The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (642 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.48, 5-year impact factor: 4.497
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84958280806&partnerID=40&md5=f8641bd7b0cd2a98f09add524f2a1687
Keywords: Alzheimer, S Disease, Cell Cycle, Flavopiridol, Flavopiridol (pubchem Cid: 9910986), Memory Deficit, Oligomers, Beta-Amyloid, β-Amyloid,
Affiliations:
*** IBB - CNR ***
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy., National Research Council, Institute of Neurological Sciences (ISN-CNR), Catania, Italy; IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, Troina, EN, Italy., National Research Council, Institute of Neurological Sciences (ISN-CNR), Catania, Italy., Pharmacokinetic Unit, Unifarm Research Center, Catania, Italy., Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; Pharmacokinetic Unit, Unifarm Research Center, Catania, Italy., IRCCS Neuromed, Pozzilli IS, Italy; Department of Physiology and Pharmacology, University of Rome Sapienza, Italy., National Research Council, Institute of Biostructure and Bioimaging (IBB-CNR), Catania, Italy; Department of Drug Sciences, University of Catania, Catania, Italy., IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, Troina, EN, Italy; Department of Drug Sciences, University of Catania, Catania, Italy. Electronic address: carafil@hotmail.com.,
References:
Hardy, J., The amyloid hypothesis for Alzheimer's disease: a critical reappraisal (2009) J. Neurochem., 110, pp. 1129-113
Giacobini, E., Gold, G., Alzheimer disease therapy-moving from amyloid-β to tau (2013) Nat. Rev. Neurol., 9, pp. 677-686
Walsh, D.M., Selkoe, D.J., A beta oligomers - a decade of discovery (2007) J. Neurochem., 101, pp. 1172-1184
Hynd, M.R., Scott, H.L., Dodd, P.R., Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease (2004) Neurochem. Int., 45, pp. 583-595
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Storto, M., Nicoletti, F., Induction of Dickkopf-1 a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (2004) J. Neurosci., 24, pp. 6021-6027
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., Divide and die: cell cycle events as triggers of nerve cell death (2004) J. Neurosci., 24, pp. 9232-9239
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J., 13, pp. 2225-2234
Copani, A., Hoozemans, J.J., Caraci, F., Calafiore, M., Van Haaster, E.S., Veerhius, R., Rozemuller, A.J.M., Nicoletti, F., DNA polymerase-ß is early expressed in neurons of Alzheimer's disease brain and is loaded into DNA replication forks ni neurons challenged with ß-amyloid (2006) J. Neurosci., 26, pp. 10949-10957
Arendt, T., Brückner, M.K., Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity (2010) Biochim. Biophys. Acta., 1772, pp. 413-421
Ueberham, U., Arendt, T., The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease (2005) Curr. Drug Targets CNS Neurol. Disord., 4, pp. 293-306
Wu, J., Stoica, B.A., Dinizo, M., Pajoohesh-Ganji, A., Piao, C., Faden, A.I., Delayed cell cycle pathway modulation facilitates recovery after spinal cord injury (2012) Cell Cycle, 11, pp. 1782-1795
Pallàs, M., Verdaguer, E., Jordà, E.G., Jiménez, A., Canudas, A.M., Camins, A., Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases (2005) Med. Hypotheses, 64 (2005), pp. 120-123
Osuga, H., Osuga, S., Wang, F., Fetni, R., Hogan, M.J., Slack, R.S., Hakim, A.M., Park, D.S., Cyclin-dependent kinases as a therapeutic target for stroke (2000) Proc. Natl. Acad. Sci. U. S. A., 97, pp. 10254-10259
Carlson, B.A., Dubay, M.M., Sausville, E.A., Worland, P.J., Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (cdk) 2 and cdk4 in human breast carcinoma cells (1996) Cancer Res., 56, pp. 2973-2978
Ledo, J.H., Azevedo, E.P., Clarke, J.R., Ribeiro, F.C., Figueiredo, C.P., Foguel, D., De Felice, F.G., Ferreira, S.T., Amyloid-β oligomers link depression-like behavior and cognitive deficits in mice (2001) Mol. Psychiatry, 18, pp. 1053-1054
