Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct (365 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic, 1043-6618linking), 1991 Apr; 23(3): 241-246.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0.47, 5-year impact factor: 2.17
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0025767765&partnerID=40&md5=6c0c3fcf8a272a112f6df2e2f96a46a2
Keywords: Brain Imaging, Cerebral Blood Flow, Cerebrovascular Disease, Neuropharmacology, Acetylcarnitine, Xenon 133, Adult, Article, Brain Blood Flow, Chronic Disease, Clinical Article, Controlled Study, Female, Human, Intravenous Drug Administration, Single Photon Emission Computer Tomography, Cerebral Infarction, Cerebrovascular Circulation, Cerebrovascular Disorders, Middle Age, Emission-Computed, Single-Photon,
Affiliations:
Clinica Medica, Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, Italy
Department of Nuclear Medicine, 2nd Medical School, University of Naples, Italy
Institute of Pharmacology, 2nd Medical School, University of Naples, Italy
References:
Fritz, Carnitine and its role in fatty acid metabolism (1963) Advances in lipid research, pp. 285-334. , Paoletti R, Kritchewsky D, Academic Press, New Yor
Janiri, Tempesta, A pharmacological profile of the effects of carnitine and acetylcarnitine on the central nervous system (1983) Int J Clin Pharmac Res, 3 (4), pp. 295-306
Dolezal, Tucek, Utilization of citrate, acetylcarnitine, acetate pyruvate and glucose for the synthesis of acetylcholine in rat brain slices (1981) J Neurochem, 36, pp. 1323-1330
Sugden, Newsholme, Activities of choline acetyltransferase, glutamate decarboxylase, 4-aminobutyrate aminotransferase in nervous tissue from some vertebrates and invertebrates (1977) Comp Biochem Physiol, 56, pp. 89-94
Calvani, Iannuccelli, Colasimone, Orfalian, Chronicle of the development of an endogenous substance for dementia: acetyl-l-carnitine (1986) Senile dementias: early detection, pp. 394-400. , Bes A, Cahn J, Hoyer S, Marc-Vezgnes JP, Wishiewski HM, John Libbey Eurotext, London/Paris
Martucci, Agnoli, Manna, Is acetyl-l-carnitine a cholinergic substance? (1986) Senile dementias: early detection, pp. 401-407. , Bes A, Cahn J, Hoyer S, Marc-Vezgnes JP, Wishiewski HM, John Libbey Eurotext, London/Paris
Edwards, Chase, Edwards, Carnitine acetyltransferase: the question of multiple forms (1974) Eur J Biochem, 46, pp. 209-215
Reed, Murray, Roche, Acetylcarnitine and cholinergic receptors (1980) J Pharmac Sci, 69, pp. 1065-1070
Onofrj, Bodis-Wollner, Pola, Calvani, Central cholinergic effects of levoacetylcarnitine on the central nervous system (1983) Drugs Exp Clin Res, 9 (2), pp. 161-169
Falchetto, Kato, Provivini, The action of carnitines on cortical neurons (1971) Can J Physiol Pharmac, 49 (1), pp. 1-8
Fritz, Properties of partial purified carnitine acetyl transferase (1963) J Biol Chem, 238 (7), pp. 2509-2513
Pacifici, Effect of acetyl-l-carnitine (ALCAR) on EEG activity in the rat (1984) 22th Congresso Società Italiana Farmacologia, , (Abstract), Bologna
Testa, Giaretta, Pellegrini, Chemello, Treddo, Corrado, Studio preliminare nell'uso della acetil carnitina in pazienti con deterioramento mentale (1982) Riv Neurol, 52, pp. 119-131
Drago, Arnico-Roxan, Matera, Effects of l-AC on the electroretinographic responses in patients with central retinal artery occlusion (1982) Acta Ther, 8, pp. 201-208
Battistin, Pizzolato, Dam, Single photon emission computed tomography studies with 99mTc-hexamethylpropyleneamine oxime in dementia: effects of acute administration of l-acetylcarnitine (1989) Eur Neurol, 29, pp. 261-265
Gambi, Onofrj, Calvani, Neurophysiological studies of l-acetylcarnitine administration in man (1989) Drugs Exp Clin Res, 15 (9), pp. 435-446
Celsis, Goldman, Henriksen, Lassen, A Method for Calculating Regional Cerebral Blood Flow from Emission Computed Tomography of Inert Gas Concentrations (1981) Journal of Computer Assisted Tomography, 5, pp. 640-645
