Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis (393 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2003 Jun; 88(6): 2900-2907.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.873, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037901947&partnerID=40&md5=276cdd233a2f010e899401707f9fe1a4
Keywords: Benzyloxycarbonylvalylalanylaspartyl Fluoromethylketone, Bovine Seminal Ribonuclease, Caspase, Caspase Inhibitor, Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase, Pancreatic Ribonuclease, Protein Kinase B, Protein Serine Threonine Kinase, Unclassified Drug, Animal Experiment, Animal Model, Antineoplastic Activity, Apoptosis, Article, Cancer Cell, Cancer Cell Culture, Carcinoma Cell, Cell Killing, Cell Survival, Controlled Study, Drug Effect, Drug Selectivity, Human, Human Cell, Mouse, Nonhuman, Nude Mouse, Priority Journal, Protein Degradation, Protein Phosphorylation, Thyroid Carcinoma, Amino Acid Chloromethyl Ketones, Antineoplastic Agents, Cysteine Proteinase Inhibitors, Endoribonucleases, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins C-Akt, Thyroid Neoplasms, Tumor Cells, Mus Musculus,
Affiliations:
*** IBB - CNR ***
Ist. Endocrinol. Oncol. Sperim. C., Dipto. Biol. e Patol. Cell. e Molec., Univ. di Napoli Federico II, 80131 Naples, Italy
Dipartimento di Chimica Biologica, Univ. di Napoli Federico II, 80134 Naples, Italy
Ist. Biostrutture e Bioimmagini-CNR, 80134 Naples, Italy
References:
Hedinger, C., Williams, E.D., Sobin, L.H., The WHO histological classification of thyroid tumors: A commentary on the second edition (1989) Cancer, 63, pp. 980-91
Rosai, J., Carcangiu, M.L., DeLellis, R.A., (1992) Atlas of Tumor Pathology: Tumors of the Thyroid Gland, 3rd Ser, , Washington DC: Armed Force Institute of Pathology
Youle, J.R., D'Alessio, G., Antitumor RNases (1997) Ribonucleases: Structures and Functions, pp. 491-514. , D'Alessio G, Riordan JF, eds. New York: Academic Press
D'Alessio, G., Di Donato, A., Mazzarella, L., Piccoli, R., Seminal ribonuclease: The importance of diversity (1997) Ribonucleases: Structures and Functions, pp. 383-423. , D'Alessio G, Riordan JF, eds. New York: Academic Press
Laccetti, P., Spalletti-Cernia, D., Portella, G., De Corato, P., D'Alessio, G., Vecchio, G., Seminal ribonuclease inhibits tumor growth and reduces the metastatic potential of Lewis lung carcinoma (1994) Cancer Res, 54, pp. 4253-4256
Matousek, J., Ribonucleases and their antitumor activity (2001) Comp Biochem Physiol C Toxicol Pharmacol, 129, pp. 175-191
Mikulski, S.M., Costanzi, J.J., Vogelzang, N.J., McCachren, S., Taub, R.N., Chun, H., Mittelman, A., Shogen, K., Phase II trial of a single weekly intravenous dose of ranpimase in patients with unresectable malignant mesothelioma (2002) J Clin Oncol, 20, pp. 274-281
Newton, D.L., Hansen, H.J., Mikulski, S.M., Goldenberg, D.M., Rybak, S.M., Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: Potential for the treatment of non-Hodgkin lymphoma (2001) Blood, 97, pp. 528-535
Mastronicola, M.R., Piccoli, R., D'Alessio, G., Key extracellular and intracellular steps in the antitumor action of seminal ribonuclease (1995) Eur J Biochem, 230, pp. 242-249
Bracale, A., Spalletti-Cernia, D., Mastronicola, M.R., Castaldi, F., Mannucci, R., Nitsch, L., D'Alessio, G., Essential stations in the intracellular pathway of cytotoxic bovine seminal ribonuclease (2002) Biochem J, 362, pp. 553-560
Wu, Y., Mikulski, S.M., Ardelt, W., Rybak, S.M., Youle, R.J., A cytotoxic ribonuclease. Study of the mechanism of Onconase cytotoxicity (1993) J Biol Chem, 268, pp. 10686-10693
Kim, J.S., Soucek, J., Matousek, J., Raines, R.T., Mechanism of ribonuclease cytotoxicity (1995) J Biol Chem, 270, pp. 31097-31102
Murthy, B.S., De Lorenzo, C., Piccoli, R., D'Alessio, G., Sirdeshmukh, R., Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase (1996) Biochemistry, 35, pp. 3880-3885
Leland, P.A., Staniszewski, K.E., Kim, B.M., Raines, R.T., Endowing human pancreatic ribonuclease with toxicity for cancer cells (2001) J Biol Chem, 276, pp. 43095-43102
Antignani, A., Naddeo, M., Cubellis, M.V., Russo, A., D'Alessio, G., Antitumor action of seminal ribonuclease, its dimeric structure, and its resistance to the cytosolic ribonuclease inhibitor (2001) Biochemistry, 40, pp. 3492-3496
Piccoli, R., Di Gaetano, S., De Lorenzo, C., Grauso, M., Monaco, C., Spalletti-Cernia, D., Laccetti, P., D'Alessio, G., A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells (1999) Proc Natl Acad Sci USA, 96, pp. 7768-7773
Di Gaetano, S., D'Alessio, G., Piccoli, R., Second generation antitumour human RNase: Significance of its structural and functional features for the mechanism of antitumour action (2001) Biochem J, 358, pp. 241-247
Iordanov, M.S., Ryabinina, O.P., Wong, J., Dinh, T.H., Newton, D.L., Rybak, S.M., Magun, B.E., Molecular determinants of apoptosis induced by the cytotoxic ribonuclease Onconase: Evidence for cytotoxic mechanisms different from inhibition of protein synthesis (2000) Cancer Res, 60, pp. 1983-1994
