Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake (394 views)
Cell Signal (ISSN: 0898-6568), 2009 May; 21(5): 786-792.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.094, 5-year impact factor: 4.102
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-60549101660&partnerID=40&md5=996316fe483aa6614b82fc1e79dfff89
Keywords: Camk, Cellular Signalling, Glucose Uptake, Insulin, Calcium Calmodulin Dependent Protein Kinase Ii, Glucose Transporter 4, Insulin Receptor Substrate 1, Mitogen Activated Protein Kinase 1, Raf Protein, Thymidine, Animal Cell, Article, Cell Membrane, Cell Proliferation, Dna Synthesis, Down Regulation, Enzyme Activation, Enzyme Phosphorylation, Negative Feedback, Nonhuman, Priority Journal, Skeletal Muscle, Biological Transport, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Cell Line, Down-Regulation, Mitogen-Activated Protein Kinase 3, Proto-Oncogene Proteins C-Akt, Proto-Oncogene Proteins C-Raf, Signal Transduction, Rattus,
Affiliations:
*** IBB - CNR ***
Department of Biologia e Patologia Cellulare e Molecolare, University of Naples Federico II, Naples, Italy
Institute of Biostrutture e Bioimmagini, University of Naples Federico II, Naples, Italy
Department Medicina Clinica e Scienze Cardiovascolari e Immunologiche, University of Naples Federico II, Naples, Italy
Department of Endocrinologia e Oncologia Molecolare e Clinica, University of Naples Federico II, Naples, Italy
Institute of Endocrinologia e Oncologia Sperimentale, CNR, Naples, Italy
References:
White, M.F., (1997) Diabetologia, 40 (SUPPL. 2), pp. S
Sun, X.J., Rothenberg, P., Kahn, C.R., Backer, J.M., Araki, E., Wilden, P.A., Cahill, D.A., White, M.F., (1991) Nature, 352 (6330), p. 73
Chuang, L.M., Myers Jr., M.G., Seidner, G.A., Birnbaum, M.J., White, M.F., Kahn, C.R., (1993) Proc. Natl. Acad. Sci. U. S. A., 90 (11), p. 5172
Wang, L.M., Myers Jr., M.G., Sun, X.J., Aaronson, S.A., White, M., Pierce, J.H., (1993) Science, 261 (5128), p. 1591
Sawka-Verhelle, D., Filloux, C., Tartare-Deckert, S., Mothe, I., Van Obberghen, E., (1997) Eur. J. Biochem., 250 (2), p. 411
Czech, M.P., Corvera, S., (1999) J. Biol. Chem., 274 (4), p. 1865
De Fea, K., Roth, R.A., (1997) J. Biol. Chem., 272 (50), p. 31400
Bard-Chapeau, E.A., Hevener, A.L., Long, S., Zhang, E.E., Olefsky, J.M., Feng, G.S., (2005) Nat. Med., 11 (5), p. 567
Pershadsingh, H.A., Gale, R.D., McDonald, J.M., (1987) Endocrinology, 121 (5), p. 1727
Etter, E.F., Minta, A., Poenie, M., Fay, F.S., (1996) Proc. Natl. Acad. Sci. U. S. A., 93 (11), p. 5368
Bruton, J.D., Katz, A., Westerblad, H., (1999) Proc. Natl. Acad. Sci. U. S. A., 96 (6), p. 3281
Means, A.R., (2000) Mol. Endocrinol., 14 (1), p. 4
Matthews, R.P., Guthrie, C.R., Wailes, L.M., Zhao, X., Means, A.R., McKnight, G.S., (1994) Mol. Cell. Biol., 14 (9), p. 6107
Tombes, R.M., Faison, M.O., Turbeville, J.M., (2003) Gene, 322, p. 17
Illario, M., Cavallo, A.L., Bayer, K.U., Di Matola, T., Fenzi, G., Rossi, G., Vitale, M., (2003) J. Biol. Chem., 278 (46), p. 45101
Enslen, H., Tokumitsu, H., Stork, P.J., Davis, R.J., Soderling, T.R., (1996) Proc. Natl. Acad. Sci. U. S. A., 93 (20), p. 10803
Curtis, J., Finkbeiner, S., (1999) J. Neurosci. Res., 58 (1), p. 88
