A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats (658 views)
J Neurosci (ISSN: 0270-6474, 0270-0647, 1529-2401), 2008 Mar 12; 28(11): 2698-2709.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.452, 5-year impact factor: 8.122
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-40849083920&partnerID=40&md5=e9aed0b257c9894870e1f81dce18974b
Keywords: Bioactive Peptides, Gliosis, Neuropathic Pain, Nmr Structure, Agents Interacting With Transmitter, Hormone Or Drug Receptors, Brain Derived Neurotrophic Factor Receptor, Nerve Growth Factor Agonist, Protein L1l4, Protein Nl1l4, Protein Tyrosine Kinase A, Unclassified Drug, Amino Terminal Sequence, Animal Cell, Article, Cell Proliferation, Controlled Study, Fibroblast, Human, Human Cell, Nonhuman, Nuclear Magnetic Resonance, Peripheral Neuropathy, Priority Journal, Protein Phosphorylation, Protein Structure, Protein Synthesis, Biomimetic Materials, Cultured, Chick Embryo, Pain Measurement, Pc12 Cells, Peripheral Nervous System Diseases, Sprague-Dawley, Sciatic Neuropathy,
Affiliations:
*** IBB - CNR ***
Laboratorio di Neuroscienze R. Levi-Montalcini, Dipartimento di Biotecnologie e Bioscienze, Universit di Milano-Bicocca, 20126 Milan, Italy
Laboratorio di Morfologia Delle Reti Neuronali, Dipartimento di Medicina Pubblica Clinica e Preventiva, Seconda Universit di Napoli, 80138 Naples, Italy
Centro Interuniversitario di Ricerca Sui Peptidi Bioattivi, Dipartimento Delle Scienze Biologiche, Consiglio Nazionale Delle Ricerche, 80138 Naples, Italy
Primm Srl, 20132 Milan, Italy
Primm Srl, Via Olgettina 58, 20132 Milan, Italy
References:
Progress in brain research (2004) NGF and related molecules in health and diseases, 146. , Aloe L, Calz L eds, Amsterdam: Elsevie
Apfel, S. C., Nerve growth factor for the treatment of diabetic neuropathy: What went wrong, what went right, and what does the future hold? (2002) Int Rev Neurobiol, 50, pp. 393-413
Bai, Y. H., Takemitsu, M., Atsuta, Y., Matsuno, T., Peripheral mononeuropathy induced by loose ligation of the sciatic nerve in the rat: Behavioral, electrophysiological and histopathologic studies (1999) Exp Anim, 48, pp. 87-94
Bartels, C., Xia, T., Billeter, M., G ntert, P., W thrich, K., The program XEASY for computer-supported NMR spectral analysis of biological macromolecules (1995) J Biomol NMR, 5, pp. 1-10
Bennet, G. J., Xie, Y. K., A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man (1998) Pain, 33, pp. 87-107
Bradshaw, R. A., Murray-Rust, J., Ib nez, C. F., McDonald, N. Q., Lapatto, R., Blundell, T. L., Nerve growth factor: Structure/function relationship (1994) Protein Sci, 3, pp. 1901-1913
Bruno, M. A., Clarke, P. B., Seltzer, A., Quirion, R., Burgess, K., Cuello, A. C., Saragovi, H. U., Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA (2004) J Neurosci, 24, pp. 8009-8018
Cahill, C. M., Dray, A., Coderre, T. J., Intrathecal nerve growth factor restores opioid effectiveness in an animal model of neuropathic pain (2003) Neuropharmacology, 45, pp. 543-552
Chao, M. V., Neurotrophins and their receptors: A convergence point for many signalling pathways (2003) Nat Rev Neurosci, 4, pp. 299-309
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., Yaksh, T. L., Quantitative assessment of tactile allodynia in the rat paw (1994) J Neurosci Methods, 53, pp. 55-63
Coderre, T. J., Contribution of protein kinase C to central sensitization and persistent pain following tissue injury (1992) Neurosci Lett, 140, pp. 181-184