Gong, Y., Klein, W.L., Alzheimer's disease-affected brain: presence of oligomeric Abeta ligands (ADDLs) suggests a molecular basis for reversible memory loss (2003) PNAS., 100, pp. 10417-10422
Maurice, T., Lockhart, B.P., Privat, A., Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction (1996) Brain Res., 706, pp. 181-193
Micale, V., Cristino, L., Tamburella, A., Petrosino, S., Leggio, G.M., Di Marzo, V., Drago, F., Enhanced cognitive performance of dopamine D3 receptor knock-out mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems (2010) Pharmacol. Res., 61, pp. 531-536
Puzzo, D., Bizzoca, A., Loreto, C., Guida, C.A., Gulisano, W., Frasca, G., Bellomo, M., Palmeri, A., Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice (2015) Neurobiol. Aging, 36, pp. 1702-1715
Varvel, N.H., Bhaskar, K., Patil, A.R., Pimplikar, S.W., Herrup, K., Lamb, B.T., Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease (2008) J. Neurosci., 28, pp. 10786-10793
Caraci, F., Gulisano, W., Guida, A.C., Impellizzeri, A.R., Drago, F., Puzzo, D., Palmeri, A., A key role for TGF-β1 in hippocampal synaptic plasticity and memory (2015) Sci. Rep., 5, p. 11252
Zhou, L., Schmidt, K., Nelson, F.R., Zelesky, V., Troutman, M.D., Feng, B., The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl) ethoxy) phenyl) propanoic acid (PF-407288) in mice (2009) Drug. Metab. Dispos., 37, pp. 946-955
Kodaira, H., Kusuhara, H., Fujita, T., Ushiki, J., Fuse, E., Sugiyama, Y., Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate (2011) J. Pharmacol. Exp. Ther., 339, pp. 935-944
Broadbent, N.J., Gaskin, S., Squire, L.R., Clark, R.E., Object recognition memory and the rodent hippocampus (2009) Learn. Mem., 17, pp. 5-11
Barker, G.R., Bird, F., Alexander, V., Warburton, E.C., Recognition memory for objects place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex (2007) J. Neurosci., 27, pp. 2948-2957
De La Torre, A.V., Junyent, F., Folch, J., Pelegrí, C., Vilaplana, J., Auladell, C., Beas-Zarate, C., Camins, A., GSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons (2012) Pharmacol. Res., 65, pp. 66-73
Tu, S., Okamoto, S., Lipton, S.A., Xu, H., Oligomeric Aβ-induced synaptic dysfunction in alzheimer's disease (2014) Mol. Neurodegener., 9, p. 48
Klein, W.L., Synaptotoxic amyloid-β oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease (2013) J. Alzheimers Dis., 33 (S1), pp. S49-S65
Ferretti, M.T., Bruno, M.A., Ducatenzeiler, A., Klein, W.L., Cuello, A.C., Intracellular abeta-oligomers and early inflammation in a model of Alzheimer's disease (2012) Neurobiol. Aging, 33, pp. 1329-1342
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., Beta-amyloidmonomers are neuroprotective (2009) J. Neurosci., 29, pp. 10582-10587
Caraci, F., Pappalardo, G., Basile, L., Giuffrida, A., Copani, A., Tosto, R., Sinopoli, A., Guccione, S., Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity (2015) Eur. J. Pharmacol., 764, pp. 256-263
Epelbaum, S., Youssef, I., Lacor, P.N., Chaurand, P., Duplus, E., Brugg, B., Duyckaerts, C., Delatour, B., Acute amnestic encephalopathy in amyloid-β oligomer-injected mice is due to their widespread diffusion in vivo (2015) Neurobiol. Aging, 36, pp. 2043-2052
Fluharty, B.R., Biasini, E., Stravalaci, M., Sclip, A., Diomede, L., Balducci, C., La Vitola, P., Harris, D.A., An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo (2013) J. Biol. Chem., 288, pp. 7857-7866
Balducci, C., Beeg, M., Stravalaci, M., Bastone, A., Sclip, A., Biasini, E., Tapella, L., Forloni, G., Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein (2010) Proc. Natl. Acad. Sci. U. S. A., 107, pp. 2295-2300
Youssef, I., Florent-Béchard, S., Malaplate-Armand, C., Koziel, V., Bihain, B., Olivier, J.-L., Leininger-Muller, B., Pillot, T., N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosis (2008) Neurobiol. Aging, 29, pp. 1319-1333