Hu, C.-C.A., Tang, C.-H.A., Wang, J.-J., Caspase activation in response to cytotoxic Rana catesbiana ribonuclease in MCF-7 cells (2001) FEBS Lett, 503, pp. 65-68
Cinatl J., Jr., Cinatl, J., Kotchetkov, R., Vogel, J.U., Woodcock, B.G., Matousek, J., Pouckova, P., Kornhuber, B., Bovine seminal ribonuclease selectively kills human multidrug-resistant neuroblastoma cells via induction of apoptosis (1999) Int J Oncol, 15, pp. 1001-1009
Laccetti, P., Portella, G., Mastronicola, M.R., Russo, A., Piccoli, R., D'Alessio, G., Vecchio, G., In vivo and in vitro growth-inhibitory effect of bovine seminal ribonuclease on a system of rat thyroid epithelial transformed cells and tumors (1992) Cancer Res, 52, pp. 4582-4586
Kotchetkov, R., Cinatl, J., Krivtchik, A.A., Vogel, J.U., Matousek, J., Pouckova, P., Kornhuber, B., Cinatl J., Jr., Selective activity of BS-RNase against anaplastic thyroid cancer (2001) Anticancer Res, 21, pp. 1035-1042
Hansen, R., Oren, M., p53
from inductive signal to cellular effect (1997) Curr Opin Genet Dev, 7, pp. 46-51
Earnshaw, W.C., Martins, L.M., Kanfmann, S.H., Mammalian caspases
structure, activation, substrates and functions during apoptosis (1999) Annu Rev Biochem, 68, pp. 383-424
an assay for the selective cytotoxicity of the enzyme (2001) Methods Enzymol, 341, pp. 248-263
Fagin, J.A., Matsuo, K., Karmakar, A., Chen, D.L., Tang, S.H., Koeffler, H.P., High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas (1993) J Clin Invest, 91, pp. 179-184
Gioanni, J., Zanghellini, E., Mazeau, C., Zhang, D., Courdi, A., Farges, M., Lambert, J.C., Schneider, M., Characterization of a human cell line from an anaplastic carcinoma of the thyroid gland (1991) Bull Cancer, 78, pp. 1053-1062
Ain, K.B., Tofiq, S., Taylor, K.D., Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo (1996) J Clin Endocrinol Metab, 81, pp. 3650-3653
Testa, J.R., Bellacosa, A., AKT plays a central role in tumorigenesis (2001) Proc Natl Acad Sci USA, 98, pp. 10983-10985
Ringel, M.D., Hayre, N., Saito, J., Saunier, B., Schuppert, F., Burch, H., Bernet, V., Saji, M., Overexpression and overactivation of Akt in thyroid carcinoma (2001) Cancer Res, 61, pp. 6105-6111
Bruni, P., Boccia, A., Baldassarre, G., Trapasso, F., Santoro, M., Chiappetta, G., Fusco, A., Viglietto, G., PTEN expression is reduced in a subset of sporadic thyroid carcinomas: Evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1 (2000) Oncogene, 19, pp. 3146-3155
Weng, L.P., Gimm, O., Kum, J.B., Smith, W.M., Zhou, X.P., Wynford-Thomas, D., Leone, G., Eng, C., Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death (2001) Hum Mol Genet, 10, pp. 251-258
Blagosklonny, M.V., Giannakakou, P., Wojtowicz, M., Romanova, L.Y., Ain, K.B., Bates, S.E., Fojo, T., (1998) Effects of p53-expressing Adenovirus on the Chemosensitivity and Differentiation of Anaplastic Thyroid Cancer Cells, 83, pp. 2516-2522
Sellers, W.R., Fisher, D.E., Apoptosis and cancer drug targeting (1999) J Clin Invest, 104, pp. 1655-1661
Mitsiades, N., Poulaki, V., Tseleni-Balafouta, S., Koutras, D.A., Stamenkovic, I., Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive tumor necrosis factor-related apoptosis-inducing ligand (2000) Cancer Res, 60, pp. 4122-4129
Iordanov, M.S., Wong, J., Newton, D.L., Rybak, S.M., Bright, R.K., Flavell, R.A., Davis, R.J., Magun, B.E., Differential requirement for the stress-activated protein kinase/c-Jun NH2-terminal kinase in RNA damage-induced apoptosis in primary and in immortalized fibroblasts (2000) Mol Cell Biol Res Commun, 4, pp. 122-128
Youle, J. R., D'Alessio, G., Antitumor RNases (1997) Ribonucleases: Structures and Functions, pp. 491-514. , D'Alessio G, Riordan JF, eds. New York: Academic Press
Mikulski, S. M., Costanzi, J. J., Vogelzang, N. J., McCachren, S., Taub, R. N., Chun, H., Mittelman, A., Shogen, K., Phase II trial of a single weekly intravenous dose of ranpimase in patients with unresectable malignant mesothelioma (2002) J Clin Oncol, 20, pp. 274-281
Newton, D. L., Hansen, H. J., Mikulski, S. M., Goldenberg, D. M., Rybak, S. M., Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: Potential for the treatment of non-Hodgkin lymphoma (2001) Blood, 97, pp. 528-535
Mastronicola, M. R., Piccoli, R., D'Alessio, G., Key extracellular and intracellular steps in the antitumor action of seminal ribonuclease (1995) Eur J Biochem, 230, pp. 242-249
Kim, J. S., Soucek, J., Matousek, J., Raines, R. T., Mechanism of ribonuclease cytotoxicity (1995) J Biol Chem, 270, pp. 31097-31102
Murthy, B. S., De Lorenzo, C., Piccoli, R., D'Alessio, G., Sirdeshmukh, R., Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase (1996) Biochemistry, 35, pp. 3880-3885