Colangelo, A. M., Finotti, N., Ceriani, M., Alberghina, L., Martegani, E., Aloe, L., Lenzi, L., Levi-Montalcini, R., Recombinant human nerve growth factor with a marked activity in vitro and in vivo (2005) Proc Natl Acad Sci USA, 102, pp. 18658-18663
Davies, A. M., Thoenen, H., Barde, Y. A., The response of chick sensory neurons to brain-derived neurotrophic factor (1986) J Neurosci, 6, pp. 1897-1904
Drinkwater, C. C., Barker, P. A., Suter, U., Shooter, E. M., The carboxyl terminus of nerve growth factor is required for biological activity (1993) J Biol Chem, 268, pp. 23202-23207
Gold, B. G., Mobley, W. C., Matheson, S. F., Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor (1991) J Neurosci, 11, pp. 943-955
Greene, L. A., Tischler, A. S., Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor (1976) Proc Natl Acad Sci USA, 73, pp. 2424-2428
Griesinger, C., Otting, G., Wuthrich, K., Ernst, R. R., Clean tocsy for H-1 spin system-identification in macromolecules (1988) J Am Chem Soc, 110, pp. 7870-7872
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Herrmann, T., G ntert, P., W thrich, K., Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA (2000) J Mol Biol, 319, pp. 209-227
Huang, E. J., Reichardt, L. F., Trk receptors: Roles in neuronal signal transduction (2003) Annu Rev Biochem, 72, pp. 609-642
Ib nez, C. F., Ebendal, T., Barbany, G., Murray-Rust, J., Blundell, T. L., Persson, H., Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product (1992) Cell, 69, pp. 329-341
Ji, R. R., Strichartz, G., Cell signaling and the genesis of neuropathic pain (2004) Sci STKE, 252, pp. reE14
Jullien, J., Guili, V., Reichardt, L. F., Rudkin, B. B., Molecular kinetics of nerve growth factor receptor trafficking and activation (2002) J Biol Chem, 277, pp. 38700-38708
Kahle, P., Burton, L. E., Schmelzer, C. H., Hertel, C., The amino terminus of nerve growth factor is involved in the interaction with the receptor tyrosine kinase p140trkA (1992) J Biol Chem, 267, pp. 22707-22710
Kr ttgen, A., Heymach, J. V., Kahle, P. J., Shooter, E. M., The role of the nerve growth factor carboxyl terminus in receptor binding and conformational stability (1997) J Biol Chem, 272, pp. 29222-29228
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Ryd n, M., Ib ez, C. F., A second determinant of binding to the p75 neurotrophin receptor revealed by Alanine-Scanning mutagenesis of a conserved loop in nerve growth factor (1997) J Biol Chem, 272, pp. 33085-33091
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Williams, B. J., Eriksdotte-Jonhagen, M., Granholm, A. C., Nerve growth factor in treatment and pathogenesis of Alzheimer's disease (2006) Prog Neurobiol, 80, pp. 114-128
Woo, S. B., Timm, D. E., Neet, K. E., Alteration of NH2-terminal residues of nerve growth factor affects activity and Trk binding without affecting stability or conformation (1995) J Biol Chem, 270, pp. 6278-6285
Xie, Y., Tisi, M. A., Yeo, T. T., Longo, F. M., Nerve growth factor (NGF) loop 4 dimeric mimetics activate ERK and AKT and promote NGF-like neurotrophic effects (2000) J Biol Chem, 275, pp. 29868-29874
Apfel, S.C., Nerve growth factor for the treatment of diabetic neuropathy: What went wrong, what went right, and what does the future hold? (2002) Int Rev Neurobiol, 50, pp. 393-413
Bai, Y.H., Takemitsu, M., Atsuta, Y., Matsuno, T., Peripheral mononeuropathy induced by loose ligation of the sciatic nerve in the rat: Behavioral, electrophysiological and histopathologic studies (1999) Exp Anim, 48, pp. 87-94
Bennet, G.J., Xie, Y.K., A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man (1998) Pain, 33, pp. 87-107