Caruso, M., Miele, C., Oriente, F., Maitan, A., Bifulco, G., Andreozzi, F., Condorelli, G., Beguinot, F., (1999) J. Biol. Chem., 274 (40), p. 28637
Colomer, J.M., Means, A.R., (2000) Mol. Endocrinol., 14 (8), p. 1125
Hanson, P.I., Kapiloff, M.S., Lou, L.L., Rosenfeld, M.G., Schulman, H., (1989) Neuron, 3 (1), p. 59
Cruzalegui, F.H., Means, A.R., (1993) J. Biol. Chem., 268 (35), p. 26171
Chang, B.H., Mukherji, S., Soderling, T.R., (1998) Proc. Natl. Acad. Sci. U. S. A., 95 (18), p. 10890
Vest, R.S., Davies, K.D., O'Leary, H., Port, J.D., Bayer, K.U., (2007) Mol. Biol. Cell, 18 (12), p. 5024
Illario, M., Amideo, V., Casamassima, A., Andreucci, M., di Matola, T., Miele, C., Rossi, G., Vitale, M., (2003) J. Clin. Endocrinol. Metab., 88 (1), p. 260
Youn, J.H., Gulve, E.A., Henriksen, E.J., Holloszy, J.O., (1994) Am. J. Physiol., 267 (4 PART 2), pp. R888
Young, J.C., Balon, T.W., (1997) Life. Sci., 61 (3), p. 335
Cartee, G.D., Briggs-Tung, C., Holloszy, J.O., (1992) Am. J. Physiol., 263 (1 PART 2), pp. R70
Klip, A., Li, G., Logan, W.J., (1984) Am. J. Physiol., 247 (3 PART 1), pp. E297
Espinosa, A., Estrada, M., Jaimovich, E., (2004) J. Endocrinol., 182 (2), p. 339
Wright, D.C., Fick, C.A., Olesen, J.B., Lim, K., Barnes, B.R., Craig, B.W., (2004) Life. Sci., 74 (7), p. 815
Konstantopoulos, N., Marcuccio, S., Kyi, S., Stoichevska, V., Castelli, L.A., Ward, C.W., Macaulay, S.L., (2007) Endocrinology, 148 (1), p. 374
Huang, C., Thirone, A.C., Huang, X., Klip, A., (2005) J. Biol. Chem., 280 (19), p. 19426
Saltiel, A.R., Kahn, C.R., (2001) Nature, 414 (6865), p. 799
Lee, A.D., Gulve, E.A., Chen, M., Schluter, J., Holloszy, J.O., (1995) Am. J. Physiol., 268 (4 PART 2), pp. R997
Carlson, C.J., Koterski, S., Sciotti, R.J., Poccard, G.B., Rondinone, C.M., (2003) Diabetes, 52 (3), p. 634
White, M. F., (1997) Diabetologia, 40 (SUPPL. 2), pp. S
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., White, M. F., (1991) Nature, 352 (6330), p. 73
Chuang, L. M., Myers Jr., M. G., Seidner, G. A., Birnbaum, M. J., White, M. F., Kahn, C. R., (1993) Proc. Natl. Acad. Sci. U. S. A., 90 (11), p. 5172
Wang, L. M., Myers Jr., M. G., Sun, X. J., Aaronson, S. A., White, M., Pierce, J. H., (1993) Science, 261 (5128), p. 1591
Czech, M. P., Corvera, S., (1999) J. Biol. Chem., 274 (4), p. 1865
Bard-Chapeau, E. A., Hevener, A. L., Long, S., Zhang, E. E., Olefsky, J. M., Feng, G. S., (2005) Nat. Med., 11 (5), p. 567
Pershadsingh, H. A., Gale, R. D., McDonald, J. M., (1987) Endocrinology, 121 (5), p. 1727
Etter, E. F., Minta, A., Poenie, M., Fay, F. S., (1996) Proc. Natl. Acad. Sci. U. S. A., 93 (11), p. 5368
Bruton, J. D., Katz, A., Westerblad, H., (1999) Proc. Natl. Acad. Sci. U. S. A., 96 (6), p. 3281
Means, A. R., (2000) Mol. Endocrinol., 14 (1), p. 4
Matthews, R. P., Guthrie, C. R., Wailes, L. M., Zhao, X., Means, A. R., McKnight, G. S., (1994) Mol. Cell. Biol., 14 (9), p. 6107
Tombes, R. M., Faison, M. O., Turbeville, J. M., (2003) Gene, 322, p. 17
Colomer, J. M., Means, A. R., (2000) Mol. Endocrinol., 14 (8), p. 1125
Hanson, P. I., Kapiloff, M. S., Lou, L. L., Rosenfeld, M. G., Schulman, H., (1989) Neuron, 3 (1), p. 59
Cruzalegui, F. H., Means, A. R., (1993) J. Biol. Chem., 268 (35), p. 26171
