A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.087, 5-year impact factor: 3.693
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-65949095206&partnerID=40&md5=546e5dfcb59cdca197df3886437d652b
Keywords: Amd3100, Chemokine Receptor, Chemotactic Factor, Chemotaxis, Colon Cancer, Cxc Chemokine Receptor, Cxcl12, G-Protein Coupled Receptor (gpcr), Gi Subfamily, Melanoma, Perk, Chemokine Receptor Cxcr4, Mitogen Activated Protein Kinase 1, Plerixafor, Stromal Cell Derived Factor 1, Animal Experiment, Article, Cancer Cell Culture, Carcinoma Cell, Cell Growth, Cell Migration, Colon Carcinoma, Female, Gene Expression, Gene Function, Genetic Transfection, Human, Human Cell, Human Cell Culture, In Vitro Study, In Vivo Study, Melanoma Cell, Mouse, Mutant, Nonhuman, Point Mutation, Protein Phosphorylation, Squamous Cell Carcinoma, Tumor Growth, Wild Type, Alanine, Amino Acid Sequence, Amino Acid Substitution, Cell Line, Cell Movement, Cell Proliferation, Chemokine Cxcl12, Glycine, Molecular Sequence Data, Mutant Proteins, Neoplasms,
Affiliations:
*** IBB - CNR ***
Clinical Immunology, G. Pascale National Cancer Institute, Fondazione G. Pascale, Naples, Italy
Animal Facility, G. Pascale National Cancer Institute, Fondazione G. Pascale, Naples, Italy
Pathology, G. Pascale National Cancer Institute, Fondazione G. Pascale, Naples, Italy
Istituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, Traversa La Crucca, Italy
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale Ricerche, Naples, Italy
References:
Aiuti, A., Webb, I.J., Bleul, C., Springer, T., Gutierrez-Ramos, J.C., The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood (1997) J Exp Med, 185, pp. 111-12
Gupta, S.K., Lysko, P.G., Pillarisetti, K., Ohlstein, E., Stadel, J.M., Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines (1998) J Biol Chem, 273, pp. 4282-4287
Ma, Q., Jones, D., Borghesani, P.R., Segal, R.A., Nagasawa, T., Kishimoto, T., Impaired B-lymphopoiesis, myelopoiesis and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice (1998) Proc Natl Acad Sci USA, 95, pp. 9448-9453
Baggiolini, M., Chemokines and leukocyte traffic (1998) Nature, 392 (6676), pp. 565-568. , DOI 10.1038/33340
Lataillade, J.J., Clay, D., Bourin, P., Herodin, F., Dupuy, C., Jasmin, C., Stromal cell derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34(+) cells: Evidence for an autocrine/paracrine mechanism (2002) Blood, 99, pp. 1117-1129
Molyneaux, K.A., Zinszner, H., Kunwar, P.S., Schaible, K., Stebler, J., Sunshine, M.J., O'Brien, W., Lehmann, R., The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival (2003) Development, 130 (18), pp. 4279-4286. , DOI 10.1242/dev.00640
Burger, J.A., Tsukada, N., Burger, M., Zvaifler, N.J., Dell'Aquila, M., Kipps, T.J., Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cellderived factor-1 (2000) Blood, 96, pp. 2655-2663
Zhou, Y., Larsen, P.H., Hao, C., Yong, V.W., CXCR4 is a major chemokine receptor on glioma cells and mediates their survival (2002) Journal of Biological Chemistry, 277 (51), pp. 49481-49487. , DOI 10.1074/jbc.M206222200
Geminder, H., Sagi-Assif, O., Goldberg, L., Meshel, T., Rechavi, G., Witz, I.P., Ben-Baruch, A., A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma (2001) Journal of Immunology, 167 (8), pp. 4747-4757
Zeelenberg, I.S., Ruuls-Van Stalle, L., Roos, E., The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases (2003) Cancer Research, 63 (13), pp. 3833-3839
Wang, J., Wang, J., Sun, Y., Song, W., Nor, J.E., Wang, C.Y., Taichman, R.S., Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis (2005) Cellular Signalling, 17 (12), pp. 1578-1592. , DOI 10.1016/j.cellsig.2005.03.022, PII S0898656805000677
Scotton, C.J., Wilson, J.L., Scott, K., Stamp, G., Wilbanks, G.D., Fricker, S., Bridger, G., Balkwill, F.R., Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer (2002) Cancer Research, 62 (20), pp. 5930-5938
Muller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M.E., McClanahan, T., Zlotnik, A., Involvement of chemokine receptors in breast cancer metastasis (2001) Nature, 410 (6824), pp. 50-56. , DOI 10.1038/35065016
