The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability (358 views)
Mol Cell Biol (ISSN: 1098-5549, 0270-7306), 2009 Sep 1; 29(17): 4812-4830.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 6.057, 5-year impact factor: 6.367
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-68849121025&partnerID=40&md5=c44b0a54ee181c26e4365897ef9b6d56
Keywords: Cell Cycle Protein 37, Endoplasmic Reticulum Golgi Intermediate Compartment Protein, Gamma Tubulin, Geldanamycin, Heat Shock Protein 90, Lectin, Polo Like Kinase, Protein Tyrosine Kinase A, Protein Tyrosine Phosphatase, Separase, Unclassified Drug, Anaphase, Animal Cell, Article, Catalysis, Centrosome, Chromosome Segregation, Controlled Study, Enzyme Binding, Enzyme Localization, Enzyme Phosphorylation, Genetic Stability, Golgi Complex, Human, Human Cell, Interphase, Mouse, Neuroblastoma, Nonhuman, Oncogene, Priority Journal, Protein Expression, Protein Function, Protein Interaction, Protein Variant, Alternative Splicing, Calcium-Binding Proteins, Cell Line, Chromosomal Proteins, Non-Histone, Endopeptidases, Enzyme Activation, Exons, Genomic Instability, Intracellular Membranes, Protein Isoforms, Protein-Serine-Threonine Kinases, Rabbits, Receptor, Recombinant Fusion Proteins, Signal Transduction,
Affiliations:
*** IBB - CNR ***
Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy.
Section of Molecular Pathology, Department of Experimental Medicine, University of L'Aquila, Coppito 2, Via Vetoio, L'Aquila 67100, Italy
Department of Biological Science, University of Naples Federico II, Naples, Italy
Neuromed Institute, 86077 Pozzilli, Italy
References:
Appenzeller-Herzog, C., Hauri, H.-P., The ER-Golgi intermediate compartment (ERGIC): In search of its identity and function (2006) J. Cell Sci, 119, pp. 2173-218
Arevalo, J.C., Conde, B., Hempstead, B.L., Chao, M.V., Martin-Zanca, D., Perez, P., TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor (2000) Mol. Cell. Biol, 20, pp. 5908-5916
Blume-Jensen, P., Hunter, T., Oncogenic kinase signalling (2001) Nature, 411, pp. 355-365
Camoratto, A.M., Jani, J.P., Angeles, T.S., Maroney, A.C., Sanders, C.Y., Murakata, C., Neff, N.T., Dionne, C.A., CEP-751 inhibits Trk receptor tyrosine kinase activity in vitro and exhibits anti-tumor activity (1997) Int. J. Cancer, 72, pp. 673-679
Collier, E., Carpentier, J.L., Beitz, L., Caro, H., Taylor, S.I., Gorden, P., Specific glycosylation site mutations of insulin receptor alpha subunit impairs intracellular transport (1993) Biochemistry, 32, pp. 7818-7823
Delaval, B., Létard, S., Lelièvre, H., Chevrier, V., Daviet, L., Dubreuil, P., Birnbaum, D., Oncogenic tyrosine kinase of malignant hemopathy targets the centrosome (2005) Cancer Res, 65, pp. 7231-7240
Dikovskaya, D., Schiffmann, D., Newton, I.P., Oakley, A., Kroboth, K., Sansom, O., Jamieson, T.J., Nathke, I.S., Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis (2007) J. Cell Biol, 176, pp. 183-195
Dionisotti, S., Ongini, E., Zocchi, C., Kull, B., Arslan, G., Fredholm, B.B., Characterisation of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261 (1997) Br. J. Pharmacol, 121, pp. 353-360
Eggert, A., Grotzer, M.A., Ikegaki, N., Liu, X.G., Evans, A.E., Brodeur, G.M., Expression of the neurotrophin receptor TrkA down-regulates expression and function of angiogenic stimulators in SH-SY5Y neuroblastoma cells (2002) Cancer Res, 62, pp. 1802-1808
Frangioni, J.V., Beahm, P.H., Shifrin, V., Jost, C.A., Neel, B.G., The non transmembrane tyrosine phosphatase PTP-1B localises to the endoplasmic reticulum via its 35 amino acid C-terminal sequence (1992) Cell, 68, pp. 545-560
Fukasawa, K., Centrosome amplification, chromosome instability and cancer development (2005) Cancer Lett, 230, pp. 6-19
