A targeted secretome profiling by multiplexed immunoassay revealed that secreted chemokine ligand 2 (MCP-1/CCL2) affects neural differentiation in mesencephalic neural progenitor cells (588 views)
Proteomics (ISSN: 1615-9853), 2015 Feb; 15(4): 714-724.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.079, 5-year impact factor: 3.666
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84922950095&partnerID=40&md5=ef8c1e7e53d97b3dc4f4b1b95aa8f36b
Keywords: Ccl2, Cell Biology, Cytokine Profiling, Multiplexed Immunoassay, Neural Differentiation, Secretome, Gamma Interferon, Interleukin 10, Interleukin 12p70, Interleukin 1alpha, Interleukin 1beta, Monocyte Chemotactic Protein 1, Myc Protein, Rantes, Tumor Necrosis Factor Alpha, Animal Cell, Animal Tissue, Article, Cell Fate, Cell Proliferation, Cell Viability Assay, Culture Medium, Cytokine Release, Embryo, Mesencephalon, Mouse, Nerve Cell Culture, Nerve Cell Differentiation, Neural Stem Cell, Neuroblast, Nonhuman, Phenotype, Pluripotent Stem Cell, Primary Culture, Priority Journal, Protein Expression, Signal Transduction, Tissue Culture,
Affiliations:
*** IBB - CNR ***
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of NaplesCaserta, Italy
CIRN, Inter-University Center for Research in NeuroscienceNapoli, Italy
Department of Pharmacy, University of Naples Federico IINaples, Italy
Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNRNaples, Italy
Institute of Biostructures and Bioimaging - IBB, CNR and CIRPeBNapoli, Italy
Department of Translational Medical Sciences, Federico II University of NaplesNapoli, Italy
IRCCSMultimedica, Milano, Italy
IRCCS, Multimedica, Milano, Italy
References:
Chang, M.Y., Son, H., Lee, Y.S., Lee, S.H., Neurons and astrocytes secrete factors that cause stem cells to differentiate into neurons and astrocytes, respectively (2003) Mol. Cell. Neurosci., 23, pp. 414-42
Schubert, D., Herrera, F., Cumming, R., Read, J., Neural cells secrete a unique repertoire of proteins (2009) J. Neurochem., 109, pp. 427-435
Letourneau, P.C., Condic, M.L., Snow, D.M., Interactions of developing neurons with the extracellular matrix (1994) J. Neurosci., 14, pp. 915-928
Fuentealba, L.C., Obernier, K., Alvarez-Buylla, A., Adult neural stem cells bridge their niche (2012) Cell Stem Cell, 10, pp. 698-708
Ramasamy, S., Narayanan, G., Sankaran, S., Yu, Y.H., Ahmed, S., Neural stem cell survival factors (2013) Arch. Biochem. Biophys., 534, pp. 71-87
Yoshimura, S., Takagi, Y., Harada, J., Teramoto, T., FGF-2 regulation of neurogenesis in adult hippocampus after brain injury (2001) Proc. Natl. Acad. Sci. USA, 98, pp. 5874-5879
Schmidt, H.D., Duman, R.S., The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007) Behav. Pharmacol., 18, pp. 391-418
Lim, D.A., Tramontin, A.D., Trevejo, J.M., Herrera, D.G., Noggin antagonizes BMP signaling to create a niche for adult neurogenesis (2000) Neuron, 28, pp. 713-726
Bauer, S., Patterson, P.H., Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain (2006) J. Neurosci., 26, pp. 12089-12099
Tropepe, V., Craig, C.G., Morshead, C.M., van der Kooy, D., Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma (1997) J. Neurosci., 17, pp. 7850-7859
Jin, K., Zhu, Y., Sun, Y., Mao, X.O., Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo (2002) Proc. Natl. Acad. Sci. USA, 99, pp. 11946-11950
Mathieu, P., Battista, D., Depino, A., Roca, V., The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain (2010) J. Neurochem., 112, pp. 1368-1385
Bauer, S., Kerr, B.J., Patterson, P.H., The neuropoietic cytokine family in development, plasticity, disease and injury (2007) Nat. Rev. Neurosci., 8, pp. 221-232
Breton, J., Mao-Draayer, Y., Impact of cytokines on neural stem/progenitor cell fate (2011) Neurol. Neurophysiol.