Bradshaw, R.A., Murray-Rust, J., Ibànez, C.F., McDonald, N.Q., Lapatto, R., Blundell, T.L., Nerve growth factor: Structure/function relationship (1994) Protein Sci, 3, pp. 1901-1913
Bruno, M.A., Clarke, P.B., Seltzer, A., Quirion, R., Burgess, K., Cuello, A.C., Saragovi, H.U., Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA (2004) J Neurosci, 24, pp. 8009-8018
Cahill, C.M., Dray, A., Coderre, T.J., Intrathecal nerve growth factor restores opioid effectiveness in an animal model of neuropathic pain (2003) Neuropharmacology, 45, pp. 543-552
Chao, M.V., Neurotrophins and their receptors: A convergence point for many signalling pathways (2003) Nat Rev Neurosci, 4, pp. 299-309
Chaplan, S.R., Bach, F.W., Pogrel, J.W., Chung, J.M., Yaksh, T.L., Quantitative assessment of tactile allodynia in the rat paw (1994) J Neurosci Methods, 53, pp. 55-63
Coderre, T.J., Contribution of protein kinase C to central sensitization and persistent pain following tissue injury (1992) Neurosci Lett, 140, pp. 181-184
Colangelo, A.M., Finotti, N., Ceriani, M., Alberghina, L., Martegani, E., Aloe, L., Lenzi, L., Levi-Montalcini, R., Recombinant human nerve growth factor with a marked activity in vitro and in vivo (2005) Proc Natl Acad Sci USA, 102, pp. 18658-18663
Davies, A.M., Thoenen, H., Barde, Y.A., The response of chick sensory neurons to brain-derived neurotrophic factor (1986) J Neurosci, 6, pp. 1897-1904
Drinkwater, C.C., Barker, P.A., Suter, U., Shooter, E.M., The carboxyl terminus of nerve growth factor is required for biological activity (1993) J Biol Chem, 268, pp. 23202-23207
Gold, B.G., Mobley, W.C., Matheson, S.F., Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor (1991) J Neurosci, 11, pp. 943-955
Greene, L.A., Tischler, A.S., Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor (1976) Proc Natl Acad Sci USA, 73, pp. 2424-2428
Hempstead, B.L., Rabin, S.J., Kaplan, L., Reid, S., Parada, L.F., Kaplan, D.R., Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation (1992) Neuron, 9, pp. 883-896
Herrmann, T., Güntert, P., Wüthrich, K., Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA (2000) J Mol Biol, 319, pp. 209-227
Huang, E.J., Reichardt, L.F., Trk receptors: Roles in neuronal signal transduction (2003) Annu Rev Biochem, 72, pp. 609-642
Ibànez, C.F., Ebendal, T., Barbany, G., Murray-Rust, J., Blundell, T.L., Persson, H., Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product (1992) Cell, 69, pp. 329-341
Ji, R.R., Strichartz, G., Cell signaling and the genesis of neuropathic pain (2004) Sci STKE, 252, pp. reE14
Krüttgen, A., Heymach, J.V., Kahle, P.J., Shooter, E.M., The role of the nerve growth factor carboxyl terminus in receptor binding and conformational stability (1997) J Biol Chem, 272, pp. 29222-29228
Lobsiger, C.S., Cleveland, D.W., Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease (2007) Nat Neurosci, 10, pp. 1355-1360
Longo, F.M., Vu, T.K., Mobley, W.C., The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides (1990) Cell Regul, 1, pp. 189-195
Longo, F.M., Manthorpe, M., Xie, Y.M., Varon, S., Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism (1997) J Neurosci Res, 48, pp. 1-17
Marini, A.M., Rabin, S.J., Lipsky, R.H., Mocchetti, I., Activity-dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-methyl-D-aspartate (1998) J Biol Chem, 273, pp. 29394-29399
McDonald, N.Q., Chao, M.V., Structural determinants of neurotrophin action (1995) J Biol Chem, 270, pp. 19669-19672
McMahon, S.B., Bennet, D.L., Bevan, S., Inflammatory mediators and modulators (2006) Text-book of pain, pp. 49-72. , McMahon SB, Koltzenburg M, eds, pp, London: Elsevier
