by small organic molecules (2004) Chem Biol, 11, pp. 1107-1117
Bermpohl, D., You, Z., Korsmeyer, S.J., Moskowitz, M.A., Whalen, M.J., Traumatic brain injury in mice deficient in Bid: Effects on histopathology and functional outcome (2006) J Cereb Blood Flow Metab, 26, pp. 625-633
Brustovetsky, N., Dubinsky, J.M., Antonsson, B., Jemmerson, R., Two pathways for tBID-induced cytochrome c release from rat brain mitochondria: Bak-versus BAX-dependence (2003) J Neurochem, 84, pp. 196-207
Burdo, J., Dargusch, R., Schubert, D., Distribution of the cystine/glutamate antiporter system xc-in the brain, kidney, and duodenum (2006) J Histochem Cytochem, 54, pp. 549-557
Clerc, P., Polster, B.M., Investigation of mitochondrial dysfunction by sequential microplate-based respiration measurements from intact and permeabilized neurons (2012) PLoS ONE, 7, pp. e34465
Culmsee, C., Landshamer, S., Molecular insights into mechanisms of the cell death program: Role in the progression of neurodegenerative disorders (2006) Curr Alzheimer Res, 3, pp. 269-283
Culmsee, C., Plesnila, N., Targeting Bid to prevent programmed cell death in neurons (2006) Biochem Soc Trans, 34, pp. 1334-1340
Culmsee, C., Zhu, C., Landshamer, S., Becattini, B., Wagner, E., Pellecchia, M., Blomgren, K., Plesnila, N., Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia (2005) J Neurosci, 25, pp. 10262-10272
Diemert, S., Dolga, A.M., Tobaben, S., Grohm, J., Pfeifer, S., Oexler, E., Culmsee, C., Impedance measurement for real time detection of neuronal cell death (2012) J Neurosci Methods, 203, pp. 69-77
Friedlander, R.M., Apoptosis and caspases in neurodegenerative diseases (2003) N Engl J Med, 348, pp. 1365-1375
Geffken, D., Synthesis and properties of 3-alkoxy(hydroxy)thiazolidine-2,4-diones (1987) Zeitschrift für Naturforschung, B: Chemical Sciences, 42 B, pp. 1202-1206
Gohil, V.M., Sheth, S.A., Nilsson, R., Wojtovich, A.P., Lee, J.H., Perocchi, F., Chen, W., Brookes, P.S., Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis (2010) Nat Biotechnol, 28, pp. 249-255
Grohm, J., Kim, S.W., Mamrak, U., Tobaben, S., Cassidy-Stone, A., Nunnari, J., Plesnila, N., Culmsee, C., Inhibition of Drp1 provides neuroprotection in vitro and in vivo (2012) Cell Death Differ, 19, pp. 1446-1458
Grohm, J., Plesnila, N., Culmsee, C., Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death (2010) Brain Behav Immun, 24, pp. 831-838
Gross, A., Yin, X.M., Wang, K., Wei, M.C., Jockel, J., Milliman, C., Erdjument-Bromage, H., Korsmeyer, S.J., Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death (1999) J Biol Chem, 274, pp. 1156-1163
Guégan, C., Vila, M., Teismann, P., Chen, C., Onténiente, B., Li, M., Friedlander, R.M., Przedborski, S., Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS (2002) Mol Cell Neurosci, 20, pp. 553-562
Kazhdan, I., Long, L., Montellano, R., Cavazos, D.A., Marciniak, R.A., Targeted gene therapy for breast cancer with truncated Bid (2006) Cancer Gene Ther, 13, pp. 141-149
König, H.G., Rehm, M., Gudorf, D., Krajewski, S., Gross, A., Ward, M.W., Prehn, J.H., Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons (2007) BMC Cell Biol, 8, p. 7
Kroemer, G., Galluzzi, L., Brenner, C., Mitochondrial membrane permeabilization in cell death (2007) Physiol Rev, 87, pp. 99-163
Landshamer, S., Hoehn, M., Barth, N., Duvezin-Caubet, S., Schwake, G., Tobaben, S., Kazhdan, I., Vollmar, A., Bid-induced release of AIF from mitochondria causes immediate neuronal cell death (2008) Cell Death Differ, 15, pp. 1553-1563
Li, H., Zhu, H., Xu, C.J., Yuan, J., Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis (1998) Cell, 94, pp. 491-501
McDonnell, J.M., Fushman, D., Milliman, C.L., Korsmeyer, S.J., Cowburn, D., Solution structure of the proapoptotic molecule BID: A structural basis for apoptotic agonists and antagonists (1999) Cell, 96, pp. 625-634
Murphy, T.H., Miyamoto, M., Sastre, A., Schnaar, R.L., Coyle, J.T., Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress (1989) Neuron, 2, pp. 1547-1558
O'Malley, S.M., Xie, X., Frutos, A.G., Label-free high-throughput functional lytic assays (2007) J Biomol Screen, 12, pp. 117-125
Plesnila, N., Zinkel, S., Le, D.A., Amin-Hanjani, S., Wu, Y., Qiu, J., Chiarugi, A., Korsmeyer, S.J., BID mediates neuronal cell death after oxygen/glucose deprivation and focal cerebral ischemia (2001) Proc Natl Acad Sci USA, 98, pp. 15318-15323
Rarey, M., Kramer, B., Lengauer, T., Klebe, G., A fast flexible docking method using an incremental construction algorithm (1996) J Mol Biol, 261, pp. 470-489
Stierand, K., Rarey, M., From modeling to medicinal chemistry: Automatic generation of two-dimensional complex diagrams (2007) ChemMedChem, 2, pp. 853-860
Waldmeier, P.C., Prospects for antiapoptotic drug therapy of neurodegenerative diseases (2003) Prog Neuropsychopharmacol Biol Psychiatry, 27, pp. 303-321
Ward, M.W., Rehm, M., Duessmann, H., Kacmar, S., Concannon, C.G., Prehn, J.H., Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis (2006) J Biol Chem, 281, pp. 5837-5844
Yin, X.M., Luo, Y., Cao, G., Bai, L., Pei, W., Kuharsky, D.K., Chen, J., Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia (2002) J Biol Chem, 277, pp. 42074-42081
Friedlander, R. M., Apoptosis and caspases in neurodegenerative diseases (2003) N Engl J Med, 348, pp. 1365-1375
Gohil, V. M., Sheth, S. A., Nilsson, R., Wojtovich, A. P., Lee, J. H., Perocchi, F., Chen, W., Brookes, P. S., Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis (2010) Nat Biotechnol, 28, pp. 249-255
Grohm, J., Kim, S. W., Mamrak, U., Tobaben, S., Cassidy-Stone, A., Nunnari, J., Plesnila, N., Culmsee, C., Inhibition of Drp1 provides neuroprotection in vitro and in vivo (2012) Cell Death Differ, 19, pp. 1446-1458
Gross, A., Yin, X. M., Wang, K., Wei, M. C., Jockel, J., Milliman, C., Erdjument-Bromage, H., Korsmeyer, S. J., Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death (1999) J Biol Chem, 274, pp. 1156-1163
Gu gan, C., Vila, M., Teismann, P., Chen, C., Ont niente, B., Li, M., Friedlander, R. M., Przedborski, S., Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS (2002) Mol Cell Neurosci, 20, pp. 553-562
K nig, H. G., Rehm, M., Gudorf, D., Krajewski, S., Gross, A., Ward, M. W., Prehn, J. H., Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons (2007) BMC Cell Biol, 8, p. 7
McDonnell, J. M., Fushman, D., Milliman, C. L., Korsmeyer, S. J., Cowburn, D., Solution structure of the proapoptotic molecule BID: A structural basis for apoptotic agonists and antagonists (1999) Cell, 96, pp. 625-634
Murphy, T. H., Miyamoto, M., Sastre, A., Schnaar, R. L., Coyle, J. T., Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress (1989) Neuron, 2, pp. 1547-1558