Fukasawa, K., Oncogenes and tumour suppressors take on the centrosome (2007) Nat. Rev. Cancer, 7, pp. 911-924
Gibbs, L., Legeai-Mallet, L., FGFR3 intracellular mutations induce tyrosine phosphorylation in the Golgi and defective glycosylation (2007) Biochim. Biophys. Acta, 1773, pp. 502-512
Guarguaglini, G., Duncan, P.I., Stierhof, Y.D., Holmstrom, T., Duensing, S., Nigg, E.A., The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles (2005) Mol. Biol. Cell, 16, pp. 1095-1107
Jesch, S.A., Linstedt, A.D., The Golgi and endoplasmic reticulum remain independent during mitosis in HeLa cells (1998) Mol. Biol. Cell, 9, pp. 623-635
Kaihatsu, K., Huffman, K.E., Corey, D.A., Intracellular uptake and inhibition of gene expression by PNAs and PNA-peptide conjugates (2004) Biochemistry, 43, pp. 14340-14347
Kalnina, Z., Zayakin, P., Silina, K., Line, A., Alterations of premRNA splicing in cancer (2005) Genes Chromosomes Cancer, 42, pp. 342-357
Kleylein-Sohn, J., Westerndorf, J., Le Clech, M., Habedank, R., Stierhof, Y.D., Nigg, E.A., Plk-4 induced centriole biogenesis in human cells (2007) Dev. Cell, 13, pp. 190-202
Lavenius, E., Gestblom, C., Johansson, I., Nanberg, E., Pahlman, S., Transfection of Trk-A into human neuroblastoma cells restores their ability to differentiate in response to nerve growth factor (1995) Cell Growth Differ, 6, pp. 727-736
Liu, G., Shang, Y., Yu, Y., Induced endoplasmic reticulum (ER) stress and binding of over-expressed ER specific chaperone GRP78/BIP with dimerized epidermal growth factor receptor in mammalian cells exposed to low concentration of N′-methyl-N-nitro-N-nitrosoguanidine (2006) Mutat. Res, 596, pp. 12-21
Löffler, H., Lukas, J., Bartek, J., Kramer, A., Structure meets function-centrosomes, genome maintenance and the DNA damage response (2006) Exp. Cell Res, 312, pp. 2633-2640
Lucarelli, E., Kaplan, D., Thiele, C.J., Activation of trk-A but not trk-B signal transduction pathway inhibits growth of neuroblastoma cells (1997) Eur. J. Cancer, 33, pp. 2068-2070
Lüders, J., Stearns, T., Microtubule organising centres: A reevaluation (2007) Nat. Rev. Mol. Cell Biol, 8, pp. 161-167
Lüders, J., Patel, U.K., Stearns, T., GCP-WD is a gamma tubulin targeting factor required for centrosomal and chromatin mediated microtubule nucleation (2006) Nat. Cell Biol, 8, pp. 137-147
Meakin, S.O., Shooter, E.M., Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex (1991) Proc. Natl. Acad. Sci. USA, 88, pp. 5862-5866
Meijer, G.A., Chromosomes and cancer. Boveri revisited (2005) Cell. Oncol, 27, pp. 273-275
Meraldi, P., Nigg, E.A., Centrosome cohesion is regulated by a balance of kinase and phosphatase activities (2001) J. Cell Sci, 114, pp. 3749-3757
Missbach, M., Altmann, E., Widler, L., Susa, M., Buchdunger, E., Mett, H., Meyer, T., Green, J., Substituted 5, 7-diphenyl-pyrrolo [2,3d] pyrimidines: Potent inhibitors of the tyrosine kinase c-Src (2000) Bioorg. Med. Chem. Lett, 10, pp. 945-949
Modrek, B., Lee, C., A genomic view of alternative splicing (2002) Nat. Genet, 30, pp. 13-19
Nakagawara, A., Trk receptor tyrosine kinases: A bridge between cancer and neural development (2001) Cancer Lett, 169, pp. 107-114
Noll, A., Ruppenthal, S.L., Montenarh, M., The mitotic phosphatase cdc25C at the Golgi apparatus (2006) Biochem. Biophys. Res. Commun, 351, pp. 825-830
Onuoha, S.C., Mukund, S.R., Coulstock, E.T., Sengerova, B., Shaw, J., Mclaughlin, S.H., Jackson, S.E., Mechanistic studies on Hsp90 inhibition by ansamycin derivatives (2007) J. Mol. Biol, 372, pp. 287-297
Piel, M., Meyer, P., Khodjakov, A., Reider, C.L., Bornens, M., The respective contributions of the mother and daughter centrioles to centrosome activity and behaviour in vertebrate cells (2000) J. Cell Biol, 149, pp. 317-330