Chang, B. H., Mukherji, S., Soderling, T. R., (1998) Proc. Natl. Acad. Sci. U. S. A., 95 (18), p. 10890
Vest, R. S., Davies, K. D., O'Leary, H., Port, J. D., Bayer, K. U., (2007) Mol. Biol. Cell, 18 (12), p. 5024
Youn, J. H., Gulve, E. A., Henriksen, E. J., Holloszy, J. O., (1994) Am. J. Physiol., 267 (4 PART 2), pp. R888
Young, J. C., Balon, T. W., (1997) Life. Sci., 61 (3), p. 335
Cartee, G. D., Briggs-Tung, C., Holloszy, J. O., (1992) Am. J. Physiol., 263 (1 PART 2), pp. R70
Wright, D. C., Fick, C. A., Olesen, J. B., Lim, K., Barnes, B. R., Craig, B. W., (2004) Life. Sci., 74 (7), p. 815
Saltiel, A. R., Kahn, C. R., (2001) Nature, 414 (6865), p. 799
Lee, A. D., Gulve, E. A., Chen, M., Schluter, J., Holloszy, J. O., (1995) Am. J. Physiol., 268 (4 PART 2), pp. R997
Carlson, C. J., Koterski, S., Sciotti, R. J., Poccard, G. B., Rondinone, C. M., (2003) Diabetes, 52 (3), p. 634
Cell Signal (ISSN: 0898-6568), 2009 May; 21(5): 786-792.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.094, 5-year impact factor: 4.102
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-60549101660&partnerID=40&md5=996316fe483aa6614b82fc1e79dfff89
Keywords: Camk, Cellular Signalling, Glucose Uptake, Insulin, Calcium Calmodulin Dependent Protein Kinase Ii, Glucose Transporter 4, Insulin Receptor Substrate 1, Mitogen Activated Protein Kinase 1, Raf Protein, Thymidine, Animal Cell, Article, Cell Membrane, Cell Proliferation, Dna Synthesis, Down Regulation, Enzyme Activation, Enzyme Phosphorylation, Negative Feedback, Nonhuman, Priority Journal, Skeletal Muscle, Biological Transport, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Cell Line, Down-Regulation, Mitogen-Activated Protein Kinase 3, Proto-Oncogene Proteins C-Akt, Proto-Oncogene Proteins C-Raf, Signal Transduction, Rattus,
Affiliations:
*** IBB - CNR ***
Department of Biologia e Patologia Cellulare e Molecolare, University of Naples Federico II, Naples, Italy
Institute of Biostrutture e Bioimmagini, University of Naples Federico II, Naples, Italy
Department Medicina Clinica e Scienze Cardiovascolari e Immunologiche, University of Naples Federico II, Naples, Italy
Department of Endocrinologia e Oncologia Molecolare e Clinica, University of Naples Federico II, Naples, Italy
Institute of Endocrinologia e Oncologia Sperimentale, CNR, Naples, Italy
References:
White, M.F., (1997) Diabetologia, 40 (SUPPL. 2), pp. S
Sun, X.J., Rothenberg, P., Kahn, C.R., Backer, J.M., Araki, E., Wilden, P.A., Cahill, D.A., White, M.F., (1991) Nature, 352 (6330), p. 73
Chuang, L.M., Myers Jr., M.G., Seidner, G.A., Birnbaum, M.J., White, M.F., Kahn, C.R., (1993) Proc. Natl. Acad. Sci. U. S. A., 90 (11), p. 5172
Wang, L.M., Myers Jr., M.G., Sun, X.J., Aaronson, S.A., White, M., Pierce, J.H., (1993) Science, 261 (5128), p. 1591
Sawka-Verhelle, D., Filloux, C., Tartare-Deckert, S., Mothe, I., Van Obberghen, E., (1997) Eur. J. Biochem., 250 (2), p. 411
Czech, M.P., Corvera, S., (1999) J. Biol. Chem., 274 (4), p. 1865
De Fea, K., Roth, R.A., (1997) J. Biol. Chem., 272 (50), p. 31400
Bard-Chapeau, E.A., Hevener, A.L., Long, S., Zhang, E.E., Olefsky, J.M., Feng, G.S., (2005) Nat. Med., 11 (5), p. 567
Pershadsingh, H.A., Gale, R.D., McDonald, J.M., (1987) Endocrinology, 121 (5), p. 1727