Leland, P. A., Staniszewski, K. E., Kim, B. M., Raines, R. T., Endowing human pancreatic ribonuclease with toxicity for cancer cells (2001) J Biol Chem, 276, pp. 43095-43102
Iordanov, M. S., Ryabinina, O. P., Wong, J., Dinh, T. H., Newton, D. L., Rybak, S. M., Magun, B. E., Molecular determinants of apoptosis induced by the cytotoxic ribonuclease Onconase: Evidence for cytotoxic mechanisms different from inhibition of protein synthesis (2000) Cancer Res, 60, pp. 1983-1994
Hu, C. -C. A., Tang, C. -H. A., Wang, J. -J., Caspase activation in response to cytotoxic Rana catesbiana ribonuclease in MCF-7 cells (2001) FEBS Lett, 503, pp. 65-68
Earnshaw, W. C., Martins, L. M., Kanfmann, S. H., Mammalian caspases
Fagin, J. A., Matsuo, K., Karmakar, A., Chen, D. L., Tang, S. H., Koeffler, H. P., High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas (1993) J Clin Invest, 91, pp. 179-184
Ain, K. B., Tofiq, S., Taylor, K. D., Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo (1996) J Clin Endocrinol Metab, 81, pp. 3650-3653
Testa, J. R., Bellacosa, A., AKT plays a central role in tumorigenesis (2001) Proc Natl Acad Sci USA, 98, pp. 10983-10985
Ringel, M. D., Hayre, N., Saito, J., Saunier, B., Schuppert, F., Burch, H., Bernet, V., Saji, M., Overexpression and overactivation of Akt in thyroid carcinoma (2001) Cancer Res, 61, pp. 6105-6111
Weng, L. P., Gimm, O., Kum, J. B., Smith, W. M., Zhou, X. P., Wynford-Thomas, D., Leone, G., Eng, C., Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death (2001) Hum Mol Genet, 10, pp. 251-258
Blagosklonny, M. V., Giannakakou, P., Wojtowicz, M., Romanova, L. Y., Ain, K. B., Bates, S. E., Fojo, T., (1998) Effects of p53-expressing Adenovirus on the Chemosensitivity and Differentiation of Anaplastic Thyroid Cancer Cells, 83, pp. 2516-2522
Sellers, W. R., Fisher, D. E., Apoptosis and cancer drug targeting (1999) J Clin Invest, 104, pp. 1655-1661
Iordanov, M. S., Wong, J., Newton, D. L., Rybak, S. M., Bright, R. K., Flavell, R. A., Davis, R. J., Magun, B. E., Differential requirement for the stress-activated protein kinase/c-Jun NH2-terminal kinase in RNA damage-induced apoptosis in primary and in immortalized fibroblasts (2000) Mol Cell Biol Res Commun, 4, pp. 122-128
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2003 Jun; 88(6): 2900-2907.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.873, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037901947&partnerID=40&md5=276cdd233a2f010e899401707f9fe1a4
Keywords: Benzyloxycarbonylvalylalanylaspartyl Fluoromethylketone, Bovine Seminal Ribonuclease, Caspase, Caspase Inhibitor, Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase, Pancreatic Ribonuclease, Protein Kinase B, Protein Serine Threonine Kinase, Unclassified Drug, Animal Experiment, Animal Model, Antineoplastic Activity, Apoptosis, Article, Cancer Cell, Cancer Cell Culture, Carcinoma Cell, Cell Killing, Cell Survival, Controlled Study, Drug Effect, Drug Selectivity, Human, Human Cell, Mouse, Nonhuman, Nude Mouse, Priority Journal, Protein Degradation, Protein Phosphorylation, Thyroid Carcinoma, Amino Acid Chloromethyl Ketones, Antineoplastic Agents, Cysteine Proteinase Inhibitors, Endoribonucleases, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins C-Akt, Thyroid Neoplasms, Tumor Cells, Mus Musculus,
Affiliations:
*** IBB - CNR ***
Ist. Endocrinol. Oncol. Sperim. C., Dipto. Biol. e Patol. Cell. e Molec., Univ. di Napoli Federico II, 80131 Naples, Italy
Dipartimento di Chimica Biologica, Univ. di Napoli Federico II, 80134 Naples, Italy
Ist. Biostrutture e Bioimmagini-CNR, 80134 Naples, Italy
References:
Hedinger, C., Williams, E.D., Sobin, L.H., The WHO histological classification of thyroid tumors: A commentary on the second edition (1989) Cancer, 63, pp. 980-91
Rosai, J., Carcangiu, M.L., DeLellis, R.A., (1992) Atlas of Tumor Pathology: Tumors of the Thyroid Gland, 3rd Ser, , Washington DC: Armed Force Institute of Pathology
Youle, J.R., D'Alessio, G., Antitumor RNases (1997) Ribonucleases: Structures and Functions, pp. 491-514. , D'Alessio G, Riordan JF, eds. New York: Academic Press
D'Alessio, G., Di Donato, A., Mazzarella, L., Piccoli, R., Seminal ribonuclease: The importance of diversity (1997) Ribonucleases: Structures and Functions, pp. 383-423. , D'Alessio G, Riordan JF, eds. New York: Academic Press
Laccetti, P., Spalletti-Cernia, D., Portella, G., De Corato, P., D'Alessio, G., Vecchio, G., Seminal ribonuclease inhibits tumor growth and reduces the metastatic potential of Lewis lung carcinoma (1994) Cancer Res, 54, pp. 4253-4256
Matousek, J., Ribonucleases and their antitumor activity (2001) Comp Biochem Physiol C Toxicol Pharmacol, 129, pp. 175-191
Mikulski, S.M., Costanzi, J.J., Vogelzang, N.J., McCachren, S., Taub, R.N., Chun, H., Mittelman, A., Shogen, K., Phase II trial of a single weekly intravenous dose of ranpimase in patients with unresectable malignant mesothelioma (2002) J Clin Oncol, 20, pp. 274-281
