ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs (724 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 156: 145-152.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.348, 5-year impact factor: 3.207
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84954202975&partnerID=40&md5=b452999b8983a065457be0c9911b8325
Keywords: Atox1, Chelating Drugs, Colon Cancer, Copper, Ionophores, Adenosine Triphosphatase, Chaperone, Chelating Agent, Cloxiquine, Copper Chelating Agent, Copper Ion, Copper Ionophore, Tetrakis(2 Pyridylmethyl)ethylenediamine, Peroxiredoxin 3, Unclassified Drug, Article, Caco 2 Cell Line, Cell Level, Controlled Study, Copper Protein Binding, Cytosol, Cytotoxicity, Drug Sensitivity, Gene Silencing, Homeostasis, Human, Human Cell, In Vitro Study, Intracellular Transport, Protein Depletion, Protein Expression, Protein Function, Rna Interference, Trans Golgi Network,
Affiliations:
*** IBB - CNR ***
Department of Biomedical and Biotechnological Sciences, Unit of Medical Biochemistry, University of Catania, Via S. Sofia 64, Catania, Italy
Institute of Biostructures and Bioimaging, National Council of Research, UOS Catania, Italy
References:
Festa, R.A., Thiele, D.J., Copper: An essential metal in biology (2011) Curr. Biol., 21 (21), pp. R877-R883. ,
Lutsenko, S., Human copper homeostasis: A network of interconnected pathways (2010) Curr. Opin. Chem. Biol., 14 (2), pp. 211-217
Robinson, N.J., Winge, D.R., Copper metallochaperones (2010) Annu. Rev. Biochem., 79, pp. 537-562
Harrison, M.D., Jones, C.E., Solioz, M., Dameron, C.T., Intracellular copper routing: The role of copper chaperones (2000) Trends Biochem. Sci., 25, pp. 29-32
Ding, W.Q., Liu, B., Vaught, J.L., Anticancer activity of the antibiotic clioquinol (2005) Cancer Res., 65, pp. 3389-3395
Ding, W.Q., Lind, S.E., Metal ionophores - An emerging class of anticancer drugs (2009) IUBMB Life, 61 (11), pp. 1013-1018
Margalioth, E.J., Schenker, J.G., Chevion, M., Copper and zinc levels in normal and malignant tissues (1983) Cancer, 52 (5), pp. 868-872. , (1)
Dìez, M., Cerdàn, F.J., Arroyo, M., Balibrea, J.L., Use of the copper/zinc ratio in the diagnosis of lung cancer (1989) Cancer, 63 (4), pp. 726-730. , (15)
Mao, X., Li, X., Sprangers, R., Wang, X., Venugopal, A., Wood, T., Zhang, Y., Schimmer, A.D., Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma (2009) Leukemia, 23, pp. 585-590
Mao, X., Schimmer, A.D., The toxicology of clioquinol (2008) Toxicol. Lett., 182, pp. 1-6
Chen, D., Cui, Q.C., Yang, H., Barrea, R.A., Sarkar, F.H., Sheng, S., Yan, B., Dou, Q.P., Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts (2007) Cancer Res., 67, pp. 1636-1644
Daniel, K.G., Chen, D., Orlu, S., Cui, Q.C., Miller, F.R., Dou, Q.P., Clioquinol and pyrrolidinedithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells (2005) Breast Cancer Res., 7 (6), pp. R897-R908
Cao, B., Li, J., Zhu, J., Shen, M., Han, K., Zhang, Z., Yu, Y., Mao, X., The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity (2013) J. Biol. Chem., 288 (47), pp. 34181-34189. , 22
Zhai, S., Yang, L., Cui, Q.C., Sun, Y., Dou, Q.P., Yan, B., Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells (2010) J. Biol. Inorg. Chem., 15 (2), pp. 259-269
Sperandio, S., De Belle, I., Bredesen, D.E., An alternative, nonapoptotic form of programmed cell death (2000) Proc. Natl. Acad. Sci. U. S. A., 97, p. 14376
Tardito, S., Barilli, A., Bassanetti, I., Tegoni, M., Bussolati, O., Franchi-Gazzola, R., Mucchino, C., Marchiò, L., Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation (2012) J. Med. Chem., 55, pp. 10448-10459
Carraway, R.E., Dobner, P.R., Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells (2012) Biochim. Biophys. Acta, 1823 (2), pp. 544-557
Pang, W., Leng, X., Lu, H., Yang, H., Song, N., Tan, L., Jiang, Y., Guo, C., Depletion of intracellular zinc induces apoptosis of cultured hippocampal neurons through suppression of ERK signaling pathway and activation of caspase-3 (2013) Neurosci. Lett., 552, pp. 140-145. , 27