O'Malley, S. M., Xie, X., Frutos, A. G., Label-free high-throughput functional lytic assays (2007) J Biomol Screen, 12, pp. 117-125
Waldmeier, P. C., Prospects for antiapoptotic drug therapy of neurodegenerative diseases (2003) Prog Neuropsychopharmacol Biol Psychiatry, 27, pp. 303-321
Ward, M. W., Rehm, M., Duessmann, H., Kacmar, S., Concannon, C. G., Prehn, J. H., Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis (2006) J Biol Chem, 281, pp. 5837-5844
Yin, X. M., Luo, Y., Cao, G., Bai, L., Pei, W., Kuharsky, D. K., Chen, J., Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia (2002) J Biol Chem, 277, pp. 42074-42081
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.972, 5-year impact factor: 3.819
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84904992419&partnerID=40&md5=c9a7395249ff9b0dd571ca55ae53fb5b
Keywords: Animals, Apoptosis Drug Effects, Bh3 Interacting Domain Death Agonist Protein Toxicity, Cells, Cultured, Glutamic Acid Toxicity, Humans, Membrane Potential, Mitochondrial Drug Effects, Neurons Drug Effects, Neuroprotective Agents Pharmacology, Structure-Activity Relationship, Thiazolidinediones Pharmacology, 4 Thiazolidinedione Derivative, 4 Dimethoxyphenyl)thiazolidine 2, 4 Dione, 4 Dimethylphenyl)thiazolidine 2, 3 (4 Benzylphenyl)thiazolidine 2, 3 (4 Methoxyphenyl)thiazolidine 2, 3 (4 Phenoxyphenyl)thiazolidine 2, 8 Tetrahydronaphthalen 2 Yl)tiazolidine 2, 3 2 Tolylthiazolidine 2, 3 4 Tolylthiazolidine 2, 3 Phenylthiazolidine 2, 3 [4 (methylsulfonyl)phenyl]thiazolidine 2, 5 (2, 4 Dioxothiazolidin 3 Yl) 2 Methylbenzonitrile, Adenosine Triphosphate, Bi 2a1, Bi 6c9, N [3 (2, 4 Dioxothiazolidin 3 Yl)phenyl]acetamide, Protein Bid, Protein Inhibitor, Truncated Protein Bid, Unclassified Drug, [n [4 [(4 Aminophenyl)thio]phenyl] 4 [[(4 Methoxyphenyl)sulfonyl]amino]butanamide], Animal Cell, Animal Experiment, Animal Model, Article, Binding Affinity, Cell Death, Cell Differentiation, Cell Proliferation, Cell Structure, Cell Survival, Cell Viability, Concentration (parameters), Concentration Response, Degenerative Disease, Disorders Of Mitochondrial Functions, Drug Cytotoxicity, Drug Determination, Drug Potency, Drug Screening, Drug Structure, Drug Synthesis, Excitotoxicity, Gene Overexpression, Gene Transfer, Hippocampus, Human Cell, Median Effective Concentration, Mitochondrial Membrane Potential, Mitochondrial Respiration, Mouse, Nerve Cell, Neurotoxicity, Nonhuman, Oxygen Consumption, Plasmid, Priority Journal, Protein Depletion, Structure Activity Relation, 4 Dimethoxyphenyl) Thiazolidine 2, 4 Dimethylphenyl) Thiazolidine 2, 3 (4 Benzylphenyl) Thiazolidine 2, 3 (4 Methoxyphenyl) Thiazolidine 2, 3 (4 Phenoxyphenyl) Thiazolidine 2, 8 Tetrahydronaphthalen 2 Yl) Tiazolidine 2, 3 [4 (methylsulfonyl) Phenyl] Thiazolidine 2, 4 Dioxothiazolidin 3 Yl) Phenyl] Acetamide, [n [4 [(4 Aminophenyl) Thio] Phenyl] 4 [[(4 Methoxyphenyl) Sulfonyl] Amino] Butanamide],
Affiliations:
*** IBB - CNR ***
Institute for Pharmacology and Clinical Pharmacy, Faculty of Pharmacy (S.O., K.E., A.M.D., C.C.) and Institute for Pharmaceutical Chemistry, Faculty of Pharmacy, Philipps University of Marburg, Marburg, Germany (F.C.S., A.L.K., C.W.-G., M.S.)
and Institute of Biostructures and Bioimaging, Naples, Italy (N.D.).