Newton, D.L., Hansen, H.J., Mikulski, S.M., Goldenberg, D.M., Rybak, S.M., Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: Potential for the treatment of non-Hodgkin lymphoma (2001) Blood, 97, pp. 528-535
Mastronicola, M.R., Piccoli, R., D'Alessio, G., Key extracellular and intracellular steps in the antitumor action of seminal ribonuclease (1995) Eur J Biochem, 230, pp. 242-249
Bracale, A., Spalletti-Cernia, D., Mastronicola, M.R., Castaldi, F., Mannucci, R., Nitsch, L., D'Alessio, G., Essential stations in the intracellular pathway of cytotoxic bovine seminal ribonuclease (2002) Biochem J, 362, pp. 553-560
Wu, Y., Mikulski, S.M., Ardelt, W., Rybak, S.M., Youle, R.J., A cytotoxic ribonuclease. Study of the mechanism of Onconase cytotoxicity (1993) J Biol Chem, 268, pp. 10686-10693
Kim, J.S., Soucek, J., Matousek, J., Raines, R.T., Mechanism of ribonuclease cytotoxicity (1995) J Biol Chem, 270, pp. 31097-31102
Murthy, B.S., De Lorenzo, C., Piccoli, R., D'Alessio, G., Sirdeshmukh, R., Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase (1996) Biochemistry, 35, pp. 3880-3885
Leland, P.A., Staniszewski, K.E., Kim, B.M., Raines, R.T., Endowing human pancreatic ribonuclease with toxicity for cancer cells (2001) J Biol Chem, 276, pp. 43095-43102
Antignani, A., Naddeo, M., Cubellis, M.V., Russo, A., D'Alessio, G., Antitumor action of seminal ribonuclease, its dimeric structure, and its resistance to the cytosolic ribonuclease inhibitor (2001) Biochemistry, 40, pp. 3492-3496
Piccoli, R., Di Gaetano, S., De Lorenzo, C., Grauso, M., Monaco, C., Spalletti-Cernia, D., Laccetti, P., D'Alessio, G., A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells (1999) Proc Natl Acad Sci USA, 96, pp. 7768-7773
Di Gaetano, S., D'Alessio, G., Piccoli, R., Second generation antitumour human RNase: Significance of its structural and functional features for the mechanism of antitumour action (2001) Biochem J, 358, pp. 241-247
Iordanov, M.S., Ryabinina, O.P., Wong, J., Dinh, T.H., Newton, D.L., Rybak, S.M., Magun, B.E., Molecular determinants of apoptosis induced by the cytotoxic ribonuclease Onconase: Evidence for cytotoxic mechanisms different from inhibition of protein synthesis (2000) Cancer Res, 60, pp. 1983-1994
Hu, C.-C.A., Tang, C.-H.A., Wang, J.-J., Caspase activation in response to cytotoxic Rana catesbiana ribonuclease in MCF-7 cells (2001) FEBS Lett, 503, pp. 65-68
Cinatl J., Jr., Cinatl, J., Kotchetkov, R., Vogel, J.U., Woodcock, B.G., Matousek, J., Pouckova, P., Kornhuber, B., Bovine seminal ribonuclease selectively kills human multidrug-resistant neuroblastoma cells via induction of apoptosis (1999) Int J Oncol, 15, pp. 1001-1009
Laccetti, P., Portella, G., Mastronicola, M.R., Russo, A., Piccoli, R., D'Alessio, G., Vecchio, G., In vivo and in vitro growth-inhibitory effect of bovine seminal ribonuclease on a system of rat thyroid epithelial transformed cells and tumors (1992) Cancer Res, 52, pp. 4582-4586
Kotchetkov, R., Cinatl, J., Krivtchik, A.A., Vogel, J.U., Matousek, J., Pouckova, P., Kornhuber, B., Cinatl J., Jr., Selective activity of BS-RNase against anaplastic thyroid cancer (2001) Anticancer Res, 21, pp. 1035-1042
Hansen, R., Oren, M., p53
from inductive signal to cellular effect (1997) Curr Opin Genet Dev, 7, pp. 46-51
Earnshaw, W.C., Martins, L.M., Kanfmann, S.H., Mammalian caspases
structure, activation, substrates and functions during apoptosis (1999) Annu Rev Biochem, 68, pp. 383-424
an assay for the selective cytotoxicity of the enzyme (2001) Methods Enzymol, 341, pp. 248-263
Fagin, J.A., Matsuo, K., Karmakar, A., Chen, D.L., Tang, S.H., Koeffler, H.P., High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas (1993) J Clin Invest, 91, pp. 179-184
Gioanni, J., Zanghellini, E., Mazeau, C., Zhang, D., Courdi, A., Farges, M., Lambert, J.C., Schneider, M., Characterization of a human cell line from an anaplastic carcinoma of the thyroid gland (1991) Bull Cancer, 78, pp. 1053-1062
Ain, K.B., Tofiq, S., Taylor, K.D., Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo (1996) J Clin Endocrinol Metab, 81, pp. 3650-3653
Testa, J.R., Bellacosa, A., AKT plays a central role in tumorigenesis (2001) Proc Natl Acad Sci USA, 98, pp. 10983-10985
Ringel, M.D., Hayre, N., Saito, J., Saunier, B., Schuppert, F., Burch, H., Bernet, V., Saji, M., Overexpression and overactivation of Akt in thyroid carcinoma (2001) Cancer Res, 61, pp. 6105-6111
Bruni, P., Boccia, A., Baldassarre, G., Trapasso, F., Santoro, M., Chiappetta, G., Fusco, A., Viglietto, G., PTEN expression is reduced in a subset of sporadic thyroid carcinomas: Evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1 (2000) Oncogene, 19, pp. 3146-3155
Weng, L.P., Gimm, O., Kum, J.B., Smith, W.M., Zhou, X.P., Wynford-Thomas, D., Leone, G., Eng, C., Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death (2001) Hum Mol Genet, 10, pp. 251-258