Etter, E.F., Minta, A., Poenie, M., Fay, F.S., (1996) Proc. Natl. Acad. Sci. U. S. A., 93 (11), p. 5368
Bruton, J.D., Katz, A., Westerblad, H., (1999) Proc. Natl. Acad. Sci. U. S. A., 96 (6), p. 3281
Means, A.R., (2000) Mol. Endocrinol., 14 (1), p. 4
Matthews, R.P., Guthrie, C.R., Wailes, L.M., Zhao, X., Means, A.R., McKnight, G.S., (1994) Mol. Cell. Biol., 14 (9), p. 6107
Tombes, R.M., Faison, M.O., Turbeville, J.M., (2003) Gene, 322, p. 17
Illario, M., Cavallo, A.L., Bayer, K.U., Di Matola, T., Fenzi, G., Rossi, G., Vitale, M., (2003) J. Biol. Chem., 278 (46), p. 45101
Enslen, H., Tokumitsu, H., Stork, P.J., Davis, R.J., Soderling, T.R., (1996) Proc. Natl. Acad. Sci. U. S. A., 93 (20), p. 10803
Curtis, J., Finkbeiner, S., (1999) J. Neurosci. Res., 58 (1), p. 88
Caruso, M., Miele, C., Oriente, F., Maitan, A., Bifulco, G., Andreozzi, F., Condorelli, G., Beguinot, F., (1999) J. Biol. Chem., 274 (40), p. 28637
Colomer, J.M., Means, A.R., (2000) Mol. Endocrinol., 14 (8), p. 1125
Hanson, P.I., Kapiloff, M.S., Lou, L.L., Rosenfeld, M.G., Schulman, H., (1989) Neuron, 3 (1), p. 59
Cruzalegui, F.H., Means, A.R., (1993) J. Biol. Chem., 268 (35), p. 26171
Chang, B.H., Mukherji, S., Soderling, T.R., (1998) Proc. Natl. Acad. Sci. U. S. A., 95 (18), p. 10890
Vest, R.S., Davies, K.D., O'Leary, H., Port, J.D., Bayer, K.U., (2007) Mol. Biol. Cell, 18 (12), p. 5024
Illario, M., Amideo, V., Casamassima, A., Andreucci, M., di Matola, T., Miele, C., Rossi, G., Vitale, M., (2003) J. Clin. Endocrinol. Metab., 88 (1), p. 260
Youn, J.H., Gulve, E.A., Henriksen, E.J., Holloszy, J.O., (1994) Am. J. Physiol., 267 (4 PART 2), pp. R888
Young, J.C., Balon, T.W., (1997) Life. Sci., 61 (3), p. 335
Cartee, G.D., Briggs-Tung, C., Holloszy, J.O., (1992) Am. J. Physiol., 263 (1 PART 2), pp. R70
Klip, A., Li, G., Logan, W.J., (1984) Am. J. Physiol., 247 (3 PART 1), pp. E297
Espinosa, A., Estrada, M., Jaimovich, E., (2004) J. Endocrinol., 182 (2), p. 339
Wright, D.C., Fick, C.A., Olesen, J.B., Lim, K., Barnes, B.R., Craig, B.W., (2004) Life. Sci., 74 (7), p. 815
Konstantopoulos, N., Marcuccio, S., Kyi, S., Stoichevska, V., Castelli, L.A., Ward, C.W., Macaulay, S.L., (2007) Endocrinology, 148 (1), p. 374
Huang, C., Thirone, A.C., Huang, X., Klip, A., (2005) J. Biol. Chem., 280 (19), p. 19426
Saltiel, A.R., Kahn, C.R., (2001) Nature, 414 (6865), p. 799
Lee, A.D., Gulve, E.A., Chen, M., Schluter, J., Holloszy, J.O., (1995) Am. J. Physiol., 268 (4 PART 2), pp. R997
Carlson, C.J., Koterski, S., Sciotti, R.J., Poccard, G.B., Rondinone, C.M., (2003) Diabetes, 52 (3), p. 634
White, M. F., (1997) Diabetologia, 40 (SUPPL. 2), pp. S
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., White, M. F., (1991) Nature, 352 (6330), p. 73
Chuang, L. M., Myers Jr., M. G., Seidner, G. A., Birnbaum, M. J., White, M. F., Kahn, C. R., (1993) Proc. Natl. Acad. Sci. U. S. A., 90 (11), p. 5172
Wang, L. M., Myers Jr., M. G., Sun, X. J., Aaronson, S. A., White, M., Pierce, J. H., (1993) Science, 261 (5128), p. 1591
Czech, M. P., Corvera, S., (1999) J. Biol. Chem., 274 (4), p. 1865
Bard-Chapeau, E. A., Hevener, A. L., Long, S., Zhang, E. E., Olefsky, J. M., Feng, G. S., (2005) Nat. Med., 11 (5), p. 567