Poduslo, J.F., Curran, G.L., Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF (1996) Mol Brain Res, 36, pp. 280-286
Ro, L.S., Chen, S.T., Tang, L.M., Jacobs, J.M., Effect of NGF and anti-NGF on neuropathic pain in rats following chronic constriction injury of the sciatic nerve (1999) Pain, 79, pp. 265-274
Rydén, M., Ibàñez, C.F., A second determinant of binding to the p75 neurotrophin receptor revealed by Alanine-Scanning mutagenesis of a conserved loop in nerve growth factor (1997) J Biol Chem, 272, pp. 33085-33091
Sah, D.W., Ossipo, M.H., Porreca, F., Neurotrophic factors as novel therapeutics for neuropathic pain (2003) Nat Rev Drug Discov, 2, pp. 460-472
Song, P., Zhao, Z.Q., The involvement of glial cells in the development of morphine tolerance (2001) Neurosci Res, 39, pp. 281-286
Wild, K.D., Bian, D., Zhu, D., Davis, J., Bannon, A.W., Zhang, T.J., Louis, J.C., Antibodies to nerve growth factor reverse established tactile allodynia in rodent models of neuropathic pain without tolerance (2007) J Pharmacol Exp Ther, 322, pp. 282-287
Williams, B.J., Eriksdotte-Jonhagen, M., Granholm, A.C., Nerve growth factor in treatment and pathogenesis of Alzheimer's disease (2006) Prog Neurobiol, 80, pp. 114-128
Woo, S.B., Timm, D.E., Neet, K.E., Alteration of NH2-terminal residues of nerve growth factor affects activity and Trk binding without affecting stability or conformation (1995) J Biol Chem, 270, pp. 6278-6285
Xie, Y., Tisi, M.A., Yeo, T.T., Longo, F.M., Nerve growth factor (NGF) loop 4 dimeric mimetics activate ERK and AKT and promote NGF-like neurotrophic effects (2000) J Biol Chem, 275, pp. 29868-29874
J Neurosci (ISSN: 0270-6474, 0270-0647, 1529-2401), 2008 Mar 12; 28(11): 2698-2709.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.452, 5-year impact factor: 8.122
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-40849083920&partnerID=40&md5=e9aed0b257c9894870e1f81dce18974b
Keywords: Bioactive Peptides, Gliosis, Neuropathic Pain, Nmr Structure, Agents Interacting With Transmitter, Hormone Or Drug Receptors, Brain Derived Neurotrophic Factor Receptor, Nerve Growth Factor Agonist, Protein L1l4, Protein Nl1l4, Protein Tyrosine Kinase A, Unclassified Drug, Amino Terminal Sequence, Animal Cell, Article, Cell Proliferation, Controlled Study, Fibroblast, Human, Human Cell, Nonhuman, Nuclear Magnetic Resonance, Peripheral Neuropathy, Priority Journal, Protein Phosphorylation, Protein Structure, Protein Synthesis, Biomimetic Materials, Cultured, Chick Embryo, Pain Measurement, Pc12 Cells, Peripheral Nervous System Diseases, Sprague-Dawley, Sciatic Neuropathy,
Affiliations:
*** IBB - CNR ***
Laboratorio di Neuroscienze R. Levi-Montalcini, Dipartimento di Biotecnologie e Bioscienze, Universit di Milano-Bicocca, 20126 Milan, Italy
Laboratorio di Morfologia Delle Reti Neuronali, Dipartimento di Medicina Pubblica Clinica e Preventiva, Seconda Universit di Napoli, 80138 Naples, Italy
Centro Interuniversitario di Ricerca Sui Peptidi Bioattivi, Dipartimento Delle Scienze Biologiche, Consiglio Nazionale Delle Ricerche, 80138 Naples, Italy
Primm Srl, 20132 Milan, Italy
Primm Srl, Via Olgettina 58, 20132 Milan, Italy
References:
Progress in brain research (2004) NGF and related molecules in health and diseases, 146. , Aloe L, Calz L eds, Amsterdam: Elsevie
Apfel, S. C., Nerve growth factor for the treatment of diabetic neuropathy: What went wrong, what went right, and what does the future hold? (2002) Int Rev Neurobiol, 50, pp. 393-413