Blagosklonny, M.V., Giannakakou, P., Wojtowicz, M., Romanova, L.Y., Ain, K.B., Bates, S.E., Fojo, T., (1998) Effects of p53-expressing Adenovirus on the Chemosensitivity and Differentiation of Anaplastic Thyroid Cancer Cells, 83, pp. 2516-2522
Sellers, W.R., Fisher, D.E., Apoptosis and cancer drug targeting (1999) J Clin Invest, 104, pp. 1655-1661
Mitsiades, N., Poulaki, V., Tseleni-Balafouta, S., Koutras, D.A., Stamenkovic, I., Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive tumor necrosis factor-related apoptosis-inducing ligand (2000) Cancer Res, 60, pp. 4122-4129
Iordanov, M.S., Wong, J., Newton, D.L., Rybak, S.M., Bright, R.K., Flavell, R.A., Davis, R.J., Magun, B.E., Differential requirement for the stress-activated protein kinase/c-Jun NH2-terminal kinase in RNA damage-induced apoptosis in primary and in immortalized fibroblasts (2000) Mol Cell Biol Res Commun, 4, pp. 122-128
Youle, J. R., D'Alessio, G., Antitumor RNases (1997) Ribonucleases: Structures and Functions, pp. 491-514. , D'Alessio G, Riordan JF, eds. New York: Academic Press
Mikulski, S. M., Costanzi, J. J., Vogelzang, N. J., McCachren, S., Taub, R. N., Chun, H., Mittelman, A., Shogen, K., Phase II trial of a single weekly intravenous dose of ranpimase in patients with unresectable malignant mesothelioma (2002) J Clin Oncol, 20, pp. 274-281
Newton, D. L., Hansen, H. J., Mikulski, S. M., Goldenberg, D. M., Rybak, S. M., Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: Potential for the treatment of non-Hodgkin lymphoma (2001) Blood, 97, pp. 528-535
Mastronicola, M. R., Piccoli, R., D'Alessio, G., Key extracellular and intracellular steps in the antitumor action of seminal ribonuclease (1995) Eur J Biochem, 230, pp. 242-249
Kim, J. S., Soucek, J., Matousek, J., Raines, R. T., Mechanism of ribonuclease cytotoxicity (1995) J Biol Chem, 270, pp. 31097-31102
Murthy, B. S., De Lorenzo, C., Piccoli, R., D'Alessio, G., Sirdeshmukh, R., Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase (1996) Biochemistry, 35, pp. 3880-3885
Leland, P. A., Staniszewski, K. E., Kim, B. M., Raines, R. T., Endowing human pancreatic ribonuclease with toxicity for cancer cells (2001) J Biol Chem, 276, pp. 43095-43102
Iordanov, M. S., Ryabinina, O. P., Wong, J., Dinh, T. H., Newton, D. L., Rybak, S. M., Magun, B. E., Molecular determinants of apoptosis induced by the cytotoxic ribonuclease Onconase: Evidence for cytotoxic mechanisms different from inhibition of protein synthesis (2000) Cancer Res, 60, pp. 1983-1994
Hu, C. -C. A., Tang, C. -H. A., Wang, J. -J., Caspase activation in response to cytotoxic Rana catesbiana ribonuclease in MCF-7 cells (2001) FEBS Lett, 503, pp. 65-68
Earnshaw, W. C., Martins, L. M., Kanfmann, S. H., Mammalian caspases
Fagin, J. A., Matsuo, K., Karmakar, A., Chen, D. L., Tang, S. H., Koeffler, H. P., High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas (1993) J Clin Invest, 91, pp. 179-184
Ain, K. B., Tofiq, S., Taylor, K. D., Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo (1996) J Clin Endocrinol Metab, 81, pp. 3650-3653
Testa, J. R., Bellacosa, A., AKT plays a central role in tumorigenesis (2001) Proc Natl Acad Sci USA, 98, pp. 10983-10985
Ringel, M. D., Hayre, N., Saito, J., Saunier, B., Schuppert, F., Burch, H., Bernet, V., Saji, M., Overexpression and overactivation of Akt in thyroid carcinoma (2001) Cancer Res, 61, pp. 6105-6111
Weng, L. P., Gimm, O., Kum, J. B., Smith, W. M., Zhou, X. P., Wynford-Thomas, D., Leone, G., Eng, C., Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death (2001) Hum Mol Genet, 10, pp. 251-258
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Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis
Bovine seminal ribonuclease ( BS- RNase), a natural dimeric homolog of bovine pancreatic RNase ( RNase A), and HHP2-RNase, an engineered dimeric form of human pancreatic RNase ( HP- RNase), are endowed with powerful antitumor effects. Here we show that BS- and HHP2- RNases, but not monomeric RNase A, induce apoptosis of human thyroid carcinoma cell lines. RNase- induced apoptosis was associated with activation of initiation caspase- 8 and - 9. This was followed by activation of executioner caspase- 3, leading to the proteolytic cleavage of poly( ADP- ribose) polymerase. The caspase inhibitor Z- Val- Ala- Asp-( OMe)- fluoromethylketone protected thyroid cancer cells from BS- RNase- induced apoptosis. RNase- triggered apoptosis and caspase activation were accompanied by reduced phosphorylation of Akt/ protein kinase B ( PKB), a serine- threonine kinase that when phosphorylated is able to deliver survival signals to cancer cells. BS- RNase antitumor effects in nude mice were accompanied by caspase activation and apoptosis. Because of the high selectivity of apoptotic effects for malignant cells, BS- and HHP2- RNase are promising tools for the treatment of aggressive thyroid cancer.
