Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery

Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (682 views)

Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A

J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.

Export to BibTeX Export to EndNote

Paper type: Journal Article,

Impact factor: 1.951, 5-year impact factor: 1.707

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84928784909&partnerID=40&md5=8f1a25adce5e0b8fc70daf5ee0c6717d

Keywords: Cell-Penetrating Peptides, Click Chemistry, Drug Delivery Systems, Homing Peptides, Liposomes, Cell Penetrating Peptide, Cytokeratin 8, Dithiothreitol, Doxorubicin, R8 Cell Penetrating Peptide, Unclassified Drug, Amino Acid Sequence, Article, Disulfide Bond, Flow Cytometry, Fluorescence Resonance Energy Transfer, Priority Journal, Protein Modification, Protein Synthesis, Target Cell,

Affiliations:
*** IBB - CNR ***

Department of Pharmacy, CIRPeB, Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples 'Federico II', Via Mezzocannone 16, Naples, Italy
IBB, CNR, Via Mezzocannone 16, Naples, Italy
IBB CNR Via Mezzocannone 16 80134 Naples Italy

References:
Not available.

Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery

A new dual-ligand liposomal doxorubicin delivery system, which couples targeting to enhanced cellular uptake and may lead to a more efficient drug delivery system, is here designed and synthetized. Liposomes based on the composition 1,2-dioleoyl-sn-glycero-3-phosphocholine/1,2-distearoyl-sn-glycero-3-phosphoethanolamine-Peg2000-R8/(C18)2-L5-SS-CCK8 (87/8/5 mol/mol/mol) were prepared and loaded with doxorubicin. Presence of the two peptides on the external surface is demonstrated by fluorescence resonance energy transfer assay. The combination of the R8 cell-penetrating peptide and of the CCK8 targeting peptide (homing peptide) on the liposome surface is obtained by combining pre-modification and post-modification methods. In the dual-ligand system, the CCK8 peptide is anchored to the liposome surface by using a disulfide bond. This chemical function is inserted in order to promote the selective cleavage of the homing peptide under the reductive conditions expected in proximity of the tumor site, thus allowing targeting and internalization of the liposomal drug. Copyright © 2015 European Peptide Society and John Wiley & Sons, Ltd.

Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery

Your query: [atitle, adesc, keywords] "Cell-Penetrating Peptides" OR [atitle, adesc, keywords] "Click Chemistry" OR [atitle, adesc, keywords] "Drug Delivery Systems" OR [atitle, adesc, keywords] "Homing Peptides" OR [atitle, adesc, keywords] "Cell Penetrating Peptide"

Your query: [atitle, adesc, keywords] "Cell-Penetrating Peptides" OR [atitle, adesc, keywords] "Click Chemistry" OR [atitle, adesc, keywords] "Drug Delivery Systems" OR [atitle, adesc, keywords] "Homing Peptides" OR [atitle, adesc, keywords] "Cell Penetrating Peptide"

No results.

Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery

Your query: [btitle, keywords] "Cell-Penetrating Peptides" [btitle, keywords] "Click Chemistry" [btitle, keywords] "Drug Delivery Systems" [btitle, keywords] "Homing Peptides" [btitle, keywords] "Cell Penetrating Peptide"

Your query: [btitle, keywords] "Cell-Penetrating Peptides" [btitle, keywords] "Click Chemistry" [btitle, keywords] "Drug Delivery Systems" [btitle, keywords] "Homing Peptides" [btitle, keywords] "Cell Penetrating Peptide"

Filter those results▼

Other filter: ([btitle,keywords] "Cell-Penetrating Pep ...

End of page Copy&Paste Friendly Export all to BibTeX Export all to EndNote

Sort by: date ▼▲ title ▲ ▼ journal ▲ ▼ authors ▲ ▼ I.F. ▲ ▼

Giunta D, Roviello GN, Solinas M
* Design and synthesis of new benzoxazole derivatives and study of their interactions with a G4 model by UV spectroscopy and in silico methods (281 views)
Journal Of Molecular Liquids, 2024 Jul; N/D: N/D-N/D.
Impact Factor: 5.3
View    Export to BibTeX    Export to EndNote