Hyun, H.J., Sohn, J.H., Ha, D.W., Ahn, Y.H., Koh, J.Y., Yoon, Y.H., Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells (2001) Invest. Ophthalmol. Vis. Sci., 42 (2)
Klomp, L.W., Lin, S.J., Yuan, D.S., Klausner, R.D., Culotta, V.C., Gitlin, J.D., Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis (1997) J. Biol. Chem., 272 (14), pp. 9221-9226. , 4
Hamza, I., Prohaska, J., Gitlin, J.D., Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase (2003) Proc. Natl. Acad. Sci. U. S. A., 100 (3), pp. 1215-1220. , 4
Miyayama, T., Suzuki, K.T., Ogra, Y., Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone. Atox1 (2009) Toxicol. Appl. Pharmacol., 237 (2), pp. 205-213
McRae, R., Lai, B., Fahrni, C.J., Copper redistribution in Atox1-deficient mouse fibroblast cells (2010) J. Biol. Inorg. Chem., 15 (1), pp. 99-105
Barresi, V., Palumbo, G.A., Musso, N., Consoli, C., Capizzi, C., Meli, C.R., Romano, A., Condorelli, D.F., Clonal selection of 11q CN-LOH and CBL gene mutation in a serially studied patient during MDS progression to AML (2010) Leuk. Res., 34 (11), pp. 1539-1542
Barresi, V., Romano, A., Musso, N., Capizzi, C., Consoli, C., Martelli, M.P., Palumbo, G.A., Condorelli, D.F., Broad copy neutral-loss of heterozygosity regions and rare recurring copy number abnormalities in normal karyotype-acute myeloid leukemia genomes (2010) Genes Chromosom. Cancer, 49 (11), pp. 1014-1023
Irizarry, R.A., Hobbs, B., Collin, F., Beazer-Barclay, Y.D., Antonellis, K.J., Scherf, U., Speed, T.P., Exploration, normalization, and summaries of high density oligonucleotide array probe level data (2003) Biostatistics, 4 (2), pp. 249-264
Mosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays (1983) J. Immunol. Methods, 65, pp. 55-63. , 55
Scherf, U., Ross, D.T., Waltham, M., Smith, L.H., Lee, J.K., Tanabe, L., Kohn, K.W., Weinstein, J.N., A gene expression database for the molecular pharmacology of cancer (2000) Nat. Genet., 24 (3), pp. 236-244
Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(- delta delta C(T)) method (2001) Methods, 25 (4), pp. 402-408
Barresi, V., Ragusa, A., Fichera, M., Musso, N., Castiglia, L., Rappazzo, G., Travali, S., Condorelli, D.F., Decreased expression of GRAF1/OPHN-1-L in the X-linked alpha thalassemia mental retardation syndrome (2010) BMC Med. Genet., 3, p. 28. , 6
Sheffer, M., Bacolod, M.D., Zuk, O., Giardina, S.F., Pincas, H., Barany, F., Paty, P.B., Domany, E., Association of survival and disease progression with chromosomal instability: A genomic exploration of colorectal cancer (2009) Proc. Natl. Acad. Sci. U. S. A., 106 (17), pp. 7131-7136. , 28
Lee, J., Peña, M.M., Nose, Y., Thiele, D.J., Biochemical characterization of the human copper transporter Ctr1 (2002) J. Biol. Chem., 277 (6), pp. 4380-4387
Itoh, S., Kim, H.W., Nakagawa, O., Ozumi, K., Lessner, S.M., Aoki, H., Akram, K., Fukai, T., Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation (2008) J. Biol. Chem., 283 (14), pp. 9157-9167. , 4
Muller, P.A., Klomp, L.W., ATOX1: A novel copper-responsive transcription factor in mammals? (2009) Int. J. Biochem. Cell Biol., 41, pp. 1233-1236
Fatfat, M., Merhi, R.A., Rahal, O., Stoyanovsky, D.A., Zaki, A., Haidar, H., Kagan, V.E., Machaca, K., Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species (2014) BMC Cancer, 14, p. 527. , 21
Safaei, R., Maktabi, M.H., Blair, B.G., Larson, C.A., Howell, S.B., Effects of the loss of Atox1 on the cellular pharmacology of cisplatin (2009) J. Inorg. Biochem., 103, pp. 333-341
Van Den Berghe, P.V., Folmer, D.E., Malingre, H.E., Van Beurden, E., Klomp, A.E., Van De Sluis, B., Merkx, M., Klomp, L.W., Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake (2007) Biochem. J., 407, pp. 49-59
Milardi, D., Rizzarelli, E., Neurodegeneration: Metallostasis and proteostasis (2011) R. Chem. Soc.
