SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment (504 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jun; 37(6): 1156-1163.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.036, 5-year impact factor: 4.665
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77954888295&partnerID=40&md5=76556b0525c1b07d6be1e3bd80c00124
Keywords: Alzheimer, Benzodiazepine Receptors, Cerebral Perfusion, Iomazenil, Mild Cognitive Impairment, Spect, 4 Aminobutyrate Aminotransferase, Hexamethylpropylene Amine Oxime Technetium Tc 99m, Iomazenil I 123, Radiopharmaceutical Agent, Unclassified Drug, Alzheimer Disease, Amnesia, Article, Brain Blood Flow, Brain Cortex, Brain Perfusion, Cell Loss, Cingulate Gyrus, Clinical Article, Controlled Study, Episodic Memory, Female, Follow Up, Human, In Vivo Study, Limbic Cortex, Neocortex, Nerve Cell, Receptor Binding, Single Photon Emission Computer Tomography, Synapse, Voxel Based Morphometry, Case-Control Studies, Cerebrovascular Circulation, Cognition Disorders, Flumazenil, Middle Aged, Gaba-A, Emission-Computed, Single-Photon, Alzheimer Disease Metabolism Pathology Physiopathology Radionuclide Imaging, Cognition Disorders Metabolism Pathology Physiopathology Radionuclide Imaging, Flumazenil Analogs, Derivatives Metabolism, Gaba-A Metabolism, Synapses Metabolism, Alzheimer Disease Diagnostic Imaging Metabolism Pathology Physiopathology , Cognition Disorders Diagnostic Imaging Metabolism Pathology Physiopathology,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, CNR, Via Pansini 5, 80131 Naples, Italy
Department of Clinical and Experimental Medicine, University Federico II, Naples, Italy
Department of Biomorphological and Functional Sciences, University Federico II, Naples, Italy
Neurologic and Stroke Unit, CTO Hospital, Naples, Italy
References:
Pappatà, S., Salvatore, E., Postiglione, A., In vivo imaging of neurotransmission and brain receptors in dementia (2008) J. Neuroimaging, 18, pp. 111-2
Rissman, R.A., De Blas, A.L., Armstrong, D.M., GABA (A) receptors in aging and Alzheimer's disease (2007) J. Neurochem., 103, pp. 1285-92
Möhler, H., Molecular regulation of cognitive functions and developmental plasticity: Impact of GABAA receptors (2007) J. Neurochem., 102, pp. 1-12
Lanctot, K.L., Herrmann, N., Mazzotta, P., Khan, L.R., Ingber, N., GABAergic function in Alzheimer's disease: Evidence for dysfunction and potential as a therapeutic target for the treatment of behavioral and psychological symptoms of dementia (2004) Can J. Psychiatry, 49, pp. 439-53
Louzada, P.R., Lima, A.C.P., Mendonca-Silva, D.L., Noël, F., De Mello, F.G., Ferreira, S.T., Taurine prevents the neurotoxicity of betaamyloid and glutamate receptor agonists: Activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders (2004) FASEB J., 18, pp. 511-8
Rissman, R.A., Bennett, D.A., Armstrong, D.M., Subregional analysis of GABA (A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment (2004) J. Chem. Neuroanat, 28, pp. 17-25
Soricelli, A., Postiglione, A., Grivet-Fojaja, M.R., Mainenti, P.P., Discepolo, A., Varrone, A., Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (1996) Eur. J. Nucl Med., 23, pp. 1323-8
Fukuchi, K., Hashikawa, K., Seike, Y., Moriwaki, H., Oku, N., Ishida, M., Comparison of iodine-123-iomazenil SPECT and technetium-99m-HMPAO-SPECT in Alzheimer's disease (1997) J. Nucl Med., 38, pp. 467-70
Meyer, M., Koeppe, R.A., Frey, K.A., Foster, N.L., Kuhl, D.E., Positron emission tomography measures of benzodiazepine binding in Alzheimer's disease (1995) Arch. Neurol., 52, pp. 314-7
Ohyama, M., Senda, M., Ishiwata, K., Kitamura, S., Mishina, M., Ishii, K., Preserved benzodiazepine receptors in Alzheimer's disease measured with C-11 flumazenil PET and I-123 iomazenil SPECT in comparison with CBF (1999) Ann. Nucl Med., 13, pp. 309-15
Petersen, R.C., Smith, G.E., Waring, S.C., Ivnik, R.J., Tangalos, E.G., Kokmen, E., Mild cognitive impairment: Clinical characterization and outcome (1999) Arch. Neurol., 56, pp. 303-8
Millet, P., Graf, C., Buck, A., Walder, B., Westera, G., Broggini, C., Similarity and robustness of PET and SPECT binding parameters for benzodiazepine receptors (2000) J. Cereb. Blood Flow Metab., 20, pp. 1587-603
Greenamyre, J.T., Penney, J.B., D'Amato, C.J., Young, A.B., Dementia of the Alzheimer's type: Changes in hippocampal L-[3H]glutamate binding (1987) J. Neurochem., 48, pp. 543-51
Jansen, K.L., Faull, R.L., Dragunow, M., Synek, B.L., Alzheimer's disease: Changes in hippocampal N-methyl-D-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors - An autoradiographic study (1990) Neuroscience, 39, pp. 613-27
Shimohama, S., Taniguchi, T., Fujiwara, M., Kameyama, M., Changes in benzodiazepine receptors in Alzheimer-type dementia (1988) Ann. Neurol., 23, pp. 404-6
Cross, A.J., Crow, T.J., Ferrier, I.N., Johnson, J.A., The selectivity of the reduction of serotonin S2 receptors in Alzheimer-type dementia (1986) Neurobiol. Aging, 7, pp. 3-7
Owen, F., Poulter, M., Waddington, J.L., Mashal, R.D., Crow, T.J., [3H]R05-4864 and [3H]flunitrazepam binding in kainatelesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type (1983) Brain Res., 278, pp. 373-5
