Copper(II) complexes of prion protein PEG11-tetraoctarepeat fragment: spectroscopic and voltammetric studies(486 views) Bonomo RP, Di Natale G, Rizzarelli E, Tabbì G, Vagliasindi LI
Dipartimento di Scienze Chimiche, Universita di Catania, Viale A. Doria 6, 95125, Catania, Italy. rbonomo@unict. it
Istituto di Biostrutture e Bioimmagini, CNR, Unit Organizzativa di Supporto di Catania, Viale A. Doria 6, 95125, Catania, Italy
References: Not available.
Copper(II) complexes of prion protein PEG11-tetraoctarepeat fragment: spectroscopic and voltammetric studies
Spectroscopic (UV-Vis and EPR) and voltammetric studies have been carried out on the copper (ii) complexes with the Ac-PEG11- (PHGGGWGQ) 4-NH2 (L) polypeptide. In the ratios Cu: L 3: 1 and 4: 1, the two [Cu3 (L) H-6] and [Cu4 (L) H-8] complex species have been characterized at neutral pH values. All the copper atoms occupy similar coordination sites formed by imidazole, peptidic nitrogen atoms and carbonyl oxygen atoms in a square base pyramidal geometry. Voltammetric measurements on these systems point out the cooperativity in the electron transfer processes among the copper (ii) sites during their reduction. NO interaction with these polynuclear copper species is characterized by the reduction of the copper sites through the formation of two different intermediate complex species. When an excess of the Ac-PEG11- (PHGGGWGQ) 4-NH2 ligand is considered, frozen solution EPR parameters and UV-Vis spectroscopic data identify the [Cu (Nim) 4] 2+ chromophore, which does not interact with NO. 2009 The Royal Society of Chemistry
Copper(II) complexes of prion protein PEG11-tetraoctarepeat fragment: spectroscopic and voltammetric studies
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Copper(II) complexes of prion protein PEG11-tetraoctarepeat fragment: spectroscopic and voltammetric studies
Kállay C, Dávid A, Timári S, Nagy EM, Sanna D, Garribba E, Micera G, De Bona P, Pappalardo G, Rizzarelli E, Sóvágó I * Copper(II) complexes of rat amylin fragments(517 views) Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2011 Oct 14; 40(38): 9711-9721. Impact Factor:3.838 ViewExport to BibTeXExport to EndNote