Balkwill, F., The significance of cancer cell expression of the chemokine receptor CXCR4 (2004) Seminars in Cancer Biology, 14 (3), pp. 171-179. , DOI 10.1016/j.semcancer.2003.10.003, PII S1044579X03000981
Scala, S., Ottaiano, A., Ascierto, P.A., Cavalli, M., Simeone, E., Giuliano, P., Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma (2005) Clin Cancer Res, 5, pp. 1835-1841
Ottaiano, A., Franco, R., Aiello Talamanca, A., Liguori, G., Tatangelo, F., Delrio, P., Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients (2006) Clin Cancer Res, 9, pp. 2795-2803
Kim, J., Takeuchi, H., Lam, S.T., Turner, R.R., Wang, H.-J., Kuo, C., Foshag, L., Hoon, D.S.B., Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival (2005) Journal of Clinical Oncology, 23 (12), pp. 2744-2753. , DOI 10.1200/JCO.2005.07.078
Ganju, R.K., Brubaker, S.A., Meyer, J., Dutt, P., Yang, Y., Qin, S., Newman, W., Groopman, J.E., The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways (1998) Journal of Biological Chemistry, 273 (36), pp. 23169-23175. , DOI 10.1074/jbc.273.36.23169
Hamm, H.E., The many faces of G protein signaling (1998) Journal of Biological Chemistry, 273 (2), pp. 669-672. , DOI 10.1074/jbc.273.2.669
Bockaert, J., Fagni, L., Dumuis, A., Marin, P., GPCR interacting proteins (GIP) (2004) Pharmacology and Therapeutics, 103 (3), pp. 203-221. , DOI 10.1016/j.pharmthera.2004.06.004, PII S0163725804001007
Tian, S., Choi, W.T., Liu, D., Pesavento, J., Wang, Y., An, J., Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domains (2005) J Virol, 79, pp. 12667-12673
Brelot, A., Heveker, N., Montes, M., Alizon, M., Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor (2000) Journal of Biological Chemistry, 275 (31), pp. 23736-23744. , DOI 10.1074/jbc.M000776200
Ueda, Y., Neel, N.F., Schutyser, E., Raman, D., Richmond, A., Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells (2006) Cancer Research, 66 (11), pp. 5665-5675. , DOI 10.1158/0008-5472.CAN-05-3579
Roland, J., Murphy, B.J., Ahr, B., Robert-Hebmann, V., Delauzun, V., Nye, K.E., Role of the intracellular domains of CXCR4 in CXCL12-mediated signaling (2003) Blood, 101, pp. 399-406
Teicher, B.A., In vivo tumor response end points (2002) Tumor Models in Cancer Research, pp. 593-616. , Teicher B, editor. Totowa: Humana Press
Wang, J., He, L., Combs, C.A., Roderiquez, G., Norcross, M.A., Dimerization of CXCR4 in living malignant cells: Control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions (2006) Molecular Cancer Therapeutics, 5 (10), pp. 2474-2483. , DOI 10.1158/1535-7163.MCT-05-0261
Labrosse, B., Brelot, A., Heveker, N., Sol, N., Schols, D., De Clercq, E., Alizon, M., Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100 (1998) Journal of Virology, 72 (8), pp. 6381-6388
Zhang, W.B., Navenot, J.M., Haribabu, B., Tamamura, H., Hiramatu, K., Omagari, A., A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists (2002) J Biol Chem, 277, pp. 24515-24521
Hatse, S., Princen, K., Gerlach, L.O., Bridger, G., Henson, G., De Clercq, E., Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100 (2001) Mol Pharmacol, 1, pp. 164-173
Rosenkilde, M.M., Gerlach, L.-O., Hatse, S., Skerlj, R.T., Schols, D., Bridger, G.J., Schwartz, T.W., Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor (2007) Journal of Biological Chemistry, 282 (37), pp. 27354-27365. , http://www.jbc.org/cgi/reprint/282/37/27354, DOI 10.1074/jbc.M704739200
Kawai, T., Choi, U., Cardwell, L., DeRavin, S.S., Naumann, N., Whiting-Theobald, N.L., WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with Cterminus-truncated CXCR4 (2007) Blood, 109, pp. 78-84
Busillo, J.M., Benovic, J.L., Regulation of CXCR4 signaling (2007) Biochimica et Biophysica Acta - Biomembranes, 1768 (4), pp. 952-963. , DOI 10.1016/j.bbamem.2006.11.002, PII S0005273606004214
Schuller, U., Koch, A., Hartmann, W., Garre, M.L., Goodyer, C.G., Cama, A., Subtypespecific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas (2005) Int J Cancer, 1, pp. 82-89
Diaz, G.A., CXCR4 mutations in WHIM syndrome: A misguided immune system? (2005) Immunol Rev, 203, pp. 235-243
