A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (509 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.447, 5-year impact factor: 4.176
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-52949119162&partnerID=40&md5=bebb973538a18ab66a94b982979bb5de
Keywords: Atp Synthesis, Cerebellar Granule Cells, Mitochondria, Neurotoxicity, Oxidative Phosphorylation, Tau Fragment, Adenine Nucleotide Translocase, Cytochrome C Oxidase, Proton Transporting Adenosine Triphosphate Synthase, Tau Protein, Amino Terminal Sequence, Animal Cell, Animal Tissue, Article, Cerebellum Cortex, Controlled Study, Electron Transport, Enzyme Activity, Membrane Potential, Mitochondrial Membrane Potential, Mitochondrial Respiration, Nonhuman, Oxygen Consumption, Priority Journal, Respiratory Chain, Adenosine Diphosphate, Electron Transport Complex Iv, Mitochondrial Adp, Atp Translocases, Mitochondrial Proton-Translocating Atpases, Peptide Fragments, Wistar, Adenoviridae,
Affiliations:
*** IBB - CNR ***
Institute of Biomembranes and Bioenergetics, CNR, Via G. Amendola 165 /A, 70126 Bari, Italy
Institute of Neurobiology and Molecular Medicine, CNR, Via del Fosso di Fiorano 64-65, 00143 Rome, Italy
European Brain Research Institute (EBRI), Via del Fosso di Fiorano 64-65, 00143 Rome, Italy
Institute of Biostructures and Bioimaging, CNR, Viale A. Doria 6, 95125 Catania, Italy
Department of Health Sciences, University of Molise, Via F. De Sanctis, 86100 Campobasso, Italy
References:
Amadoro, G., Serafino, A.L., Barbato, C., Ciotti, M.T., Sacco, A., Calissano, P., Canu, N., Role of N-terminal tau domain integrity on the survival of cerebellar granule neurons (2004) Cell Death Differ., 11, pp. 217-23
Rohn, T.T., Rissman, R.A., Davis, M.C., Kim, Y.E., Cotman, C.W., Head, E., Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain (2002) Neurobiol. Dis., 11, pp. 341-354
Fasulo, L., Ugolini, G., Visentin, M., Bradbury, A., Brancolini, C., Verzillo, V., Novak, M., Cattaneo, A., The neuronal microtubule-associated protein tau is substrate of caspase-3 and an effector of apoptosis (2000) J. Neurochem., 75, pp. 624-633
Chung, C.W., Song, Y.H., Kim, I.K., Yoon, W.J., Ryu, B.R., Jo, D.G., Woo, H.N., Jung, Y.K., Proapoptotic effects of tau cleavage product generated by caspase-3 (2001) Neurobiol. Dis., 8, pp. 162-172
Avila, J., Lucas, J.J., Perez, M., Hernandez, F., Role of tau protein in both physiological and pathological conditions (2004) Physiol. Rev., 84, pp. 361-384. , (Review)
Amadoro, G., Ciotti, M.T., Costanzi, M., Cestari, V., Calissano, P., Canu, N., NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation (2006) Proc. Natl. Acad. Sci. U. S. A., 103, pp. 2892-2897
Levi, G., Aloisi, F., Ciotti, M.T., Gallo, V., Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures (1984) Brain Res., 290, pp. 77-86
Almeida, A., Medina, J.M., A rapid method for the isolation of metabolically mitochondria form rat neurons and astrocytes in primary culture (1998) Brain Res. Brain Res. Protoc., 3, pp. 209-214
Waddel, W.J., Hill, C., A simple ultraviolet spectrophotometer method for the determination of protein (1956) J. Lab. Clin. Med., 48, pp. 311-314
Atlante, A., Bobba, A., de Bari, L., Fontana, F., Calissano, P., Marra, E., Passarella, S., Caspase-dependent alteration of the ADP/ATP translocator triggers the mitochondrial permeability transition which is not required for the low-potassium-dependent apoptosis of cerebellar granule cells (2006) J. Neurochem., 97, pp. 1166-1181
Trumbeckaite, S., Opalka, J.R., Neuhof, C., Zierz, S., Gellerich, F.N., Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function (2001) Eur. J. Biochem., 268, pp. 1422-1429
Wharton, D.C., Tzagaloff, A., Cytochrome c oxidase from beef heart mitochondria (1967) Methods Enzymol., 10, pp. 245-253
Atlante, A., de Bari, L., Bobba, A., Marra, E., Calissano, P., Passarella, S., Cytochrome c, released from cerebellar granule cells undergoing apoptosis or excytotoxic death, can generate protonmotive force and drive ATP synthesis in isolated mitochondria (2003) J. Neurochem., 86, pp. 591-604
Atlante, A., Passarella, S., Quagliariello, E., Moreno, G., Salet, C., Haematoporphyrin derivative (Photofrin II) photosensitization of isolated mitochondria: inhibition of ADP/ATP translocator (1989) J. Photochem. Photobiol. B, 4, pp. 35-46
Canu, N., Dus, L., Barbato, C., Ciotti, M.T., Brancolini, C., Rinaldi, A.M., Novak, M., Calissano, P., Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis (1998) J. Neurosci., 18, pp. 7061-7074
Rohn, T.T., Head, E., Su, J.H., Anderson, A.J., Bahr, B.A., Cotman, C.W., Cribbs, D.H., Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease (2001) Am. J. Pathol., 158, pp. 189-198
Ugolini, G., Cattaneo, A., Novak, M., Co-localization of truncated tau and DNA fragmentation in Alzheimer's diseases neurons (1997) Neuroreport, 8, pp. 3709-3712
Gastard, M.C., Troncoso, J.C., Koliatsos, V.E., Caspase activation in the limbic cortex of subjects with early Alzheimer's disease (2003) Ann. Neurol., 54, pp. 393-398
Saito, K., Elce, J.S., Hamos, J.E., Nixon, R.A., Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration (1993) Proc. Natl. Acad. Sci. U. S. A., 90, pp. 26-28
Veeranna, Kaji, T., Boland, B., Odrljin, T., Mohan, P., Basavarajappa, B.S., Peterhoff, C., Nixon, R.A., Calpain mediates calcium-induced activation of the ERK1/2, MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease (2004) Am. J. Pathol., 165, pp. 795-805
Cardoso, S.M., Santana, I., Swerdlow, R.H., Oliveira, C.R., Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity (2004) J. Neurochem., 89, pp. 1417-1426
Mancuso, M., Coppedè, F., Murri, L., Siciliano, G., Mitochondrial cascade hypothesis of Alzheimer's disease: myth or reality? (2007) Antioxid. Redox Signal., 9, pp. 1631-1646
Kish, S.J., Bergeron, C., Rajput, A., Dozic, S., Mastrogiacomo, F., Chang, L.J., Wilson, J.M., Nobrega, J.N., Brain cytochrome oxidase in Alzheimer's disease (1992) J. Neurochem., 59, pp. 776-779
Davis, R.E., Miller, S., Herrnstadt, C., Ghosh, S.S., Fahy, E., Shinobu, L.A., Galasko, D., Jr Parker, W.D., Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease (1997) Proc. Natl. Acad. Sci. U. S. A., 94, pp. 4526-4531