Pihan, G.A., Purohit, A., Wallace, J., Knecht, H., Woda, B., Queensberry, P., Doxsey, S.J., Centrosome defects and genetic instability in malignant tumors (1998) Cancer Res, 58, pp. 3974-3985
Plo, I., Nakatake, M., Malivert, L., de Villartay, J.P., Giraudier, S., Villeval, J.L., Wiesmuller, L., Vainchenker, W., JAK2 stimulates homologous recombination and genetic instability: Potential implication in the heterogeneity of myeloproliferative disorders (2008) Blood, 122, pp. 1402-1412
Rajagopal, R., Chen, Z.Y., Lee, F.S., Chao, M.V., Transactivation of Trk neurotrophin receptors by G-protein coupled receptor ligands occurs on intracellular membranes (2004) J. Neurosci, 24, pp. 6650-6658
Rios, R.M., Bornens, M., The Golgi apparatus at the cell centre (2003) Curr. Opin. Cell Biol, 15, pp. 60-66
Ríos, R.M., Sanchis, A., Tassin, A.M., Fedriani, C., Bornens, M., GMAP-210 recruits gamma tubulin complexes to cis-Golgi membranes and is required for Golgi ribbon formation (2004) Cell, 118, pp. 323-335
Shen, K., Wang, Y., Brooks, S.C., Raz, A., Wang, Y.A., ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells (2006) J. Cell. Biochem, 99, pp. 1267-1274
Shepard, J.L., Amatruda, J.F., Finkelstein, D., Ziai, J., Finley, K.R., Stern, H.M., Chiang, K., Zon, L.I., A mutation in separase causes genome instability and increased susceptibility to epithelial cancer (2007) Genes Dev, 21, pp. 55-59
Suizu, F., Ryo, A., Wulf, G., Lim, J., Lu, K.P., Pin1 regulates centrosome duplication, and its overexpression induces centrosome ampli-fication, chromosome instability and oncogenesis (2006) Mol. Cell. Biol, 26, pp. 1463-1479
Szul, T., Grabski, R., Lyons, S., Morohashi, Y., Shestopal, S., Lowe, M., Sztul, E., Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking (2007) J. Cell Sci, 120, pp. 3929-3940
Tacconelli, A., Farina, A.R., Cappabianca, L., DeSantis, G., Tessitore, A., Vetuschi, A., Sferra, R., Mackay, A.R., TrkA alternative splicing: A regulated tumor-promoting switch in human neuroblastoma (2004) Cancer Cell, 6, pp. 347-360
Takahashi, T., Shibuya, M., The 230kDa mature form of KDR/ Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts (1997) Oncogene, 14, pp. 2079-2089
Tsou, M.F., Stearns, T., Mechanism limiting centrosome duplication to once per cell cycle (2006) Nature, 442, pp. 947-951
Watson, F.L., Porcionatto, M.A., Bhattacharyya, A., Stiles, C.D., Segal, R.A., TrkA glycosylation regulates receptor localisation and activity (1999) J. Neurobiol, 39, pp. 323-336
Weber, R.G., Bridger, J.M., Benner, A., Weisenberger, D., Ehemann, V., Reifenberger, G., Lichter, P., Centrosome amplification as a possible mechanism for numerical chromosome aberrations in cerebral primitive neuroectodermal tumors with TP53 mutations (1998) Cytogenet. Cell Genet, 83, pp. 266-269
Wikstrand, C.J., McLendon, R.E., Friedman, A.H., Bigner, D.D., Cell surface localization and density of the tumor-associated variant of the epidermal growth factor, EGFRvIII (1997) Cancer Res, 57, pp. 4130-4140
Yoshida, H., Unconventional splicing of XBP-1 mRNA in the unfolded protein response (2007) Antioxid. Redox Signal, 9, pp. 2323-2333
Yoshimura, S.I., Nakamura, N., Barr, F.A., Misumi, Y., Ikehara, Y., Ohuno, H., Sakaguchi, M., Mihara, K., Direct targeting of cis-Golgi matrix proteins to the Golgi apparatus (2001) J. Cell Sci, 114, pp. 4105-4115
Zyss, D., Montcourrier, P., Vidal, B., Anguille, C., Merezegue, F., Sahuquet, A., Mangeat, P.H., Coopman, P.J., The syk tyrosine kinase localises to the centrosome and negatively affects mitotic progression (2005) Cancer Res, 65, pp. 10872-10880
Mol Cell Biol (ISSN: 1098-5549, 0270-7306), 2009 Sep 1; 29(17): 4812-4830.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 6.057, 5-year impact factor: 6.367
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-68849121025&partnerID=40&md5=c44b0a54ee181c26e4365897ef9b6d56