Bovine seminal ribonuclease ( BS- RNase), a natural dimeric homolog of bovine pancreatic RNase ( RNase A), and HHP2-RNase, an engineered dimeric form of human pancreatic RNase ( HP- RNase), are endowed with powerful antitumor effects. Here we show that BS- and HHP2- RNases, but not monomeric RNase A, induce apoptosis of human thyroid carcinoma cell lines. RNase- induced apoptosis was associated with activation of initiation caspase- 8 and - 9. This was followed by activation of executioner caspase- 3, leading to the proteolytic cleavage of poly( ADP- ribose) polymerase. The caspase inhibitor Z- Val- Ala- Asp-( OMe)- fluoromethylketone protected thyroid cancer cells from BS- RNase- induced apoptosis. RNase- triggered apoptosis and caspase activation were accompanied by reduced phosphorylation of Akt/ protein kinase B ( PKB), a serine- threonine kinase that when phosphorylated is able to deliver survival signals to cancer cells. BS- RNase antitumor effects in nude mice were accompanied by caspase activation and apoptosis. Because of the high selectivity of apoptotic effects for malignant cells, BS- and HHP2- RNase are promising tools for the treatment of aggressive thyroid cancer.
Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis
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Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis
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Magrì A, Tabbì G, Breglia R, De Gioia L, Fantucci P, Bruschi M, Bonomo RP, La Mendola D
* Copper ion interaction with the RNase catalytic site fragment of the angiogenin protein: an experimental and theoretical investigation (389 views) (PDF 179 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2017 Jul 04; 46(26): 8524-8538.
Impact Factor: 4.099
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Picone D, Donnarumma F, Ferraro G, Russo Krauss I, Fagagnini A, Gotte G, Merlino A
* Platinated oligomers of bovine pancreatic ribonuclease: Structure and stability (414 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 146: 37-43.
Impact Factor: 3.205
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Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
* Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound (340 views)
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Impact Factor: 3.585
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Russo E, Guerra A, Marotta V, Faggiano A, Colao A, Del Vecchio S, Tonacchera M, Vitale M
* Radioiodide induces apoptosis in human thyroid tissue in culture (363 views)
Endocrine (ISSN: 1355-008x, 1355-008xlinking), 2013 Dec; 44(3): 729-734.
Impact Factor: 3.527
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Sica F, Pica A, Merlino A, Russo Krauss I, Ercole C, Picone D
* The multiple forms of bovine seminal ribonuclease: Structure and stability of a C-terminal swapped dimer (328 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013 Nov 29; 587(23): 3755-3762.
Impact Factor: 3.341
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Vergara A, Russo Krauss I, Montesarchio D, Paduano L, Merlino A
* Investigating the Ruthenium Metalation of Proteins: X-ray Structure and Raman Microspectroscopy of the Complex between RNase A and AziRu (309 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2013 Oct 7; 52(19): 10714-10716.
Impact Factor: 4.794
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Pica A, Merlino A, Buell AK, Knowles TJ, Pizzo E, D'Alessio G, Sica F, Mazzarella L
* Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase (961 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Oct; 69: 2116-2123.
Impact Factor: 7.232
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (425 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
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Merlino A, Picone D, Ercole C, Balsamo A, Sica F
* Chain termini cross-talk in the swapping process of bovine pancreatic ribonuclease (284 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 May; 94(5): 1108-1118.
Impact Factor: 3.142
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La Mendola D, Farkas D, Bellia F, Magri A, Travaglia A, Hansson O, Rizzarelli E
* Probing the copper(II) binding features of angiogenin. Similarities and differences between a N-terminus peptide fragment and the recombinant human protein (469 views)
Inorg Chem (ISSN: 1520-510x, 0020-1669, 1520-510xelectronic), 2012 Jan 2; 51(1): 128-141.
Impact Factor: 4.593
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D'Errico G, Ercole C, Lista M, Pizzo E, Falanga A, Galdiero S, Spadaccini R, Picone D
* Enforcing the positive charge of N-termini enhances membrane interaction and antitumor activity of bovine seminal ribonuclease (556 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Dec; 1808(12): 3007-3015.
Impact Factor: 3.99
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (448 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
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Merlino A, Russo Krauss I, Perillo M, Mattia CA, Ercole C, Picone D, Vergara A, Sica F
* Toward an Antitumor Form of Bovine Pancreatic Ribonuclease: The Crystal Structure of Three Noncovalent Dimeric Mutants (399 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1029-1037.
Impact Factor: 2.605
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Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (354 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
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Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F
* The buried diversity of bovine seminal ribonuclease: Shape and cytotoxicity of the swapped non-covalent form of the enzyme (546 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2008 Feb 15; 376(2): 427-437.