Beal, M.F., Oxidative metabolism (2000) Ann. N. Y. Acad. Sci., 924, pp. 164-169
Mutisya, E.M., Bowling, A.C., Beal, M.F., Cortical cytochrome oxidase activity is reduced in Alzheimer's disease (1994) J. Neurochem., 63, pp. 2179-2184
Sims, N.R., Finegan, J.M., Blass, J.P., Bowen, D.M., Neary, D., Mitochondrial function in brain tissue in primary degenerative dementia (1987) Brain Res., 436, pp. 30-38
Reynolds, M.R., Berry, R.W., Binder, L.I., Site-specific nitration differentially influences tau assembly in vitro (2005) Biochemistry, 44, pp. 13997-14009
Gamblin, T.C., Berry, R.W., Binder, L.I., Modeling tau polymerization in vitro. A review and synthesis (2003) Biochemistry, 42, pp. 15009-15017
Yang, L.S., Ksiezak-Reding, H., Calpain-induced proteolysis of normal human tau and tau associated with paired helical filaments (1995) Eur. J. Biochem., 233, pp. 9-17
Cente, M., Filipcik, P., Pevalova, M., Novak, M., Expression of a truncated tau protein induces oxidative stress in a rodent model of tauopathy (2006) Eur. J. Neurosci., 24, pp. 1085-1090
Chothia, C., Janin, J., Principles of protein-protein recognition (1975) Nature, 256, pp. 705-708
Tsai, C.J., Lin, S.L., Wolfson, H.J., Nussinov, R., Studies of protein-protein interfaces: a statistical analysis of the hydrophobic effect (1997) Protein Sci., 6, pp. 53-64
Janin, J., Chothia, C., The structure of protein-protein recognition sites (1990) J. Biol. Chem., 265, pp. 16027-16030
Korn, A.P., Burnett, R.M., Distribution and complementarity of hydropathy in multisubunit proteins (1991) Proteins, 9, pp. 37-55
Vakser, I.A., Aflalo, C., Hydrophobic docking: a proposed enhancement to molecular recognition techniques (1994) Proteins, 20, pp. 320-329
Young, L., Jernigan, R.L., Covell, D.G., A role for surface hydrophobicity in protein-protein recognition (1994) Protein Sci., 3, pp. 717-729
Jones, S., Thornton, J.M., Protein-protein interaction: a review of protein dimer structures (1995) Prog. Biophys. Mol. Biol., 63, pp. 131-165
Larsen, T.A., Olson, A.J., Goodsell, D.S., Morphology of protein-protein interfaces (1998) Structure, 6, pp. 421-427
Lo Conte, L., Chothia, C., Janin, J., The atomic structure of protein-protein recognition sites (1999) J. Mol. Biol., 285, pp. 2177-2198
Glaser, F., Steinberg, D.M., Vakser, A., Ben-Tal, N., Residue frequencies and pairing preferences at protein-protein interfaces (2001) Proteins, 43, pp. 89-102
Chakrabarti, P., Janin, J., Dissecting protein-protein recognition sites (2002) Proteins, 47, pp. 334-343
Klingenberg, M., Molecular aspects of the adenine nucleotide carrier from mitochondria (1989) Arch. Biochem. Biophys., 270, pp. 1-14
Majima, E., Yamaguchi, N., Chuman, H., Shinohara, Y., Ishida, M., Goto, S., Terada, H., Binding of the fluorescein derivative eosin Y to the mitochondrial ADP/ATP carrier: characterization of the adenine nucleotide binding site (1998) Biochemistry, 37, pp. 424-432
Kini, R.M., Evans, H.J., Prediction of potential protein-protein interaction sites from amino acid sequence identification of a fibrin polymerization site (1996) FEBS Lett., 385, pp. 81-86
Stamer, K., Vogel, R., Thies, E., Mandelkow, E., Mandelkow, E.M., Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhance oxidative stress (2002) J. Cell Biol., 156, pp. 1051-1063
Ebneth, A., Godemann, R., Stamer, K., Illenberger, S., Trinczek, B., Mandelkow, E., Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implication for Alzheimer's disease (1998) J. Cell Biol., 143, pp. 777-794
Santagata, D.D., Fulga, T., Duttaroy, A., Feany, M.B., Oxidative stress mediates tau-induced neurodegeneration in Drosophila (2007) J. Clin. Inv., 117, pp. 236-245
David, D.C., Hauptmann, S., Scherping, I., Schuessel, K., Keil, U., Rizzu, P., Ravid, R., Gotz, J., Proteomic and functional analyses reveal a mitochondrial dysfunction in P3201L tau transgenic mice (2005) J. Biol. Chem., 280, pp. 23802-23814
Zilka, N., Filipcik, P., Koson, P., Fialova, L., Skrabana, R., Zilkova, M., Rolkova, G., Novak, M., Truncated tau form sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo (2006) FEBS Lett., 580, pp. 3582-3588
Liu, R., Yuan, B., Emadi, S., Zameer, A., Schulz, P., McAllister, C., Lyubchenko, Y., Sierks, M.R., Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity (2004) Biochemistry, 43, pp. 6959-6967
Ferri, A., Cozzolino, M., Crosio, C., Nencini, M., Casciati, A., Gralla, E.B.V., Rotilio, G., Carrì, M.T., familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials (2006) Proc. Natl. Acad. Sci., 103, pp. 13860-13865
Panov, A.V., Gutekunst, C.A., Leavitt, B.R., Hayden, M.R., Burke, J.R., Strittmatter, W.J., Greenamyre, J.T., Early mitochondrial calcium defects in Hungtington's disease are direct effect of polyglutamines (2002) N. Neurosci., 5, pp. 731-736
Panov, A.V., Burke, J.R., Strittmatter, W.J., Greenamyre, J.T., In vitro effects pf polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Hungtington's disease (2003) Arch. Biochem. Biophys., 410, pp. 1-6
Seong, I.S., Ivanova, E., Lee, J.M., Choo, Y.S., Fossale, E., Anderson, M.A., Gusella, J.F., MacDonald, M.E., HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism (2005) Hum. Mol. Genet., 14, pp. 2871-2880
Rendon, A., Jung, D., Jancsik, V., Interaction of microtubules and microtubule-associated proteins (MAPs) with rat brain mitochondria (1990) Biochem. J., 269, pp. 555-556
Lustbader, J.W., Cirilli, M., Lin, C., Xu, H.W., Takuma, K., Wang, N., Caspersen, C., Wu, H., ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease (2004) Science, 304, pp. 448-452
Lipton, P., Ischemic cell death in brain neurons (1999) Physiol. Rev., 79, pp. 1431-1568. , (Review)
Pettmann, B., Henderson, C.E., Neuronal cell death (1998) Neuron, 20, pp. 633-647. , (Review)
Rothman, S.M., Olney, J.W., Excitotoxicity and the NMDA receptor-still lethal after eight years (1995) Trends Neurosci., 18, pp. 57-58. , (Review)
Danbolt, N.C., Glutamate uptake (2001) Prog. Neurobiol., 65, pp. 1-105