McLean, C.A., Cherny, R.A., Fraser, F.W., Fuller, S.J., Smith, M.J., Beyreuther, K., Bush, A.I., Masters, C.L., Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease (1999) Ann. Neurol., 46, pp. 860-866
Webster, S.J., Bachstetter, A.D., Nelson, P.T., Schmitt, F.A., Van Eldik, L.J., Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models (2014) Front. Genet., 5, p. 88
Van DerPoel, A.M., Ethological study of the behaviour of the albino rat in a passive-avoidance test (1967) Acta Physiol. Pharmacol. Neerl., 14, pp. 503-505
Filali, M., Lalonde, R., Theriault, P., Julien, C., Calon, F., Planel, E., Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP PS1, and Mapt (3xTg-AD) (2012) Behav. Brain Res., 234, pp. 334-342
Herrup, K., The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer's disease (2012) Front. Biosci., 24, pp. 2101-2109
Yang, Y., Geldmacher, D.S., Herrup, K., DNA replication precedes neuronal cell death in Alzheimer's disease (2001) J. Neurosci., 21, pp. 2661-2668
Van Leeuwen, L.A., Hoozemans, J.J., Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's disease (2015) Acta Neuropathol., 129, pp. 511-525
Bhaskar, K., Maphis, N., Xu, G., Varvel, N.H., Kokiko-Cochran, O.N., Weick, J.P., Staugaitis, S.M., Lamb, B.T., Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events (2014) Neurobiol. Dis., 62, pp. 273-285
Sivilia, S., Lorenzini, L., Giuliani, A., Gusciglio, M., Fernandez, M., Baldassarro, V.A., Mangano, C., Giardino, L., Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice (2013) BMC Neurosci., 14, p. 44
Yang, Y., Varvel, N.H., Lamb, B.T., Herrup, K., Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models (2006) J. Neurosci., 26, pp. 775-784
Morris, D.G., Bramwell, V.H., Turcotte, R., Figueredo, A.T., Blackstein, M.E., Verma, S., Matthews, S., Eisenhauer, E.A., A phase II study of flavopiridol in patients with previously untreated advanced soft tissue sarcoma (2006) Sarcoma, 2006, p. 64374
Bose, P., Simmons, G.L., Grant, S., Cyclin-dependent kinase inhibitor therapy for hematologic malignancies (2013) Expert Opin. Investig. Drugs, 22, pp. 723-738
Sanphui, P., Pramanik, S.K., Chatterjee, N., Moorthi, P., Banerji, B., Biswas, S.C., Efficacy of cyclin dependent kinase 4 inhibitors as potent neuroprotective agents against insults relevant to Alzheimer's disease (2013) PLoS One, 8
Giovanni, A., Wirtz-Brugger, F., Keramaris, E., Slack, R., Park, D.S., Involvement of cell cycle elements cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death (1999) J. Biol. Chem., 274, pp. 19011-19016
Stinson, S.F., Hill, K., Siford, T.J., Phillips, L.R., Daw, T.W., Determination of flavopiridol (L86 8275
NSC 649890) in human plasma by reversed-phase liquid chromatography with electrochemical detection (1998) Cancer Chemother. Pharmacol., 42, pp. 261-265
Ganguli, M., Cancer and dementia: it's complicated (2015) Alzheimer Dis. Assoc. Disord., 29, pp. 177-182
Leclerc, S., Garnier, M., Hoessel, R., Marko, D., Bibb, J.A., Snyder, G.L., Greengard, P., Meijer, L., Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25: two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease A property common to most cyclin-dependent kinase inhibitors? (2001) J. Biol. Chem., 276, pp. 251-260
Martinez, A., Perez, D.I., Gil, C., Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer's disease (2013) Curr. Top. Med. Chem., 13, pp. 1808-1819
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.48, 5-year impact factor: 4.497
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84958280806&partnerID=40&md5=f8641bd7b0cd2a98f09add524f2a1687
Keywords: Alzheimer, S Disease, Cell Cycle, Flavopiridol, Flavopiridol (pubchem Cid: 9910986), Memory Deficit, Oligomers, Beta-Amyloid, β-Amyloid,
Affiliations:
*** IBB - CNR ***
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy., National Research Council, Institute of Neurological Sciences (ISN-CNR), Catania, Italy; IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, Troina, EN, Italy., National Research Council, Institute of Neurological Sciences (ISN-CNR), Catania, Italy., Pharmacokinetic Unit, Unifarm Research Center, Catania, Italy., Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; Pharmacokinetic Unit, Unifarm Research Center, Catania, Italy., IRCCS Neuromed, Pozzilli IS, Italy; Department of Physiology and Pharmacology, University of Rome Sapienza, Italy., National Research Council, Institute of Biostructure and Bioimaging (IBB-CNR), Catania, Italy; Department of Drug Sciences, University of Catania, Catania, Italy., IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, Troina, EN, Italy; Department of Drug Sciences, University of Catania, Catania, Italy. Electronic address: carafil@hotmail.com.,
References:
Hardy, J., The amyloid hypothesis for Alzheimer's disease: a critical reappraisal (2009) J. Neurochem., 110, pp. 1129-113
Giacobini, E., Gold, G., Alzheimer disease therapy-moving from amyloid-β to tau (2013) Nat. Rev. Neurol., 9, pp. 677-686
Walsh, D.M., Selkoe, D.J., A beta oligomers - a decade of discovery (2007) J. Neurochem., 101, pp. 1172-1184
Hynd, M.R., Scott, H.L., Dodd, P.R., Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease (2004) Neurochem. Int., 45, pp. 583-595
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Storto, M., Nicoletti, F., Induction of Dickkopf-1 a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (2004) J. Neurosci., 24, pp. 6021-6027
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., Divide and die: cell cycle events as triggers of nerve cell death (2004) J. Neurosci., 24, pp. 9232-9239
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J., 13, pp. 2225-2234
Copani, A., Hoozemans, J.J., Caraci, F., Calafiore, M., Van Haaster, E.S., Veerhius, R., Rozemuller, A.J.M., Nicoletti, F., DNA polymerase-ß is early expressed in neurons of Alzheimer's disease brain and is loaded into DNA replication forks ni neurons challenged with ß-amyloid (2006) J. Neurosci., 26, pp. 10949-10957
Arendt, T., Brückner, M.K., Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity (2010) Biochim. Biophys. Acta., 1772, pp. 413-421
Ueberham, U., Arendt, T., The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease (2005) Curr. Drug Targets CNS Neurol. Disord., 4, pp. 293-306
Wu, J., Stoica, B.A., Dinizo, M., Pajoohesh-Ganji, A., Piao, C., Faden, A.I., Delayed cell cycle pathway modulation facilitates recovery after spinal cord injury (2012) Cell Cycle, 11, pp. 1782-1795
Pallàs, M., Verdaguer, E., Jordà, E.G., Jiménez, A., Canudas, A.M., Camins, A., Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases (2005) Med. Hypotheses, 64 (2005), pp. 120-123
Osuga, H., Osuga, S., Wang, F., Fetni, R., Hogan, M.J., Slack, R.S., Hakim, A.M., Park, D.S., Cyclin-dependent kinases as a therapeutic target for stroke (2000) Proc. Natl. Acad. Sci. U. S. A., 97, pp. 10254-10259
Carlson, B.A., Dubay, M.M., Sausville, E.A., Worland, P.J., Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (cdk) 2 and cdk4 in human breast carcinoma cells (1996) Cancer Res., 56, pp. 2973-2978
Ledo, J.H., Azevedo, E.P., Clarke, J.R., Ribeiro, F.C., Figueiredo, C.P., Foguel, D., De Felice, F.G., Ferreira, S.T., Amyloid-β oligomers link depression-like behavior and cognitive deficits in mice (2001) Mol. Psychiatry, 18, pp. 1053-1054
Gong, Y., Klein, W.L., Alzheimer's disease-affected brain: presence of oligomeric Abeta ligands (ADDLs) suggests a molecular basis for reversible memory loss (2003) PNAS., 100, pp. 10417-10422
Maurice, T., Lockhart, B.P., Privat, A., Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction (1996) Brain Res., 706, pp. 181-193
Micale, V., Cristino, L., Tamburella, A., Petrosino, S., Leggio, G.M., Di Marzo, V., Drago, F., Enhanced cognitive performance of dopamine D3 receptor knock-out mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems (2010) Pharmacol. Res., 61, pp. 531-536
Puzzo, D., Bizzoca, A., Loreto, C., Guida, C.A., Gulisano, W., Frasca, G., Bellomo, M., Palmeri, A., Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice (2015) Neurobiol. Aging, 36, pp. 1702-1715