Scala, S., Giuliano, P., Ascierto, P.A., Ierano, C., Franco, R., Napolitano, M., Human melanoma metastases express functional CXCR4 (2006) Clin Cancer Res, 8, pp. 2427-2433
Miller, R.J., Banisadr, G., Bhattacharyya, B.J., CXCR4 signaling in the regulation of stem cell migration and development (2008) J Neuroimmunol, 198, pp. 31-38
Hermann, P.C., Huber, S.L., Herrler, T., Aicher, A., Ellwart, J.W., Guba, M., Bruns, C.J., Heeschen, C., Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer (2007) Cell Stem Cell, 1 (3), pp. 313-323. , DOI 10.1016/j.stem.2007.06.002, PII S1934590907000665
Gupta, S. K., Lysko, P. G., Pillarisetti, K., Ohlstein, E., Stadel, J. M., Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines (1998) J Biol Chem, 273, pp. 4282-4287
Lataillade, J. J., Clay, D., Bourin, P., Herodin, F., Dupuy, C., Jasmin, C., Stromal cell derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G (0) /G (1) transition in CD34 (+) cells: Evidence for an autocrine/paracrine mechanism (2002) Blood, 99, pp. 1117-1129
Molyneaux, K. A., Zinszner, H., Kunwar, P. S., Schaible, K., Stebler, J., Sunshine, M. J., O'Brien, W., Lehmann, R., The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival (2003) Development, 130 (18), pp. 4279-4286. , DOI 10. 1242/dev. 00640
Burger, J. A., Tsukada, N., Burger, M., Zvaifler, N. J., Dell'Aquila, M., Kipps, T. J., Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cellderived factor-1 (2000) Blood, 96, pp. 2655-2663
Zeelenberg, I. S., Ruuls-Van Stalle, L., Roos, E., The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases (2003) Cancer Research, 63 (13), pp. 3833-3839
Scotton, C. J., Wilson, J. L., Scott, K., Stamp, G., Wilbanks, G. D., Fricker, S., Bridger, G., Balkwill, F. R., Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer (2002) Cancer Research, 62 (20), pp. 5930-5938
Ganju, R. K., Brubaker, S. A., Meyer, J., Dutt, P., Yang, Y., Qin, S., Newman, W., Groopman, J. E., The -chemokine, stromal cell-derived factor-1, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways (1998) Journal of Biological Chemistry, 273 (36), pp. 23169-23175. , DOI 10. 1074/jbc. 273. 36. 23169
Hamm, H. E., The many faces of G protein signaling (1998) Journal of Biological Chemistry, 273 (2), pp. 669-672. , DOI 10. 1074/jbc. 273. 2. 669
Tian, S., Choi, W. T., Liu, D., Pesavento, J., Wang, Y., An, J., Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domains (2005) J Virol, 79, pp. 12667-12673
Ueda, Y., Neel, N. F., Schutyser, E., Raman, D., Richmond, A., Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells (2006) Cancer Research, 66 (11), pp. 5665-5675. , DOI 10. 1158/0008-5472. CAN-05-3579
Teicher, B. A., In vivo tumor response end points (2002) Tumor Models in Cancer Research, pp. 593-616. , Teicher B, editor. Totowa: Humana Press
Zhang, W. B., Navenot, J. M., Haribabu, B., Tamamura, H., Hiramatu, K., Omagari, A., A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists (2002) J Biol Chem, 277, pp. 24515-24521
Rosenkilde, M. M., Gerlach, L. -O., Hatse, S., Skerlj, R. T., Schols, D., Bridger, G. J., Schwartz, T. W., Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor (2007) Journal of Biological Chemistry, 282 (37), pp. 27354-27365. , http: //www. jbc. org/cgi/reprint/282/37/27354, DOI 10. 1074/jbc. M704739200
Busillo, J. M., Benovic, J. L., Regulation of CXCR4 signaling (2007) Biochimica et Biophysica Acta - Biomembranes, 1768 (4), pp. 952-963. , DOI 10. 1016/j. bbamem. 2006. 11. 002, PII S0005273606004214
Diaz, G. A., CXCR4 mutations in WHIM syndrome: A misguided immune system? (2005) Immunol Rev, 203, pp. 235-243
Miller, R. J., Banisadr, G., Bhattacharyya, B. J., CXCR4 signaling in the regulation of stem cell migration and development (2008) J Neuroimmunol, 198, pp. 31-38
Hermann, P. C., Huber, S. L., Herrler, T., Aicher, A., Ellwart, J. W., Guba, M., Bruns, C. J., Heeschen, C., Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer (2007) Cell Stem Cell, 1 (3), pp. 313-323. , DOI 10. 1016/j. stem. 2007. 06. 002, PII S1934590907000665