Choi, D.W., Glutamate receptors and the induction of excitotoxic neuronal death (1994) Prog. Brain Res., 100, pp. 47-51
Rohn, T. T., Rissman, R. A., Davis, M. C., Kim, Y. E., Cotman, C. W., Head, E., Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain (2002) Neurobiol. Dis., 11, pp. 341-354
Chung, C. W., Song, Y. H., Kim, I. K., Yoon, W. J., Ryu, B. R., Jo, D. G., Woo, H. N., Jung, Y. K., Proapoptotic effects of tau cleavage product generated by caspase-3 (2001) Neurobiol. Dis., 8, pp. 162-172
Waddel, W. J., Hill, C., A simple ultraviolet spectrophotometer method for the determination of protein (1956) J. Lab. Clin. Med., 48, pp. 311-314
Wharton, D. C., Tzagaloff, A., Cytochrome c oxidase from beef heart mitochondria (1967) Methods Enzymol., 10, pp. 245-253
Rohn, T. T., Head, E., Su, J. H., Anderson, A. J., Bahr, B. A., Cotman, C. W., Cribbs, D. H., Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease (2001) Am. J. Pathol., 158, pp. 189-198
Gastard, M. C., Troncoso, J. C., Koliatsos, V. E., Caspase activation in the limbic cortex of subjects with early Alzheimer's disease (2003) Ann. Neurol., 54, pp. 393-398
Cardoso, S. M., Santana, I., Swerdlow, R. H., Oliveira, C. R., Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity (2004) J. Neurochem., 89, pp. 1417-1426
Kish, S. J., Bergeron, C., Rajput, A., Dozic, S., Mastrogiacomo, F., Chang, L. J., Wilson, J. M., Nobrega, J. N., Brain cytochrome oxidase in Alzheimer's disease (1992) J. Neurochem., 59, pp. 776-779
Davis, R. E., Miller, S., Herrnstadt, C., Ghosh, S. S., Fahy, E., Shinobu, L. A., Galasko, D., Jr Parker, W. D., Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease (1997) Proc. Natl. Acad. Sci. U. S. A., 94, pp. 4526-4531
Beal, M. F., Oxidative metabolism (2000) Ann. N. Y. Acad. Sci., 924, pp. 164-169
Mutisya, E. M., Bowling, A. C., Beal, M. F., Cortical cytochrome oxidase activity is reduced in Alzheimer's disease (1994) J. Neurochem., 63, pp. 2179-2184
Sims, N. R., Finegan, J. M., Blass, J. P., Bowen, D. M., Neary, D., Mitochondrial function in brain tissue in primary degenerative dementia (1987) Brain Res., 436, pp. 30-38
Reynolds, M. R., Berry, R. W., Binder, L. I., Site-specific nitration differentially influences tau assembly in vitro (2005) Biochemistry, 44, pp. 13997-14009
Gamblin, T. C., Berry, R. W., Binder, L. I., Modeling tau polymerization in vitro. A review and synthesis (2003) Biochemistry, 42, pp. 15009-15017
Yang, L. S., Ksiezak-Reding, H., Calpain-induced proteolysis of normal human tau and tau associated with paired helical filaments (1995) Eur. J. Biochem., 233, pp. 9-17
Tsai, C. J., Lin, S. L., Wolfson, H. J., Nussinov, R., Studies of protein-protein interfaces: a statistical analysis of the hydrophobic effect (1997) Protein Sci., 6, pp. 53-64
Korn, A. P., Burnett, R. M., Distribution and complementarity of hydropathy in multisubunit proteins (1991) Proteins, 9, pp. 37-55
Vakser, I. A., Aflalo, C., Hydrophobic docking: a proposed enhancement to molecular recognition techniques (1994) Proteins, 20, pp. 320-329
Larsen, T. A., Olson, A. J., Goodsell, D. S., Morphology of protein-protein interfaces (1998) Structure, 6, pp. 421-427
Kini, R. M., Evans, H. J., Prediction of potential protein-protein interaction sites from amino acid sequence identification of a fibrin polymerization site (1996) FEBS Lett., 385, pp. 81-86
Santagata, D. D., Fulga, T., Duttaroy, A., Feany, M. B., Oxidative stress mediates tau-induced neurodegeneration in Drosophila (2007) J. Clin. Inv., 117, pp. 236-245
David, D. C., Hauptmann, S., Scherping, I., Schuessel, K., Keil, U., Rizzu, P., Ravid, R., Gotz, J., Proteomic and functional analyses reveal a mitochondrial dysfunction in P3201L tau transgenic mice (2005) J. Biol. Chem., 280, pp. 23802-23814
Panov, A. V., Gutekunst, C. A., Leavitt, B. R., Hayden, M. R., Burke, J. R., Strittmatter, W. J., Greenamyre, J. T., Early mitochondrial calcium defects in Hungtington's disease are direct effect of polyglutamines (2002) N. Neurosci., 5, pp. 731-736
Panov, A. V., Burke, J. R., Strittmatter, W. J., Greenamyre, J. T., In vitro effects pf polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Hungtington's disease (2003) Arch. Biochem. Biophys., 410, pp. 1-6
Seong, I. S., Ivanova, E., Lee, J. M., Choo, Y. S., Fossale, E., Anderson, M. A., Gusella, J. F., MacDonald, M. E., HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism (2005) Hum. Mol. Genet., 14, pp. 2871-2880
Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Wu, H., ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease (2004) Science, 304, pp. 448-452
Rothman, S. M., Olney, J. W., Excitotoxicity and the NMDA receptor-still lethal after eight years (1995) Trends Neurosci., 18, pp. 57-58. , (Review)
Danbolt, N. C., Glutamate uptake (2001) Prog. Neurobiol., 65, pp. 1-105
Choi, D. W., Glutamate receptors and the induction of excitotoxic neuronal death (1994) Prog. Brain Res., 100, pp. 47-51
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.447, 5-year impact factor: 4.176
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-52949119162&partnerID=40&md5=bebb973538a18ab66a94b982979bb5de
Keywords: Atp Synthesis, Cerebellar Granule Cells, Mitochondria, Neurotoxicity, Oxidative Phosphorylation, Tau Fragment, Adenine Nucleotide Translocase, Cytochrome C Oxidase, Proton Transporting Adenosine Triphosphate Synthase, Tau Protein, Amino Terminal Sequence, Animal Cell, Animal Tissue, Article, Cerebellum Cortex, Controlled Study, Electron Transport, Enzyme Activity, Membrane Potential, Mitochondrial Membrane Potential, Mitochondrial Respiration, Nonhuman, Oxygen Consumption, Priority Journal, Respiratory Chain, Adenosine Diphosphate, Electron Transport Complex Iv, Mitochondrial Adp, Atp Translocases, Mitochondrial Proton-Translocating Atpases, Peptide Fragments, Wistar, Adenoviridae,
Affiliations:
*** IBB - CNR ***
Institute of Biomembranes and Bioenergetics, CNR, Via G. Amendola 165 /A, 70126 Bari, Italy
Institute of Neurobiology and Molecular Medicine, CNR, Via del Fosso di Fiorano 64-65, 00143 Rome, Italy
European Brain Research Institute (EBRI), Via del Fosso di Fiorano 64-65, 00143 Rome, Italy