Keywords: Cell Cycle Protein 37, Endoplasmic Reticulum Golgi Intermediate Compartment Protein, Gamma Tubulin, Geldanamycin, Heat Shock Protein 90, Lectin, Polo Like Kinase, Protein Tyrosine Kinase A, Protein Tyrosine Phosphatase, Separase, Unclassified Drug, Anaphase, Animal Cell, Article, Catalysis, Centrosome, Chromosome Segregation, Controlled Study, Enzyme Binding, Enzyme Localization, Enzyme Phosphorylation, Genetic Stability, Golgi Complex, Human, Human Cell, Interphase, Mouse, Neuroblastoma, Nonhuman, Oncogene, Priority Journal, Protein Expression, Protein Function, Protein Interaction, Protein Variant, Alternative Splicing, Calcium-Binding Proteins, Cell Line, Chromosomal Proteins, Non-Histone, Endopeptidases, Enzyme Activation, Exons, Genomic Instability, Intracellular Membranes, Protein Isoforms, Protein-Serine-Threonine Kinases, Rabbits, Receptor, Recombinant Fusion Proteins, Signal Transduction,
Affiliations:
*** IBB - CNR ***
Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy.
Section of Molecular Pathology, Department of Experimental Medicine, University of L'Aquila, Coppito 2, Via Vetoio, L'Aquila 67100, Italy
Department of Biological Science, University of Naples Federico II, Naples, Italy
Neuromed Institute, 86077 Pozzilli, Italy
References:
Appenzeller-Herzog, C., Hauri, H.-P., The ER-Golgi intermediate compartment (ERGIC): In search of its identity and function (2006) J. Cell Sci, 119, pp. 2173-218
Arevalo, J.C., Conde, B., Hempstead, B.L., Chao, M.V., Martin-Zanca, D., Perez, P., TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor (2000) Mol. Cell. Biol, 20, pp. 5908-5916
Blume-Jensen, P., Hunter, T., Oncogenic kinase signalling (2001) Nature, 411, pp. 355-365
Camoratto, A.M., Jani, J.P., Angeles, T.S., Maroney, A.C., Sanders, C.Y., Murakata, C., Neff, N.T., Dionne, C.A., CEP-751 inhibits Trk receptor tyrosine kinase activity in vitro and exhibits anti-tumor activity (1997) Int. J. Cancer, 72, pp. 673-679
Collier, E., Carpentier, J.L., Beitz, L., Caro, H., Taylor, S.I., Gorden, P., Specific glycosylation site mutations of insulin receptor alpha subunit impairs intracellular transport (1993) Biochemistry, 32, pp. 7818-7823
Delaval, B., Létard, S., Lelièvre, H., Chevrier, V., Daviet, L., Dubreuil, P., Birnbaum, D., Oncogenic tyrosine kinase of malignant hemopathy targets the centrosome (2005) Cancer Res, 65, pp. 7231-7240
Dikovskaya, D., Schiffmann, D., Newton, I.P., Oakley, A., Kroboth, K., Sansom, O., Jamieson, T.J., Nathke, I.S., Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis (2007) J. Cell Biol, 176, pp. 183-195
Dionisotti, S., Ongini, E., Zocchi, C., Kull, B., Arslan, G., Fredholm, B.B., Characterisation of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261 (1997) Br. J. Pharmacol, 121, pp. 353-360
Eggert, A., Grotzer, M.A., Ikegaki, N., Liu, X.G., Evans, A.E., Brodeur, G.M., Expression of the neurotrophin receptor TrkA down-regulates expression and function of angiogenic stimulators in SH-SY5Y neuroblastoma cells (2002) Cancer Res, 62, pp. 1802-1808
Frangioni, J.V., Beahm, P.H., Shifrin, V., Jost, C.A., Neel, B.G., The non transmembrane tyrosine phosphatase PTP-1B localises to the endoplasmic reticulum via its 35 amino acid C-terminal sequence (1992) Cell, 68, pp. 545-560
Fukasawa, K., Centrosome amplification, chromosome instability and cancer development (2005) Cancer Lett, 230, pp. 6-19
Fukasawa, K., Oncogenes and tumour suppressors take on the centrosome (2007) Nat. Rev. Cancer, 7, pp. 911-924
Gibbs, L., Legeai-Mallet, L., FGFR3 intracellular mutations induce tyrosine phosphorylation in the Golgi and defective glycosylation (2007) Biochim. Biophys. Acta, 1773, pp. 502-512