Varvel, N.H., Bhaskar, K., Patil, A.R., Pimplikar, S.W., Herrup, K., Lamb, B.T., Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease (2008) J. Neurosci., 28, pp. 10786-10793
Caraci, F., Gulisano, W., Guida, A.C., Impellizzeri, A.R., Drago, F., Puzzo, D., Palmeri, A., A key role for TGF-β1 in hippocampal synaptic plasticity and memory (2015) Sci. Rep., 5, p. 11252
Zhou, L., Schmidt, K., Nelson, F.R., Zelesky, V., Troutman, M.D., Feng, B., The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl) ethoxy) phenyl) propanoic acid (PF-407288) in mice (2009) Drug. Metab. Dispos., 37, pp. 946-955
Kodaira, H., Kusuhara, H., Fujita, T., Ushiki, J., Fuse, E., Sugiyama, Y., Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate (2011) J. Pharmacol. Exp. Ther., 339, pp. 935-944
Broadbent, N.J., Gaskin, S., Squire, L.R., Clark, R.E., Object recognition memory and the rodent hippocampus (2009) Learn. Mem., 17, pp. 5-11
Barker, G.R., Bird, F., Alexander, V., Warburton, E.C., Recognition memory for objects place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex (2007) J. Neurosci., 27, pp. 2948-2957
De La Torre, A.V., Junyent, F., Folch, J., Pelegrí, C., Vilaplana, J., Auladell, C., Beas-Zarate, C., Camins, A., GSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons (2012) Pharmacol. Res., 65, pp. 66-73
Tu, S., Okamoto, S., Lipton, S.A., Xu, H., Oligomeric Aβ-induced synaptic dysfunction in alzheimer's disease (2014) Mol. Neurodegener., 9, p. 48
Klein, W.L., Synaptotoxic amyloid-β oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease (2013) J. Alzheimers Dis., 33 (S1), pp. S49-S65
Ferretti, M.T., Bruno, M.A., Ducatenzeiler, A., Klein, W.L., Cuello, A.C., Intracellular abeta-oligomers and early inflammation in a model of Alzheimer's disease (2012) Neurobiol. Aging, 33, pp. 1329-1342
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., Beta-amyloidmonomers are neuroprotective (2009) J. Neurosci., 29, pp. 10582-10587
Caraci, F., Pappalardo, G., Basile, L., Giuffrida, A., Copani, A., Tosto, R., Sinopoli, A., Guccione, S., Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity (2015) Eur. J. Pharmacol., 764, pp. 256-263
Epelbaum, S., Youssef, I., Lacor, P.N., Chaurand, P., Duplus, E., Brugg, B., Duyckaerts, C., Delatour, B., Acute amnestic encephalopathy in amyloid-β oligomer-injected mice is due to their widespread diffusion in vivo (2015) Neurobiol. Aging, 36, pp. 2043-2052
Fluharty, B.R., Biasini, E., Stravalaci, M., Sclip, A., Diomede, L., Balducci, C., La Vitola, P., Harris, D.A., An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo (2013) J. Biol. Chem., 288, pp. 7857-7866
Balducci, C., Beeg, M., Stravalaci, M., Bastone, A., Sclip, A., Biasini, E., Tapella, L., Forloni, G., Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein (2010) Proc. Natl. Acad. Sci. U. S. A., 107, pp. 2295-2300
Youssef, I., Florent-Béchard, S., Malaplate-Armand, C., Koziel, V., Bihain, B., Olivier, J.-L., Leininger-Muller, B., Pillot, T., N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosis (2008) Neurobiol. Aging, 29, pp. 1319-1333
McLean, C.A., Cherny, R.A., Fraser, F.W., Fuller, S.J., Smith, M.J., Beyreuther, K., Bush, A.I., Masters, C.L., Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease (1999) Ann. Neurol., 46, pp. 860-866
Webster, S.J., Bachstetter, A.D., Nelson, P.T., Schmitt, F.A., Van Eldik, L.J., Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models (2014) Front. Genet., 5, p. 88
Van DerPoel, A.M., Ethological study of the behaviour of the albino rat in a passive-avoidance test (1967) Acta Physiol. Pharmacol. Neerl., 14, pp. 503-505
Filali, M., Lalonde, R., Theriault, P., Julien, C., Calon, F., Planel, E., Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP PS1, and Mapt (3xTg-AD) (2012) Behav. Brain Res., 234, pp. 334-342
Herrup, K., The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer's disease (2012) Front. Biosci., 24, pp. 2101-2109