Institute of Biostructures and Bioimaging, CNR, Viale A. Doria 6, 95125 Catania, Italy
Department of Health Sciences, University of Molise, Via F. De Sanctis, 86100 Campobasso, Italy
References:
Amadoro, G., Serafino, A.L., Barbato, C., Ciotti, M.T., Sacco, A., Calissano, P., Canu, N., Role of N-terminal tau domain integrity on the survival of cerebellar granule neurons (2004) Cell Death Differ., 11, pp. 217-23
Rohn, T.T., Rissman, R.A., Davis, M.C., Kim, Y.E., Cotman, C.W., Head, E., Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain (2002) Neurobiol. Dis., 11, pp. 341-354
Fasulo, L., Ugolini, G., Visentin, M., Bradbury, A., Brancolini, C., Verzillo, V., Novak, M., Cattaneo, A., The neuronal microtubule-associated protein tau is substrate of caspase-3 and an effector of apoptosis (2000) J. Neurochem., 75, pp. 624-633
Chung, C.W., Song, Y.H., Kim, I.K., Yoon, W.J., Ryu, B.R., Jo, D.G., Woo, H.N., Jung, Y.K., Proapoptotic effects of tau cleavage product generated by caspase-3 (2001) Neurobiol. Dis., 8, pp. 162-172
Avila, J., Lucas, J.J., Perez, M., Hernandez, F., Role of tau protein in both physiological and pathological conditions (2004) Physiol. Rev., 84, pp. 361-384. , (Review)
Amadoro, G., Ciotti, M.T., Costanzi, M., Cestari, V., Calissano, P., Canu, N., NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation (2006) Proc. Natl. Acad. Sci. U. S. A., 103, pp. 2892-2897
Levi, G., Aloisi, F., Ciotti, M.T., Gallo, V., Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures (1984) Brain Res., 290, pp. 77-86
Almeida, A., Medina, J.M., A rapid method for the isolation of metabolically mitochondria form rat neurons and astrocytes in primary culture (1998) Brain Res. Brain Res. Protoc., 3, pp. 209-214
Waddel, W.J., Hill, C., A simple ultraviolet spectrophotometer method for the determination of protein (1956) J. Lab. Clin. Med., 48, pp. 311-314
Atlante, A., Bobba, A., de Bari, L., Fontana, F., Calissano, P., Marra, E., Passarella, S., Caspase-dependent alteration of the ADP/ATP translocator triggers the mitochondrial permeability transition which is not required for the low-potassium-dependent apoptosis of cerebellar granule cells (2006) J. Neurochem., 97, pp. 1166-1181
Trumbeckaite, S., Opalka, J.R., Neuhof, C., Zierz, S., Gellerich, F.N., Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function (2001) Eur. J. Biochem., 268, pp. 1422-1429
Wharton, D.C., Tzagaloff, A., Cytochrome c oxidase from beef heart mitochondria (1967) Methods Enzymol., 10, pp. 245-253
Atlante, A., de Bari, L., Bobba, A., Marra, E., Calissano, P., Passarella, S., Cytochrome c, released from cerebellar granule cells undergoing apoptosis or excytotoxic death, can generate protonmotive force and drive ATP synthesis in isolated mitochondria (2003) J. Neurochem., 86, pp. 591-604
Atlante, A., Passarella, S., Quagliariello, E., Moreno, G., Salet, C., Haematoporphyrin derivative (Photofrin II) photosensitization of isolated mitochondria: inhibition of ADP/ATP translocator (1989) J. Photochem. Photobiol. B, 4, pp. 35-46
Canu, N., Dus, L., Barbato, C., Ciotti, M.T., Brancolini, C., Rinaldi, A.M., Novak, M., Calissano, P., Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis (1998) J. Neurosci., 18, pp. 7061-7074
Rohn, T.T., Head, E., Su, J.H., Anderson, A.J., Bahr, B.A., Cotman, C.W., Cribbs, D.H., Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease (2001) Am. J. Pathol., 158, pp. 189-198
Ugolini, G., Cattaneo, A., Novak, M., Co-localization of truncated tau and DNA fragmentation in Alzheimer's diseases neurons (1997) Neuroreport, 8, pp. 3709-3712
Gastard, M.C., Troncoso, J.C., Koliatsos, V.E., Caspase activation in the limbic cortex of subjects with early Alzheimer's disease (2003) Ann. Neurol., 54, pp. 393-398
Saito, K., Elce, J.S., Hamos, J.E., Nixon, R.A., Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration (1993) Proc. Natl. Acad. Sci. U. S. A., 90, pp. 26-28
Veeranna, Kaji, T., Boland, B., Odrljin, T., Mohan, P., Basavarajappa, B.S., Peterhoff, C., Nixon, R.A., Calpain mediates calcium-induced activation of the ERK1/2, MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease (2004) Am. J. Pathol., 165, pp. 795-805
Cardoso, S.M., Santana, I., Swerdlow, R.H., Oliveira, C.R., Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity (2004) J. Neurochem., 89, pp. 1417-1426
Mancuso, M., Coppedè, F., Murri, L., Siciliano, G., Mitochondrial cascade hypothesis of Alzheimer's disease: myth or reality? (2007) Antioxid. Redox Signal., 9, pp. 1631-1646
Kish, S.J., Bergeron, C., Rajput, A., Dozic, S., Mastrogiacomo, F., Chang, L.J., Wilson, J.M., Nobrega, J.N., Brain cytochrome oxidase in Alzheimer's disease (1992) J. Neurochem., 59, pp. 776-779
Davis, R.E., Miller, S., Herrnstadt, C., Ghosh, S.S., Fahy, E., Shinobu, L.A., Galasko, D., Jr Parker, W.D., Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease (1997) Proc. Natl. Acad. Sci. U. S. A., 94, pp. 4526-4531
Beal, M.F., Oxidative metabolism (2000) Ann. N. Y. Acad. Sci., 924, pp. 164-169
Mutisya, E.M., Bowling, A.C., Beal, M.F., Cortical cytochrome oxidase activity is reduced in Alzheimer's disease (1994) J. Neurochem., 63, pp. 2179-2184
Sims, N.R., Finegan, J.M., Blass, J.P., Bowen, D.M., Neary, D., Mitochondrial function in brain tissue in primary degenerative dementia (1987) Brain Res., 436, pp. 30-38
Reynolds, M.R., Berry, R.W., Binder, L.I., Site-specific nitration differentially influences tau assembly in vitro (2005) Biochemistry, 44, pp. 13997-14009
Gamblin, T.C., Berry, R.W., Binder, L.I., Modeling tau polymerization in vitro. A review and synthesis (2003) Biochemistry, 42, pp. 15009-15017
Yang, L.S., Ksiezak-Reding, H., Calpain-induced proteolysis of normal human tau and tau associated with paired helical filaments (1995) Eur. J. Biochem., 233, pp. 9-17
Cente, M., Filipcik, P., Pevalova, M., Novak, M., Expression of a truncated tau protein induces oxidative stress in a rodent model of tauopathy (2006) Eur. J. Neurosci., 24, pp. 1085-1090
Chothia, C., Janin, J., Principles of protein-protein recognition (1975) Nature, 256, pp. 705-708