Impact Factor: 4.146
View Export to BibTeX Export to EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (679 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Picone D, Di Fiore A, Ercole C, Franzese M, Sica F, Tomaselli S, Mazzarella L
* The role of the hinge loop in domain swapping - The special case of bovine seminal ribonuclease (376 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Apr 8; 280(14): 13771-13778.
Impact Factor: 5.854
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Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (524 views)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
View Export to BibTeX Export to EndNote
Esposito L, Daggett V
* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (446 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
Impact Factor: 3.848
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Merlino A, Ceruso MA, Vitagliano L, Mazzarella L
* Open interface and large quaternary structure movements in 3D domain swapped proteins: Insights from molecular dynamics simulations of the C-terminal swapped dimer of ribonuclease (603 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2005 Mar; 88(3): 2003-2012.
Impact Factor: 4.507
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Sica F, Di Fiore A, Merlino A, Mazzarella L
* Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (443 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Sep 27; 279(35): 36753-36760.
Impact Factor: 6.355
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Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L
* Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer (385 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 689-695.
Impact Factor: 2.863
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Berisio R, Sica F, De Lorenzo C, Di Fiore A, Piccoli R, Zagari A, Mazzarella L
* Crystal Structure Of The Dimeric Un-Swapped Form Of Bovine Seminal Ribonuclease (384 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Nov 6; 554(1-2): 105-110.
Impact Factor: 3.609
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Sica F, Di Fiore A, Zagari A, Mazzarella L
* The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative (355 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2003 Sep 1; 52(2): 263-271.
Impact Factor: 4.313
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Berisio R, Sica F, Lamzin VS, Wilson KS, Zagari A, Mazzarella L
* Atomic resolution structures of ribonuclease A at six pH values (634 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2002; 58(3): 441-450.
Impact Factor: 1.76
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Esposito L, Vitagliano L, Sica F, Sorrentino G, Zagari A, Mazzarella L
The ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: Hydration and sterochemical analysis (713 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Mar 31; 297(3): 713-732.
Impact Factor: 5.388
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Vitagliano L, Adinolfi S, Sica F, Merlino A, Zagari A, Mazzarella L
A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease (384 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Oct 29; 293(3): 569-577.
Impact Factor: 5.501
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Sica F, Adinolfi S, Berisio R, De Lorenzo C, Mazzarella L, Piccoli R, Vitagliano L, Zagari A
Crystallization of multiple forms of bovine seminal ribonuclease in the liganded and unliganded state (282 views)
J Cryst Growth (ISSN: 0022-0248), 1999; 196(2-4): 305-312.
Impact Factor: 1.492
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Vitagliano L, Adinolfi S, Riccio A, Sica F, Zagari A, Mazzarella L
Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2 ', 5 ')adenosine (465 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1998 Sep; 7(8): 1691-1699.
Impact Factor: 4.44
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Sica F, Adinolfi S, Vitagliano L, Zagari A, Capasso S, Mazzarella L
Cosolute effect on crystallization of two dinucleotide complexes of bovine seminal ribonuclease from concentrated salt solutions (294 views)
J Cryst Growth (ISSN: 0022-0248), 1996; 168(1-4): 192-197.
Impact Factor: 1.259
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Capasso S, Di Donato A, Esposito L, Sica F, Sorrentino G, Vitagliano L, Zagari A, Mazzarella L
Deamidation in proteins: The crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67 (488 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1996; 257(3): 492-496.
Impact Factor: 5.673
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* Copper ion interaction with the RNase catalytic site fragment of the angiogenin protein: an experimental and theoretical investigation (389 views) (PDF 179 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2017 Jul 04; 46(26): 8524-8538.
Impact Factor: 4.099
View Export to BibTeX Export to EndNote
Picone D, Donnarumma F, Ferraro G, Russo Krauss I, Fagagnini A, Gotte G, Merlino A
* Platinated oligomers of bovine pancreatic ribonuclease: Structure and stability (414 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 146: 37-43.
Impact Factor: 3.205
View Export to BibTeX Export to EndNote
Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
* Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound (340 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014; 6(2): 233-236.
Impact Factor: 3.585
View Export to BibTeX Export to EndNote
Russo E, Guerra A, Marotta V, Faggiano A, Colao A, Del Vecchio S, Tonacchera M, Vitale M
* Radioiodide induces apoptosis in human thyroid tissue in culture (363 views)
Endocrine (ISSN: 1355-008x, 1355-008xlinking), 2013 Dec; 44(3): 729-734.
Impact Factor: 3.527
View Export to BibTeX Export to EndNote
Sica F, Pica A, Merlino A, Russo Krauss I, Ercole C, Picone D
* The multiple forms of bovine seminal ribonuclease: Structure and stability of a C-terminal swapped dimer (328 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013 Nov 29; 587(23): 3755-3762.
Impact Factor: 3.341
View Export to BibTeX Export to EndNote
Vergara A, Russo Krauss I, Montesarchio D, Paduano L, Merlino A
* Investigating the Ruthenium Metalation of Proteins: X-ray Structure and Raman Microspectroscopy of the Complex between RNase A and AziRu (309 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2013 Oct 7; 52(19): 10714-10716.
Impact Factor: 4.794
View Export to BibTeX Export to EndNote
Pica A, Merlino A, Buell AK, Knowles TJ, Pizzo E, D'Alessio G, Sica F, Mazzarella L
* Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase (961 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Oct; 69: 2116-2123.
Impact Factor: 7.232
View Export to BibTeX Export to EndNote
Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (425 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
View Export to BibTeX Export to EndNote
Merlino A, Picone D, Ercole C, Balsamo A, Sica F
* Chain termini cross-talk in the swapping process of bovine pancreatic ribonuclease (284 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 May; 94(5): 1108-1118.