Gage, F.H., Neurogenesis in the adult brain (2002) J. Neurosci., 22, pp. 612-613
Gage, F.H., Coates, P.W., Palmer, T.D., Kuhn, H.G., Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 11879-11883
Gonzalez-Perez, O., Gutierrez-Fernandez, F., Lopez-Virgen, V., Collas-Aguilar, J., Immunological regulation of neurogenic niches in the adult brain (2012) Neuroscience, 226, pp. 270-281
Leong, S.Y., Turnley, A.M., Regulation of adult neural precursor cell migration (2011) Neurochem. Int., 59, pp. 382-393
Colucci-D'Amato, L., Farina, A., Vissers, J.P., Chambery, A., Quantitative neuroproteomics: classical and novel tools for studying neural differentiation and function (2011) Stem Cell Rev., 7, pp. 77-93
Severino, V., Farina, A., Colucci-D'Amato, L., Reccia, M.G., Secretome profiling of differentiated neural mes-c-myc A1 cell line endowed with stem cell properties (2013) Biochim. Biophys. Acta, 1834, pp. 2385-2395
Colucci-D'Amato, G.L., Tino, A., Pernas-Alonso, R., ffrench-Mullen, J.M., di Porzio, U., Neuronal and glial properties coexist in a novel mouse CNS immortalized cell line (1999) Exp. Cell Res., 252, pp. 383-391
Di Lieto, A., Leo, D., Volpicelli, F., di Porzio, U., Colucci-D'Amato, L., FLUOXETINE modifies the expression of serotonergic markers in a differentiation-dependent fashion in the mesencephalic neural cell line A1 mes c-myc (2007) Brain Res., 1143, pp. 1-10
Gentile, M.T., Nawa, Y., Lunardi, G., Florio, T., Tryptophan hydroxylase 2 (TPH2) in a neuronal cell line: modulation by cell differentiation and NRSF/rest activity (2012) J. Neurochem., 123, pp. 963-970
Ianora, A., Miralto, A., Poulet, S.A., Carotenuto, Y., Aldehyde suppression of copepod recruitment in blooms of a ubiquitous planktonic diatom (2004) Nature, 429, pp. 403-407
Nizzari, M., Barbieri, F., Gentile, M.T., Passarella, D., Amyloid-beta protein precursor regulates phosphorylation and cellular compartmentalization of microtubule associated protein tau (2012) J. Alzheimers Dis., 29, pp. 211-227
Volpicelli, F., Consales, C., Caiazzo, M., Colucci-D'Amato, L., Enhancement of dopaminergic differentiation in proliferating midbrain neuroblasts by sonic hedgehog and ascorbic acid (2004) Neural. Plast., 11, pp. 45-57
Volpicelli, F., Perrone-Capano, C., Da Pozzo, P., Colucci-D'Amato, L., di Porzio, U., Modulation of nurr1 gene expression in mesencephalic dopaminergic neurones (2004) J. Neurochem., 88, pp. 1283-1294
Schmittgen, T.D., Livak, K.J., Analyzing real-time PCR data by the comparative C(T) method (2008) Nat. Protoc., 3, pp. 1101-1108
Hopkins, S.J., Rothwell, N.J., Cytokines and the nervous system. I: expression and recognition (1995) Trends Neurosci., 18, pp. 83-88
Pitossi, F., del Rey, A., Kabiersch, A., Besedovsky, H., Induction of cytokine transcripts in the central nervous system and pituitary following peripheral administration of endotoxin to mice (1997) J. Neurosci. Res., 48, pp. 287-298
Ben-Hur, T., Ben-Menachem, O., Furer, V., Einstein, O., Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells (2003) Mol. Cell. Neurosci., 24, pp. 623-631
Koo, J.W., Duman, R.S., IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress (2008) Proc. Natl. Acad. Sci. USA, 105, pp. 751-756
Ajmone-Cat, M.A., Cacci, E., Ragazzoni, Y., Minghetti, L., Biagioni, S., Pro-gliogenic effect of IL-1alpha in the differentiation of embryonic neural precursor cells in vitro (2010) J. Neurochem., 113, pp. 1060-1072
Monje, M.L., Toda, H., Palmer, T.D., Inflammatory blockade restores adult hippocampal neurogenesis (2003) Science, 302, pp. 1760-1765
Iosif, R.E., Ekdahl, C.T., Ahlenius, H., Pronk, C.J., Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis (2006) J. Neurosci., 26, pp. 9703-9712
Widera, D., Mikenberg, I., Elvers, M., Kaltschmidt, C., Kaltschmidt, B., Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling (2006) BMC Neurosci., 7, p. 64
Hirano, T., Akira, S., Taga, T., Kishimoto, T., Biological and clinical aspects of interleukin 6 (1990) Immunol. Today, 11, pp. 443-449