References:
Becattini, B., Culmsee, C., Leone, M., Zhai, D., Zhang, X., Crowell, K.J., Rega, M.F., Plesnila, N., Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid (2006) Proc Natl Acad Sci USA, 103, pp. 12602-1260
Becattini, B., Sareth, S., Zhai, D., Crowell, K.J., Leone, M., Reed, J.C., Pellecchia, M., Targeting apoptosis via chemical design: Inhibition of bid-induced cell death by small organic molecules (2004) Chem Biol, 11, pp. 1107-1117
Bermpohl, D., You, Z., Korsmeyer, S.J., Moskowitz, M.A., Whalen, M.J., Traumatic brain injury in mice deficient in Bid: Effects on histopathology and functional outcome (2006) J Cereb Blood Flow Metab, 26, pp. 625-633
Brustovetsky, N., Dubinsky, J.M., Antonsson, B., Jemmerson, R., Two pathways for tBID-induced cytochrome c release from rat brain mitochondria: Bak-versus BAX-dependence (2003) J Neurochem, 84, pp. 196-207
Burdo, J., Dargusch, R., Schubert, D., Distribution of the cystine/glutamate antiporter system xc-in the brain, kidney, and duodenum (2006) J Histochem Cytochem, 54, pp. 549-557
Clerc, P., Polster, B.M., Investigation of mitochondrial dysfunction by sequential microplate-based respiration measurements from intact and permeabilized neurons (2012) PLoS ONE, 7, pp. e34465
Culmsee, C., Landshamer, S., Molecular insights into mechanisms of the cell death program: Role in the progression of neurodegenerative disorders (2006) Curr Alzheimer Res, 3, pp. 269-283
Culmsee, C., Plesnila, N., Targeting Bid to prevent programmed cell death in neurons (2006) Biochem Soc Trans, 34, pp. 1334-1340
Culmsee, C., Zhu, C., Landshamer, S., Becattini, B., Wagner, E., Pellecchia, M., Blomgren, K., Plesnila, N., Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia (2005) J Neurosci, 25, pp. 10262-10272
Diemert, S., Dolga, A.M., Tobaben, S., Grohm, J., Pfeifer, S., Oexler, E., Culmsee, C., Impedance measurement for real time detection of neuronal cell death (2012) J Neurosci Methods, 203, pp. 69-77
Friedlander, R.M., Apoptosis and caspases in neurodegenerative diseases (2003) N Engl J Med, 348, pp. 1365-1375
Geffken, D., Synthesis and properties of 3-alkoxy(hydroxy)thiazolidine-2,4-diones (1987) Zeitschrift für Naturforschung, B: Chemical Sciences, 42 B, pp. 1202-1206
Gohil, V.M., Sheth, S.A., Nilsson, R., Wojtovich, A.P., Lee, J.H., Perocchi, F., Chen, W., Brookes, P.S., Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis (2010) Nat Biotechnol, 28, pp. 249-255
Grohm, J., Kim, S.W., Mamrak, U., Tobaben, S., Cassidy-Stone, A., Nunnari, J., Plesnila, N., Culmsee, C., Inhibition of Drp1 provides neuroprotection in vitro and in vivo (2012) Cell Death Differ, 19, pp. 1446-1458
Grohm, J., Plesnila, N., Culmsee, C., Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death (2010) Brain Behav Immun, 24, pp. 831-838
Gross, A., Yin, X.M., Wang, K., Wei, M.C., Jockel, J., Milliman, C., Erdjument-Bromage, H., Korsmeyer, S.J., Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death (1999) J Biol Chem, 274, pp. 1156-1163
Guégan, C., Vila, M., Teismann, P., Chen, C., Onténiente, B., Li, M., Friedlander, R.M., Przedborski, S., Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS (2002) Mol Cell Neurosci, 20, pp. 553-562
Kazhdan, I., Long, L., Montellano, R., Cavazos, D.A., Marciniak, R.A., Targeted gene therapy for breast cancer with truncated Bid (2006) Cancer Gene Ther, 13, pp. 141-149
König, H.G., Rehm, M., Gudorf, D., Krajewski, S., Gross, A., Ward, M.W., Prehn, J.H., Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons (2007) BMC Cell Biol, 8, p. 7
Kroemer, G., Galluzzi, L., Brenner, C., Mitochondrial membrane permeabilization in cell death (2007) Physiol Rev, 87, pp. 99-163
Landshamer, S., Hoehn, M., Barth, N., Duvezin-Caubet, S., Schwake, G., Tobaben, S., Kazhdan, I., Vollmar, A., Bid-induced release of AIF from mitochondria causes immediate neuronal cell death (2008) Cell Death Differ, 15, pp. 1553-1563
Li, H., Zhu, H., Xu, C.J., Yuan, J., Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis (1998) Cell, 94, pp. 491-501
McDonnell, J.M., Fushman, D., Milliman, C.L., Korsmeyer, S.J., Cowburn, D., Solution structure of the proapoptotic molecule BID: A structural basis for apoptotic agonists and antagonists (1999) Cell, 96, pp. 625-634
Murphy, T.H., Miyamoto, M., Sastre, A., Schnaar, R.L., Coyle, J.T., Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress (1989) Neuron, 2, pp. 1547-1558
O'Malley, S.M., Xie, X., Frutos, A.G., Label-free high-throughput functional lytic assays (2007) J Biomol Screen, 12, pp. 117-125
Plesnila, N., Zinkel, S., Le, D.A., Amin-Hanjani, S., Wu, Y., Qiu, J., Chiarugi, A., Korsmeyer, S.J., BID mediates neuronal cell death after oxygen/glucose deprivation and focal cerebral ischemia (2001) Proc Natl Acad Sci USA, 98, pp. 15318-15323