Guarguaglini, G., Duncan, P.I., Stierhof, Y.D., Holmstrom, T., Duensing, S., Nigg, E.A., The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles (2005) Mol. Biol. Cell, 16, pp. 1095-1107
Jesch, S.A., Linstedt, A.D., The Golgi and endoplasmic reticulum remain independent during mitosis in HeLa cells (1998) Mol. Biol. Cell, 9, pp. 623-635
Kaihatsu, K., Huffman, K.E., Corey, D.A., Intracellular uptake and inhibition of gene expression by PNAs and PNA-peptide conjugates (2004) Biochemistry, 43, pp. 14340-14347
Kalnina, Z., Zayakin, P., Silina, K., Line, A., Alterations of premRNA splicing in cancer (2005) Genes Chromosomes Cancer, 42, pp. 342-357
Kleylein-Sohn, J., Westerndorf, J., Le Clech, M., Habedank, R., Stierhof, Y.D., Nigg, E.A., Plk-4 induced centriole biogenesis in human cells (2007) Dev. Cell, 13, pp. 190-202
Lavenius, E., Gestblom, C., Johansson, I., Nanberg, E., Pahlman, S., Transfection of Trk-A into human neuroblastoma cells restores their ability to differentiate in response to nerve growth factor (1995) Cell Growth Differ, 6, pp. 727-736
Liu, G., Shang, Y., Yu, Y., Induced endoplasmic reticulum (ER) stress and binding of over-expressed ER specific chaperone GRP78/BIP with dimerized epidermal growth factor receptor in mammalian cells exposed to low concentration of N′-methyl-N-nitro-N-nitrosoguanidine (2006) Mutat. Res, 596, pp. 12-21
Löffler, H., Lukas, J., Bartek, J., Kramer, A., Structure meets function-centrosomes, genome maintenance and the DNA damage response (2006) Exp. Cell Res, 312, pp. 2633-2640
Lucarelli, E., Kaplan, D., Thiele, C.J., Activation of trk-A but not trk-B signal transduction pathway inhibits growth of neuroblastoma cells (1997) Eur. J. Cancer, 33, pp. 2068-2070
Lüders, J., Stearns, T., Microtubule organising centres: A reevaluation (2007) Nat. Rev. Mol. Cell Biol, 8, pp. 161-167
Lüders, J., Patel, U.K., Stearns, T., GCP-WD is a gamma tubulin targeting factor required for centrosomal and chromatin mediated microtubule nucleation (2006) Nat. Cell Biol, 8, pp. 137-147
Meakin, S.O., Shooter, E.M., Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex (1991) Proc. Natl. Acad. Sci. USA, 88, pp. 5862-5866
Meijer, G.A., Chromosomes and cancer. Boveri revisited (2005) Cell. Oncol, 27, pp. 273-275
Meraldi, P., Nigg, E.A., Centrosome cohesion is regulated by a balance of kinase and phosphatase activities (2001) J. Cell Sci, 114, pp. 3749-3757
Missbach, M., Altmann, E., Widler, L., Susa, M., Buchdunger, E., Mett, H., Meyer, T., Green, J., Substituted 5, 7-diphenyl-pyrrolo [2,3d] pyrimidines: Potent inhibitors of the tyrosine kinase c-Src (2000) Bioorg. Med. Chem. Lett, 10, pp. 945-949
Modrek, B., Lee, C., A genomic view of alternative splicing (2002) Nat. Genet, 30, pp. 13-19
Nakagawara, A., Trk receptor tyrosine kinases: A bridge between cancer and neural development (2001) Cancer Lett, 169, pp. 107-114
Noll, A., Ruppenthal, S.L., Montenarh, M., The mitotic phosphatase cdc25C at the Golgi apparatus (2006) Biochem. Biophys. Res. Commun, 351, pp. 825-830
Onuoha, S.C., Mukund, S.R., Coulstock, E.T., Sengerova, B., Shaw, J., Mclaughlin, S.H., Jackson, S.E., Mechanistic studies on Hsp90 inhibition by ansamycin derivatives (2007) J. Mol. Biol, 372, pp. 287-297
Piel, M., Meyer, P., Khodjakov, A., Reider, C.L., Bornens, M., The respective contributions of the mother and daughter centrioles to centrosome activity and behaviour in vertebrate cells (2000) J. Cell Biol, 149, pp. 317-330
Pihan, G.A., Purohit, A., Wallace, J., Knecht, H., Woda, B., Queensberry, P., Doxsey, S.J., Centrosome defects and genetic instability in malignant tumors (1998) Cancer Res, 58, pp. 3974-3985
Plo, I., Nakatake, M., Malivert, L., de Villartay, J.P., Giraudier, S., Villeval, J.L., Wiesmuller, L., Vainchenker, W., JAK2 stimulates homologous recombination and genetic instability: Potential implication in the heterogeneity of myeloproliferative disorders (2008) Blood, 122, pp. 1402-1412