Bai, Y. H., Takemitsu, M., Atsuta, Y., Matsuno, T., Peripheral mononeuropathy induced by loose ligation of the sciatic nerve in the rat: Behavioral, electrophysiological and histopathologic studies (1999) Exp Anim, 48, pp. 87-94
Bartels, C., Xia, T., Billeter, M., G ntert, P., W thrich, K., The program XEASY for computer-supported NMR spectral analysis of biological macromolecules (1995) J Biomol NMR, 5, pp. 1-10
Bennet, G. J., Xie, Y. K., A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man (1998) Pain, 33, pp. 87-107
Bradshaw, R. A., Murray-Rust, J., Ib nez, C. F., McDonald, N. Q., Lapatto, R., Blundell, T. L., Nerve growth factor: Structure/function relationship (1994) Protein Sci, 3, pp. 1901-1913
Bruno, M. A., Clarke, P. B., Seltzer, A., Quirion, R., Burgess, K., Cuello, A. C., Saragovi, H. U., Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA (2004) J Neurosci, 24, pp. 8009-8018
Cahill, C. M., Dray, A., Coderre, T. J., Intrathecal nerve growth factor restores opioid effectiveness in an animal model of neuropathic pain (2003) Neuropharmacology, 45, pp. 543-552
Chao, M. V., Neurotrophins and their receptors: A convergence point for many signalling pathways (2003) Nat Rev Neurosci, 4, pp. 299-309
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., Yaksh, T. L., Quantitative assessment of tactile allodynia in the rat paw (1994) J Neurosci Methods, 53, pp. 55-63
Coderre, T. J., Contribution of protein kinase C to central sensitization and persistent pain following tissue injury (1992) Neurosci Lett, 140, pp. 181-184
Colangelo, A. M., Finotti, N., Ceriani, M., Alberghina, L., Martegani, E., Aloe, L., Lenzi, L., Levi-Montalcini, R., Recombinant human nerve growth factor with a marked activity in vitro and in vivo (2005) Proc Natl Acad Sci USA, 102, pp. 18658-18663
Davies, A. M., Thoenen, H., Barde, Y. A., The response of chick sensory neurons to brain-derived neurotrophic factor (1986) J Neurosci, 6, pp. 1897-1904
Drinkwater, C. C., Barker, P. A., Suter, U., Shooter, E. M., The carboxyl terminus of nerve growth factor is required for biological activity (1993) J Biol Chem, 268, pp. 23202-23207
Gold, B. G., Mobley, W. C., Matheson, S. F., Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor (1991) J Neurosci, 11, pp. 943-955
Greene, L. A., Tischler, A. S., Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor (1976) Proc Natl Acad Sci USA, 73, pp. 2424-2428
Griesinger, C., Otting, G., Wuthrich, K., Ernst, R. R., Clean tocsy for H-1 spin system-identification in macromolecules (1988) J Am Chem Soc, 110, pp. 7870-7872
Guex, N., Peitsch, M. C., SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling (1997) Electrophoresis, 18, pp. 2714-2723
Guntert, P., Wider, G., Wuthrich, K., Processing of multidimensional NMR data with the new software prosa (1992) J Biomol NMR, 2, pp. 619-629
Hargreaves, K., Dubner, R., Brown, F., Flores, C., Joris, J., A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia (1988) Pain, 32, pp. 77-88
Hempstead, B. L., Rabin, S. J., Kaplan, L., Reid, S., Parada, L. F., Kaplan, D. R., Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation (1992) Neuron, 9, pp. 883-896
Herrmann, T., G ntert, P., W thrich, K., Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA (2000) J Mol Biol, 319, pp. 209-227
Huang, E. J., Reichardt, L. F., Trk receptors: Roles in neuronal signal transduction (2003) Annu Rev Biochem, 72, pp. 609-642
Ib nez, C. F., Ebendal, T., Barbany, G., Murray-Rust, J., Blundell, T. L., Persson, H., Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product (1992) Cell, 69, pp. 329-341
Ji, R. R., Strichartz, G., Cell signaling and the genesis of neuropathic pain (2004) Sci STKE, 252, pp. reE14