Shebl, F.M., Pinto, L.A., Garcia-Pineres, A., Lempicki, R., Comparison of mRNA and protein measures of cytokines following vaccination with human papillomavirus-16 L1 virus-like particles (2010) Cancer Epidemiol. Biomarkers Prev., 19, pp. 978-981
Sullivan, K.E., Cutilli, J., Piliero, L.M., Ghavimi-Alagha, D., Measurement of cytokine secretion, intracellular protein expression, and mRNA in resting and stimulated peripheral blood mononuclear cells (2000) Clin. Diagn. Lab. Immunol., 7, pp. 920-924
D'Esposito, V., Passaretti, F., Hammarstedt, A., Liguoro, D., Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro (2012) Diabetologia, 55, pp. 2811-2822
Le, Y., Zhou, Y., Iribarren, P., Wang, J., Chemokines and chemokine receptors: their manifold roles in homeostasis and disease (2004) Cell. Mol. Immunol., 1, pp. 95-104
Laing, K.J., Secombes, C.J., (2004) Chemokines. Dev. Comp. Immunol., 28, pp. 443-460
Turbic, A., Leong, S.Y., Turnley, A.M., Chemokines and inflammatory mediators interact to regulate adult murine neural precursor cell proliferation, survival and differentiation (2011) PLoS One, 6, p. e25406
Nakashima, K., Taga, T., Mechanisms underlying cytokine-mediated cell-fate regulation in the nervous system (2002) Mol. Neurobiol., 25, pp. 233-244
Meucci, O., Fatatis, A., Simen, A.A., Miller, R.J., Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 8075-8080
Park, M.H., Lee, Y.K., Lee, Y.H., Kim, Y.B., Chemokines released from astrocytes promote chemokine receptor 5-mediated neuronal cell differentiation (2009) Exp. Cell Res., 315, pp. 2715-2726
Tran, P.B., Ren, D., Veldhouse, T.J., Miller, R.J., Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells (2004) J. Neurosci. Res., 76, pp. 20-34
Liu, X.S., Zhang, Z.G., Zhang, R.L., Gregg, S.R., Chemokine ligand 2 (CCL2) induces migration and differentiation of subventricular zone cells after stroke (2007) J. Neurosci. Res., 85, pp. 2120-2125
Edman, L.C., Mira, H., Arenas, E., The beta-chemokines CCL2 and CCL7 are two novel differentiation factors for midbrain dopaminergic precursors and neurons (2008) Exp. Cell Res., 314, pp. 2123-2130
Lawrence, D.M., Seth, P., Durham, L., Diaz, F., Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells (2006) Glia, 53, pp. 81-91
Graham, V., Khudyakov, J., Ellis, P., Pevny, L., SOX2 functions to maintain neural progenitor identity (2003) Neuron, 39, pp. 749-765
Chew, L.J., Gallo, V., The Yin and Yang of Sox proteins: activation and repression in development and disease (2009) J. Neurosci. Res., 87, pp. 3277-3287
Moore, M.A., Cytokine and chemokine networks influencing stem cell proliferation, differentiation, and marrow homing (2002) J. Cell. Biochem. Suppl., 38, pp. 29-38
Krathwohl, M.D., Kaiser, J.L., Chemokines promote quiescence and survival of human neural progenitor cells (2004) Stem Cells, 22, pp. 109-118
Stumm, R.K., Zhou, C., Ara, T., Lazarini, F., CXCR4 regulates interneuron migration in the developing neocortex (2003) J. Neurosci., 23, pp. 5123-5130
Lu, M., Grove, E.A., Miller, R.J., Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor (2002) Proc. Natl. Acad. Sci. USA, 99, pp. 7090-7095
Ransohoff, R.M., Glabinski, A., Tani, M., Chemokines in immune-mediated inflammation of the central nervous system (1996) Cytokine Growth Factor Rev., 7, pp. 35-46
Ransohoff, R.M., Tani, M., Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation (1998) Trends Neurosci., 21, pp. 154-159
Minami, M., Satoh, M., Chemokines and their receptors in the brain: pathophysiological roles in ischemic brain injury (2003) Life Sci., 74, pp. 321-327
Johnstone, M., Gearing, A.J., Miller, K.M., A central role for astrocytes in the inflammatory response to beta-amyloid
chemokines, cytokines and reactive oxygen species are produced (1999) J. Neuroimmunol., 93, pp. 182-193
Bajetto, A., Bonavia, R., Barbero, S., Schettini, G., Characterization of chemokines and their receptors in the central nervous system: physiopathological implications (2002) J. Neurochem., 82, pp. 1311-1329
Gordon, R.J., Mehrabi, N.F., Maucksch, C., Connor, B., Chemokines influence the migration and fate of neural precursor cells from the young adult and middle-aged rat subventricular zone (2012) Exp. Neurol., 233, pp. 587-594