Fulda, S., Vucic, D., Targeting IAP proteins for therapeutic intervention in cancer (2012) Nat. Rev. Drug Discov., (11), pp. 109-124
Cater, M.A., Haupt, Y., Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): Therapeutic indication for prostate cancer (2011) Biochem. J., 436, pp. 481-491
Yoshizawa, K., Nozaki, S., Kitahara, H., Ohara, T., Kato, K., Kawashiri, S., Yamamoto, E., Copper efflux transporter (ATP7B) contributes to the acquisition of cisplatin-resistance in human oral squamous cell lines (2007) Oncol. Rep., 18, pp. 987-991
Ishida, S., Lee, J., Thiele, D.J., Herskowitz, I., Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals (2002) Proc. Natl. Acad. Sci. U. S. A., 99, pp. 14298-14302
Kelner, G.S., Lee, M., Clark, M.E., Maciejewski, D., McGrath, D., Rabizadeh, S., Lyons, T., Maki, R.A., The copper transport protein Atox1 promotes neuronal survival (2000) J. Biol. Chem., 275, pp. 580-584
Hatori, Y., Clasen, S., Hasan, N.M., Barry, A.N., Lutsenko, S., Functional partnership of the copper export machinery and glutathione balance in human cells (2012) J. Biol. Chem., 287, pp. 26678-26687
Jeney, V., Itoh, S., Wendt, M., Gradek, Q., Ushio-Fukai, M., Harrison, D.G., Fukai, T., Role of antioxidant-1 in extracellular superoxide dismutase function and expression (2005) Circ. Res., 96, pp. 723-729
Hatori, Y., Lutsenko, S., An expanding range of functions for the copper chaperone/antioxidant protein Atox1 (2013) Antioxid. Redox Signal., 19, pp. 945-957
Burkhead, J.L., Ralle, M., Wilmarth, P., David, L., Lutsenko, S., Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson disease (2011) J. Mol. Biol., 406, pp. 44-58
Suzuki, K.T., Someya, A., Komada, Y., Ogra, Y., Roles of metallothionein in copper homeostasis: Responses to copper-deficient diets in mice (2002) J. Inorg. Biochem., 88, pp. 173-182
Nartey, N.O., Frei, J.V., Cherian, M.G., Hepatic copper and metallothionein distribution in Wilson disease (hepatolenticular degeneration) (1987) Lab. Investig., 57, pp. 397-401
Makhov, P., Golovine, K., Uzzo, R.G., Rothman, J., Crispen, P.L., Shaw, T., Scoll, B.J., Kolenko, V.M., Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis (XIAP) and sensitizes prostate cancer cells to TRAIL-mediated apoptosis (2008) Cell Death Differ., 15 (11), pp. 1745-1751
Nakatani, T., Tawaramoto, M., Opare, K.D., Kojima, A., Matsui-Yuasa, I., Apoptosis induced by chelation of intracellular zinc is associated with depletion of cellular reduced glutathione level in rat hepatocytes (2000) Chem. Biol. Interact., 125, pp. 151-163
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 156: 145-152.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.348, 5-year impact factor: 3.207
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84954202975&partnerID=40&md5=b452999b8983a065457be0c9911b8325
Keywords: Atox1, Chelating Drugs, Colon Cancer, Copper, Ionophores, Adenosine Triphosphatase, Chaperone, Chelating Agent, Cloxiquine, Copper Chelating Agent, Copper Ion, Copper Ionophore, Tetrakis(2 Pyridylmethyl)ethylenediamine, Peroxiredoxin 3, Unclassified Drug, Article, Caco 2 Cell Line, Cell Level, Controlled Study, Copper Protein Binding, Cytosol, Cytotoxicity, Drug Sensitivity, Gene Silencing, Homeostasis, Human, Human Cell, In Vitro Study, Intracellular Transport, Protein Depletion, Protein Expression, Protein Function, Rna Interference, Trans Golgi Network,
Affiliations:
*** IBB - CNR ***
Department of Biomedical and Biotechnological Sciences, Unit of Medical Biochemistry, University of Catania, Via S. Sofia 64, Catania, Italy
Institute of Biostructures and Bioimaging, National Council of Research, UOS Catania, Italy
References:
Festa, R.A., Thiele, D.J., Copper: An essential metal in biology (2011) Curr. Biol., 21 (21), pp. R877-R883. ,
Lutsenko, S., Human copper homeostasis: A network of interconnected pathways (2010) Curr. Opin. Chem. Biol., 14 (2), pp. 211-217
Robinson, N.J., Winge, D.R., Copper metallochaperones (2010) Annu. Rev. Biochem., 79, pp. 537-562
Harrison, M.D., Jones, C.E., Solioz, M., Dameron, C.T., Intracellular copper routing: The role of copper chaperones (2000) Trends Biochem. Sci., 25, pp. 29-32
Ding, W.Q., Liu, B., Vaught, J.L., Anticancer activity of the antibiotic clioquinol (2005) Cancer Res., 65, pp. 3389-3395
Ding, W.Q., Lind, S.E., Metal ionophores - An emerging class of anticancer drugs (2009) IUBMB Life, 61 (11), pp. 1013-1018
Margalioth, E.J., Schenker, J.G., Chevion, M., Copper and zinc levels in normal and malignant tissues (1983) Cancer, 52 (5), pp. 868-872. , (1)
Dìez, M., Cerdàn, F.J., Arroyo, M., Balibrea, J.L., Use of the copper/zinc ratio in the diagnosis of lung cancer (1989) Cancer, 63 (4), pp. 726-730. , (15)
Mao, X., Li, X., Sprangers, R., Wang, X., Venugopal, A., Wood, T., Zhang, Y., Schimmer, A.D., Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma (2009) Leukemia, 23, pp. 585-590
Mao, X., Schimmer, A.D., The toxicology of clioquinol (2008) Toxicol. Lett., 182, pp. 1-6
Chen, D., Cui, Q.C., Yang, H., Barrea, R.A., Sarkar, F.H., Sheng, S., Yan, B., Dou, Q.P., Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts (2007) Cancer Res., 67, pp. 1636-1644
Daniel, K.G., Chen, D., Orlu, S., Cui, Q.C., Miller, F.R., Dou, Q.P., Clioquinol and pyrrolidinedithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells (2005) Breast Cancer Res., 7 (6), pp. R897-R908
Cao, B., Li, J., Zhu, J., Shen, M., Han, K., Zhang, Z., Yu, Y., Mao, X., The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity (2013) J. Biol. Chem., 288 (47), pp. 34181-34189. , 22
Zhai, S., Yang, L., Cui, Q.C., Sun, Y., Dou, Q.P., Yan, B., Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells (2010) J. Biol. Inorg. Chem., 15 (2), pp. 259-269
Sperandio, S., De Belle, I., Bredesen, D.E., An alternative, nonapoptotic form of programmed cell death (2000) Proc. Natl. Acad. Sci. U. S. A., 97, p. 14376
Tardito, S., Barilli, A., Bassanetti, I., Tegoni, M., Bussolati, O., Franchi-Gazzola, R., Mucchino, C., Marchiò, L., Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation (2012) J. Med. Chem., 55, pp. 10448-10459
Carraway, R.E., Dobner, P.R., Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells (2012) Biochim. Biophys. Acta, 1823 (2), pp. 544-557
Pang, W., Leng, X., Lu, H., Yang, H., Song, N., Tan, L., Jiang, Y., Guo, C., Depletion of intracellular zinc induces apoptosis of cultured hippocampal neurons through suppression of ERK signaling pathway and activation of caspase-3 (2013) Neurosci. Lett., 552, pp. 140-145. , 27
Hyun, H.J., Sohn, J.H., Ha, D.W., Ahn, Y.H., Koh, J.Y., Yoon, Y.H., Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells (2001) Invest. Ophthalmol. Vis. Sci., 42 (2)
Klomp, L.W., Lin, S.J., Yuan, D.S., Klausner, R.D., Culotta, V.C., Gitlin, J.D., Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis (1997) J. Biol. Chem., 272 (14), pp. 9221-9226. , 4