Tsai, C.J., Lin, S.L., Wolfson, H.J., Nussinov, R., Studies of protein-protein interfaces: a statistical analysis of the hydrophobic effect (1997) Protein Sci., 6, pp. 53-64
Janin, J., Chothia, C., The structure of protein-protein recognition sites (1990) J. Biol. Chem., 265, pp. 16027-16030
Korn, A.P., Burnett, R.M., Distribution and complementarity of hydropathy in multisubunit proteins (1991) Proteins, 9, pp. 37-55
Vakser, I.A., Aflalo, C., Hydrophobic docking: a proposed enhancement to molecular recognition techniques (1994) Proteins, 20, pp. 320-329
Young, L., Jernigan, R.L., Covell, D.G., A role for surface hydrophobicity in protein-protein recognition (1994) Protein Sci., 3, pp. 717-729
Jones, S., Thornton, J.M., Protein-protein interaction: a review of protein dimer structures (1995) Prog. Biophys. Mol. Biol., 63, pp. 131-165
Larsen, T.A., Olson, A.J., Goodsell, D.S., Morphology of protein-protein interfaces (1998) Structure, 6, pp. 421-427
Lo Conte, L., Chothia, C., Janin, J., The atomic structure of protein-protein recognition sites (1999) J. Mol. Biol., 285, pp. 2177-2198
Glaser, F., Steinberg, D.M., Vakser, A., Ben-Tal, N., Residue frequencies and pairing preferences at protein-protein interfaces (2001) Proteins, 43, pp. 89-102
Chakrabarti, P., Janin, J., Dissecting protein-protein recognition sites (2002) Proteins, 47, pp. 334-343
Klingenberg, M., Molecular aspects of the adenine nucleotide carrier from mitochondria (1989) Arch. Biochem. Biophys., 270, pp. 1-14
Majima, E., Yamaguchi, N., Chuman, H., Shinohara, Y., Ishida, M., Goto, S., Terada, H., Binding of the fluorescein derivative eosin Y to the mitochondrial ADP/ATP carrier: characterization of the adenine nucleotide binding site (1998) Biochemistry, 37, pp. 424-432
Kini, R.M., Evans, H.J., Prediction of potential protein-protein interaction sites from amino acid sequence identification of a fibrin polymerization site (1996) FEBS Lett., 385, pp. 81-86
Stamer, K., Vogel, R., Thies, E., Mandelkow, E., Mandelkow, E.M., Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhance oxidative stress (2002) J. Cell Biol., 156, pp. 1051-1063
Ebneth, A., Godemann, R., Stamer, K., Illenberger, S., Trinczek, B., Mandelkow, E., Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implication for Alzheimer's disease (1998) J. Cell Biol., 143, pp. 777-794
Santagata, D.D., Fulga, T., Duttaroy, A., Feany, M.B., Oxidative stress mediates tau-induced neurodegeneration in Drosophila (2007) J. Clin. Inv., 117, pp. 236-245
David, D.C., Hauptmann, S., Scherping, I., Schuessel, K., Keil, U., Rizzu, P., Ravid, R., Gotz, J., Proteomic and functional analyses reveal a mitochondrial dysfunction in P3201L tau transgenic mice (2005) J. Biol. Chem., 280, pp. 23802-23814
Zilka, N., Filipcik, P., Koson, P., Fialova, L., Skrabana, R., Zilkova, M., Rolkova, G., Novak, M., Truncated tau form sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo (2006) FEBS Lett., 580, pp. 3582-3588
Liu, R., Yuan, B., Emadi, S., Zameer, A., Schulz, P., McAllister, C., Lyubchenko, Y., Sierks, M.R., Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity (2004) Biochemistry, 43, pp. 6959-6967
Ferri, A., Cozzolino, M., Crosio, C., Nencini, M., Casciati, A., Gralla, E.B.V., Rotilio, G., Carrì, M.T., familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials (2006) Proc. Natl. Acad. Sci., 103, pp. 13860-13865
Panov, A.V., Gutekunst, C.A., Leavitt, B.R., Hayden, M.R., Burke, J.R., Strittmatter, W.J., Greenamyre, J.T., Early mitochondrial calcium defects in Hungtington's disease are direct effect of polyglutamines (2002) N. Neurosci., 5, pp. 731-736
Panov, A.V., Burke, J.R., Strittmatter, W.J., Greenamyre, J.T., In vitro effects pf polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Hungtington's disease (2003) Arch. Biochem. Biophys., 410, pp. 1-6
Seong, I.S., Ivanova, E., Lee, J.M., Choo, Y.S., Fossale, E., Anderson, M.A., Gusella, J.F., MacDonald, M.E., HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism (2005) Hum. Mol. Genet., 14, pp. 2871-2880
Rendon, A., Jung, D., Jancsik, V., Interaction of microtubules and microtubule-associated proteins (MAPs) with rat brain mitochondria (1990) Biochem. J., 269, pp. 555-556
Lustbader, J.W., Cirilli, M., Lin, C., Xu, H.W., Takuma, K., Wang, N., Caspersen, C., Wu, H., ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease (2004) Science, 304, pp. 448-452
Lipton, P., Ischemic cell death in brain neurons (1999) Physiol. Rev., 79, pp. 1431-1568. , (Review)
Pettmann, B., Henderson, C.E., Neuronal cell death (1998) Neuron, 20, pp. 633-647. , (Review)
Rothman, S.M., Olney, J.W., Excitotoxicity and the NMDA receptor-still lethal after eight years (1995) Trends Neurosci., 18, pp. 57-58. , (Review)
Danbolt, N.C., Glutamate uptake (2001) Prog. Neurobiol., 65, pp. 1-105
Choi, D.W., Glutamate receptors and the induction of excitotoxic neuronal death (1994) Prog. Brain Res., 100, pp. 47-51
Rohn, T. T., Rissman, R. A., Davis, M. C., Kim, Y. E., Cotman, C. W., Head, E., Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain (2002) Neurobiol. Dis., 11, pp. 341-354
Chung, C. W., Song, Y. H., Kim, I. K., Yoon, W. J., Ryu, B. R., Jo, D. G., Woo, H. N., Jung, Y. K., Proapoptotic effects of tau cleavage product generated by caspase-3 (2001) Neurobiol. Dis., 8, pp. 162-172
Waddel, W. J., Hill, C., A simple ultraviolet spectrophotometer method for the determination of protein (1956) J. Lab. Clin. Med., 48, pp. 311-314
Wharton, D. C., Tzagaloff, A., Cytochrome c oxidase from beef heart mitochondria (1967) Methods Enzymol., 10, pp. 245-253
Rohn, T. T., Head, E., Su, J. H., Anderson, A. J., Bahr, B. A., Cotman, C. W., Cribbs, D. H., Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease (2001) Am. J. Pathol., 158, pp. 189-198
Gastard, M. C., Troncoso, J. C., Koliatsos, V. E., Caspase activation in the limbic cortex of subjects with early Alzheimer's disease (2003) Ann. Neurol., 54, pp. 393-398
Cardoso, S. M., Santana, I., Swerdlow, R. H., Oliveira, C. R., Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity (2004) J. Neurochem., 89, pp. 1417-1426