Phelps, Mazziotta, Huang, Study of cerebral function with positron computed tomography (1982) J Cereb Blood Flow Metab, 2, pp. 113-162
Reichle, Grubb, Gado, Eichling, Ter-Pogossian, Correlation Between Regional Cerebral Blood Flow and Oxidative Metabolism (1976) Archives of Neurology, 15, pp. 523-526
Dam, Pizzolato, Ricchieri, Ferlin, Battistin, Effects of acetyl-l-carnitine on local cerebral glucose utilization in the rat brain (1988) Neurochem Int, 13, p. 102
Dacey, Bassett, Cholinergic vasodilatation of intracerebral arterioles in rats (1987) Am J Physiol, pp. H253-H260. , (Heart Circulation Physiol 22)
Heistad, Marcus, Said, Gross, Effect of acetylcholine and vasoactive intestinal peptide on cerebral blood flow (1980) Am J Physiol, 239, pp. H73-H80. , (Heart Circulation Physiol 8)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic, 1043-6618linking), 1991 Apr; 23(3): 241-246.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0.47, 5-year impact factor: 2.17
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0025767765&partnerID=40&md5=6c0c3fcf8a272a112f6df2e2f96a46a2
Keywords: Brain Imaging, Cerebral Blood Flow, Cerebrovascular Disease, Neuropharmacology, Acetylcarnitine, Xenon 133, Adult, Article, Brain Blood Flow, Chronic Disease, Clinical Article, Controlled Study, Female, Human, Intravenous Drug Administration, Single Photon Emission Computer Tomography, Cerebral Infarction, Cerebrovascular Circulation, Cerebrovascular Disorders, Middle Age, Emission-Computed, Single-Photon,
Affiliations:
Clinica Medica, Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, Italy
Department of Nuclear Medicine, 2nd Medical School, University of Naples, Italy
Institute of Pharmacology, 2nd Medical School, University of Naples, Italy
References:
Fritz, Carnitine and its role in fatty acid metabolism (1963) Advances in lipid research, pp. 285-334. , Paoletti R, Kritchewsky D, Academic Press, New Yor
Janiri, Tempesta, A pharmacological profile of the effects of carnitine and acetylcarnitine on the central nervous system (1983) Int J Clin Pharmac Res, 3 (4), pp. 295-306
Dolezal, Tucek, Utilization of citrate, acetylcarnitine, acetate pyruvate and glucose for the synthesis of acetylcholine in rat brain slices (1981) J Neurochem, 36, pp. 1323-1330
Sugden, Newsholme, Activities of choline acetyltransferase, glutamate decarboxylase, 4-aminobutyrate aminotransferase in nervous tissue from some vertebrates and invertebrates (1977) Comp Biochem Physiol, 56, pp. 89-94
Calvani, Iannuccelli, Colasimone, Orfalian, Chronicle of the development of an endogenous substance for dementia: acetyl-l-carnitine (1986) Senile dementias: early detection, pp. 394-400. , Bes A, Cahn J, Hoyer S, Marc-Vezgnes JP, Wishiewski HM, John Libbey Eurotext, London/Paris
Martucci, Agnoli, Manna, Is acetyl-l-carnitine a cholinergic substance? (1986) Senile dementias: early detection, pp. 401-407. , Bes A, Cahn J, Hoyer S, Marc-Vezgnes JP, Wishiewski HM, John Libbey Eurotext, London/Paris
Edwards, Chase, Edwards, Carnitine acetyltransferase: the question of multiple forms (1974) Eur J Biochem, 46, pp. 209-215
Reed, Murray, Roche, Acetylcarnitine and cholinergic receptors (1980) J Pharmac Sci, 69, pp. 1065-1070
Onofrj, Bodis-Wollner, Pola, Calvani, Central cholinergic effects of levoacetylcarnitine on the central nervous system (1983) Drugs Exp Clin Res, 9 (2), pp. 161-169
Falchetto, Kato, Provivini, The action of carnitines on cortical neurons (1971) Can J Physiol Pharmac, 49 (1), pp. 1-8
Fritz, Properties of partial purified carnitine acetyl transferase (1963) J Biol Chem, 238 (7), pp. 2509-2513
Pacifici, Effect of acetyl-l-carnitine (ALCAR) on EEG activity in the rat (1984) 22th Congresso Società Italiana Farmacologia, , (Abstract), Bologna