Chu, D.C., Penney Jr., J.B., Young, A.B., Cortical GABAB and GABAA receptors in Alzheimer's disease: A quantitative autoradiographic study (1987) Neurology, 37, pp. 1454-9
Lloyd, G.K., Lowenthal, A., Javoy-Agid, F., Constantidinis, J., GABAA receptor complex function in frontal cortex membranes from control and neurological patients (1991) Eur. J. Pharmacol., 197, pp. 33-9
Vogt, B.A., Crino, P.B., Volicer, L., Laminar alterations in gammaaminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease (1991) J. Neurochem., 57, pp. 282-90
Howell, O., Atack, J.R., Dewar, D., McKernan, R.M., Sur, C., Density and pharmacology of alpha5 subunit-containing GABA (A) receptors are preserved in hippocampus of Alzheimer's disease patients (2000) Neuroscience, 98, pp. 669-75
Mizukami, K., Ikonomovic, M.D., Grayson, D.R., Immunohistochemical study of GABAA receptor alpha1 subunit in the hippocampal formation of aged brains with Alzheimer-related neuropathologic changes (1998) Brain Res., 799, pp. 148-55
Penney, J.B., Maragos, W.F., Greenamyre, J.T., Debowey, D.L., Hollingsworth, Z., Young, A.B., Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias (1990) J. Neurol. Neurosurg. Psychiatry, 53, pp. 314-20
Hof, P.R., Cox, K., Young, W.G., Celio, M.R., Rogers, J., Morrison, J.H., Parvalbumin-immunoreactive neurons in the neocortex are resistant to degeneration in Alzheimer's disease (1991) J. Neuropathol Exp. Neurol., 50, pp. 451-62
Price, J.L., Ko, A.I., Wade, M.J., Tsou, S.K., McKeel, D.W., Morris, J.C., Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease (2001) Arch. Neurol., 58, pp. 1395-402
Bell, K.F., Cuello, A.C., Altered synaptic function in Alzheimer's disease (2006) Eur. J. Pharmacol., 545, pp. 11-21
Palop, J.J., Chin, J., Roberson, E.D., Wang, J., Thwin, M.T., Bien-Ly, N., Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease (2007) Neuron, 55, pp. 697-711
DeKosky, S.T., Ikonomovic, M.D., Styren, S.D., Beckett, L., Wisniewski, S., Bennett, D.A., Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment (2002) Ann. Neurol., 51, pp. 145-55
Truchot, L., Costes, S.N., Zimmer, L., Laurent, B., Le Bars, D., Thomas-Antérion, C., Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment (2007) Neurology, 69, pp. 1012-7
Borroni, B., Anchisi, D., Paghera, B., Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD (2006) Neurobiol. Aging, 27, pp. 24-31
Chetelat, G., Desgranges, B., De La Sayette, V., Viader, F., Berkouk, K., Landeau, B., Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment (2003) Brain, 126, pp. 1955-67
Pappat, S., Salvatore, E., Postiglione, A., In vivo imaging of neurotransmission and brain receptors in dementia (2008) J. Neuroimaging, 18, pp. 111-2
Rissman, R. A., De Blas, A. L., Armstrong, D. M., GABA (A) receptors in aging and Alzheimer's disease (2007) J. Neurochem., 103, pp. 1285-92
M hler, H., Molecular regulation of cognitive functions and developmental plasticity: Impact of GABAA receptors (2007) J. Neurochem., 102, pp. 1-12
Lanctot, K. L., Herrmann, N., Mazzotta, P., Khan, L. R., Ingber, N., GABAergic function in Alzheimer's disease: Evidence for dysfunction and potential as a therapeutic target for the treatment of behavioral and psychological symptoms of dementia (2004) Can J. Psychiatry, 49, pp. 439-53
Louzada, P. R., Lima, A. C. P., Mendonca-Silva, D. L., No l, F., De Mello, F. G., Ferreira, S. T., Taurine prevents the neurotoxicity of betaamyloid and glutamate receptor agonists: Activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders (2004) FASEB J., 18, pp. 511-8
Rissman, R. A., Bennett, D. A., Armstrong, D. M., Subregional analysis of GABA (A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment (2004) J. Chem. Neuroanat, 28, pp. 17-25
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., Kokmen, E., Mild cognitive impairment: Clinical characterization and outcome (1999) Arch. Neurol., 56, pp. 303-8
Greenamyre, J. T., Penney, J. B., D'Amato, C. J., Young, A. B., Dementia of the Alzheimer's type: Changes in hippocampal L- [3H] glutamate binding (1987) J. Neurochem., 48, pp. 543-51
Jansen, K. L., Faull, R. L., Dragunow, M., Synek, B. L., Alzheimer's disease: Changes in hippocampal N-methyl-D-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors - An autoradiographic study (1990) Neuroscience, 39, pp. 613-27
Cross, A. J., Crow, T. J., Ferrier, I. N., Johnson, J. A., The selectivity of the reduction of serotonin S2 receptors in Alzheimer-type dementia (1986) Neurobiol. Aging, 7, pp. 3-7
Chu, D. C., Penney Jr., J. B., Young, A. B., Cortical GABAB and GABAA receptors in Alzheimer's disease: A quantitative autoradiographic study (1987) Neurology, 37, pp. 1454-9
Lloyd, G. K., Lowenthal, A., Javoy-Agid, F., Constantidinis, J., GABAA receptor complex function in frontal cortex membranes from control and neurological patients (1991) Eur. J. Pharmacol., 197, pp. 33-9
Vogt, B. A., Crino, P. B., Volicer, L., Laminar alterations in gammaaminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease (1991) J. Neurochem., 57, pp. 282-90
Penney, J. B., Maragos, W. F., Greenamyre, J. T., Debowey, D. L., Hollingsworth, Z., Young, A. B., Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias (1990) J. Neurol. Neurosurg. Psychiatry, 53, pp. 314-20