Pershadsingh, H. A., Gale, R. D., McDonald, J. M., (1987) Endocrinology, 121 (5), p. 1727
Etter, E. F., Minta, A., Poenie, M., Fay, F. S., (1996) Proc. Natl. Acad. Sci. U. S. A., 93 (11), p. 5368
Bruton, J. D., Katz, A., Westerblad, H., (1999) Proc. Natl. Acad. Sci. U. S. A., 96 (6), p. 3281
Means, A. R., (2000) Mol. Endocrinol., 14 (1), p. 4
Matthews, R. P., Guthrie, C. R., Wailes, L. M., Zhao, X., Means, A. R., McKnight, G. S., (1994) Mol. Cell. Biol., 14 (9), p. 6107
Tombes, R. M., Faison, M. O., Turbeville, J. M., (2003) Gene, 322, p. 17
Colomer, J. M., Means, A. R., (2000) Mol. Endocrinol., 14 (8), p. 1125
Hanson, P. I., Kapiloff, M. S., Lou, L. L., Rosenfeld, M. G., Schulman, H., (1989) Neuron, 3 (1), p. 59
Cruzalegui, F. H., Means, A. R., (1993) J. Biol. Chem., 268 (35), p. 26171
Chang, B. H., Mukherji, S., Soderling, T. R., (1998) Proc. Natl. Acad. Sci. U. S. A., 95 (18), p. 10890
Vest, R. S., Davies, K. D., O'Leary, H., Port, J. D., Bayer, K. U., (2007) Mol. Biol. Cell, 18 (12), p. 5024
Youn, J. H., Gulve, E. A., Henriksen, E. J., Holloszy, J. O., (1994) Am. J. Physiol., 267 (4 PART 2), pp. R888
Young, J. C., Balon, T. W., (1997) Life. Sci., 61 (3), p. 335
Cartee, G. D., Briggs-Tung, C., Holloszy, J. O., (1992) Am. J. Physiol., 263 (1 PART 2), pp. R70
Wright, D. C., Fick, C. A., Olesen, J. B., Lim, K., Barnes, B. R., Craig, B. W., (2004) Life. Sci., 74 (7), p. 815
Saltiel, A. R., Kahn, C. R., (2001) Nature, 414 (6865), p. 799
Lee, A. D., Gulve, E. A., Chen, M., Schluter, J., Holloszy, J. O., (1995) Am. J. Physiol., 268 (4 PART 2), pp. R997
Carlson, C. J., Koterski, S., Sciotti, R. J., Poccard, G. B., Rondinone, C. M., (2003) Diabetes, 52 (3), p. 634
Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake
Cellular growth and glucose uptake are regulated by multiple signals generated by the insulin receptor. The mechanisms of individual modulation of these signals remain somewhat elusive. We investigated the role of CaMKII in insulin signalling in a rat skeletal muscle cell line, demonstrating that CaMKII modulates the insulin action on DNA synthesis and the negative feedback that down regulates glucose uptake. Insulin stimulation generated partly independent signals leading to the rapid activation of Akt, Erk-1/2 and CaMKII Akt activation was followed by Glut-4 translocation to the plasma membrane and increase of glucose uptake. Then, IRS-1 was phosphorylated at S612, the IRS-1/p85PI3K complex was disrupted, Akt was no more phosphorylated and both Glut-4 translocation and glucose uptake were reduced. Inhibition of CaMKII abrogated the insulin-induced Erk-1/2 activation, DNA synthesis and phosphorylation of IRS-1 at S612. Inhibition of CaMKII also abrogated the down-regulation of insulin-stimulated Akt phosphorylation, Glut-4 membrane translocation and glucose uptake. These results demonstrate that: 1 - CaMKII modulates the insulin-induced Erk-1/2 activation and cell proliferation; 2 - after the initial stimulation of the IRS-1/Akt pathway, CaMKII mediates the down-regulation of stimulated glucose uptake. This represents a novel mechanism in the selective control of insulin signals, and a possible site for pharmacological intervention. (C) 2009 Elsevier Inc. All rights reserved.