Kish, S. J., Bergeron, C., Rajput, A., Dozic, S., Mastrogiacomo, F., Chang, L. J., Wilson, J. M., Nobrega, J. N., Brain cytochrome oxidase in Alzheimer's disease (1992) J. Neurochem., 59, pp. 776-779
Davis, R. E., Miller, S., Herrnstadt, C., Ghosh, S. S., Fahy, E., Shinobu, L. A., Galasko, D., Jr Parker, W. D., Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease (1997) Proc. Natl. Acad. Sci. U. S. A., 94, pp. 4526-4531
Beal, M. F., Oxidative metabolism (2000) Ann. N. Y. Acad. Sci., 924, pp. 164-169
Mutisya, E. M., Bowling, A. C., Beal, M. F., Cortical cytochrome oxidase activity is reduced in Alzheimer's disease (1994) J. Neurochem., 63, pp. 2179-2184
Sims, N. R., Finegan, J. M., Blass, J. P., Bowen, D. M., Neary, D., Mitochondrial function in brain tissue in primary degenerative dementia (1987) Brain Res., 436, pp. 30-38
Reynolds, M. R., Berry, R. W., Binder, L. I., Site-specific nitration differentially influences tau assembly in vitro (2005) Biochemistry, 44, pp. 13997-14009
Gamblin, T. C., Berry, R. W., Binder, L. I., Modeling tau polymerization in vitro. A review and synthesis (2003) Biochemistry, 42, pp. 15009-15017
Yang, L. S., Ksiezak-Reding, H., Calpain-induced proteolysis of normal human tau and tau associated with paired helical filaments (1995) Eur. J. Biochem., 233, pp. 9-17
Tsai, C. J., Lin, S. L., Wolfson, H. J., Nussinov, R., Studies of protein-protein interfaces: a statistical analysis of the hydrophobic effect (1997) Protein Sci., 6, pp. 53-64
Korn, A. P., Burnett, R. M., Distribution and complementarity of hydropathy in multisubunit proteins (1991) Proteins, 9, pp. 37-55
Vakser, I. A., Aflalo, C., Hydrophobic docking: a proposed enhancement to molecular recognition techniques (1994) Proteins, 20, pp. 320-329
Larsen, T. A., Olson, A. J., Goodsell, D. S., Morphology of protein-protein interfaces (1998) Structure, 6, pp. 421-427
Kini, R. M., Evans, H. J., Prediction of potential protein-protein interaction sites from amino acid sequence identification of a fibrin polymerization site (1996) FEBS Lett., 385, pp. 81-86
Santagata, D. D., Fulga, T., Duttaroy, A., Feany, M. B., Oxidative stress mediates tau-induced neurodegeneration in Drosophila (2007) J. Clin. Inv., 117, pp. 236-245
David, D. C., Hauptmann, S., Scherping, I., Schuessel, K., Keil, U., Rizzu, P., Ravid, R., Gotz, J., Proteomic and functional analyses reveal a mitochondrial dysfunction in P3201L tau transgenic mice (2005) J. Biol. Chem., 280, pp. 23802-23814
Panov, A. V., Gutekunst, C. A., Leavitt, B. R., Hayden, M. R., Burke, J. R., Strittmatter, W. J., Greenamyre, J. T., Early mitochondrial calcium defects in Hungtington's disease are direct effect of polyglutamines (2002) N. Neurosci., 5, pp. 731-736
Panov, A. V., Burke, J. R., Strittmatter, W. J., Greenamyre, J. T., In vitro effects pf polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Hungtington's disease (2003) Arch. Biochem. Biophys., 410, pp. 1-6
Seong, I. S., Ivanova, E., Lee, J. M., Choo, Y. S., Fossale, E., Anderson, M. A., Gusella, J. F., MacDonald, M. E., HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism (2005) Hum. Mol. Genet., 14, pp. 2871-2880
Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Wu, H., ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease (2004) Science, 304, pp. 448-452
Rothman, S. M., Olney, J. W., Excitotoxicity and the NMDA receptor-still lethal after eight years (1995) Trends Neurosci., 18, pp. 57-58. , (Review)
Danbolt, N. C., Glutamate uptake (2001) Prog. Neurobiol., 65, pp. 1-105
Choi, D. W., Glutamate receptors and the induction of excitotoxic neuronal death (1994) Prog. Brain Res., 100, pp. 47-51
A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator
Having confirmed that adenovirus-mediated overexpression of NH2-tau fragment lacking the first 25 aminoacids evokes a potent neurotoxic effect, sustained by protracted stimulation of NMDA receptors, in primary neuronal cultures we investigated whether and how chemically synthesized NH2-derived tau peptides, i.e. NH2-26-44 and NH2-1-25 fragments, affect mitochondrial function. We tested both fragments on each step of the processes leading to ATP synthesis via oxidative phosphorylation: i) electron flow via the respiratory chain from physiological substrates to oxygen with the activity of each individual complex of the respiratory chain investigated in some detail, ii) membrane potential generation arising from externally added succinate and iii) the activity of both the adenine nucleotide translocator and iv) ATP synthase. Oxidative phosphorylation is not affected by NH2-1-25 tau fragment, but dramatically impaired by NH2-26-44 tau fragment. Both cytochrome c oxidase and the adenine nucleotide translocator are targets of NH2-26-44 tau fragment, but adenine nucleotide translocator is the unique mitochondrial target responsible for impairment of oxidative phosphorylation by the NH2-26-44 tau fragment, which then exerts deleterious effects on cellular availability of ATP synthesized into mitochondria. © 2008.
Having confirmed that adenovirus-mediated overexpression of NH2-tau fragment lacking the first 25 aminoacids evokes a potent neurotoxic effect, sustained by protracted stimulation of NMDA receptors, in primary neuronal cultures we investigated whether and how chemically synthesized NH2-derived tau peptides, i.e. NH2-26-44 and NH2-1-25 fragments, affect mitochondrial function. We tested both fragments on each step of the processes leading to ATP synthesis via oxidative phosphorylation: i) electron flow via the respiratory chain from physiological substrates to oxygen with the activity of each individual complex of the respiratory chain investigated in some detail, ii) membrane potential generation arising from externally added succinate and iii) the activity of both the adenine nucleotide translocator and iv) ATP synthase. Oxidative phosphorylation is not affected by NH2-1-25 tau fragment, but dramatically impaired by NH2-26-44 tau fragment. Both cytochrome c oxidase and the adenine nucleotide translocator are targets of NH2-26-44 tau fragment, but adenine nucleotide translocator is the unique mitochondrial target responsible for impairment of oxidative phosphorylation by the NH2-26-44 tau fragment, which then exerts deleterious effects on cellular availability of ATP synthesized into mitochondria. © 2008.