Yang, Y., Geldmacher, D.S., Herrup, K., DNA replication precedes neuronal cell death in Alzheimer's disease (2001) J. Neurosci., 21, pp. 2661-2668
Van Leeuwen, L.A., Hoozemans, J.J., Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's disease (2015) Acta Neuropathol., 129, pp. 511-525
Bhaskar, K., Maphis, N., Xu, G., Varvel, N.H., Kokiko-Cochran, O.N., Weick, J.P., Staugaitis, S.M., Lamb, B.T., Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events (2014) Neurobiol. Dis., 62, pp. 273-285
Sivilia, S., Lorenzini, L., Giuliani, A., Gusciglio, M., Fernandez, M., Baldassarro, V.A., Mangano, C., Giardino, L., Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice (2013) BMC Neurosci., 14, p. 44
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The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice
The ectopic re-activation of cell cycle in neurons is an early event in the pathogenesis of Alzheimer's disease (AD), which could lead to synaptic failure and ensuing cognitive deficits before frank neuronal death. Cytostatic drugs that act as cyclin-dependent kinase (CDK) inhibitors have been poorly investigated in animal models of AD. In the present study, we examined the effects of flavopiridol, an inhibitor of CDKs currently used as antineoplastic drug, against cell cycle reactivation and memory loss induced by intracerebroventricular injection of Aß1-42 oligomers in CD1 mice. Cycling neurons, scored as NeuN-positive cells expressing cyclin A, were found both in the frontal cortex and in the hippocampus of Aβ-injected mice, paralleling memory deficits. Starting from three days after Aβ injection, flavopiridol (0.5, 1 and 3 mg/kg) was intraperitoneally injected daily, for eleven days. Here we show that a treatment with flavopiridol (0.5 and 1 mg/kg) was able to rescue the loss of memory induced by Aβ1-42, and to prevent the occurrence of ectopic cell-cycle events in the mouse frontal cortex and hippocampus. This is the first evidence that a cytostatic drug can prevent cognitive deficits in a non-transgenic animal model of AD. © 2016 Elsevier Ltd. All rights reserved.
The ectopic re-activation of cell cycle in neurons is an early event in the pathogenesis of Alzheimer's disease (AD), which could lead to synaptic failure and ensuing cognitive deficits before frank neuronal death. Cytostatic drugs that act as cyclin-dependent kinase (CDK) inhibitors have been poorly investigated in animal models of AD. In the present study, we examined the effects of flavopiridol, an inhibitor of CDKs currently used as antineoplastic drug, against cell cycle reactivation and memory loss induced by intracerebroventricular injection of Aß1-42 oligomers in CD1 mice. Cycling neurons, scored as NeuN-positive cells expressing cyclin A, were found both in the frontal cortex and in the hippocampus of Aβ-injected mice, paralleling memory deficits. Starting from three days after Aβ injection, flavopiridol (0.5, 1 and 3 mg/kg) was intraperitoneally injected daily, for eleven days. Here we show that a treatment with flavopiridol (0.5 and 1 mg/kg) was able to rescue the loss of memory induced by Aβ1-42, and to prevent the occurrence of ectopic cell-cycle events in the mouse frontal cortex and hippocampus. This is the first evidence that a cytostatic drug can prevent cognitive deficits in a non-transgenic animal model of AD. © 2016 Elsevier Ltd. All rights reserved.
The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice
| ▼ Structural characterization of the porphyrins/proteasome interaction |
The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice
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Farina AR, Tacconelli A, Cappabianca L, Cea G, Panella S, Chioda A, Romanelli A, Pedone C, Gulino A, Mackay AR
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
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* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 16; 21 (2 ): N/D-N/D.
