Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (501 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
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Paper type: Journal Article,
Impact factor: 1.654, 5-year impact factor: 1.782
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-50449109791&partnerID=40&md5=95ed4874c34e00526c96795f76a72228
Keywords: Cck8 Peptide, Micelles, Peptide-Conjugate Amphiphile (pca), Small-Angle Neutron Scattering, Amphophile, Carbon, Chelating Agent, Cholecystokinin Octapeptide, Pentetic Acid Derivative, Water, Article, Chemical Structure, Concentration (parameters), Contrast Enhancement, Controlled Study, Fluorescence Analysis, Fluorescence Spectroscopy, Hydrophobicity, Nuclear Magnetic Resonance Imaging, Priority Journal, Protein Assembly, Synthesis, Molecular Structure, Neutron Diffraction, Peptide Fragments, Small Angle, Sincalide, Solutions, Spectrometry, Surface-Active Agents,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB University of Naples 'Federico II', IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Department of Chemistry, University of Naples 'Federico II', Via Cinthia, 80126 Naples, Italy
References:
Not available.
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.654, 5-year impact factor: 1.782
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-50449109791&partnerID=40&md5=95ed4874c34e00526c96795f76a72228
Keywords: Cck8 Peptide, Micelles, Peptide-Conjugate Amphiphile (pca), Small-Angle Neutron Scattering, Amphophile, Carbon, Chelating Agent, Cholecystokinin Octapeptide, Pentetic Acid Derivative, Water, Article, Chemical Structure, Concentration (parameters), Contrast Enhancement, Controlled Study, Fluorescence Analysis, Fluorescence Spectroscopy, Hydrophobicity, Nuclear Magnetic Resonance Imaging, Priority Journal, Protein Assembly, Synthesis, Molecular Structure, Neutron Diffraction, Peptide Fragments, Small Angle, Sincalide, Solutions, Spectrometry, Surface-Active Agents,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB University of Naples 'Federico II', IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Department of Chemistry, University of Naples 'Federico II', Via Cinthia, 80126 Naples, Italy
References:
Not available.
Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization
The chemical synthesis by solid-phase methods of a novel amphiphilic peptide, peptide-conjugate amphiphile (PCA), containing in the same molecule three different functions: (i) the N,N-bis[2-[bis(carboxy-ethyl)aminolethyl]-L-glutamic acid (DTPAGlu) chelating agent, (ii) the CCK8 bioactive peptide, and (iii) a hydrophobic moiety containing four alkyl chains with 18 carbon atoms each, is reported. In water solution at pH 7.4, PCA self-assembles in very stable micelles at very low concentration [critical micellar concentration (cmc) values of 5 × 10-7 mol kg-1] as confirmed by fluorescence spectroscopy. The structural characterization, obtained with small-angle neutron scattering (SANS) measurements, indicates that the aggregates are substantially represented by ellipsoidal micelles with an aggregation number of 39 ± 2 and the two micellar axes of about 52 and 26 Å. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
The chemical synthesis by solid-phase methods of a novel amphiphilic peptide, peptide-conjugate amphiphile (PCA), containing in the same molecule three different functions: (i) the N,N-bis[2-[bis(carboxy-ethyl)aminolethyl]-L-glutamic acid (DTPAGlu) chelating agent, (ii) the CCK8 bioactive peptide, and (iii) a hydrophobic moiety containing four alkyl chains with 18 carbon atoms each, is reported. In water solution at pH 7.4, PCA self-assembles in very stable micelles at very low concentration [critical micellar concentration (cmc) values of 5 × 10-7 mol kg-1] as confirmed by fluorescence spectroscopy. The structural characterization, obtained with small-angle neutron scattering (SANS) measurements, indicates that the aggregates are substantially represented by ellipsoidal micelles with an aggregation number of 39 ± 2 and the two micellar axes of about 52 and 26 Å. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization
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Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization
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Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (900 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (506 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (527 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (522 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (464 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (435 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (515 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
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Aloj L, Zannetti A, Caraco C, Del Vecchio S, Tasauro D, De Luca S, Brunetti A, Aime S, Morelli G, Pedone C
* Characterization of 111In labeled CCK8 peptide coupled to a novel DTPA-like derivative in CCK-B receptor overexpressing cells (445 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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33 Records (29 excluding Abstracts).
Total impact factor: 96.038 (79.917 excluding Abstracts).
Total 5 year impact factor: 98.439 (80.533 excluding Abstracts).
Total impact factor: 96.038 (79.917 excluding Abstracts).
Total 5 year impact factor: 98.439 (80.533 excluding Abstracts).
501 views. Last view on Tuesday 10 September 2024, 22:37:18
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