Hof, P. R., Cox, K., Young, W. G., Celio, M. R., Rogers, J., Morrison, J. H., Parvalbumin-immunoreactive neurons in the neocortex are resistant to degeneration in Alzheimer's disease (1991) J. Neuropathol Exp. Neurol., 50, pp. 451-62
Price, J. L., Ko, A. I., Wade, M. J., Tsou, S. K., McKeel, D. W., Morris, J. C., Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease (2001) Arch. Neurol., 58, pp. 1395-402
Bell, K. F., Cuello, A. C., Altered synaptic function in Alzheimer's disease (2006) Eur. J. Pharmacol., 545, pp. 11-21
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease (2007) Neuron, 55, pp. 697-711
DeKosky, S. T., Ikonomovic, M. D., Styren, S. D., Beckett, L., Wisniewski, S., Bennett, D. A., Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment (2002) Ann. Neurol., 51, pp. 145-55
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jun; 37(6): 1156-1163.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.036, 5-year impact factor: 4.665
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77954888295&partnerID=40&md5=76556b0525c1b07d6be1e3bd80c00124
Keywords: Alzheimer, Benzodiazepine Receptors, Cerebral Perfusion, Iomazenil, Mild Cognitive Impairment, Spect, 4 Aminobutyrate Aminotransferase, Hexamethylpropylene Amine Oxime Technetium Tc 99m, Iomazenil I 123, Radiopharmaceutical Agent, Unclassified Drug, Alzheimer Disease, Amnesia, Article, Brain Blood Flow, Brain Cortex, Brain Perfusion, Cell Loss, Cingulate Gyrus, Clinical Article, Controlled Study, Episodic Memory, Female, Follow Up, Human, In Vivo Study, Limbic Cortex, Neocortex, Nerve Cell, Receptor Binding, Single Photon Emission Computer Tomography, Synapse, Voxel Based Morphometry, Case-Control Studies, Cerebrovascular Circulation, Cognition Disorders, Flumazenil, Middle Aged, Gaba-A, Emission-Computed, Single-Photon, Alzheimer Disease Metabolism Pathology Physiopathology Radionuclide Imaging, Cognition Disorders Metabolism Pathology Physiopathology Radionuclide Imaging, Flumazenil Analogs, Derivatives Metabolism, Gaba-A Metabolism, Synapses Metabolism, Alzheimer Disease Diagnostic Imaging Metabolism Pathology Physiopathology , Cognition Disorders Diagnostic Imaging Metabolism Pathology Physiopathology,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, CNR, Via Pansini 5, 80131 Naples, Italy
Department of Clinical and Experimental Medicine, University Federico II, Naples, Italy
Department of Biomorphological and Functional Sciences, University Federico II, Naples, Italy
Neurologic and Stroke Unit, CTO Hospital, Naples, Italy
References:
Pappatà, S., Salvatore, E., Postiglione, A., In vivo imaging of neurotransmission and brain receptors in dementia (2008) J. Neuroimaging, 18, pp. 111-2
Rissman, R.A., De Blas, A.L., Armstrong, D.M., GABA (A) receptors in aging and Alzheimer's disease (2007) J. Neurochem., 103, pp. 1285-92
Möhler, H., Molecular regulation of cognitive functions and developmental plasticity: Impact of GABAA receptors (2007) J. Neurochem., 102, pp. 1-12
Lanctot, K.L., Herrmann, N., Mazzotta, P., Khan, L.R., Ingber, N., GABAergic function in Alzheimer's disease: Evidence for dysfunction and potential as a therapeutic target for the treatment of behavioral and psychological symptoms of dementia (2004) Can J. Psychiatry, 49, pp. 439-53
Louzada, P.R., Lima, A.C.P., Mendonca-Silva, D.L., Noël, F., De Mello, F.G., Ferreira, S.T., Taurine prevents the neurotoxicity of betaamyloid and glutamate receptor agonists: Activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders (2004) FASEB J., 18, pp. 511-8
Rissman, R.A., Bennett, D.A., Armstrong, D.M., Subregional analysis of GABA (A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment (2004) J. Chem. Neuroanat, 28, pp. 17-25
Soricelli, A., Postiglione, A., Grivet-Fojaja, M.R., Mainenti, P.P., Discepolo, A., Varrone, A., Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (1996) Eur. J. Nucl Med., 23, pp. 1323-8
Fukuchi, K., Hashikawa, K., Seike, Y., Moriwaki, H., Oku, N., Ishida, M., Comparison of iodine-123-iomazenil SPECT and technetium-99m-HMPAO-SPECT in Alzheimer's disease (1997) J. Nucl Med., 38, pp. 467-70
Meyer, M., Koeppe, R.A., Frey, K.A., Foster, N.L., Kuhl, D.E., Positron emission tomography measures of benzodiazepine binding in Alzheimer's disease (1995) Arch. Neurol., 52, pp. 314-7
Ohyama, M., Senda, M., Ishiwata, K., Kitamura, S., Mishina, M., Ishii, K., Preserved benzodiazepine receptors in Alzheimer's disease measured with C-11 flumazenil PET and I-123 iomazenil SPECT in comparison with CBF (1999) Ann. Nucl Med., 13, pp. 309-15
Petersen, R.C., Smith, G.E., Waring, S.C., Ivnik, R.J., Tangalos, E.G., Kokmen, E., Mild cognitive impairment: Clinical characterization and outcome (1999) Arch. Neurol., 56, pp. 303-8
Millet, P., Graf, C., Buck, A., Walder, B., Westera, G., Broggini, C., Similarity and robustness of PET and SPECT binding parameters for benzodiazepine receptors (2000) J. Cereb. Blood Flow Metab., 20, pp. 1587-603
Greenamyre, J.T., Penney, J.B., D'Amato, C.J., Young, A.B., Dementia of the Alzheimer's type: Changes in hippocampal L-[3H]glutamate binding (1987) J. Neurochem., 48, pp. 543-51
Jansen, K.L., Faull, R.L., Dragunow, M., Synek, B.L., Alzheimer's disease: Changes in hippocampal N-methyl-D-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors - An autoradiographic study (1990) Neuroscience, 39, pp. 613-27