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Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (158 views)
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Impact Factor: 3.345
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Carella A, Roviello V, Iannitti R, Palumbo R, La Manna S, Marasco D, Trifuoggi M, Diana R, Roviello GN
* Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities (411 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jan; 121: 77-88.
Impact Factor: 4.784
View Export to BibTeX Export to EndNote
Ciarmiello A, Tartaglione A, Giovannini E, Riondato M, Giovacchini G, Ferrando O, De Biasi M, Passera C, Carabelli E, Mannironi A, Foppiano F, Alfano B, Mansi L
* Amyloid burden identifies neuropsychological phenotypes at increased risk of progression to Alzheimer's disease in mild cognitive impairment patients (486 views)
Eur J Nucl Med (ISSN: 1619-7070linking, 1619-7070print, 1619-7089electronic), 2018 Sep 22; 46(2): 288-296.
Impact Factor: 7.704
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Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (288 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
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Copani A
* The underexplored question of beta-amyloid monomers (299 views)
Eur J Pharmacol (ISSN: 0014-2999), 2017 May 31; N/D: N/D-N/D.
Impact Factor: 3.04
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Alterio V, Langella E, De Simone G, Monti SM
* Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (645 views)
Mar Drugs (ISSN: 1660-3397, 1660-3397linking), 2015 Mar 25; 13(4): 1688-1697.
Impact Factor: 3.345
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (524 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (437 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Nov 6; 9(11): e112082-e112082.
Impact Factor: 3.234
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (623 views)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Giuffrida M, Caraci F, Tomasello F, Pappalardo G, Rizzarelli E, Nicoletti F, Copani AG
* Shared and distinct features of beta-amyloid peptides (415 views)
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2013; 43: N/D-N/D.
Impact Factor: 0
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Ruggiero A, De Simone P, Smaldone G, Squeglia F, Berisio R
* Bacterial cell division regulation by Ser/Thr kinases: A structural perspective (581 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 756-766.
Impact Factor: 2.326
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1532 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (364 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (615 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (527 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Giuffrida M, Tomasello F, Caraci F, Pandini G, Chiechio S, Pappalardo G, Vigneri R, Rizzarelli E, Nicoletti F, Copani AG
* Monomeric beta-amyloid activities relay on specific receptor engagement (316 views)
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2012; 42: N/D-N/D.
Impact Factor: 0
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Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (887 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
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Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (362 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
Impact Factor: 2.921
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Giuffrida M-, Tomasello F, Caraci F, Pandini G, Chiechio S, Battaglia G, De Bona P, Pappalardo G, Vigneri R, Nicoletti F, Rizzarelli E, Copani AG
* A new function for beta-amyloid monomers (298 views)
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2011; 41: N/D-N/D.
Impact Factor: 0
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Giuffrida M, Tomasello F, Caraci F, Pappalardo G, Rizzarelli E, Nicoletti F, Copani AG
* Basic understanding of the activities of beta-amyloid (A beta) monomers (271 views)
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2010; 40: N/D-N/D.
Impact Factor: 0
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (681 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (708 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Farina AR, Tacconelli A, Cappabianca L, Cea G, Panella S, Chioda A, Romanelli A, Pedone C, Gulino A, Mackay AR
* The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability (358 views)
Mol Cell Biol (ISSN: 1098-5549, 0270-7306), 2009 Sep 1; 29(17): 4812-4830.
Impact Factor: 6.057
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Giuffrida M, Caraci F, Molinaro G, Cataldo S, Pignataro B, Bruno V, De Bona P, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani AG
* Monomers of beta-amyloid protein are endowed with neuroprotective activity (260 views)
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2009; 39: N/D-N/D.
Impact Factor: 0
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Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (484 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
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Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (569 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
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Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (490 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
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Damante C, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sovago I
* Metal ion interactions within the 1-16 N-terminal region of beta-amyloid (267 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (313 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (622 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (517 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (375 views)
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
Impact Factor: 2.085
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Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (600 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
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Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (524 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (408 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (502 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
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Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (559 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
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46 Records (38 excluding Abstracts).
Total impact factor: 181.115 (172.497 excluding Abstracts).
Total 5 year impact factor: 191.559 (181.831 excluding Abstracts).
Total impact factor: 181.115 (172.497 excluding Abstracts).
Total 5 year impact factor: 191.559 (181.831 excluding Abstracts).
642 views. Last view on Tuesday 30 May 2023, 12:16:08
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