Impact Factor: 3.142
View Export to BibTeX Export to EndNote
La Mendola D, Farkas D, Bellia F, Magri A, Travaglia A, Hansson O, Rizzarelli E
* Probing the copper(II) binding features of angiogenin. Similarities and differences between a N-terminus peptide fragment and the recombinant human protein (469 views)
Inorg Chem (ISSN: 1520-510x, 0020-1669, 1520-510xelectronic), 2012 Jan 2; 51(1): 128-141.
Impact Factor: 4.593
View Export to BibTeX Export to EndNote
D'Errico G, Ercole C, Lista M, Pizzo E, Falanga A, Galdiero S, Spadaccini R, Picone D
* Enforcing the positive charge of N-termini enhances membrane interaction and antitumor activity of bovine seminal ribonuclease (556 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Dec; 1808(12): 3007-3015.
Impact Factor: 3.99
View Export to BibTeX Export to EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (448 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Merlino A, Russo Krauss I, Perillo M, Mattia CA, Ercole C, Picone D, Vergara A, Sica F
* Toward an Antitumor Form of Bovine Pancreatic Ribonuclease: The Crystal Structure of Three Noncovalent Dimeric Mutants (399 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1029-1037.
Impact Factor: 2.605
View Export to BibTeX Export to EndNote
Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (354 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
View Export to BibTeX Export to EndNote
Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F
* The buried diversity of bovine seminal ribonuclease: Shape and cytotoxicity of the swapped non-covalent form of the enzyme (546 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2008 Feb 15; 376(2): 427-437.
Impact Factor: 4.146
View Export to BibTeX Export to EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (679 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
View Export to BibTeX Export to EndNote
Picone D, Di Fiore A, Ercole C, Franzese M, Sica F, Tomaselli S, Mazzarella L
* The role of the hinge loop in domain swapping - The special case of bovine seminal ribonuclease (376 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Apr 8; 280(14): 13771-13778.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (524 views)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
View Export to BibTeX Export to EndNote
Esposito L, Daggett V
* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (446 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
Impact Factor: 3.848
View Export to BibTeX Export to EndNote
Merlino A, Ceruso MA, Vitagliano L, Mazzarella L
* Open interface and large quaternary structure movements in 3D domain swapped proteins: Insights from molecular dynamics simulations of the C-terminal swapped dimer of ribonuclease (603 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2005 Mar; 88(3): 2003-2012.
Impact Factor: 4.507
View Export to BibTeX Export to EndNote
Sica F, Di Fiore A, Merlino A, Mazzarella L
* Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (443 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Sep 27; 279(35): 36753-36760.
Impact Factor: 6.355
View Export to BibTeX Export to EndNote
Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L
* Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer (385 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 689-695.
Impact Factor: 2.863
View Export to BibTeX Export to EndNote
Berisio R, Sica F, De Lorenzo C, Di Fiore A, Piccoli R, Zagari A, Mazzarella L
* Crystal Structure Of The Dimeric Un-Swapped Form Of Bovine Seminal Ribonuclease (384 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Nov 6; 554(1-2): 105-110.
Impact Factor: 3.609
View Export to BibTeX Export to EndNote
Sica F, Di Fiore A, Zagari A, Mazzarella L
* The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative (355 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2003 Sep 1; 52(2): 263-271.
Impact Factor: 4.313
View Export to BibTeX Export to EndNote
Berisio R, Sica F, Lamzin VS, Wilson KS, Zagari A, Mazzarella L
* Atomic resolution structures of ribonuclease A at six pH values (634 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2002; 58(3): 441-450.
Impact Factor: 1.76
View Export to BibTeX Export to EndNote
Esposito L, Vitagliano L, Sica F, Sorrentino G, Zagari A, Mazzarella L
The ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: Hydration and sterochemical analysis (713 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Mar 31; 297(3): 713-732.
Impact Factor: 5.388
View Export to BibTeX Export to EndNote
Vitagliano L, Adinolfi S, Sica F, Merlino A, Zagari A, Mazzarella L
A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease (384 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Oct 29; 293(3): 569-577.
Impact Factor: 5.501
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Sica F, Adinolfi S, Berisio R, De Lorenzo C, Mazzarella L, Piccoli R, Vitagliano L, Zagari A
Crystallization of multiple forms of bovine seminal ribonuclease in the liganded and unliganded state (282 views)
J Cryst Growth (ISSN: 0022-0248), 1999; 196(2-4): 305-312.
Impact Factor: 1.492
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Vitagliano L, Adinolfi S, Riccio A, Sica F, Zagari A, Mazzarella L
Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2 ', 5 ')adenosine (465 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1998 Sep; 7(8): 1691-1699.
Impact Factor: 4.44
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Sica F, Adinolfi S, Vitagliano L, Zagari A, Capasso S, Mazzarella L
Cosolute effect on crystallization of two dinucleotide complexes of bovine seminal ribonuclease from concentrated salt solutions (294 views)
J Cryst Growth (ISSN: 0022-0248), 1996; 168(1-4): 192-197.
Impact Factor: 1.259
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Capasso S, Di Donato A, Esposito L, Sica F, Sorrentino G, Vitagliano L, Zagari A, Mazzarella L
Deamidation in proteins: The crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67 (488 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1996; 257(3): 492-496.
Impact Factor: 5.673
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32 Records (31 excluding Abstracts).
Total impact factor: 126.186 (121.972 excluding Abstracts).
Total 5 year impact factor: 128.218 (123.96 excluding Abstracts).
Total impact factor: 126.186 (121.972 excluding Abstracts).
Total 5 year impact factor: 128.218 (123.96 excluding Abstracts).
393 views. Last view on Thursday 27 April 2023, 21:00:14
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