Hamza, I., Prohaska, J., Gitlin, J.D., Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase (2003) Proc. Natl. Acad. Sci. U. S. A., 100 (3), pp. 1215-1220. , 4
Miyayama, T., Suzuki, K.T., Ogra, Y., Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone. Atox1 (2009) Toxicol. Appl. Pharmacol., 237 (2), pp. 205-213
McRae, R., Lai, B., Fahrni, C.J., Copper redistribution in Atox1-deficient mouse fibroblast cells (2010) J. Biol. Inorg. Chem., 15 (1), pp. 99-105
Barresi, V., Palumbo, G.A., Musso, N., Consoli, C., Capizzi, C., Meli, C.R., Romano, A., Condorelli, D.F., Clonal selection of 11q CN-LOH and CBL gene mutation in a serially studied patient during MDS progression to AML (2010) Leuk. Res., 34 (11), pp. 1539-1542
Barresi, V., Romano, A., Musso, N., Capizzi, C., Consoli, C., Martelli, M.P., Palumbo, G.A., Condorelli, D.F., Broad copy neutral-loss of heterozygosity regions and rare recurring copy number abnormalities in normal karyotype-acute myeloid leukemia genomes (2010) Genes Chromosom. Cancer, 49 (11), pp. 1014-1023
Irizarry, R.A., Hobbs, B., Collin, F., Beazer-Barclay, Y.D., Antonellis, K.J., Scherf, U., Speed, T.P., Exploration, normalization, and summaries of high density oligonucleotide array probe level data (2003) Biostatistics, 4 (2), pp. 249-264
Mosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays (1983) J. Immunol. Methods, 65, pp. 55-63. , 55
Scherf, U., Ross, D.T., Waltham, M., Smith, L.H., Lee, J.K., Tanabe, L., Kohn, K.W., Weinstein, J.N., A gene expression database for the molecular pharmacology of cancer (2000) Nat. Genet., 24 (3), pp. 236-244
Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(- delta delta C(T)) method (2001) Methods, 25 (4), pp. 402-408
Barresi, V., Ragusa, A., Fichera, M., Musso, N., Castiglia, L., Rappazzo, G., Travali, S., Condorelli, D.F., Decreased expression of GRAF1/OPHN-1-L in the X-linked alpha thalassemia mental retardation syndrome (2010) BMC Med. Genet., 3, p. 28. , 6
Sheffer, M., Bacolod, M.D., Zuk, O., Giardina, S.F., Pincas, H., Barany, F., Paty, P.B., Domany, E., Association of survival and disease progression with chromosomal instability: A genomic exploration of colorectal cancer (2009) Proc. Natl. Acad. Sci. U. S. A., 106 (17), pp. 7131-7136. , 28
Lee, J., Peña, M.M., Nose, Y., Thiele, D.J., Biochemical characterization of the human copper transporter Ctr1 (2002) J. Biol. Chem., 277 (6), pp. 4380-4387
Itoh, S., Kim, H.W., Nakagawa, O., Ozumi, K., Lessner, S.M., Aoki, H., Akram, K., Fukai, T., Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation (2008) J. Biol. Chem., 283 (14), pp. 9157-9167. , 4
Muller, P.A., Klomp, L.W., ATOX1: A novel copper-responsive transcription factor in mammals? (2009) Int. J. Biochem. Cell Biol., 41, pp. 1233-1236
Fatfat, M., Merhi, R.A., Rahal, O., Stoyanovsky, D.A., Zaki, A., Haidar, H., Kagan, V.E., Machaca, K., Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species (2014) BMC Cancer, 14, p. 527. , 21
Safaei, R., Maktabi, M.H., Blair, B.G., Larson, C.A., Howell, S.B., Effects of the loss of Atox1 on the cellular pharmacology of cisplatin (2009) J. Inorg. Biochem., 103, pp. 333-341
Van Den Berghe, P.V., Folmer, D.E., Malingre, H.E., Van Beurden, E., Klomp, A.E., Van De Sluis, B., Merkx, M., Klomp, L.W., Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake (2007) Biochem. J., 407, pp. 49-59
Milardi, D., Rizzarelli, E., Neurodegeneration: Metallostasis and proteostasis (2011) R. Chem. Soc.