Testa, Giaretta, Pellegrini, Chemello, Treddo, Corrado, Studio preliminare nell'uso della acetil carnitina in pazienti con deterioramento mentale (1982) Riv Neurol, 52, pp. 119-131
Drago, Arnico-Roxan, Matera, Effects of l-AC on the electroretinographic responses in patients with central retinal artery occlusion (1982) Acta Ther, 8, pp. 201-208
Battistin, Pizzolato, Dam, Single photon emission computed tomography studies with 99mTc-hexamethylpropyleneamine oxime in dementia: effects of acute administration of l-acetylcarnitine (1989) Eur Neurol, 29, pp. 261-265
Gambi, Onofrj, Calvani, Neurophysiological studies of l-acetylcarnitine administration in man (1989) Drugs Exp Clin Res, 15 (9), pp. 435-446
Celsis, Goldman, Henriksen, Lassen, A Method for Calculating Regional Cerebral Blood Flow from Emission Computed Tomography of Inert Gas Concentrations (1981) Journal of Computer Assisted Tomography, 5, pp. 640-645
Phelps, Mazziotta, Huang, Study of cerebral function with positron computed tomography (1982) J Cereb Blood Flow Metab, 2, pp. 113-162
Reichle, Grubb, Gado, Eichling, Ter-Pogossian, Correlation Between Regional Cerebral Blood Flow and Oxidative Metabolism (1976) Archives of Neurology, 15, pp. 523-526
Dam, Pizzolato, Ricchieri, Ferlin, Battistin, Effects of acetyl-l-carnitine on local cerebral glucose utilization in the rat brain (1988) Neurochem Int, 13, p. 102
Dacey, Bassett, Cholinergic vasodilatation of intracerebral arterioles in rats (1987) Am J Physiol, pp. H253-H260. , (Heart Circulation Physiol 22)
Heistad, Marcus, Said, Gross, Effect of acetylcholine and vasoactive intestinal peptide on cerebral blood flow (1980) Am J Physiol, 239, pp. H73-H80. , (Heart Circulation Physiol 8)
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct
The effect of l-acetyl carnitine (l-AC) on cerebral blood flow (CBF) was evaluated in 20 patients with chronic cerebrovascular disease, who suffered an ischaemic stroke at least 6 months before the study. All patients performed a CT scan and were investigated with xenon-133 by brain dedicated single photon emission computed tomography (SPECT, Tomomatic 32, Medimatic Inc., Copenhagen). A single high dose (1.5 g) of l-acetyl carnitine was intravenously administered to 10 patients, while sodium acetate as placebo was injected to 10 other subjects. Cerebral blood flow (ml/min × 100 g) was evaluated before and 45 min after the injection. No changes were observed after placebo injection (43 ± 12 ml/min × 100 g versus 43 ± 10 ml/min × 100 g). CBF increased (from 42 ± 9 ml/min × 100 g to 46 ± 9, P
The effect of l-acetyl carnitine (l-AC) on cerebral blood flow (CBF) was evaluated in 20 patients with chronic cerebrovascular disease, who suffered an ischaemic stroke at least 6 months before the study. All patients performed a CT scan and were investigated with xenon-133 by brain dedicated single photon emission computed tomography (SPECT, Tomomatic 32, Medimatic Inc., Copenhagen). A single high dose (1.5 g) of l-acetyl carnitine was intravenously administered to 10 patients, while sodium acetate as placebo was injected to 10 other subjects. Cerebral blood flow (ml/min × 100 g) was evaluated before and 45 min after the injection. No changes were observed after placebo injection (43 ± 12 ml/min × 100 g versus 43 ± 10 ml/min × 100 g). CBF increased (from 42 ± 9 ml/min × 100 g to 46 ± 9, P
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct
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Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct
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De Michele G, Mainenti PP, Soricelli A, Di Salle F, Salvatore E, Longobardi MR, Postiglione A, Salvatore M, Filla A
Cerebral blood flow in spinocerebellar degenerations: a single photon emission tomography study in 28 patients (292 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 1998 Sep; 245(9): 603-608.