Monti A, Sturlese M, Caporale A, Roger JA, Mascanzoni F, Ruvo M, Doti N
* Design, synthesis, structural analysis and biochemical studies of stapled AIF(370-394) analogues as ligand of CypA (290 views)
Bba-Gen Subjects (ISSN: 0304-4165linking, 0005-2728, 0006-3002print), 2020 Dec; 1864(12): 129717-129717.
Impact Factor: 3.422
View    Export to BibTeX    Export to EndNote

Honarvar H, Calce E, Doti N, Langella E, Orlova A, Buijs J, D’amato V, Bianco R, Saviano M, Tolmachev V, De Luca S
* Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe (620 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2018 Feb 14; 8(1): 2998-2998.
Impact Factor: 4.259
View    Export to BibTeX    Export to EndNote

Chino M, Leone L, Maglio O, D'Alonzo D, Pirro F, Pavone V, Nastri F, Lombardi A
* A De Novo Heterodimeric Due Ferri Protein Minimizes the Release of Reactive Intermediates in Dioxygen-Dependent Oxidation (527 views) (PDF 224 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2017 Dec 4; 56(49): 15580-15583.
Impact Factor: 12.102
View    Export to BibTeX    Export to EndNote

Marchiori MF, Riul TB, Oliveira Bortot L, Andrade P, Junqueira GG, Foca G, Doti N, Ruvo M, Dias-baruffi M, Carvalho I, Campo VL
* Binding of triazole-linked galactosyl arylsulfonamides to galectin-3 affects Trypanosoma cruzi cell invasion (3124 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017 Nov 1; 25(21): 6049-6059.
Impact Factor: 2.881
View    Export to BibTeX    Export to EndNote

Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (508 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
View    Export to BibTeX    Export to EndNote

Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
* Advances in molecular preclinical therapy mediated by imaging (530 views) (PDF 263 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 76-94.
Impact Factor: 2.368
View    Export to BibTeX    Export to EndNote

Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (725 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Apr 11; 22(16): 5534-5537.
Impact Factor: 5.317
View    Export to BibTeX    Export to EndNote

Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (1169 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
View    Export to BibTeX    Export to EndNote

Morelli G, Saviano M, Grieco P
* The renaissance era of peptides in drug discovery at the 14th Naples workshop on bioactive peptides (919 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 321-322.
Impact Factor: 1.951
View    Export to BibTeX    Export to EndNote

Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (828 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
View    Export to BibTeX    Export to EndNote

Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (1618 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
View    Export to BibTeX    Export to EndNote

Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (841 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
View    Export to BibTeX    Export to EndNote

Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (815 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
View    Export to BibTeX    Export to EndNote

Accardo A, Ringhieri P, Tesauro D, Morelli G
* Liposomes derivatized with tetrabranched neurotensin peptides via click chemistry reactions (621 views)
New J Chem (ISSN: 1144-0546), 2013; 37(11): 3528-3534.
Impact Factor: 3.159
View    Export to BibTeX    Export to EndNote

Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (1157 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
View    Export to BibTeX    Export to EndNote

Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (1645 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
View    Export to BibTeX    Export to EndNote

Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (1576 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
View    Export to BibTeX    Export to EndNote

Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (965 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
View    Export to BibTeX    Export to EndNote

Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (679 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
View    Export to BibTeX    Export to EndNote

Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1820 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
View    Export to BibTeX    Export to EndNote

Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (907 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
View    Export to BibTeX    Export to EndNote

Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (1083 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
View    Export to BibTeX    Export to EndNote

Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (570 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
View    Export to BibTeX    Export to EndNote

Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (849 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
View    Export to BibTeX    Export to EndNote

25 Records (24 excluding Abstracts).
Total impact factor: 95.97 (91.711 excluding Abstracts).
Total 5 year impact factor: 95.642 (90.795 excluding Abstracts).

Top of page Copy&Paste Friendly Export all to BibTeX Export all to EndNote

Last modified by Marco Comerci on Sunday 12 July 2020, 13:14:50
682 views. Last view on Saturday 19 April 2025, 2:19:54

Query: [X]
Options:	Extended IBB affiliation

Authors: [X]
Paper type: [X]
Start date: [X]
End date: [X]
Site:
	[Clear form]

IBB website - v.1.0.340 - 14/02/2025 - by Marco Comerci. Copyright 2025 © CNR Istituto di Biostrutture e Bioimmagini. Page loaded at 20/04/2025 00:14:23.