Shimohama, S., Taniguchi, T., Fujiwara, M., Kameyama, M., Changes in benzodiazepine receptors in Alzheimer-type dementia (1988) Ann. Neurol., 23, pp. 404-6
Cross, A.J., Crow, T.J., Ferrier, I.N., Johnson, J.A., The selectivity of the reduction of serotonin S2 receptors in Alzheimer-type dementia (1986) Neurobiol. Aging, 7, pp. 3-7
Owen, F., Poulter, M., Waddington, J.L., Mashal, R.D., Crow, T.J., [3H]R05-4864 and [3H]flunitrazepam binding in kainatelesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type (1983) Brain Res., 278, pp. 373-5
Chu, D.C., Penney Jr., J.B., Young, A.B., Cortical GABAB and GABAA receptors in Alzheimer's disease: A quantitative autoradiographic study (1987) Neurology, 37, pp. 1454-9
Lloyd, G.K., Lowenthal, A., Javoy-Agid, F., Constantidinis, J., GABAA receptor complex function in frontal cortex membranes from control and neurological patients (1991) Eur. J. Pharmacol., 197, pp. 33-9
Vogt, B.A., Crino, P.B., Volicer, L., Laminar alterations in gammaaminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease (1991) J. Neurochem., 57, pp. 282-90
Howell, O., Atack, J.R., Dewar, D., McKernan, R.M., Sur, C., Density and pharmacology of alpha5 subunit-containing GABA (A) receptors are preserved in hippocampus of Alzheimer's disease patients (2000) Neuroscience, 98, pp. 669-75
Mizukami, K., Ikonomovic, M.D., Grayson, D.R., Immunohistochemical study of GABAA receptor alpha1 subunit in the hippocampal formation of aged brains with Alzheimer-related neuropathologic changes (1998) Brain Res., 799, pp. 148-55
Penney, J.B., Maragos, W.F., Greenamyre, J.T., Debowey, D.L., Hollingsworth, Z., Young, A.B., Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias (1990) J. Neurol. Neurosurg. Psychiatry, 53, pp. 314-20
Hof, P.R., Cox, K., Young, W.G., Celio, M.R., Rogers, J., Morrison, J.H., Parvalbumin-immunoreactive neurons in the neocortex are resistant to degeneration in Alzheimer's disease (1991) J. Neuropathol Exp. Neurol., 50, pp. 451-62
Price, J.L., Ko, A.I., Wade, M.J., Tsou, S.K., McKeel, D.W., Morris, J.C., Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease (2001) Arch. Neurol., 58, pp. 1395-402
Bell, K.F., Cuello, A.C., Altered synaptic function in Alzheimer's disease (2006) Eur. J. Pharmacol., 545, pp. 11-21
Palop, J.J., Chin, J., Roberson, E.D., Wang, J., Thwin, M.T., Bien-Ly, N., Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease (2007) Neuron, 55, pp. 697-711
DeKosky, S.T., Ikonomovic, M.D., Styren, S.D., Beckett, L., Wisniewski, S., Bennett, D.A., Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment (2002) Ann. Neurol., 51, pp. 145-55
Truchot, L., Costes, S.N., Zimmer, L., Laurent, B., Le Bars, D., Thomas-Antérion, C., Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment (2007) Neurology, 69, pp. 1012-7
Borroni, B., Anchisi, D., Paghera, B., Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD (2006) Neurobiol. Aging, 27, pp. 24-31
Chetelat, G., Desgranges, B., De La Sayette, V., Viader, F., Berkouk, K., Landeau, B., Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment (2003) Brain, 126, pp. 1955-67
Pappat, S., Salvatore, E., Postiglione, A., In vivo imaging of neurotransmission and brain receptors in dementia (2008) J. Neuroimaging, 18, pp. 111-2
Rissman, R. A., De Blas, A. L., Armstrong, D. M., GABA (A) receptors in aging and Alzheimer's disease (2007) J. Neurochem., 103, pp. 1285-92
M hler, H., Molecular regulation of cognitive functions and developmental plasticity: Impact of GABAA receptors (2007) J. Neurochem., 102, pp. 1-12
Lanctot, K. L., Herrmann, N., Mazzotta, P., Khan, L. R., Ingber, N., GABAergic function in Alzheimer's disease: Evidence for dysfunction and potential as a therapeutic target for the treatment of behavioral and psychological symptoms of dementia (2004) Can J. Psychiatry, 49, pp. 439-53
Louzada, P. R., Lima, A. C. P., Mendonca-Silva, D. L., No l, F., De Mello, F. G., Ferreira, S. T., Taurine prevents the neurotoxicity of betaamyloid and glutamate receptor agonists: Activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders (2004) FASEB J., 18, pp. 511-8
Rissman, R. A., Bennett, D. A., Armstrong, D. M., Subregional analysis of GABA (A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment (2004) J. Chem. Neuroanat, 28, pp. 17-25
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., Kokmen, E., Mild cognitive impairment: Clinical characterization and outcome (1999) Arch. Neurol., 56, pp. 303-8
Greenamyre, J. T., Penney, J. B., D'Amato, C. J., Young, A. B., Dementia of the Alzheimer's type: Changes in hippocampal L- [3H] glutamate binding (1987) J. Neurochem., 48, pp. 543-51
Jansen, K. L., Faull, R. L., Dragunow, M., Synek, B. L., Alzheimer's disease: Changes in hippocampal N-methyl-D-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors - An autoradiographic study (1990) Neuroscience, 39, pp. 613-27
Cross, A. J., Crow, T. J., Ferrier, I. N., Johnson, J. A., The selectivity of the reduction of serotonin S2 receptors in Alzheimer-type dementia (1986) Neurobiol. Aging, 7, pp. 3-7