Rarey, M., Kramer, B., Lengauer, T., Klebe, G., A fast flexible docking method using an incremental construction algorithm (1996) J Mol Biol, 261, pp. 470-489
Stierand, K., Rarey, M., From modeling to medicinal chemistry: Automatic generation of two-dimensional complex diagrams (2007) ChemMedChem, 2, pp. 853-860
Waldmeier, P.C., Prospects for antiapoptotic drug therapy of neurodegenerative diseases (2003) Prog Neuropsychopharmacol Biol Psychiatry, 27, pp. 303-321
Ward, M.W., Rehm, M., Duessmann, H., Kacmar, S., Concannon, C.G., Prehn, J.H., Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis (2006) J Biol Chem, 281, pp. 5837-5844
Yin, X.M., Luo, Y., Cao, G., Bai, L., Pei, W., Kuharsky, D.K., Chen, J., Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia (2002) J Biol Chem, 277, pp. 42074-42081
Friedlander, R. M., Apoptosis and caspases in neurodegenerative diseases (2003) N Engl J Med, 348, pp. 1365-1375
Gohil, V. M., Sheth, S. A., Nilsson, R., Wojtovich, A. P., Lee, J. H., Perocchi, F., Chen, W., Brookes, P. S., Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis (2010) Nat Biotechnol, 28, pp. 249-255
Grohm, J., Kim, S. W., Mamrak, U., Tobaben, S., Cassidy-Stone, A., Nunnari, J., Plesnila, N., Culmsee, C., Inhibition of Drp1 provides neuroprotection in vitro and in vivo (2012) Cell Death Differ, 19, pp. 1446-1458
Gross, A., Yin, X. M., Wang, K., Wei, M. C., Jockel, J., Milliman, C., Erdjument-Bromage, H., Korsmeyer, S. J., Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death (1999) J Biol Chem, 274, pp. 1156-1163
Gu gan, C., Vila, M., Teismann, P., Chen, C., Ont niente, B., Li, M., Friedlander, R. M., Przedborski, S., Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS (2002) Mol Cell Neurosci, 20, pp. 553-562
K nig, H. G., Rehm, M., Gudorf, D., Krajewski, S., Gross, A., Ward, M. W., Prehn, J. H., Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons (2007) BMC Cell Biol, 8, p. 7
McDonnell, J. M., Fushman, D., Milliman, C. L., Korsmeyer, S. J., Cowburn, D., Solution structure of the proapoptotic molecule BID: A structural basis for apoptotic agonists and antagonists (1999) Cell, 96, pp. 625-634
Murphy, T. H., Miyamoto, M., Sastre, A., Schnaar, R. L., Coyle, J. T., Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress (1989) Neuron, 2, pp. 1547-1558
O'Malley, S. M., Xie, X., Frutos, A. G., Label-free high-throughput functional lytic assays (2007) J Biomol Screen, 12, pp. 117-125
Waldmeier, P. C., Prospects for antiapoptotic drug therapy of neurodegenerative diseases (2003) Prog Neuropsychopharmacol Biol Psychiatry, 27, pp. 303-321
Ward, M. W., Rehm, M., Duessmann, H., Kacmar, S., Concannon, C. G., Prehn, J. H., Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis (2006) J Biol Chem, 281, pp. 5837-5844
Yin, X. M., Luo, Y., Cao, G., Bai, L., Pei, W., Kuharsky, D. K., Chen, J., Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia (2002) J Biol Chem, 277, pp. 42074-42081
Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity
Mitochondrial demise is a key feature of progressive neuronal death contributing to acute and chronic neurological disorders. Recent studies identified a pivotal role for the BH3-only protein B-cell lymphoma-2 interacting domain death antagonist (Bid) for such mitochondrial damage and delayed neuronal death after oxygen-glucose deprivation, glutamate-induced excitotoxicity, or oxidative stress in vitro and after cerebral ischemia in vivo. Therefore, we developed new N-phenyl-substituted thiazolidine-2,4-dione derivatives as potent inhibitors of Bid-dependent neurotoxicity. The new compounds 6, 7, and 16 were identified as highly protective by extensive screening in a model of glutamate toxicity in immortalized mouse hippocampal neurons (HT-22 cells). These compounds significantly prevent truncated Bid-induced toxicity in the neuronal cell line, providing strong evidence that inhibition of Bid was the underlying mechanism of the observed protective effects. Furthermore, Bid-dependent hallmarks of mitochondrial dysfunction, such as loss of mitochondrial membrane potential, ATP depletion, as well as impairments in mitochondrial respiration, are significantly prevented by compounds 6, 7, and 16. Therefore, the present study identifies a class of N-phenyl thiazolidinediones as novel Bid-inhibiting neuroprotective agents that provide promising therapeutic perspectives for neurodegenerative diseases, in which Bid-mediated mitochondrial damage and associated intrinsic death pathways contribute to the underlying progressive loss of neurons.
