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ITGB1 and DDR activation as novel mediators in acquired resistance to osimertinib and MEK inhibitors in EGFR-mutant NSCLC
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Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor
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Structural and Binding Properties of the Active Cell Wall Hydrolase RipA from M. tuberculosis, a Promising Biosensing Molecule for Early Warning Bacterial Detection
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Probing the Ca2+ Mobilizing Properties on Primary Cortical Neurons of a New Stable cADPR Mimic
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Insights into PPARγ Phosphorylation and Its Inhibition Mechanism
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The Cell Wall Hydrolytic NlpC/P60 Endopeptidases in Mycobacterial Cytokinesis: A Structural Perspective
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Chemistry of Peptidoglycan in Mycobacterium tuberculosis Life Cycle: An off-the-wall Balance of Synthesis and Degradation
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Chemistry of Peptidoglycan in Mycobacterium tuberculosis life style: an off-the-wall balance of synthesis and degradation
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Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease
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Targeting VEGF receptors with non-neutralizing cyclopeptides for imaging applications
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Editorial: Molecular Scenarios Behind Infectious Diseases
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Peptidoglycan-associated lipoprotein is a virulence factor that is involved in host cell attachment of Burkholderia cepacia complex
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Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer
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The structure of Resuscitation promoting factor B from M. tuberculosis reveals unexpected ubiquitin-like domains
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A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion
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Changes of glycolytic pathway and upregulation of oxidative phosphorylation in BCR-ABL-driven human leukemia cells treated with imatinib
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New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding
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Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons
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Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy
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A product of RpfB and RipA joint enzymatic action promotes the resuscitation of dormant mycobacteria
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Copper (II) ions modulate Angiogenin activity in human endothelial cells
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Exit from mycobacterial dormancy: a structural perspective
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Differential thermodynamic behaviours of the extra-cellular regions of two Ser/Thr PrkC kinases revealed by calorimetric studies
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Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity
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PI3K-C2γ 3 is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling
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Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models
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Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
De Rosa V, Iommelli F, Monti M, Fonti R, Del Vecchio S
Early reduction of 18F-FDG uptake in non-small lung cancer treated with EGFR tyrosine kinase inhibitors reflects reversal of Warburg effect and reactivation of oxidative phosphorylation
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2014 Oct; 41: N/D-N/D.
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Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography
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Mutational and structural study of RipA, a key enzyme in Mycobacterium tuberculosis cell division: Evidence for the l-to-d inversion of configuration of the catalytic cysteine
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Sep; 70(9): 2295-2300.
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Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis
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UPARANT: a urokinase receptor-derived peptide inhibitor of VEGF-driven angiogenesis with enhanced stability and in vitro and in vivo potency
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Quercetin: a pleiotropic kinase inhibitor against cancer
Cancer Treat Res (ISSN: 0927-3042), 2014; 159: 185-205.
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Targeting mitochondria as therapeutic strategy for metabolic disorders
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Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells
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Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases
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Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy
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Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses
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Costantini S, Sharma A, Raucci R, Costantini M, Autiero I, Colonna G
Genealogy of an ancient protein family: the Sirtuins, a family of disordered members
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Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the l, d-transpeptidase LdtMt1 from Mycobacterium tuberculosis
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High-resolution positron emission tomography/computed tomography imaging of the mouse heart
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Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells
J Proteome Res (ISSN: 1535-3893), 2013 Jan; 12(1): 282-292.
Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
Insulin has multiple antiamyloidogenic effects on human neuronal cells
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
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Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors
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Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species
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Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development
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Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins
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Editorial: cell processes in bacterial diseases
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Metallostasis And Amyloid Beta-Degrading Enzymes
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Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage
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Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity
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Interactions of two O-phosphorylresveratrol derivatives with model membranes
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New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries
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3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer
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3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer
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Editorial: Zinc Metallo-Enzymes As Target For Drug Design
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Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens
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CaMK4 gene deletion induces hypertension
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Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo
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Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells
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Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis
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Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity
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Chemical basis of peptidoglycan discrimination by PrkC, a key kinase involved in bacterial resuscitation from dormancy
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HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents
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Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ
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X-ray structural studies of the entire extracellular region of the serine/threonine kinase PrkC from Staphylococcus aureus
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Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity
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AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress
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Expression, purification, crystallization and preliminary x-ray crystallographic analysis of the peptidoglycan binding region of the ser/thr kinase PrkC from staphylococcus aureus
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Genetic screening for LRRK2 gene G2019S mutation in Parkinson's disease patients from Southern Italy
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Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis
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Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells
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Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength
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A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats
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A Peptide Containing Residues 26-44 Of Tau Protein Impairs Mithocondrial Oxodative Phosphorylation Acting At The Level Of The Adenine Nucleotide Translocator
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A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator
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The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα
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Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae
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The first crystal structure of a thioacylenzyme intermediate in the ALDH family: New coenzyme conformation and relevance to catalysis
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Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling
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Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides
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