Keywords: Bacteria, Membrane, Peptide, Virus, Amyloid, Cell Penetrating Peptide, Liposome, Polypeptide Antibiotic Agent, Virus Fusion Protein, Antimicrobial Activity, Atomic Force Microscopy, Calorimetry, Cell Membrane Permeability, Computer Simulation, Drug Delivery System, Drug Structure, Drug Transport, Experimental Study, Fluorescence Spectroscopy, Human, Lipid Bilayer, Membrane Binding, Membrane Structure, Nonhuman, Nuclear Magnetic Resonance, Peptide Analysis, Protein Lipid Interaction, Review, Structure Analysis, Surface Plasmon Resonance, Theoretical Study, Virus Cell Interaction, X Ray Diffraction, Biotechnology, Lipid Bilayers Chemistry, Lipids Chemistry, Peptides Chemistry,
Affiliations: *** IBB - CNR ***
Department of Pharmacy, CIRPEB and DFM, University of Naples 'Federico II', Via Mezzocannone 16, 80134 Napoli, Italy
Institute of Biostructures and Bioimages, CNR, Via Mezzocannone 16, 80134 Napoli, Italy
Department of Experimental Medicine, Second University of Naples, Via De Crecchio 7, 80138 Napoli, Italy
References: Not available.
Peptide-Lipid Interactions: Experiments and Applications
The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated cellular processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. Moreover, a major goal of modern biotechnology is obtaining new potent pharmaceutical agents whose biological action is dependent on the binding of peptides to lipid-bilayers. Several issues need to be addressed such as secondary structure, orientation, oligomerization and localization inside the membrane. At the same time, the structural effects which the peptides cause on the lipid bilayer are important for the interactions and need to be elucidated. The structural characterization of membrane active peptides in membranes is a harsh experimental challenge. It is in fact accepted that no single experimental technique can give a complete structural picture of the interaction, but rather a combination of different techniques is necessary.
Peptide-Lipid Interactions: Experiments and Applications
Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S * Fusion in Coq(595 views) Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596. Impact Factor:0.415 ViewExport to BibTeXExport to EndNote