Cellular growth and glucose uptake are regulated by multiple signals generated by the insulin receptor. The mechanisms of individual modulation of these signals remain somewhat elusive. We investigated the role of CaMKII in insulin signalling in a rat skeletal muscle cell line, demonstrating that CaMKII modulates the insulin action on DNA synthesis and the negative feedback that down regulates glucose uptake. Insulin stimulation generated partly independent signals leading to the rapid activation of Akt, Erk-1/2 and CaMKII Akt activation was followed by Glut-4 translocation to the plasma membrane and increase of glucose uptake. Then, IRS-1 was phosphorylated at S612, the IRS-1/p85PI3K complex was disrupted, Akt was no more phosphorylated and both Glut-4 translocation and glucose uptake were reduced. Inhibition of CaMKII abrogated the insulin-induced Erk-1/2 activation, DNA synthesis and phosphorylation of IRS-1 at S612. Inhibition of CaMKII also abrogated the down-regulation of insulin-stimulated Akt phosphorylation, Glut-4 membrane translocation and glucose uptake. These results demonstrate that: 1 - CaMKII modulates the insulin-induced Erk-1/2 activation and cell proliferation; 2 - after the initial stimulation of the IRS-1/Akt pathway, CaMKII mediates the down-regulation of stimulated glucose uptake. This represents a novel mechanism in the selective control of insulin signals, and a possible site for pharmacological intervention. (C) 2009 Elsevier Inc. All rights reserved.
Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake
| ▼ High-resolution positron emission tomography of the ischaemic mouse heart |
Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake
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Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (391 views)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
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* Leptin resistance before and after obesity: evidence that tissue glucose uptake underlies adipocyte enlargement and liver steatosis/steatohepatitis in Zucker rats from early-life stages (4 views)
Int J Obes (ISSN: 0307-0565linking), 2021 Sep 6; N/D: N/D-N/D.
Impact Factor:
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Arena F, Bardini P, Blasi F, Gianolio E, Marini G, Aime S
* Gadolinium deposition, MRI hyperintensities, and glucose uptake in the hypoperfused rat brain after repeated administrations of Gadodiamide (185 views)
Neuroradiolgy, 2018; N/D: N/D-N/D.
Impact Factor: 2.346
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Copani A
* The underexplored question of beta-amyloid monomers (299 views)
Eur J Pharmacol (ISSN: 0014-2999), 2017 May 31; N/D: N/D-N/D.
Impact Factor: 3.04
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Maddalena F, Lettini G, Gallicchio R, Sisinni L, Simeon V, Nardelli A, Venetucci AA, Storto G, Landriscina M
* Evaluation of Glucose Uptake in Normal and Cancer Cell Lines by Positron Emission Tomography (369 views)
Mol Imaging (ISSN: 1535-3508), 2015 Sep 1; 14: 490-498.
Impact Factor: 2.216
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Nguyen XC, Nguyen VK, Tran MT, Maurea S, Salvatore M
* Prognostic Value of Fluoro-D-glucose Uptake of Primary Tumor and Metastatic Lesions in Advanced Nonsmall Cell Lung Cancer (213 views)
World Journal Of Nuclear Medicine (ISSN: 1450-1147), 2014 May; 13(2): 112-119.
Impact Factor: 5.563
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Iiritano S, Chiefari E, Ventura V, Arcidiacono B, Possidente K, Nocera A, Nevolo MT, Fedele M, Greco A, Greco M, Brunetti G, Fusco A, Foti D, Brunetti A
* The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake (705 views)
Molecular Endocrinology (ISSN: 0888-8809, 1944-9917electronic), 2012 Sep; 26(9): 1578-1589.
Impact Factor: 4.746
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (519 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (437 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (391 views)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
View Export to BibTeX Export to EndNote
9 Records (8 excluding Abstracts).
Total impact factor: 58.353 (52.309 excluding Abstracts).
Total 5 year impact factor: 54.575 (48.531 excluding Abstracts).
Total impact factor: 58.353 (52.309 excluding Abstracts).
Total 5 year impact factor: 54.575 (48.531 excluding Abstracts).
394 views. Last view on Wednesday 31 May 2023, 4:12:27
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