A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator
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A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator
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Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (599 views)
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Impact Factor: 4.6
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (620 views)
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Impact Factor: 5.533
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (428 views)
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Impact Factor: 3.341
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (461 views)
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Impact Factor: 2.464
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Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (647 views)
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Impact Factor: 2.659
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (4559 views)
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Impact Factor: 3.733
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
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Impact Factor: 3.677
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Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
* Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (513 views)
Cell Signal (ISSN: 0898-6568), 2012; 24(2): 468-475.
Impact Factor: 4.304
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (612 views)
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Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
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Impact Factor: 4.883
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
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Impact Factor: 6.051
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1135 views)
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Impact Factor: 5.476
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1121 views)
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Impact Factor: 7.581
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Palladino P, Ronga L, Benedetti E, Rossi F, Ragone R
* Peptide Fragment Approach to Prion Misfolding: The Alpha-2 Domain (402 views)
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Impact Factor: 0.869
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Lettieri A, Salvatore M
* Molecular imaging of drug resistance in cancer (439 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Mar; 21(1): 31-36.
Impact Factor: 0.268
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1402 views)
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Impact Factor: 2.26
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De Bona P, Giuffrida ML, Attanasio F, Copani A, Pignataro B, Cataldo S, Rizzarelli E, Pappalardo G
* Designing trehalose-conjugated peptides for the inhibition of Alzheimer's A beta oligornerization and neurotoxicity (468 views)
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Impact Factor: 1.654
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
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Impact Factor: 6.488
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Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (398 views)
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Impact Factor: 3.379
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Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (572 views)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1010 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (336 views)
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Impact Factor: 2.662
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (629 views)
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Impact Factor: 3.268
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (440 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (680 views)
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Impact Factor: 2.187
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De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (438 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (553 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (621 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
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Saviano M, Zaccaro L, Benedetti E, Pedone C, Del Gatto A, Feliciello A, Affaiatati A, Avvedimento EV
* Development of peptides able to modulate the interaction of AKAP121 with mitochondria (418 views)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Andretta C, Catalano L, Pace L, Fonti R, Annunziata G, Rotoli B
* 99mTc-sestaMIBI scintigraphy in thalidomide-treated refractory or relapsed multiple myeloma patients [2] (306 views)
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Impact Factor: 1.163
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (529 views)
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Impact Factor: 3.324
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Grasso D, Milardi D, Guantieri V, La Rosa C, Rizzarelli E
* Interaction of prion peptide PrP 180-193 with DPPC model membranes: A thermodynamic study (384 views)
New J Chem (ISSN: 1144-0546), 2003; 27(2): 359-364.
Impact Factor: 2.272
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (741 views)
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Impact Factor: 5.359
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
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Impact Factor: 3.72
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* Targeting Mitochondrial Therapy in the Regulation of HPV Infection and HPV-Related Cancers (7 views)
Pathogens (ISSN: 2076-0817linking), 2023 Mar 2; 12(3): 402-417.