Cartier, L., Hartley, O., Dubois-Dauphin, M., Krause, K.H., Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases (2005) Brain Res. Brain Res. Rev., 48, pp. 16-42
Lue, L.F., Rydel, R., Brigham, E.F., Yang, L.B., Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro (2001) Glia, 35, pp. 72-79
Proteomics (ISSN: 1615-9853), 2015 Feb; 15(4): 714-724.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.079, 5-year impact factor: 3.666
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84922950095&partnerID=40&md5=ef8c1e7e53d97b3dc4f4b1b95aa8f36b
Keywords: Ccl2, Cell Biology, Cytokine Profiling, Multiplexed Immunoassay, Neural Differentiation, Secretome, Gamma Interferon, Interleukin 10, Interleukin 12p70, Interleukin 1alpha, Interleukin 1beta, Monocyte Chemotactic Protein 1, Myc Protein, Rantes, Tumor Necrosis Factor Alpha, Animal Cell, Animal Tissue, Article, Cell Fate, Cell Proliferation, Cell Viability Assay, Culture Medium, Cytokine Release, Embryo, Mesencephalon, Mouse, Nerve Cell Culture, Nerve Cell Differentiation, Neural Stem Cell, Neuroblast, Nonhuman, Phenotype, Pluripotent Stem Cell, Primary Culture, Priority Journal, Protein Expression, Signal Transduction, Tissue Culture,
Affiliations:
*** IBB - CNR ***
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of NaplesCaserta, Italy
CIRN, Inter-University Center for Research in NeuroscienceNapoli, Italy
Department of Pharmacy, University of Naples Federico IINaples, Italy
Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNRNaples, Italy
Institute of Biostructures and Bioimaging - IBB, CNR and CIRPeBNapoli, Italy
Department of Translational Medical Sciences, Federico II University of NaplesNapoli, Italy
IRCCSMultimedica, Milano, Italy
IRCCS, Multimedica, Milano, Italy
References:
Chang, M.Y., Son, H., Lee, Y.S., Lee, S.H., Neurons and astrocytes secrete factors that cause stem cells to differentiate into neurons and astrocytes, respectively (2003) Mol. Cell. Neurosci., 23, pp. 414-42
Schubert, D., Herrera, F., Cumming, R., Read, J., Neural cells secrete a unique repertoire of proteins (2009) J. Neurochem., 109, pp. 427-435
Letourneau, P.C., Condic, M.L., Snow, D.M., Interactions of developing neurons with the extracellular matrix (1994) J. Neurosci., 14, pp. 915-928
Fuentealba, L.C., Obernier, K., Alvarez-Buylla, A., Adult neural stem cells bridge their niche (2012) Cell Stem Cell, 10, pp. 698-708
Ramasamy, S., Narayanan, G., Sankaran, S., Yu, Y.H., Ahmed, S., Neural stem cell survival factors (2013) Arch. Biochem. Biophys., 534, pp. 71-87
Yoshimura, S., Takagi, Y., Harada, J., Teramoto, T., FGF-2 regulation of neurogenesis in adult hippocampus after brain injury (2001) Proc. Natl. Acad. Sci. USA, 98, pp. 5874-5879
Schmidt, H.D., Duman, R.S., The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007) Behav. Pharmacol., 18, pp. 391-418
Lim, D.A., Tramontin, A.D., Trevejo, J.M., Herrera, D.G., Noggin antagonizes BMP signaling to create a niche for adult neurogenesis (2000) Neuron, 28, pp. 713-726
Bauer, S., Patterson, P.H., Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain (2006) J. Neurosci., 26, pp. 12089-12099
Tropepe, V., Craig, C.G., Morshead, C.M., van der Kooy, D., Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma (1997) J. Neurosci., 17, pp. 7850-7859
Jin, K., Zhu, Y., Sun, Y., Mao, X.O., Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo (2002) Proc. Natl. Acad. Sci. USA, 99, pp. 11946-11950
Mathieu, P., Battista, D., Depino, A., Roca, V., The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain (2010) J. Neurochem., 112, pp. 1368-1385
Bauer, S., Kerr, B.J., Patterson, P.H., The neuropoietic cytokine family in development, plasticity, disease and injury (2007) Nat. Rev. Neurosci., 8, pp. 221-232
Breton, J., Mao-Draayer, Y., Impact of cytokines on neural stem/progenitor cell fate (2011) Neurol. Neurophysiol.
Gage, F.H., Neurogenesis in the adult brain (2002) J. Neurosci., 22, pp. 612-613
Gage, F.H., Coates, P.W., Palmer, T.D., Kuhn, H.G., Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 11879-11883
Gonzalez-Perez, O., Gutierrez-Fernandez, F., Lopez-Virgen, V., Collas-Aguilar, J., Immunological regulation of neurogenic niches in the adult brain (2012) Neuroscience, 226, pp. 270-281
Leong, S.Y., Turnley, A.M., Regulation of adult neural precursor cell migration (2011) Neurochem. Int., 59, pp. 382-393
Colucci-D'Amato, L., Farina, A., Vissers, J.P., Chambery, A., Quantitative neuroproteomics: classical and novel tools for studying neural differentiation and function (2011) Stem Cell Rev., 7, pp. 77-93
Severino, V., Farina, A., Colucci-D'Amato, L., Reccia, M.G., Secretome profiling of differentiated neural mes-c-myc A1 cell line endowed with stem cell properties (2013) Biochim. Biophys. Acta, 1834, pp. 2385-2395
Colucci-D'Amato, G.L., Tino, A., Pernas-Alonso, R., ffrench-Mullen, J.M., di Porzio, U., Neuronal and glial properties coexist in a novel mouse CNS immortalized cell line (1999) Exp. Cell Res., 252, pp. 383-391
Di Lieto, A., Leo, D., Volpicelli, F., di Porzio, U., Colucci-D'Amato, L., FLUOXETINE modifies the expression of serotonergic markers in a differentiation-dependent fashion in the mesencephalic neural cell line A1 mes c-myc (2007) Brain Res., 1143, pp. 1-10
Gentile, M.T., Nawa, Y., Lunardi, G., Florio, T., Tryptophan hydroxylase 2 (TPH2) in a neuronal cell line: modulation by cell differentiation and NRSF/rest activity (2012) J. Neurochem., 123, pp. 963-970
Ianora, A., Miralto, A., Poulet, S.A., Carotenuto, Y., Aldehyde suppression of copepod recruitment in blooms of a ubiquitous planktonic diatom (2004) Nature, 429, pp. 403-407
Nizzari, M., Barbieri, F., Gentile, M.T., Passarella, D., Amyloid-beta protein precursor regulates phosphorylation and cellular compartmentalization of microtubule associated protein tau (2012) J. Alzheimers Dis., 29, pp. 211-227
Volpicelli, F., Consales, C., Caiazzo, M., Colucci-D'Amato, L., Enhancement of dopaminergic differentiation in proliferating midbrain neuroblasts by sonic hedgehog and ascorbic acid (2004) Neural. Plast., 11, pp. 45-57
Volpicelli, F., Perrone-Capano, C., Da Pozzo, P., Colucci-D'Amato, L., di Porzio, U., Modulation of nurr1 gene expression in mesencephalic dopaminergic neurones (2004) J. Neurochem., 88, pp. 1283-1294
Schmittgen, T.D., Livak, K.J., Analyzing real-time PCR data by the comparative C(T) method (2008) Nat. Protoc., 3, pp. 1101-1108
Hopkins, S.J., Rothwell, N.J., Cytokines and the nervous system. I: expression and recognition (1995) Trends Neurosci., 18, pp. 83-88
Pitossi, F., del Rey, A., Kabiersch, A., Besedovsky, H., Induction of cytokine transcripts in the central nervous system and pituitary following peripheral administration of endotoxin to mice (1997) J. Neurosci. Res., 48, pp. 287-298
Ben-Hur, T., Ben-Menachem, O., Furer, V., Einstein, O., Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells (2003) Mol. Cell. Neurosci., 24, pp. 623-631
Koo, J.W., Duman, R.S., IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress (2008) Proc. Natl. Acad. Sci. USA, 105, pp. 751-756
Ajmone-Cat, M.A., Cacci, E., Ragazzoni, Y., Minghetti, L., Biagioni, S., Pro-gliogenic effect of IL-1alpha in the differentiation of embryonic neural precursor cells in vitro (2010) J. Neurochem., 113, pp. 1060-1072
Monje, M.L., Toda, H., Palmer, T.D., Inflammatory blockade restores adult hippocampal neurogenesis (2003) Science, 302, pp. 1760-1765
Iosif, R.E., Ekdahl, C.T., Ahlenius, H., Pronk, C.J., Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis (2006) J. Neurosci., 26, pp. 9703-9712
Widera, D., Mikenberg, I., Elvers, M., Kaltschmidt, C., Kaltschmidt, B., Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling (2006) BMC Neurosci., 7, p. 64
Hirano, T., Akira, S., Taga, T., Kishimoto, T., Biological and clinical aspects of interleukin 6 (1990) Immunol. Today, 11, pp. 443-449
Shebl, F.M., Pinto, L.A., Garcia-Pineres, A., Lempicki, R., Comparison of mRNA and protein measures of cytokines following vaccination with human papillomavirus-16 L1 virus-like particles (2010) Cancer Epidemiol. Biomarkers Prev., 19, pp. 978-981
Sullivan, K.E., Cutilli, J., Piliero, L.M., Ghavimi-Alagha, D., Measurement of cytokine secretion, intracellular protein expression, and mRNA in resting and stimulated peripheral blood mononuclear cells (2000) Clin. Diagn. Lab. Immunol., 7, pp. 920-924
D'Esposito, V., Passaretti, F., Hammarstedt, A., Liguoro, D., Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro (2012) Diabetologia, 55, pp. 2811-2822
Le, Y., Zhou, Y., Iribarren, P., Wang, J., Chemokines and chemokine receptors: their manifold roles in homeostasis and disease (2004) Cell. Mol. Immunol., 1, pp. 95-104
Laing, K.J., Secombes, C.J., (2004) Chemokines. Dev. Comp. Immunol., 28, pp. 443-460
Turbic, A., Leong, S.Y., Turnley, A.M., Chemokines and inflammatory mediators interact to regulate adult murine neural precursor cell proliferation, survival and differentiation (2011) PLoS One, 6, p. e25406
Nakashima, K., Taga, T., Mechanisms underlying cytokine-mediated cell-fate regulation in the nervous system (2002) Mol. Neurobiol., 25, pp. 233-244
Meucci, O., Fatatis, A., Simen, A.A., Miller, R.J., Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 8075-8080
Park, M.H., Lee, Y.K., Lee, Y.H., Kim, Y.B., Chemokines released from astrocytes promote chemokine receptor 5-mediated neuronal cell differentiation (2009) Exp. Cell Res., 315, pp. 2715-2726
Tran, P.B., Ren, D., Veldhouse, T.J., Miller, R.J., Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells (2004) J. Neurosci. Res., 76, pp. 20-34
Liu, X.S., Zhang, Z.G., Zhang, R.L., Gregg, S.R., Chemokine ligand 2 (CCL2) induces migration and differentiation of subventricular zone cells after stroke (2007) J. Neurosci. Res., 85, pp. 2120-2125
Edman, L.C., Mira, H., Arenas, E., The beta-chemokines CCL2 and CCL7 are two novel differentiation factors for midbrain dopaminergic precursors and neurons (2008) Exp. Cell Res., 314, pp. 2123-2130
Lawrence, D.M., Seth, P., Durham, L., Diaz, F., Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells (2006) Glia, 53, pp. 81-91
Graham, V., Khudyakov, J., Ellis, P., Pevny, L., SOX2 functions to maintain neural progenitor identity (2003) Neuron, 39, pp. 749-765
Chew, L.J., Gallo, V., The Yin and Yang of Sox proteins: activation and repression in development and disease (2009) J. Neurosci. Res., 87, pp. 3277-3287
Moore, M.A., Cytokine and chemokine networks influencing stem cell proliferation, differentiation, and marrow homing (2002) J. Cell. Biochem. Suppl., 38, pp. 29-38
Krathwohl, M.D., Kaiser, J.L., Chemokines promote quiescence and survival of human neural progenitor cells (2004) Stem Cells, 22, pp. 109-118
Stumm, R.K., Zhou, C., Ara, T., Lazarini, F., CXCR4 regulates interneuron migration in the developing neocortex (2003) J. Neurosci., 23, pp. 5123-5130
Lu, M., Grove, E.A., Miller, R.J., Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor (2002) Proc. Natl. Acad. Sci. USA, 99, pp. 7090-7095
Ransohoff, R.M., Glabinski, A., Tani, M., Chemokines in immune-mediated inflammation of the central nervous system (1996) Cytokine Growth Factor Rev., 7, pp. 35-46
Ransohoff, R.M., Tani, M., Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation (1998) Trends Neurosci., 21, pp. 154-159
Minami, M., Satoh, M., Chemokines and their receptors in the brain: pathophysiological roles in ischemic brain injury (2003) Life Sci., 74, pp. 321-327
Johnstone, M., Gearing, A.J., Miller, K.M., A central role for astrocytes in the inflammatory response to beta-amyloid
chemokines, cytokines and reactive oxygen species are produced (1999) J. Neuroimmunol., 93, pp. 182-193
Bajetto, A., Bonavia, R., Barbero, S., Schettini, G., Characterization of chemokines and their receptors in the central nervous system: physiopathological implications (2002) J. Neurochem., 82, pp. 1311-1329
Gordon, R.J., Mehrabi, N.F., Maucksch, C., Connor, B., Chemokines influence the migration and fate of neural precursor cells from the young adult and middle-aged rat subventricular zone (2012) Exp. Neurol., 233, pp. 587-594
Cartier, L., Hartley, O., Dubois-Dauphin, M., Krause, K.H., Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases (2005) Brain Res. Brain Res. Rev., 48, pp. 16-42
Lue, L.F., Rydel, R., Brigham, E.F., Yang, L.B., Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro (2001) Glia, 35, pp. 72-79
A targeted secretome profiling by multiplexed immunoassay revealed that secreted chemokine ligand 2 (MCP-1/CCL2) affects neural differentiation in mesencephalic neural progenitor cells
Chemokines and cytokines, primarily known for their roles in the immune and inflammatory response, have also been identified as key components of the neurogenic niche where they are involved in the modulation of neural stem cell proliferation and differentiation. However, a complete understanding of the functional role played in neural differentiation and a comprehensive profiling of these secreted molecules are lacking. By exploiting the multiplexing capability of magnetic bead-based immunoassays, we have investigated the changes of the expression levels of a set of chemokines and cytokines released from the pluripotent neural cell line mes-c-myc A1 following its differentiation from a proliferating phenotype (A1P) toward a neural (A1D) phenotype. We found a subset of molecules exclusively released from A1P, whereas others were differentially detected in A1P and A1D conditioned media. Among them, we identified monocyte chemoattractant protein-1/chemokine ligand 2 (MCP-1/CCL2) as a proneurogenic factor able to affect neuronal differentiation of A1 cells as well as of neuroblasts from primary cultures and to induce the elongation and/or formation of neuritic processes. Altogether, data are suggestive of a main role played by the CCL2/CCR2 signaling pathway and in general of the network of secreted cytokines/chemokines in the differentiation of neural progenitor cells toward a neural fate. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Chemokines and cytokines, primarily known for their roles in the immune and inflammatory response, have also been identified as key components of the neurogenic niche where they are involved in the modulation of neural stem cell proliferation and differentiation. However, a complete understanding of the functional role played in neural differentiation and a comprehensive profiling of these secreted molecules are lacking. By exploiting the multiplexing capability of magnetic bead-based immunoassays, we have investigated the changes of the expression levels of a set of chemokines and cytokines released from the pluripotent neural cell line mes-c-myc A1 following its differentiation from a proliferating phenotype (A1P) toward a neural (A1D) phenotype. We found a subset of molecules exclusively released from A1P, whereas others were differentially detected in A1P and A1D conditioned media. Among them, we identified monocyte chemoattractant protein-1/chemokine ligand 2 (MCP-1/CCL2) as a proneurogenic factor able to affect neuronal differentiation of A1 cells as well as of neuroblasts from primary cultures and to induce the elongation and/or formation of neuritic processes. Altogether, data are suggestive of a main role played by the CCL2/CCR2 signaling pathway and in general of the network of secreted cytokines/chemokines in the differentiation of neural progenitor cells toward a neural fate. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
A targeted secretome profiling by multiplexed immunoassay revealed that secreted chemokine ligand 2 (MCP-1/CCL2) affects neural differentiation in mesencephalic neural progenitor cells
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A targeted secretome profiling by multiplexed immunoassay revealed that secreted chemokine ligand 2 (MCP-1/CCL2) affects neural differentiation in mesencephalic neural progenitor cells
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Miceli M, Dell'Aversana C, Russo R, Rega C, Cupelli L, Ruvo M, Altucci L, Chambery A
* Secretome profiling of cytokines and growth factors reveals that neuro-glial differentiation is associated with the down-regulation of Chemokine Ligand 2 (MCP-1/CCL2) in amniotic fluid derived-mesenchymal progenitor cells (472 views)
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Impact Factor: 4.041
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
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Impact Factor: 4.922
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (616 views)
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Impact Factor: 4.518
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (425 views)
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Impact Factor: 2.551
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Riccio A, Cubellis MV
* Gain of function in CDKN1C (511 views)
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Impact Factor: 35.209
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Doti N, Scognamiglio PL, Madonna S, Scarponi C, Ruvo M, Perretta G, Albanesi C, Marasco D
* New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries (1334 views)
Biochemical Journal, 2012 Apr 1; 443: 231-240.
Impact Factor: 4.779
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (554 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
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Impact Factor: 2.608
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Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (775 views)
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Impact Factor: 7.871
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (668 views)
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Impact Factor: 3.268
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
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Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (570 views)
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (761 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
View Export to BibTeX Export to EndNote
* Secretome profiling of cytokines and growth factors reveals that neuro-glial differentiation is associated with the down-regulation of Chemokine Ligand 2 (MCP-1/CCL2) in amniotic fluid derived-mesenchymal progenitor cells (472 views)
Proteomics (ISSN: 1615-9853), 2016; 16(4): 674-688.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (846 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
View Export to BibTeX Export to EndNote
Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (616 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
View Export to BibTeX Export to EndNote
Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (425 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
View Export to BibTeX Export to EndNote
Riccio A, Cubellis MV
* Gain of function in CDKN1C (511 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
View Export to BibTeX Export to EndNote
Doti N, Scognamiglio PL, Madonna S, Scarponi C, Ruvo M, Perretta G, Albanesi C, Marasco D
* New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries (1334 views)
Biochemical Journal, 2012 Apr 1; 443: 231-240.
Impact Factor: 4.779
View Export to BibTeX Export to EndNote
D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (554 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
View Export to BibTeX Export to EndNote
Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (775 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
View Export to BibTeX Export to EndNote
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (668 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (448 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (570 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
View Export to BibTeX Export to EndNote
Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (761 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
View Export to BibTeX Export to EndNote
13 Records (12 excluding Abstracts).
Total impact factor: 83.732 (83.732 excluding Abstracts).
Total 5 year impact factor: 83.373 (83.373 excluding Abstracts).
Total impact factor: 83.732 (83.732 excluding Abstracts).
Total 5 year impact factor: 83.373 (83.373 excluding Abstracts).
588 views. Last view on Friday 17 February 2023, 21:43:50
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