Rajagopal, R., Chen, Z.Y., Lee, F.S., Chao, M.V., Transactivation of Trk neurotrophin receptors by G-protein coupled receptor ligands occurs on intracellular membranes (2004) J. Neurosci, 24, pp. 6650-6658
Rios, R.M., Bornens, M., The Golgi apparatus at the cell centre (2003) Curr. Opin. Cell Biol, 15, pp. 60-66
Ríos, R.M., Sanchis, A., Tassin, A.M., Fedriani, C., Bornens, M., GMAP-210 recruits gamma tubulin complexes to cis-Golgi membranes and is required for Golgi ribbon formation (2004) Cell, 118, pp. 323-335
Shen, K., Wang, Y., Brooks, S.C., Raz, A., Wang, Y.A., ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells (2006) J. Cell. Biochem, 99, pp. 1267-1274
Shepard, J.L., Amatruda, J.F., Finkelstein, D., Ziai, J., Finley, K.R., Stern, H.M., Chiang, K., Zon, L.I., A mutation in separase causes genome instability and increased susceptibility to epithelial cancer (2007) Genes Dev, 21, pp. 55-59
Suizu, F., Ryo, A., Wulf, G., Lim, J., Lu, K.P., Pin1 regulates centrosome duplication, and its overexpression induces centrosome ampli-fication, chromosome instability and oncogenesis (2006) Mol. Cell. Biol, 26, pp. 1463-1479
Szul, T., Grabski, R., Lyons, S., Morohashi, Y., Shestopal, S., Lowe, M., Sztul, E., Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking (2007) J. Cell Sci, 120, pp. 3929-3940
Tacconelli, A., Farina, A.R., Cappabianca, L., DeSantis, G., Tessitore, A., Vetuschi, A., Sferra, R., Mackay, A.R., TrkA alternative splicing: A regulated tumor-promoting switch in human neuroblastoma (2004) Cancer Cell, 6, pp. 347-360
Takahashi, T., Shibuya, M., The 230kDa mature form of KDR/ Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts (1997) Oncogene, 14, pp. 2079-2089
Tsou, M.F., Stearns, T., Mechanism limiting centrosome duplication to once per cell cycle (2006) Nature, 442, pp. 947-951
Watson, F.L., Porcionatto, M.A., Bhattacharyya, A., Stiles, C.D., Segal, R.A., TrkA glycosylation regulates receptor localisation and activity (1999) J. Neurobiol, 39, pp. 323-336
Weber, R.G., Bridger, J.M., Benner, A., Weisenberger, D., Ehemann, V., Reifenberger, G., Lichter, P., Centrosome amplification as a possible mechanism for numerical chromosome aberrations in cerebral primitive neuroectodermal tumors with TP53 mutations (1998) Cytogenet. Cell Genet, 83, pp. 266-269
Wikstrand, C.J., McLendon, R.E., Friedman, A.H., Bigner, D.D., Cell surface localization and density of the tumor-associated variant of the epidermal growth factor, EGFRvIII (1997) Cancer Res, 57, pp. 4130-4140
Yoshida, H., Unconventional splicing of XBP-1 mRNA in the unfolded protein response (2007) Antioxid. Redox Signal, 9, pp. 2323-2333
Yoshimura, S.I., Nakamura, N., Barr, F.A., Misumi, Y., Ikehara, Y., Ohuno, H., Sakaguchi, M., Mihara, K., Direct targeting of cis-Golgi matrix proteins to the Golgi apparatus (2001) J. Cell Sci, 114, pp. 4105-4115
Zyss, D., Montcourrier, P., Vidal, B., Anguille, C., Merezegue, F., Sahuquet, A., Mangeat, P.H., Coopman, P.J., The syk tyrosine kinase localises to the centrosome and negatively affects mitotic progression (2005) Cancer Res, 65, pp. 10872-10880
The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability
The hypoxia-regulated alternative TrkAIII splice variant expressed by human neuroblastomas exhibits oncogenic potential, driven by in-frame exon 6 and 7 alternative splicing, leading to omission of the receptor extracellular immunoglobulin C(1) domain and several N-glycosylation sites. Here, we show that the TrkAIII oncogene promotes genetic instability by interacting with and exhibiting catalytic activity at the centrosome. This function depends upon intracellular TrkAIII accumulation and spontaneous interphase-restricted activation, in cytoplasmic tyrosine kinase (tk) domain orientation, predominantly within structures that closely associate with the fully assembled endoplasmic reticulum intermediate compartment and Golgi network. This facilitates TrkAIII tk-mediated binding of gamma-tubulin, which is regulated by endogenous protein tyrosine phosphatases and geldanamycin-sensitive interaction with Hsp90, paving the way for TrkAIII recruitment to the centrosome. At the centrosome, TrkAIII differentially phosphorylates several centrosome-associated components, increases centrosome interaction with polo kinase 4, and decreases centrosome interaction with separase, the net results of which are centrosome amplification and increased genetic instability. The data characterize TrkAIII as a novel internal membrane-associated centrosome kinase, unveiling an important alternative mechanism to "classical" cell surface oncogenic receptor tk signaling through which stress-regulated alternative TrkAIII splicing influences the oncogenic process.
The hypoxia-regulated alternative TrkAIII splice variant expressed by human neuroblastomas exhibits oncogenic potential, driven by in-frame exon 6 and 7 alternative splicing, leading to omission of the receptor extracellular immunoglobulin C(1) domain and several N-glycosylation sites. Here, we show that the TrkAIII oncogene promotes genetic instability by interacting with and exhibiting catalytic activity at the centrosome. This function depends upon intracellular TrkAIII accumulation and spontaneous interphase-restricted activation, in cytoplasmic tyrosine kinase (tk) domain orientation, predominantly within structures that closely associate with the fully assembled endoplasmic reticulum intermediate compartment and Golgi network. This facilitates TrkAIII tk-mediated binding of gamma-tubulin, which is regulated by endogenous protein tyrosine phosphatases and geldanamycin-sensitive interaction with Hsp90, paving the way for TrkAIII recruitment to the centrosome. At the centrosome, TrkAIII differentially phosphorylates several centrosome-associated components, increases centrosome interaction with polo kinase 4, and decreases centrosome interaction with separase, the net results of which are centrosome amplification and increased genetic instability. The data characterize TrkAIII as a novel internal membrane-associated centrosome kinase, unveiling an important alternative mechanism to "classical" cell surface oncogenic receptor tk signaling through which stress-regulated alternative TrkAIII splicing influences the oncogenic process.
The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability
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The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability
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Farina AR, Tacconelli A, Cappabianca L, Cea G, Chioda A, Romanelli A, Pensato S, Pedone C, Gulino A, Mackay AR
* The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells (388 views)
Oncogene (ISSN: 1476-5594, 0950-9232), 2009 Nov 19; 28(46): 4075-4094.
Impact Factor: 7.135
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* The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells (388 views)
Oncogene (ISSN: 1476-5594, 0950-9232), 2009 Nov 19; 28(46): 4075-4094.
Impact Factor: 7.135
View Export to BibTeX Export to EndNote
1 Records (1 excluding Abstracts).
Total impact factor: 7.135 (7.135 excluding Abstracts).
Total 5 year impact factor: 6.73 (6.73 excluding Abstracts).
Total impact factor: 7.135 (7.135 excluding Abstracts).
Total 5 year impact factor: 6.73 (6.73 excluding Abstracts).
358 views. Last view on Saturday 14 January 2023, 19:11:53
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