Mitochondrial demise is a key feature of progressive neuronal death contributing to acute and chronic neurological disorders. Recent studies identified a pivotal role for the BH3-only protein B-cell lymphoma-2 interacting domain death antagonist (Bid) for such mitochondrial damage and delayed neuronal death after oxygen-glucose deprivation, glutamate-induced excitotoxicity, or oxidative stress in vitro and after cerebral ischemia in vivo. Therefore, we developed new N-phenyl-substituted thiazolidine-2,4-dione derivatives as potent inhibitors of Bid-dependent neurotoxicity. The new compounds 6, 7, and 16 were identified as highly protective by extensive screening in a model of glutamate toxicity in immortalized mouse hippocampal neurons (HT-22 cells). These compounds significantly prevent truncated Bid-induced toxicity in the neuronal cell line, providing strong evidence that inhibition of Bid was the underlying mechanism of the observed protective effects. Furthermore, Bid-dependent hallmarks of mitochondrial dysfunction, such as loss of mitochondrial membrane potential, ATP depletion, as well as impairments in mitochondrial respiration, are significantly prevented by compounds 6, 7, and 16. Therefore, the present study identifies a class of N-phenyl thiazolidinediones as novel Bid-inhibiting neuroprotective agents that provide promising therapeutic perspectives for neurodegenerative diseases, in which Bid-mediated mitochondrial damage and associated intrinsic death pathways contribute to the underlying progressive loss of neurons.
Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity
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Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity
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* Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death (11 views)
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Impact Factor:
View Export to BibTeX Export to EndNote
Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
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Impact Factor: 3.345
View Export to BibTeX Export to EndNote
Soprano M, Sorriento D, Rusciano MR, Maione AS, Limite G, Forestieri P, D'Angelo D, D'Alessio M, Campiglia P, Formisano P, Iaccarino G, Bianco R, Illario M
* Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells (249 views)
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Impact Factor: 2.806
View Export to BibTeX Export to EndNote
De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
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Impact Factor: 8.738
View Export to BibTeX Export to EndNote
Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
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Impact Factor: 13.958
View Export to BibTeX Export to EndNote
Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (565 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
View Export to BibTeX Export to EndNote
Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
* Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (865 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Nov 7; 4(11): e911-e911.
Impact Factor: 5.177
View Export to BibTeX Export to EndNote
Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
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J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Impact Factor: 2.882
View Export to BibTeX Export to EndNote
Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (599 views)
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Impact Factor: 4.6
View Export to BibTeX Export to EndNote
Sandomenico A, Russo A, Palmieri G, Bergamo P, Gogliettino M, Falcigno L, Ruvo M
* Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation (521 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012 Mar 8; 55(5): 2102-2111.
Impact Factor: 5.614
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (615 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (527 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
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Impact Factor: 6.488
View Export to BibTeX Export to EndNote
Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (509 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Impact Factor: 4.447
View Export to BibTeX Export to EndNote
Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
View Export to BibTeX Export to EndNote
15 Records (12 excluding Abstracts).
Total impact factor: 78.337 (65.264 excluding Abstracts).
Total 5 year impact factor: 81.593 (68.06 excluding Abstracts).
Total impact factor: 78.337 (65.264 excluding Abstracts).
Total 5 year impact factor: 81.593 (68.06 excluding Abstracts).
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