Impact Factor: 2.3
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Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti PP, Grivet-Fojaja MR, Covelli EM, Postiglione A, Salvatore M
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging (479 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 May; 39(5): 802-806.
Impact Factor: 3.064
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Postiglione A, Soricelli A, Grossi D, Romano M, Mainenti PP, Ruocco A, Fragrassi N, Chiacchio L, Milan G, De Chiara S, Brunetti A
Changes in cerebral blood flow during cognitive activation evaluated by single photon emission computed tomography in patients with Alzheimer's disease (449 views)
Alzheimer S Res (ISSN: 1356-918x), 1997 Jun; 3(3): 93-99.
Impact Factor: 0
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Alfano B, Brunetti A
Advances in brain imaging: A new ethical challenge (322 views) (PDF 391 views)
Ann Ist Super Sanita (ISSN: 0021-2571), 1997; 33(4): 483-488.
Impact Factor: 0.343
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Postiglione A, Soricelli A, Covelli EM, Iazzetta N, Ruocco A, Milan G, Santoro L, Alfano B, Brunetti A
Premature aging in Werner's syndrome spares the central nervous system (685 views) (PDF 210 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 1996 May; 17(3): 325-330.
Impact Factor: 2.872
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Soricelli A, Postiglione A, Cuocolo A, De Chiara S, Ruocco A, Brunetti A, Salvatore M, Ell PJ
EFFECT OF ADENOSINE ON CEREBRAL BLOOD-FLOW AS EVALUATED BY SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY IN NORMAL SUBJECTS AND IN PATIENTS WITH OCCLUSIVE CAROTID DISEASE - A COMPARISON WITH ACETAZOLAMIDE (256 views)
Stroke (ISSN: 0039-2499), 1995 Sep; 26(9): 1572-1576.
Impact Factor: 4.323
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Postiglione A, Nappi A, Brunetti A, Soricelli A, Rubba P, Gnasso A, Cammisa M, Frusciante V, Cortese C, Salvatore M
Relative protection from cerebral atherosclerosis of young patients with homozygous familial hypercholesterolemia (357 views)
Atherosclerosis (ISSN: 0021-9150, 1879-1484), 1991 Sep; 90(1): 23-30.
Impact Factor: 2.889
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Fasano ML, Ferrara LA, Mancini M
Effects Of Metoprolol On Sympathetic Nervous System And Cerebral Blood Flow In Migraine (220 views)
Cephalalgia, 1987; 7(6): 287-288.
Impact Factor: 0
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22 Records (16 excluding Abstracts).
Total impact factor: 87.914 (64.561 excluding Abstracts).
Total 5 year impact factor: 100.25 (74.467 excluding Abstracts).
Total impact factor: 87.914 (64.561 excluding Abstracts).
Total 5 year impact factor: 100.25 (74.467 excluding Abstracts).
365 views. Last view on Thursday 01 June 2023, 13:45:18
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