Fulda, S., Vucic, D., Targeting IAP proteins for therapeutic intervention in cancer (2012) Nat. Rev. Drug Discov., (11), pp. 109-124
Cater, M.A., Haupt, Y., Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): Therapeutic indication for prostate cancer (2011) Biochem. J., 436, pp. 481-491
Yoshizawa, K., Nozaki, S., Kitahara, H., Ohara, T., Kato, K., Kawashiri, S., Yamamoto, E., Copper efflux transporter (ATP7B) contributes to the acquisition of cisplatin-resistance in human oral squamous cell lines (2007) Oncol. Rep., 18, pp. 987-991
Ishida, S., Lee, J., Thiele, D.J., Herskowitz, I., Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals (2002) Proc. Natl. Acad. Sci. U. S. A., 99, pp. 14298-14302
Kelner, G.S., Lee, M., Clark, M.E., Maciejewski, D., McGrath, D., Rabizadeh, S., Lyons, T., Maki, R.A., The copper transport protein Atox1 promotes neuronal survival (2000) J. Biol. Chem., 275, pp. 580-584
Hatori, Y., Clasen, S., Hasan, N.M., Barry, A.N., Lutsenko, S., Functional partnership of the copper export machinery and glutathione balance in human cells (2012) J. Biol. Chem., 287, pp. 26678-26687
Jeney, V., Itoh, S., Wendt, M., Gradek, Q., Ushio-Fukai, M., Harrison, D.G., Fukai, T., Role of antioxidant-1 in extracellular superoxide dismutase function and expression (2005) Circ. Res., 96, pp. 723-729
Hatori, Y., Lutsenko, S., An expanding range of functions for the copper chaperone/antioxidant protein Atox1 (2013) Antioxid. Redox Signal., 19, pp. 945-957
Burkhead, J.L., Ralle, M., Wilmarth, P., David, L., Lutsenko, S., Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson disease (2011) J. Mol. Biol., 406, pp. 44-58
Suzuki, K.T., Someya, A., Komada, Y., Ogra, Y., Roles of metallothionein in copper homeostasis: Responses to copper-deficient diets in mice (2002) J. Inorg. Biochem., 88, pp. 173-182
Nartey, N.O., Frei, J.V., Cherian, M.G., Hepatic copper and metallothionein distribution in Wilson disease (hepatolenticular degeneration) (1987) Lab. Investig., 57, pp. 397-401
Makhov, P., Golovine, K., Uzzo, R.G., Rothman, J., Crispen, P.L., Shaw, T., Scoll, B.J., Kolenko, V.M., Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis (XIAP) and sensitizes prostate cancer cells to TRAIL-mediated apoptosis (2008) Cell Death Differ., 15 (11), pp. 1745-1751
Nakatani, T., Tawaramoto, M., Opare, K.D., Kojima, A., Matsui-Yuasa, I., Apoptosis induced by chelation of intracellular zinc is associated with depletion of cellular reduced glutathione level in rat hepatocytes (2000) Chem. Biol. Interact., 125, pp. 151-163
ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs
Copper is a catalytic cofactor required for the normal function of many enzymes involved in fundamental biological processes but highly cytotoxic when in excess. Therefore its homeostasis and distribution is strictly regulated by a network of transporters and intracellular chaperones. ATOX1 (antioxidant protein 1) is a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network. In the present study the Caco-2 cell line, a colon carcinoma cell line, was used as an in vitro model to evaluate if ATOX1 deficiency could affect sensitivity to experimentally induced copper dyshomeostasis. Silencing of ATOX1 increased toxicity of a short treatment with a high concentration of Cu2 +. Copper ionophores, such as 5-chloro-8-hydroxyquinoline, induced a copper-dependent cell toxicity which was significantly potentiated after ATOX1 silencing. The copper chelator TPEN (N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine) produced a form of cell toxicity that was reversed by the addition of Cu2 +. ATOX1 silencing increased Caco-2 cell sensitivity to TPEN toxicity. Our results suggest the possibility of a therapy with copper-chelating or ionophore drugs in subtypes of tumors showing specific alterations in ATOX1 expression. © 2016 Elsevier Inc. All rights reserved.