Chu, D. C., Penney Jr., J. B., Young, A. B., Cortical GABAB and GABAA receptors in Alzheimer's disease: A quantitative autoradiographic study (1987) Neurology, 37, pp. 1454-9
Lloyd, G. K., Lowenthal, A., Javoy-Agid, F., Constantidinis, J., GABAA receptor complex function in frontal cortex membranes from control and neurological patients (1991) Eur. J. Pharmacol., 197, pp. 33-9
Vogt, B. A., Crino, P. B., Volicer, L., Laminar alterations in gammaaminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease (1991) J. Neurochem., 57, pp. 282-90
Penney, J. B., Maragos, W. F., Greenamyre, J. T., Debowey, D. L., Hollingsworth, Z., Young, A. B., Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias (1990) J. Neurol. Neurosurg. Psychiatry, 53, pp. 314-20
Hof, P. R., Cox, K., Young, W. G., Celio, M. R., Rogers, J., Morrison, J. H., Parvalbumin-immunoreactive neurons in the neocortex are resistant to degeneration in Alzheimer's disease (1991) J. Neuropathol Exp. Neurol., 50, pp. 451-62
Price, J. L., Ko, A. I., Wade, M. J., Tsou, S. K., McKeel, D. W., Morris, J. C., Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease (2001) Arch. Neurol., 58, pp. 1395-402
Bell, K. F., Cuello, A. C., Altered synaptic function in Alzheimer's disease (2006) Eur. J. Pharmacol., 545, pp. 11-21
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease (2007) Neuron, 55, pp. 697-711
DeKosky, S. T., Ikonomovic, M. D., Styren, S. D., Beckett, L., Wisniewski, S., Bennett, D. A., Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment (2002) Ann. Neurol., 51, pp. 145-55
SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment
PURPOSE: The involvement of neocortical and limbic GABA(A)/benzodiazepine (BZD) receptors in Alzheimer's disease (AD) is controversial and mainly reported in advanced stages. The status of these receptors in the very early stages of AD is unclear and has not been explored in vivo. Our aims were to investigate in vivo the integrity of cerebral cortical GABA(A)/BZD receptors in subjects with amnestic mild cognitive impairment (MCI) and to compare possible receptor changes to those in cerebral perfusion. METHODS: [(123)I]Iomazenil and [(99m)Tc]HMPAO SPECT images were acquired in 16 patients with amnestic MCI and in 14 normal elderly control subjects (only [(123)I]iomazenil imaging in 5, only [(99m)Tc]HMPAO imaging in 4, and both [(123)I]iomazenil and [(99m)Tc]HMPAO imaging in 5). Region of interest (ROI) analysis and voxel-based analysis were performed with cerebellar normalization. RESULTS: Neither ROI analysis nor voxel-based analysis showed significant [(123)I]iomazenil binding changes in MCI patients compared to control subjects, either as a whole group or when considering only those patients with MCI that converted to AD within 2 years of clinical follow-up. In contrast, the ROI analysis revealed significant hypoperfusion of the precuneus and posterior cingulate cortex in the whole group of MCI patients and in MCI converters as compared to control subjects. Voxel-based analysis showed similar results. CONCLUSION: These results indicate that in the very early stages of AD, neocortical and limbic neurons/synapses expressing GABA(A)/BZD receptors are essentially preserved. They suggest that in MCI patients functional changes precede neuronal/synaptic loss in neocortical posterior regions and that [(99m)Tc]HMPAO rCBF imaging is more sensitive than [(123)I]iomazenil GABA(A)/BZD receptor imaging in detecting prodromal AD.
PURPOSE: The involvement of neocortical and limbic GABA(A)/benzodiazepine (BZD) receptors in Alzheimer's disease (AD) is controversial and mainly reported in advanced stages. The status of these receptors in the very early stages of AD is unclear and has not been explored in vivo. Our aims were to investigate in vivo the integrity of cerebral cortical GABA(A)/BZD receptors in subjects with amnestic mild cognitive impairment (MCI) and to compare possible receptor changes to those in cerebral perfusion. METHODS: [(123)I]Iomazenil and [(99m)Tc]HMPAO SPECT images were acquired in 16 patients with amnestic MCI and in 14 normal elderly control subjects (only [(123)I]iomazenil imaging in 5, only [(99m)Tc]HMPAO imaging in 4, and both [(123)I]iomazenil and [(99m)Tc]HMPAO imaging in 5). Region of interest (ROI) analysis and voxel-based analysis were performed with cerebellar normalization. RESULTS: Neither ROI analysis nor voxel-based analysis showed significant [(123)I]iomazenil binding changes in MCI patients compared to control subjects, either as a whole group or when considering only those patients with MCI that converted to AD within 2 years of clinical follow-up. In contrast, the ROI analysis revealed significant hypoperfusion of the precuneus and posterior cingulate cortex in the whole group of MCI patients and in MCI converters as compared to control subjects. Voxel-based analysis showed similar results. CONCLUSION: These results indicate that in the very early stages of AD, neocortical and limbic neurons/synapses expressing GABA(A)/BZD receptors are essentially preserved. They suggest that in MCI patients functional changes precede neuronal/synaptic loss in neocortical posterior regions and that [(99m)Tc]HMPAO rCBF imaging is more sensitive than [(123)I]iomazenil GABA(A)/BZD receptor imaging in detecting prodromal AD.
SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment
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SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment
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Ciarmiello A, Tartaglione A, Giovannini E, Riondato M, Giovacchini G, Ferrando O, De Biasi M, Passera C, Carabelli E, Mannironi A, Foppiano F, Alfano B, Mansi L
* Amyloid burden identifies neuropsychological phenotypes at increased risk of progression to Alzheimer's disease in mild cognitive impairment patients (497 views)
Eur J Nucl Med (ISSN: 1619-7070linking, 1619-7070print, 1619-7089electronic), 2018 Sep 22; 46(2): 288-296.
Impact Factor: 7.704
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Marchitelli R, Aiello M, Cachia A, Quarantelli M, Cavaliere C, Postiglione A, Tedeschi G, Montella P, Milan G, Salvatore M, Salvatore E, Baron JC, Pappata S
* Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity (1279 views)
Neuroimage (ISSN: 1053-8119linking), 2018 Aug 1; 176: 246-258.
Impact Factor: 5.835
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (527 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
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Pellecchia MT, Picillo M, Santangelo G, Longo K, Moccia M, Erro R, Amboni M, Vitale C, Vicidomini C, Salvatore M, Barone P, Pappata S
* Cognitive performances and DAT imaging in early Parkinson's disease with mild cognitive impairment: a preliminary study (497 views)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2015 Feb 3; 131(5): 275-281.
Impact Factor: 2.559
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Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
* Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting (516 views)
Neuroimage Clin (ISSN: 2213-1582, 2213-1582electronic, 2213-1582linking), 2014 Oct 24; 6: 445-454.
Impact Factor: 2.526
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Olgiati S, De Rosa A, Quadri M, Criscuolo C, Breedveld GJ, Picillo M, Pappata S, Quarantelli M, Barone P, De Michele G, Bonifati V
* Park20 Caused By Synj1 Homozygous Arg258gln Mutation In A New Italian Family (492 views)
Neurogenetics (ISSN: 1364-6745, 1364-6753), 2014 Aug; 15(3): 183-188.
Impact Factor: 2.884
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (541 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
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Pappata S, Santangelo G, Aarsland D, Vicidomini C, Longo K, Bronnick K, Amboni M, Erro R, Vitale C, Caprio MG, Pellecchia MT, Brunetti A, De Michele G, Salvatore M, Barone P
* Mild cognitive impairment in drug-naive patients with PD is associated with cerebral hypometabolism (491 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2011 Oct 4; 77(14): 1357-1362.
Impact Factor: 8.312
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Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Nagren K, Darcourt J, Tatsch K, Van Laere KJ
* EANM procedure guideline for brain perfusion SPECT using Tc-99m-labelled radiopharmaceuticals, version (580 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2093-2102.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Serrano CM, Allegri RF, Caramelli P, Taragano FE, Camera L
* Mild cognitive impairment. Survey of attitudes of specialists and general physicians (618 views)
Medicina (ISSN: 0025-7680), 2007; 67(1): 19-25.
Impact Factor: 0.193
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Pappata S, Varrone A, Milan G, Sansone V, Iavarone A, Panico M, Quarantelli M, Mollica C, De Falco C, Lore E, Postiglione A, Salvatore M
* SPECT study of GABAA/BZD receptors and cerebral blood flow in mild cognitive impairment (MCI) (351 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2006; 31: N/D-N/D.
Impact Factor: 5.559
View Export to BibTeX Export to EndNote
Rispo A, Imbriaco M, Celentano L, Cozzolino A, Camera L, Mainenti PP, Manguso F, Sabbatini F, D'Amico P, Castiglione F
* Noninvasive diagnosis of small bowel Crohn's disease: Combined use of bowel sonography and Tc-99m-HMPAO leukocyte scintigraphy (421 views)
Inflamm Bowel Dis (ISSN: 1078-0998, 1536-4844electronic), 2005 Apr; 11(4): 376-382.
Impact Factor: 3.012
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Varrone A, Pappata S, Lore E, Sansone V, Iavarone A, Carlomagno S, Brunetti A, Postiglione A, Salvatore M
* Changes of regional cerebral blood flow in mild cognitive impairment studied with [99mTc]HMPAO SPET (381 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
Impact Factor: 3.935
View Export to BibTeX Export to EndNote
Varrone A, Pappata S, Quarantelli M, Sansone V, Mollica C, Lore E, Carlomagno S, Iavarone A, Postiglione A, Alfano B, Salvatore M
* Partial volume effect correction of rCBF SPET studies in mild cognitive impairment and Alzheimer's disease (357 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
Impact Factor: 3.935
View Export to BibTeX Export to EndNote
Rispo A, Imbriaco M, Celentano L, Cozzolino A, Mainenti PP, Camera L, Di Girolamo E, De Falco T, Castiglione F
* Small bowel Crohn's disease: Comparison of enteroclysis, bowel sonography and Tc-99m-HMPAO leukocyte scintigraphy (340 views)
Eur Rev Med Pharmacol Sci (ISSN: 1128-3602), 2004 Sep; 8(5): 219-224.
Impact Factor: 0.988
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Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, Alfano B, Postiglione A, Salvatore M
* Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks (474 views) (PDF 309 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2002 Nov; 29(11): 1447-1454.