Jullien, J., Guili, V., Reichardt, L. F., Rudkin, B. B., Molecular kinetics of nerve growth factor receptor trafficking and activation (2002) J Biol Chem, 277, pp. 38700-38708
Kahle, P., Burton, L. E., Schmelzer, C. H., Hertel, C., The amino terminus of nerve growth factor is involved in the interaction with the receptor tyrosine kinase p140trkA (1992) J Biol Chem, 267, pp. 22707-22710
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A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats
Analysis of the structure of nerve growth factor (NGF) -tyrosine kinase receptor A (TrkA) complex, site-directed mutagenesis studies and results from chemical modification of amino acid residues have identified loop 1, loop 4, and the N-terminal region of the NGF molecule as the most relevant for its biological activity. We synthesized several peptides mimicking the two loops (1 and 4) linked together with an appropriate spacer, with or without the N-terminal region. Two peptides named NL1L4 and L1L4 demonstrated good NGF agonist activity at a concentration as low as 3 M. They induced differentiation of chick dorsal root ganglia and stimulated tyrosine phosphorylation of TrkA, but not TrkB, receptor. In addition L1L4 was able to induce differentiation of PC12 cells. More interestingly, the peptide with the highest "in vitro" activity (L1L4) was shown to reduce neuropathic behavior and restore neuronal function in a rat model of peripheral neuropathic pain, thereby suggesting a potential therapeutic role for this NGF-mimetic peptide. Copyright 2008 Society for Neuroscience
Analysis of the structure of nerve growth factor (NGF) -tyrosine kinase receptor A (TrkA) complex, site-directed mutagenesis studies and results from chemical modification of amino acid residues have identified loop 1, loop 4, and the N-terminal region of the NGF molecule as the most relevant for its biological activity. We synthesized several peptides mimicking the two loops (1 and 4) linked together with an appropriate spacer, with or without the N-terminal region. Two peptides named NL1L4 and L1L4 demonstrated good NGF agonist activity at a concentration as low as 3 M. They induced differentiation of chick dorsal root ganglia and stimulated tyrosine phosphorylation of TrkA, but not TrkB, receptor. In addition L1L4 was able to induce differentiation of PC12 cells. More interestingly, the peptide with the highest "in vitro" activity (L1L4) was shown to reduce neuropathic behavior and restore neuronal function in a rat model of peripheral neuropathic pain, thereby suggesting a potential therapeutic role for this NGF-mimetic peptide. Copyright 2008 Society for Neuroscience
A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats
A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats
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Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Nov 17; 10(11): e0142807-e0142807.
Impact Factor: 3.057
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Morelli G, Saviano M, Grieco P
* The renaissance era of peptides in drug discovery at the 14th Naples workshop on bioactive peptides (414 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 321-322.
Impact Factor: 1.951
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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D'Antò V, Michelotti A, Esposito L, Zagari A, Liguori R, Sacchetti L
* Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder (362 views)
J Sci Med Sport (ISSN: 1440-2440), 2010; 13(6): 174-179.