Copper is a catalytic cofactor required for the normal function of many enzymes involved in fundamental biological processes but highly cytotoxic when in excess. Therefore its homeostasis and distribution is strictly regulated by a network of transporters and intracellular chaperones. ATOX1 (antioxidant protein 1) is a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network. In the present study the Caco-2 cell line, a colon carcinoma cell line, was used as an in vitro model to evaluate if ATOX1 deficiency could affect sensitivity to experimentally induced copper dyshomeostasis. Silencing of ATOX1 increased toxicity of a short treatment with a high concentration of Cu2 +. Copper ionophores, such as 5-chloro-8-hydroxyquinoline, induced a copper-dependent cell toxicity which was significantly potentiated after ATOX1 silencing. The copper chelator TPEN (N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine) produced a form of cell toxicity that was reversed by the addition of Cu2 +. ATOX1 silencing increased Caco-2 cell sensitivity to TPEN toxicity. Our results suggest the possibility of a therapy with copper-chelating or ionophore drugs in subtypes of tumors showing specific alterations in ATOX1 expression. © 2016 Elsevier Inc. All rights reserved.
ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs
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ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs
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View Export to BibTeX Export to EndNote
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Impact Factor: 3.825
View Export to BibTeX Export to EndNote
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Impact Factor: 1.654
View Export to BibTeX Export to EndNote
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Impact Factor: 2.823
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (721 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (582 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Pedone E, Saviano M, Bartolucci S, Rossi M, Ausili A, Scire A, Bertoli E, Tanfani F
* Temperature-, SDS-, and pH-induced conformational changes in protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus: A dynamic simulation and fourier transform infrared spectroscopic study (319 views)
J Proteome Res (ISSN: 1535-3893), 2005 Nov; 4(6): 1972-1980.
Impact Factor: 6.901
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (439 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (352 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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Pedone E, Ren B, Ladenstein R, Rossi M, Bartolucci S
* Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus - A member of a novel protein family related to protein disulfide-isomerase (393 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print), 2004 Sep; 271(16): 3437-3448.
Impact Factor: 3.26
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (325 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
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Nastro P, Sodo M, Dodaro CA, Gargiulo S, Acampa W, Bracale U, Renda A
* Intraoperative radiochromoguided mapping of sentinel lymph node in colon cancer (253 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 Jul; 88(4): 352-353.
Impact Factor: 0.267
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Russo GL, Della Pietra V, Mercurio C, Palumbo R, Iacomino G, Russo M, Tosto M, Zappia V
Protective effects of butyric acid in colon cancer (245 views)
Adv Exp Med Biol (ISSN: 0065-2598print, 0065-2598linking), 1999; 472: 131-147.
Impact Factor: 0.446
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Mansi L, Rambaldi PF, Cuccurullo V, Pecori B, Quarantelli M, Fallanca F, Del Vecchio E
Diagnostic and prognostic role of 99mTc-Tetrofosmin in breast cancer (297 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1997 Sep; 41(3): 239-250.
Impact Factor: 2.125
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (588 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (301 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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39 Records (36 excluding Abstracts).
Total impact factor: 118.978 (106.321 excluding Abstracts).
Total 5 year impact factor: 120.229 (107.051 excluding Abstracts).
Total impact factor: 118.978 (106.321 excluding Abstracts).
Total 5 year impact factor: 120.229 (107.051 excluding Abstracts).
724 views. Last view on Friday 28 April 2023, 10:22:33
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