Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct(365 views) Postiglione A, Soricelli A, Cicerano U, Mansi L, De Chiara S, Gallotta G, Schettini G, Salvatore M
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic, 1043-6618linking), 1991 Apr; 23(3): 241-246.
Affiliations: Clinica Medica, Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, Italy
Department of Nuclear Medicine, 2nd Medical School, University of Naples, Italy
Institute of Pharmacology, 2nd Medical School, University of Naples, Italy
References: Fritz, Carnitine and its role in fatty acid metabolism (1963) Advances in lipid research, pp. 285-334. , Paoletti R, Kritchewsky D, Academic Press, New Yor
Janiri, Tempesta, A pharmacological profile of the effects of carnitine and acetylcarnitine on the central nervous system (1983) Int J Clin Pharmac Res, 3 (4), pp. 295-306
Dolezal, Tucek, Utilization of citrate, acetylcarnitine, acetate pyruvate and glucose for the synthesis of acetylcholine in rat brain slices (1981) J Neurochem, 36, pp. 1323-1330
Sugden, Newsholme, Activities of choline acetyltransferase, glutamate decarboxylase, 4-aminobutyrate aminotransferase in nervous tissue from some vertebrates and invertebrates (1977) Comp Biochem Physiol, 56, pp. 89-94
Calvani, Iannuccelli, Colasimone, Orfalian, Chronicle of the development of an endogenous substance for dementia: acetyl-l-carnitine (1986) Senile dementias: early detection, pp. 394-400. , Bes A, Cahn J, Hoyer S, Marc-Vezgnes JP, Wishiewski HM, John Libbey Eurotext, London/Paris
Martucci, Agnoli, Manna, Is acetyl-l-carnitine a cholinergic substance? (1986) Senile dementias: early detection, pp. 401-407. , Bes A, Cahn J, Hoyer S, Marc-Vezgnes JP, Wishiewski HM, John Libbey Eurotext, London/Paris
Edwards, Chase, Edwards, Carnitine acetyltransferase: the question of multiple forms (1974) Eur J Biochem, 46, pp. 209-215
Reed, Murray, Roche, Acetylcarnitine and cholinergic receptors (1980) J Pharmac Sci, 69, pp. 1065-1070
Onofrj, Bodis-Wollner, Pola, Calvani, Central cholinergic effects of levoacetylcarnitine on the central nervous system (1983) Drugs Exp Clin Res, 9 (2), pp. 161-169
Falchetto, Kato, Provivini, The action of carnitines on cortical neurons (1971) Can J Physiol Pharmac, 49 (1), pp. 1-8
Fritz, Properties of partial purified carnitine acetyl transferase (1963) J Biol Chem, 238 (7), pp. 2509-2513
Pacifici, Effect of acetyl-l-carnitine (ALCAR) on EEG activity in the rat (1984) 22th Congresso Società Italiana Farmacologia, , (Abstract), Bologna
Testa, Giaretta, Pellegrini, Chemello, Treddo, Corrado, Studio preliminare nell'uso della acetil carnitina in pazienti con deterioramento mentale (1982) Riv Neurol, 52, pp. 119-131
Drago, Arnico-Roxan, Matera, Effects of l-AC on the electroretinographic responses in patients with central retinal artery occlusion (1982) Acta Ther, 8, pp. 201-208
Battistin, Pizzolato, Dam, Single photon emission computed tomography studies with 99mTc-hexamethylpropyleneamine oxime in dementia: effects of acute administration of l-acetylcarnitine (1989) Eur Neurol, 29, pp. 261-265
Gambi, Onofrj, Calvani, Neurophysiological studies of l-acetylcarnitine administration in man (1989) Drugs Exp Clin Res, 15 (9), pp. 435-446
Celsis, Goldman, Henriksen, Lassen, A Method for Calculating Regional Cerebral Blood Flow from Emission Computed Tomography of Inert Gas Concentrations (1981) Journal of Computer Assisted Tomography, 5, pp. 640-645
Phelps, Mazziotta, Huang, Study of cerebral function with positron computed tomography (1982) J Cereb Blood Flow Metab, 2, pp. 113-162
Reichle, Grubb, Gado, Eichling, Ter-Pogossian, Correlation Between Regional Cerebral Blood Flow and Oxidative Metabolism (1976) Archives of Neurology, 15, pp. 523-526
Dam, Pizzolato, Ricchieri, Ferlin, Battistin, Effects of acetyl-l-carnitine on local cerebral glucose utilization in the rat brain (1988) Neurochem Int, 13, p. 102
Dacey, Bassett, Cholinergic vasodilatation of intracerebral arterioles in rats (1987) Am J Physiol, pp. H253-H260. , (Heart Circulation Physiol 22)
Heistad, Marcus, Said, Gross, Effect of acetylcholine and vasoactive intestinal peptide on cerebral blood flow (1980) Am J Physiol, 239, pp. H73-H80. , (Heart Circulation Physiol 8)
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct
The effect of l-acetyl carnitine (l-AC) on cerebral blood flow (CBF) was evaluated in 20 patients with chronic cerebrovascular disease, who suffered an ischaemic stroke at least 6 months before the study. All patients performed a CT scan and were investigated with xenon-133 by brain dedicated single photon emission computed tomography (SPECT, Tomomatic 32, Medimatic Inc., Copenhagen). A single high dose (1.5 g) of l-acetyl carnitine was intravenously administered to 10 patients, while sodium acetate as placebo was injected to 10 other subjects. Cerebral blood flow (ml/min × 100 g) was evaluated before and 45 min after the injection. No changes were observed after placebo injection (43 ± 12 ml/min × 100 g versus 43 ± 10 ml/min × 100 g). CBF increased (from 42 ± 9 ml/min × 100 g to 46 ± 9, P
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct
No results.
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G * The relationship between cerebral vascular disease and parkinsonism: The VADO study(498 views) Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780. Impact Factor:3.274 ViewExport to BibTeXExport to EndNote