Impact Factor: 3.568
View Export to BibTeX Export to EndNote
Varrone A, Soricelli A, Postiglione A, Salvatore M
Comparison between cortical distribution of I-123 lomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT (315 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1999 Sep; 24(9): 660-665.
Impact Factor: 0.253
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Postiglione A, Soricelli A, Grossi D, Romano M, Mainenti PP, Ruocco A, Fragrassi N, Chiacchio L, Milan G, De Chiara S, Brunetti A
Changes in cerebral blood flow during cognitive activation evaluated by single photon emission computed tomography in patients with Alzheimer's disease (449 views)
Alzheimer S Res (ISSN: 1356-918x), 1997 Jun; 3(3): 93-99.
Impact Factor: 0
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Postiglione A, Soricelli, Salvatore M, Lassen NA
123I-iomazenil as a clinical tool for studying neuronal loss [4] (340 views)
J Am Geriatr Soc (ISSN: 0002-8614), 1997 Apr; 45(4): 534-536.
Impact Factor: 2.806
View Export to BibTeX Export to EndNote
Soricelli A, Postiglione A, GrivetFojaja M, Mainenti PP, Discepolo A, Varrone A, Salvatore M, Lassen N
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (417 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.
Impact Factor: 2.692
View Export to BibTeX Export to EndNote
Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Functional characterization of brain tumors: An overview of the potential clinical value (850 views) (PDF 245 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
Impact Factor: 1.042
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Soricelli A, Mainenti PP, Leone D, Discepolo A, Romano M, Varrone A, Servillo G, Serio S, Brunetti A, Salvatore M
Evaluation of brain perfusion with high resolution single photon emission tomography in the diagnosis of brain death (238 views)
Minerva Anestesiol (ISSN: 0375-9393), 1996 Jun; 62(6): 209-212.
Impact Factor: 1.627
View Export to BibTeX Export to EndNote
Postiglione A, Soricelli A, Covelli EM, Iazzetta N, Ruocco A, Milan G, Santoro L, Alfano B, Brunetti A
Premature aging in Werner's syndrome spares the central nervous system (685 views) (PDF 210 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 1996 May; 17(3): 325-330.
Impact Factor: 2.872
View Export to BibTeX Export to EndNote
Soricelli A, Postiglione A, Cuocolo A, De Chiara S, Ruocco A, Brunetti A, Salvatore M, Ell PJ
EFFECT OF ADENOSINE ON CEREBRAL BLOOD-FLOW AS EVALUATED BY SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY IN NORMAL SUBJECTS AND IN PATIENTS WITH OCCLUSIVE CAROTID DISEASE - A COMPARISON WITH ACETAZOLAMIDE (256 views)
Stroke (ISSN: 0039-2499), 1995 Sep; 26(9): 1572-1576.
Impact Factor: 4.323
View Export to BibTeX Export to EndNote
* Amyloid burden identifies neuropsychological phenotypes at increased risk of progression to Alzheimer's disease in mild cognitive impairment patients (497 views)
Eur J Nucl Med (ISSN: 1619-7070linking, 1619-7070print, 1619-7089electronic), 2018 Sep 22; 46(2): 288-296.
Impact Factor: 7.704
View Export to BibTeX Export to EndNote
Marchitelli R, Aiello M, Cachia A, Quarantelli M, Cavaliere C, Postiglione A, Tedeschi G, Montella P, Milan G, Salvatore M, Salvatore E, Baron JC, Pappata S
* Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity (1279 views)
Neuroimage (ISSN: 1053-8119linking), 2018 Aug 1; 176: 246-258.
Impact Factor: 5.835
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (527 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
View Export to BibTeX Export to EndNote
Pellecchia MT, Picillo M, Santangelo G, Longo K, Moccia M, Erro R, Amboni M, Vitale C, Vicidomini C, Salvatore M, Barone P, Pappata S
* Cognitive performances and DAT imaging in early Parkinson's disease with mild cognitive impairment: a preliminary study (497 views)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2015 Feb 3; 131(5): 275-281.
Impact Factor: 2.559
View Export to BibTeX Export to EndNote
Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
* Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting (516 views)
Neuroimage Clin (ISSN: 2213-1582, 2213-1582electronic, 2213-1582linking), 2014 Oct 24; 6: 445-454.
Impact Factor: 2.526
View Export to BibTeX Export to EndNote
Olgiati S, De Rosa A, Quadri M, Criscuolo C, Breedveld GJ, Picillo M, Pappata S, Quarantelli M, Barone P, De Michele G, Bonifati V
* Park20 Caused By Synj1 Homozygous Arg258gln Mutation In A New Italian Family (492 views)
Neurogenetics (ISSN: 1364-6745, 1364-6753), 2014 Aug; 15(3): 183-188.
Impact Factor: 2.884
View Export to BibTeX Export to EndNote
Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (541 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
View Export to BibTeX Export to EndNote
Pappata S, Santangelo G, Aarsland D, Vicidomini C, Longo K, Bronnick K, Amboni M, Erro R, Vitale C, Caprio MG, Pellecchia MT, Brunetti A, De Michele G, Salvatore M, Barone P
* Mild cognitive impairment in drug-naive patients with PD is associated with cerebral hypometabolism (491 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2011 Oct 4; 77(14): 1357-1362.
Impact Factor: 8.312
View Export to BibTeX Export to EndNote
Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Nagren K, Darcourt J, Tatsch K, Van Laere KJ
* EANM procedure guideline for brain perfusion SPECT using Tc-99m-labelled radiopharmaceuticals, version (580 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2093-2102.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Serrano CM, Allegri RF, Caramelli P, Taragano FE, Camera L
* Mild cognitive impairment. Survey of attitudes of specialists and general physicians (618 views)
Medicina (ISSN: 0025-7680), 2007; 67(1): 19-25.