Impact Factor: 4.531
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De Rosa V, Iommelli F, Terlizzi C, Leggiero E, Camerlingo R, Altobelli GG, Fonti R, Pastore L, Del Vecchio S
* Non-Canonical Role of PDK1 as a Negative Regulator of Apoptosis through Macromolecular Complexes Assembly at the ER-Mitochondria Interface in Oncogene-Driven NSCLC (17 views)
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Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O , #rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N
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Impact Factor: 17.956
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Negri R, Trinchese G, Carbone F, Caprio MG, Stanzione G, Di Scala C, Micillo T, Perna F, Tarotto L, Gelzo M, Cavaliere G, Spagnuolo MI, Corso G, Mattace Raso G, Matarese G, Mollica MP, Greco L, Iorio R
* Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD) (119 views) (PDF 85 views)
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Impact Factor: 5.688
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Barone R, Alaimo S, Messina M, Pulvirenti A, Bastin J, Group MIMIC-A, F , Frye RE, Rizzo (mimic-ag A, Fiumara R, Meli C, Gulisano M, Maugeri F, Prato A, Russo G, Tabbì G
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Front Psychiatry (ISSN: 1664-0640linking), 2018 Dec 7; 9: 636-636.
Impact Factor: 2.857
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De Michele G, Sorrentino P, Nesti C, Rubegni A, Ruggiero L, Peluso S, Antenora A, Quarantelli M, Filla A, De Michele G, Santorelli FM
* Reversible Valproate-Induced Subacute Encephalopathy Associated With a MT-ATP8 Variant in the Mitochondrial Genome (271 views)
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Impact Factor: 3.508
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Skiba J, Bernas T, Trzybinski D, Wozniak K, Ferraro G, Marasco D, Merlino A, Shafikov MZ, Czerwieniec R, Kowalski K
* Mitochondria Targeting with Luminescent Rhenium(I) Complexes (316 views)
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Impact Factor: 3.098
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Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M
* Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease (460 views)
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Impact Factor: 3.746
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Magri A, Di Rosa MC, Tomasello MF, Guarino F, Reina S, Messina A, De Pinto V
* Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes (373 views)
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Impact Factor: 4.932
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Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G
* Adrenergic Receptors (273 views)
Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315.
Impact Factor: 0
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De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (653 views)
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Impact Factor: 8.738
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Monti M, De Rosa V, Iommelli F, Fonti R, Pane F, Del Vecchio S
* Changes of glycolytic pathway and upregulation of oxidative phosphorylation in BCR-ABL-driven human leukemia cells treated with imatinib (308 views)
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Impact Factor: 5.537
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Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (497 views)
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Impact Factor: 2.876
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Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (806 views)
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Impact Factor: 2.73
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Sorriento D, Del Giudice C, Bertamino A, Ciccarelli M, Gomez-Monterrey I, Campiglia P, Novellino E, Illario M, Trimarco B, De Luca N, Iaccarino G
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Impact Factor: 5.569
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
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Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
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De Rosa V, Iommelli F, Monti M, Fonti R, Del Vecchio S
* Early reduction of 18F-FDG uptake in non-small lung cancer treated with EGFR tyrosine kinase inhibitors reflects reversal of Warburg effect and reactivation of oxidative phosphorylation (275 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2014 Oct; 41: N/D-N/D.
Impact Factor: 5.383
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Gargiulo S, Petretta MP, Greco A, Panico M, Larobina M, Gramanzini M, Schiattarella GG, Esposito G, Petretta M, Brunetti A, Cuocolo A
* Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heart (448 views)
Bmc Cardiovasc Disor (ISSN: 1471-2261), 2014 Sep 8; 14(1): 98-98.
Impact Factor: 1.878
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (595 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (1262 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014 Jun 23; 81: 442-455.
Impact Factor: 3.447
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Sorriento D, Ciccarelli M, Santulli G, Illario M, Trimarco B, Iaccarino G
* Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization (252 views)
Transl Med Unisa (ISSN: 2239-9747electronic, 2239-9747linking), 2014 Apr 8; 10: 3-7.
Impact Factor: 2.256
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (565 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Giuffrida ML, Rizzarelli E, Tomaselli GA, Satriano C, Trusso Sfrazzetto G
* A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging (375 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2014; 50(69): 9835-9838.
Impact Factor: 6.834
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Sorriento D, Pascale AV, Finelli R, Carillo AL, Annunziata R, Trimarco B, Iaccarino G
* Targeting mitochondria as therapeutic strategy for metabolic disorders (616 views)
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
Impact Factor: 1.219
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Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
* Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure (428 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Impact Factor: 2.882
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (599 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (620 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (428 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (461 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (647 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (4559 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
* Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (513 views)
Cell Signal (ISSN: 0898-6568), 2012; 24(2): 468-475.
Impact Factor: 4.304
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (612 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (436 views)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1135 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1121 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Palladino P, Ronga L, Benedetti E, Rossi F, Ragone R
* Peptide Fragment Approach to Prion Misfolding: The Alpha-2 Domain (402 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2009 Sep; 15(3): 165-176.
Impact Factor: 0.869
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Lettieri A, Salvatore M
* Molecular imaging of drug resistance in cancer (439 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Mar; 21(1): 31-36.
Impact Factor: 0.268
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1402 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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De Bona P, Giuffrida ML, Attanasio F, Copani A, Pignataro B, Cataldo S, Rizzarelli E, Pappalardo G
* Designing trehalose-conjugated peptides for the inhibition of Alzheimer's A beta oligornerization and neurotoxicity (468 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
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Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (398 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Impact Factor: 3.379
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Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (572 views)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1010 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (336 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
Impact Factor: 2.662
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (629 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (440 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (680 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (438 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (553 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (621 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
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Saviano M, Zaccaro L, Benedetti E, Pedone C, Del Gatto A, Feliciello A, Affaiatati A, Avvedimento EV
* Development of peptides able to modulate the interaction of AKAP121 with mitochondria (418 views)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Andretta C, Catalano L, Pace L, Fonti R, Annunziata G, Rotoli B
* 99mTc-sestaMIBI scintigraphy in thalidomide-treated refractory or relapsed multiple myeloma patients [2] (306 views)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2003 Jun; 44(6): 1081-1082.
Impact Factor: 1.163
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (529 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Grasso D, Milardi D, Guantieri V, La Rosa C, Rizzarelli E
* Interaction of prion peptide PrP 180-193 with DPPC model membranes: A thermodynamic study (384 views)
New J Chem (ISSN: 1144-0546), 2003; 27(2): 359-364.
Impact Factor: 2.272
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (741 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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61 Records (53 excluding Abstracts).
Total impact factor: 266.267 (235.168 excluding Abstracts).
Total 5 year impact factor: 247.528 (215.393 excluding Abstracts).
Total impact factor: 266.267 (235.168 excluding Abstracts).
Total 5 year impact factor: 247.528 (215.393 excluding Abstracts).
509 views. Last view on Monday 10 April 2023, 22:27:42
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