Institute of Biostructure and Bioimaging, CNR, Via Pansini 5, 80131 Naples, Italy
Department of Clinical and Experimental Medicine, University Federico II, Naples, Italy
Department of Biomorphological and Functional Sciences, University Federico II, Naples, Italy
Neurologic and Stroke Unit, CTO Hospital, Naples, Italy
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Hof, P.R., Cox, K., Young, W.G., Celio, M.R., Rogers, J., Morrison, J.H., Parvalbumin-immunoreactive neurons in the neocortex are resistant to degeneration in Alzheimer's disease (1991) J. Neuropathol Exp. Neurol., 50, pp. 451-62
Price, J.L., Ko, A.I., Wade, M.J., Tsou, S.K., McKeel, D.W., Morris, J.C., Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease (2001) Arch. Neurol., 58, pp. 1395-402
Bell, K.F., Cuello, A.C., Altered synaptic function in Alzheimer's disease (2006) Eur. J. Pharmacol., 545, pp. 11-21
Palop, J.J., Chin, J., Roberson, E.D., Wang, J., Thwin, M.T., Bien-Ly, N., Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease (2007) Neuron, 55, pp. 697-711
DeKosky, S.T., Ikonomovic, M.D., Styren, S.D., Beckett, L., Wisniewski, S., Bennett, D.A., Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment (2002) Ann. Neurol., 51, pp. 145-55
Truchot, L., Costes, S.N., Zimmer, L., Laurent, B., Le Bars, D., Thomas-Antérion, C., Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment (2007) Neurology, 69, pp. 1012-7
Borroni, B., Anchisi, D., Paghera, B., Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD (2006) Neurobiol. Aging, 27, pp. 24-31
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Pappat, S., Salvatore, E., Postiglione, A., In vivo imaging of neurotransmission and brain receptors in dementia (2008) J. Neuroimaging, 18, pp. 111-2
Rissman, R. A., De Blas, A. L., Armstrong, D. M., GABA (A) receptors in aging and Alzheimer's disease (2007) J. Neurochem., 103, pp. 1285-92
M hler, H., Molecular regulation of cognitive functions and developmental plasticity: Impact of GABAA receptors (2007) J. Neurochem., 102, pp. 1-12
Lanctot, K. L., Herrmann, N., Mazzotta, P., Khan, L. R., Ingber, N., GABAergic function in Alzheimer's disease: Evidence for dysfunction and potential as a therapeutic target for the treatment of behavioral and psychological symptoms of dementia (2004) Can J. Psychiatry, 49, pp. 439-53
Louzada, P. R., Lima, A. C. P., Mendonca-Silva, D. L., No l, F., De Mello, F. G., Ferreira, S. T., Taurine prevents the neurotoxicity of betaamyloid and glutamate receptor agonists: Activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders (2004) FASEB J., 18, pp. 511-8
Rissman, R. A., Bennett, D. A., Armstrong, D. M., Subregional analysis of GABA (A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment (2004) J. Chem. Neuroanat, 28, pp. 17-25
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., Kokmen, E., Mild cognitive impairment: Clinical characterization and outcome (1999) Arch. Neurol., 56, pp. 303-8
Greenamyre, J. T., Penney, J. B., D'Amato, C. J., Young, A. B., Dementia of the Alzheimer's type: Changes in hippocampal L- [3H] glutamate binding (1987) J. Neurochem., 48, pp. 543-51
Jansen, K. L., Faull, R. L., Dragunow, M., Synek, B. L., Alzheimer's disease: Changes in hippocampal N-methyl-D-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors - An autoradiographic study (1990) Neuroscience, 39, pp. 613-27
Cross, A. J., Crow, T. J., Ferrier, I. N., Johnson, J. A., The selectivity of the reduction of serotonin S2 receptors in Alzheimer-type dementia (1986) Neurobiol. Aging, 7, pp. 3-7
Chu, D. C., Penney Jr., J. B., Young, A. B., Cortical GABAB and GABAA receptors in Alzheimer's disease: A quantitative autoradiographic study (1987) Neurology, 37, pp. 1454-9
Lloyd, G. K., Lowenthal, A., Javoy-Agid, F., Constantidinis, J., GABAA receptor complex function in frontal cortex membranes from control and neurological patients (1991) Eur. J. Pharmacol., 197, pp. 33-9
Vogt, B. A., Crino, P. B., Volicer, L., Laminar alterations in gammaaminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease (1991) J. Neurochem., 57, pp. 282-90
Penney, J. B., Maragos, W. F., Greenamyre, J. T., Debowey, D. L., Hollingsworth, Z., Young, A. B., Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias (1990) J. Neurol. Neurosurg. Psychiatry, 53, pp. 314-20
Hof, P. R., Cox, K., Young, W. G., Celio, M. R., Rogers, J., Morrison, J. H., Parvalbumin-immunoreactive neurons in the neocortex are resistant to degeneration in Alzheimer's disease (1991) J. Neuropathol Exp. Neurol., 50, pp. 451-62
Price, J. L., Ko, A. I., Wade, M. J., Tsou, S. K., McKeel, D. W., Morris, J. C., Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease (2001) Arch. Neurol., 58, pp. 1395-402
Bell, K. F., Cuello, A. C., Altered synaptic function in Alzheimer's disease (2006) Eur. J. Pharmacol., 545, pp. 11-21
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease (2007) Neuron, 55, pp. 697-711
DeKosky, S. T., Ikonomovic, M. D., Styren, S. D., Beckett, L., Wisniewski, S., Bennett, D. A., Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment (2002) Ann. Neurol., 51, pp. 145-55
SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment
PURPOSE: The involvement of neocortical and limbic GABA(A)/benzodiazepine (BZD) receptors in Alzheimer's disease (AD) is controversial and mainly reported in advanced stages. The status of these receptors in the very early stages of AD is unclear and has not been explored in vivo. Our aims were to investigate in vivo the integrity of cerebral cortical GABA(A)/BZD receptors in subjects with amnestic mild cognitive impairment (MCI) and to compare possible receptor changes to those in cerebral perfusion. METHODS: [(123)I]Iomazenil and [(99m)Tc]HMPAO SPECT images were acquired in 16 patients with amnestic MCI and in 14 normal elderly control subjects (only [(123)I]iomazenil imaging in 5, only [(99m)Tc]HMPAO imaging in 4, and both [(123)I]iomazenil and [(99m)Tc]HMPAO imaging in 5). Region of interest (ROI) analysis and voxel-based analysis were performed with cerebellar normalization. RESULTS: Neither ROI analysis nor voxel-based analysis showed significant [(123)I]iomazenil binding changes in MCI patients compared to control subjects, either as a whole group or when considering only those patients with MCI that converted to AD within 2 years of clinical follow-up. In contrast, the ROI analysis revealed significant hypoperfusion of the precuneus and posterior cingulate cortex in the whole group of MCI patients and in MCI converters as compared to control subjects. Voxel-based analysis showed similar results. CONCLUSION: These results indicate that in the very early stages of AD, neocortical and limbic neurons/synapses expressing GABA(A)/BZD receptors are essentially preserved. They suggest that in MCI patients functional changes precede neuronal/synaptic loss in neocortical posterior regions and that [(99m)Tc]HMPAO rCBF imaging is more sensitive than [(123)I]iomazenil GABA(A)/BZD receptor imaging in detecting prodromal AD.
SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment
No results.
SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment