The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice(642 views) Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy., National Research Council, Institute of Neurological Sciences (ISN-CNR), Catania, Italy; IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, Troina, EN, Italy., National Research Council, Institute of Neurological Sciences (ISN-CNR), Catania, Italy., Pharmacokinetic Unit, Unifarm Research Center, Catania, Italy., Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; Pharmacokinetic Unit, Unifarm Research Center, Catania, Italy., IRCCS Neuromed, Pozzilli IS, Italy; Department of Physiology and Pharmacology, University of Rome Sapienza, Italy., National Research Council, Institute of Biostructure and Bioimaging (IBB-CNR), Catania, Italy; Department of Drug Sciences, University of Catania, Catania, Italy., IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, Troina, EN, Italy; Department of Drug Sciences, University of Catania, Catania, Italy. Electronic address: carafil@hotmail.com.,
References: Hardy, J., The amyloid hypothesis for Alzheimer's disease: a critical reappraisal (2009) J. Neurochem., 110, pp. 1129-113
Giacobini, E., Gold, G., Alzheimer disease therapy-moving from amyloid-β to tau (2013) Nat. Rev. Neurol., 9, pp. 677-686
Walsh, D.M., Selkoe, D.J., A beta oligomers - a decade of discovery (2007) J. Neurochem., 101, pp. 1172-1184
Hynd, M.R., Scott, H.L., Dodd, P.R., Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease (2004) Neurochem. Int., 45, pp. 583-595
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Storto, M., Nicoletti, F., Induction of Dickkopf-1 a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (2004) J. Neurosci., 24, pp. 6021-6027
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., Divide and die: cell cycle events as triggers of nerve cell death (2004) J. Neurosci., 24, pp. 9232-9239
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J., 13, pp. 2225-2234
Copani, A., Hoozemans, J.J., Caraci, F., Calafiore, M., Van Haaster, E.S., Veerhius, R., Rozemuller, A.J.M., Nicoletti, F., DNA polymerase-ß is early expressed in neurons of Alzheimer's disease brain and is loaded into DNA replication forks ni neurons challenged with ß-amyloid (2006) J. Neurosci., 26, pp. 10949-10957
Arendt, T., Brückner, M.K., Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity (2010) Biochim. Biophys. Acta., 1772, pp. 413-421
Ueberham, U., Arendt, T., The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease (2005) Curr. Drug Targets CNS Neurol. Disord., 4, pp. 293-306
Wu, J., Stoica, B.A., Dinizo, M., Pajoohesh-Ganji, A., Piao, C., Faden, A.I., Delayed cell cycle pathway modulation facilitates recovery after spinal cord injury (2012) Cell Cycle, 11, pp. 1782-1795
Pallàs, M., Verdaguer, E., Jordà, E.G., Jiménez, A., Canudas, A.M., Camins, A., Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases (2005) Med. Hypotheses, 64 (2005), pp. 120-123
Osuga, H., Osuga, S., Wang, F., Fetni, R., Hogan, M.J., Slack, R.S., Hakim, A.M., Park, D.S., Cyclin-dependent kinases as a therapeutic target for stroke (2000) Proc. Natl. Acad. Sci. U. S. A., 97, pp. 10254-10259
Carlson, B.A., Dubay, M.M., Sausville, E.A., Worland, P.J., Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (cdk) 2 and cdk4 in human breast carcinoma cells (1996) Cancer Res., 56, pp. 2973-2978
Ledo, J.H., Azevedo, E.P., Clarke, J.R., Ribeiro, F.C., Figueiredo, C.P., Foguel, D., De Felice, F.G., Ferreira, S.T., Amyloid-β oligomers link depression-like behavior and cognitive deficits in mice (2001) Mol. Psychiatry, 18, pp. 1053-1054
Gong, Y., Klein, W.L., Alzheimer's disease-affected brain: presence of oligomeric Abeta ligands (ADDLs) suggests a molecular basis for reversible memory loss (2003) PNAS., 100, pp. 10417-10422
Maurice, T., Lockhart, B.P., Privat, A., Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction (1996) Brain Res., 706, pp. 181-193
Micale, V., Cristino, L., Tamburella, A., Petrosino, S., Leggio, G.M., Di Marzo, V., Drago, F., Enhanced cognitive performance of dopamine D3 receptor knock-out mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems (2010) Pharmacol. Res., 61, pp. 531-536
Puzzo, D., Bizzoca, A., Loreto, C., Guida, C.A., Gulisano, W., Frasca, G., Bellomo, M., Palmeri, A., Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice (2015) Neurobiol. Aging, 36, pp. 1702-1715
Varvel, N.H., Bhaskar, K., Patil, A.R., Pimplikar, S.W., Herrup, K., Lamb, B.T., Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease (2008) J. Neurosci., 28, pp. 10786-10793
Caraci, F., Gulisano, W., Guida, A.C., Impellizzeri, A.R., Drago, F., Puzzo, D., Palmeri, A., A key role for TGF-β1 in hippocampal synaptic plasticity and memory (2015) Sci. Rep., 5, p. 11252
Zhou, L., Schmidt, K., Nelson, F.R., Zelesky, V., Troutman, M.D., Feng, B., The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl) ethoxy) phenyl) propanoic acid (PF-407288) in mice (2009) Drug. Metab. Dispos., 37, pp. 946-955
Kodaira, H., Kusuhara, H., Fujita, T., Ushiki, J., Fuse, E., Sugiyama, Y., Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate (2011) J. Pharmacol. Exp. Ther., 339, pp. 935-944
Broadbent, N.J., Gaskin, S., Squire, L.R., Clark, R.E., Object recognition memory and the rodent hippocampus (2009) Learn. Mem., 17, pp. 5-11
Barker, G.R., Bird, F., Alexander, V., Warburton, E.C., Recognition memory for objects place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex (2007) J. Neurosci., 27, pp. 2948-2957
De La Torre, A.V., Junyent, F., Folch, J., Pelegrí, C., Vilaplana, J., Auladell, C., Beas-Zarate, C., Camins, A., GSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons (2012) Pharmacol. Res., 65, pp. 66-73
Klein, W.L., Synaptotoxic amyloid-β oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease (2013) J. Alzheimers Dis., 33 (S1), pp. S49-S65
Ferretti, M.T., Bruno, M.A., Ducatenzeiler, A., Klein, W.L., Cuello, A.C., Intracellular abeta-oligomers and early inflammation in a model of Alzheimer's disease (2012) Neurobiol. Aging, 33, pp. 1329-1342
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., Beta-amyloidmonomers are neuroprotective (2009) J. Neurosci., 29, pp. 10582-10587
Caraci, F., Pappalardo, G., Basile, L., Giuffrida, A., Copani, A., Tosto, R., Sinopoli, A., Guccione, S., Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity (2015) Eur. J. Pharmacol., 764, pp. 256-263
Epelbaum, S., Youssef, I., Lacor, P.N., Chaurand, P., Duplus, E., Brugg, B., Duyckaerts, C., Delatour, B., Acute amnestic encephalopathy in amyloid-β oligomer-injected mice is due to their widespread diffusion in vivo (2015) Neurobiol. Aging, 36, pp. 2043-2052
Fluharty, B.R., Biasini, E., Stravalaci, M., Sclip, A., Diomede, L., Balducci, C., La Vitola, P., Harris, D.A., An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo (2013) J. Biol. Chem., 288, pp. 7857-7866
Balducci, C., Beeg, M., Stravalaci, M., Bastone, A., Sclip, A., Biasini, E., Tapella, L., Forloni, G., Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein (2010) Proc. Natl. Acad. Sci. U. S. A., 107, pp. 2295-2300
McLean, C.A., Cherny, R.A., Fraser, F.W., Fuller, S.J., Smith, M.J., Beyreuther, K., Bush, A.I., Masters, C.L., Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease (1999) Ann. Neurol., 46, pp. 860-866
Webster, S.J., Bachstetter, A.D., Nelson, P.T., Schmitt, F.A., Van Eldik, L.J., Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models (2014) Front. Genet., 5, p. 88
Van DerPoel, A.M., Ethological study of the behaviour of the albino rat in a passive-avoidance test (1967) Acta Physiol. Pharmacol. Neerl., 14, pp. 503-505
Filali, M., Lalonde, R., Theriault, P., Julien, C., Calon, F., Planel, E., Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP PS1, and Mapt (3xTg-AD) (2012) Behav. Brain Res., 234, pp. 334-342
Herrup, K., The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer's disease (2012) Front. Biosci., 24, pp. 2101-2109
Yang, Y., Geldmacher, D.S., Herrup, K., DNA replication precedes neuronal cell death in Alzheimer's disease (2001) J. Neurosci., 21, pp. 2661-2668
Van Leeuwen, L.A., Hoozemans, J.J., Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's disease (2015) Acta Neuropathol., 129, pp. 511-525
Sivilia, S., Lorenzini, L., Giuliani, A., Gusciglio, M., Fernandez, M., Baldassarro, V.A., Mangano, C., Giardino, L., Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice (2013) BMC Neurosci., 14, p. 44
Yang, Y., Varvel, N.H., Lamb, B.T., Herrup, K., Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models (2006) J. Neurosci., 26, pp. 775-784
Morris, D.G., Bramwell, V.H., Turcotte, R., Figueredo, A.T., Blackstein, M.E., Verma, S., Matthews, S., Eisenhauer, E.A., A phase II study of flavopiridol in patients with previously untreated advanced soft tissue sarcoma (2006) Sarcoma, 2006, p. 64374
Sanphui, P., Pramanik, S.K., Chatterjee, N., Moorthi, P., Banerji, B., Biswas, S.C., Efficacy of cyclin dependent kinase 4 inhibitors as potent neuroprotective agents against insults relevant to Alzheimer's disease (2013) PLoS One, 8
Giovanni, A., Wirtz-Brugger, F., Keramaris, E., Slack, R., Park, D.S., Involvement of cell cycle elements cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death (1999) J. Biol. Chem., 274, pp. 19011-19016
Stinson, S.F., Hill, K., Siford, T.J., Phillips, L.R., Daw, T.W., Determination of flavopiridol (L86 8275
NSC 649890) in human plasma by reversed-phase liquid chromatography with electrochemical detection (1998) Cancer Chemother. Pharmacol., 42, pp. 261-265
Ganguli, M., Cancer and dementia: it's complicated (2015) Alzheimer Dis. Assoc. Disord., 29, pp. 177-182
Leclerc, S., Garnier, M., Hoessel, R., Marko, D., Bibb, J.A., Snyder, G.L., Greengard, P., Meijer, L., Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25: two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease A property common to most cyclin-dependent kinase inhibitors? (2001) J. Biol. Chem., 276, pp. 251-260
Martinez, A., Perez, D.I., Gil, C., Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer's disease (2013) Curr. Top. Med. Chem., 13, pp. 1808-1819
The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(288 views) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 ViewExport to BibTeXExport to EndNote
Giuffrida M-, Tomasello F, Caraci F, Pandini G, Chiechio S, Battaglia G, De Bona P, Pappalardo G, Vigneri R, Nicoletti F, Rizzarelli E, Copani AG * A new function for beta-amyloid monomers(298 views) Society For Neuroscience Abstract Viewer And Itinerary Planner, 2011; 41: N/D-N/D. Impact Factor:0 ViewExport to BibTeXExport to EndNote