Impact Factor: 0.193
View Export to BibTeX Export to EndNote
Pappata S, Varrone A, Milan G, Sansone V, Iavarone A, Panico M, Quarantelli M, Mollica C, De Falco C, Lore E, Postiglione A, Salvatore M
* SPECT study of GABAA/BZD receptors and cerebral blood flow in mild cognitive impairment (MCI) (351 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2006; 31: N/D-N/D.
Impact Factor: 5.559
View Export to BibTeX Export to EndNote
Rispo A, Imbriaco M, Celentano L, Cozzolino A, Camera L, Mainenti PP, Manguso F, Sabbatini F, D'Amico P, Castiglione F
* Noninvasive diagnosis of small bowel Crohn's disease: Combined use of bowel sonography and Tc-99m-HMPAO leukocyte scintigraphy (421 views)
Inflamm Bowel Dis (ISSN: 1078-0998, 1536-4844electronic), 2005 Apr; 11(4): 376-382.
Impact Factor: 3.012
View Export to BibTeX Export to EndNote
Varrone A, Pappata S, Lore E, Sansone V, Iavarone A, Carlomagno S, Brunetti A, Postiglione A, Salvatore M
* Changes of regional cerebral blood flow in mild cognitive impairment studied with [99mTc]HMPAO SPET (381 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
Impact Factor: 3.935
View Export to BibTeX Export to EndNote
Varrone A, Pappata S, Quarantelli M, Sansone V, Mollica C, Lore E, Carlomagno S, Iavarone A, Postiglione A, Alfano B, Salvatore M
* Partial volume effect correction of rCBF SPET studies in mild cognitive impairment and Alzheimer's disease (357 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
Impact Factor: 3.935
View Export to BibTeX Export to EndNote
Rispo A, Imbriaco M, Celentano L, Cozzolino A, Mainenti PP, Camera L, Di Girolamo E, De Falco T, Castiglione F
* Small bowel Crohn's disease: Comparison of enteroclysis, bowel sonography and Tc-99m-HMPAO leukocyte scintigraphy (340 views)
Eur Rev Med Pharmacol Sci (ISSN: 1128-3602), 2004 Sep; 8(5): 219-224.
Impact Factor: 0.988
View Export to BibTeX Export to EndNote
Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, Alfano B, Postiglione A, Salvatore M
* Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks (474 views) (PDF 309 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2002 Nov; 29(11): 1447-1454.
Impact Factor: 3.568
View Export to BibTeX Export to EndNote
Varrone A, Soricelli A, Postiglione A, Salvatore M
Comparison between cortical distribution of I-123 lomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT (315 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1999 Sep; 24(9): 660-665.
Impact Factor: 0.253
View Export to BibTeX Export to EndNote
Postiglione A, Soricelli A, Grossi D, Romano M, Mainenti PP, Ruocco A, Fragrassi N, Chiacchio L, Milan G, De Chiara S, Brunetti A
Changes in cerebral blood flow during cognitive activation evaluated by single photon emission computed tomography in patients with Alzheimer's disease (449 views)
Alzheimer S Res (ISSN: 1356-918x), 1997 Jun; 3(3): 93-99.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Postiglione A, Soricelli, Salvatore M, Lassen NA
123I-iomazenil as a clinical tool for studying neuronal loss [4] (340 views)
J Am Geriatr Soc (ISSN: 0002-8614), 1997 Apr; 45(4): 534-536.
Impact Factor: 2.806
View Export to BibTeX Export to EndNote
Soricelli A, Postiglione A, GrivetFojaja M, Mainenti PP, Discepolo A, Varrone A, Salvatore M, Lassen N
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (417 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.
Impact Factor: 2.692
View Export to BibTeX Export to EndNote
Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Functional characterization of brain tumors: An overview of the potential clinical value (850 views) (PDF 245 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
Impact Factor: 1.042
View Export to BibTeX Export to EndNote
Soricelli A, Mainenti PP, Leone D, Discepolo A, Romano M, Varrone A, Servillo G, Serio S, Brunetti A, Salvatore M
Evaluation of brain perfusion with high resolution single photon emission tomography in the diagnosis of brain death (238 views)
Minerva Anestesiol (ISSN: 0375-9393), 1996 Jun; 62(6): 209-212.
Impact Factor: 1.627
View Export to BibTeX Export to EndNote
Postiglione A, Soricelli A, Covelli EM, Iazzetta N, Ruocco A, Milan G, Santoro L, Alfano B, Brunetti A
Premature aging in Werner's syndrome spares the central nervous system (685 views) (PDF 210 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 1996 May; 17(3): 325-330.
Impact Factor: 2.872
View Export to BibTeX Export to EndNote
Soricelli A, Postiglione A, Cuocolo A, De Chiara S, Ruocco A, Brunetti A, Salvatore M, Ell PJ
EFFECT OF ADENOSINE ON CEREBRAL BLOOD-FLOW AS EVALUATED BY SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY IN NORMAL SUBJECTS AND IN PATIENTS WITH OCCLUSIVE CAROTID DISEASE - A COMPARISON WITH ACETAZOLAMIDE (256 views)
Stroke (ISSN: 0039-2499), 1995 Sep; 26(9): 1572-1576.
Impact Factor: 4.323
View Export to BibTeX Export to EndNote
24 Records (20 excluding Abstracts).
Total impact factor: 80.982 (64.994 excluding Abstracts).
Total 5 year impact factor: 95.514 (76.737 excluding Abstracts).
Total impact factor: 80.982 (64.994 excluding Abstracts).
Total 5 year impact factor: 95.514 (76.737 excluding Abstracts).
504 views. Last view on Wednesday 12 April 2023, 18:19:23
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