Impact Factor: 3.194
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (429 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
* Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein α2-helical 180-195 segment and comparison with full-length α2-helix-derived peptides (413 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008; 14(10): 1096-1102.
Impact Factor: 1.654
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Bianco MR, Cirillo G, Cavaliere C, Colangelo AM, Vitagliano L, Morelli G, Sarmientos P, Martegani E, Alberghina L, Papa M
* A new Nerve Growth Factor (NGF)-mimetic peptide reduces gliosis and is active on neuropathic pain in rats (316 views)
Neuron Glia Biology (ISSN: 1740-925x), 2007; 2: N/D-N/D.
Impact Factor: 6.636
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Chiechio S, Copani A, Gereau R, Nicoletti F
* Acetyl-l-carnitine in neuropathic pain (275 views)
Cns Drugs (ISSN: 1172-7047), 2007; 21: 38-38.
Impact Factor: 4.514
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Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
* NMR structure and CD titration with metal cations of human prion α2-helix-related peptides (468 views)
Bioinorg Chem Appl (ISSN: 1565-3633), 2007; 2007: N/D-N/D.
Impact Factor: 0.978
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De Luca S, Saviano M, Della Moglie R, Digilio G, Bracco C, Aloj L, Tarallo L, Pedone C, Morelli G
* Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor (421 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
Impact Factor: 3.046
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Benedetti E, Pedone C
* Cyclolinopeptide A: inhibitor, immunosuppressor or other? (568 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2005 May; 11(5): 268-272.
Impact Factor: 1.803
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (430 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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Saviano M, Rossi F, Filizola M, Isernia C, Di Blasio B, Benedetti E, Pedone C, Siemion IZ, Pedyczak A
Bioactive peptides: conformational studies of [Tyr4] cyclolinopeptide (406 views)
Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1995 Oct; 26(12): 453-460.
Impact Factor: 2.572
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Rossi F, Saviano M, Di Blasio B, Zanotti G, Maione AM, Tancredi T, Pedone C
BIOACTIVE PEPTIDES - SOLID-STATE, SOLUTION AND MOLECULAR-DYNAMICS STUDIES OF A CYCLOLINOPEPTIDE-A RELATED CYSTINYL CYCLOPENTAPEPTIDE (455 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Feb; 34(2): 273-284.
Impact Factor: 2.425
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Zanotti G, Maione A, Rossi F, Saviano M, Pedone C, Tancredi T
BIOACTIVE PEPTIDES - CONFORMATIONAL STUDY OF A CYSTINYL CYCLOHEPTAPEPTIDE IN ITS FREE AND CALCIUM COMPLEXED FORMS (581 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Jul; 33(7): 1083-1091.
Impact Factor: 2.425
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DIBLASIO B, ROSSI F, BENEDETTI E, PAVONE V, SAVIANO M, PEDONE C, ZANOTTI G, TANCREDI T
BIOACTIVE PEPTIDES - X-RAY AND NMR CONFORMATIONAL STUDY OF [AIB(5, 6)-D-ALA(8)]CYCLOLINOPEPTIDE-A (441 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1992 Oct 7; 114(21): 8277-8283.
Impact Factor: 5.65
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Blasio BD, Rossi F, Benedetti E, Pavone V, Pedone C, Temussi PA, Zanotti G, Tancredi T
Bioactive peptides: Solid-state and solution conformation of cyclolinopeptide (549 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1989; 111(25): 9089-9098.
Impact Factor: 5.65
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23 Records (20 excluding Abstracts).
Total impact factor: 85.084 (72.956 excluding Abstracts).
Total 5 year impact factor: 83.933 (74.182 excluding Abstracts).
Total impact factor: 85.084 (72.956 excluding Abstracts).
Total 5 year impact factor: 83.933 (74.182 excluding Abstracts).
658 views. Last view on Wednesday 12 April 2023, 11:17:08
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