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.087, 5-year impact factor: 3.693
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-65949095206&partnerID=40&md5=546e5dfcb59cdca197df3886437d652b
Keywords: Amd3100, Chemokine Receptor, Chemotactic Factor, Chemotaxis, Colon Cancer, Cxc Chemokine Receptor, Cxcl12, G-Protein Coupled Receptor (gpcr), Gi Subfamily, Melanoma, Perk, Chemokine Receptor Cxcr4, Mitogen Activated Protein Kinase 1, Plerixafor, Stromal Cell Derived Factor 1, Animal Experiment, Article, Cancer Cell Culture, Carcinoma Cell, Cell Growth, Cell Migration, Colon Carcinoma, Female, Gene Expression, Gene Function, Genetic Transfection, Human, Human Cell, Human Cell Culture, In Vitro Study, In Vivo Study, Melanoma Cell, Mouse, Mutant, Nonhuman, Point Mutation, Protein Phosphorylation, Squamous Cell Carcinoma, Tumor Growth, Wild Type, Alanine, Amino Acid Sequence, Amino Acid Substitution, Cell Line, Cell Movement, Cell Proliferation, Chemokine Cxcl12, Glycine, Molecular Sequence Data, Mutant Proteins, Neoplasms,
Affiliations:
*** IBB - CNR ***
Clinical Immunology, G. Pascale National Cancer Institute, Fondazione G. Pascale, Naples, Italy
Animal Facility, G. Pascale National Cancer Institute, Fondazione G. Pascale, Naples, Italy
Pathology, G. Pascale National Cancer Institute, Fondazione G. Pascale, Naples, Italy
Istituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, Traversa La Crucca, Italy
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale Ricerche, Naples, Italy
References:
Aiuti, A., Webb, I.J., Bleul, C., Springer, T., Gutierrez-Ramos, J.C., The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood (1997) J Exp Med, 185, pp. 111-12
Gupta, S.K., Lysko, P.G., Pillarisetti, K., Ohlstein, E., Stadel, J.M., Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines (1998) J Biol Chem, 273, pp. 4282-4287
Ma, Q., Jones, D., Borghesani, P.R., Segal, R.A., Nagasawa, T., Kishimoto, T., Impaired B-lymphopoiesis, myelopoiesis and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice (1998) Proc Natl Acad Sci USA, 95, pp. 9448-9453
Baggiolini, M., Chemokines and leukocyte traffic (1998) Nature, 392 (6676), pp. 565-568. , DOI 10.1038/33340
Lataillade, J.J., Clay, D., Bourin, P., Herodin, F., Dupuy, C., Jasmin, C., Stromal cell derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34(+) cells: Evidence for an autocrine/paracrine mechanism (2002) Blood, 99, pp. 1117-1129
Molyneaux, K.A., Zinszner, H., Kunwar, P.S., Schaible, K., Stebler, J., Sunshine, M.J., O'Brien, W., Lehmann, R., The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival (2003) Development, 130 (18), pp. 4279-4286. , DOI 10.1242/dev.00640
Burger, J.A., Tsukada, N., Burger, M., Zvaifler, N.J., Dell'Aquila, M., Kipps, T.J., Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cellderived factor-1 (2000) Blood, 96, pp. 2655-2663
Zhou, Y., Larsen, P.H., Hao, C., Yong, V.W., CXCR4 is a major chemokine receptor on glioma cells and mediates their survival (2002) Journal of Biological Chemistry, 277 (51), pp. 49481-49487. , DOI 10.1074/jbc.M206222200
Geminder, H., Sagi-Assif, O., Goldberg, L., Meshel, T., Rechavi, G., Witz, I.P., Ben-Baruch, A., A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma (2001) Journal of Immunology, 167 (8), pp. 4747-4757
Zeelenberg, I.S., Ruuls-Van Stalle, L., Roos, E., The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases (2003) Cancer Research, 63 (13), pp. 3833-3839
Wang, J., Wang, J., Sun, Y., Song, W., Nor, J.E., Wang, C.Y., Taichman, R.S., Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis (2005) Cellular Signalling, 17 (12), pp. 1578-1592. , DOI 10.1016/j.cellsig.2005.03.022, PII S0898656805000677
Scotton, C.J., Wilson, J.L., Scott, K., Stamp, G., Wilbanks, G.D., Fricker, S., Bridger, G., Balkwill, F.R., Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer (2002) Cancer Research, 62 (20), pp. 5930-5938
Muller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M.E., McClanahan, T., Zlotnik, A., Involvement of chemokine receptors in breast cancer metastasis (2001) Nature, 410 (6824), pp. 50-56. , DOI 10.1038/35065016
Balkwill, F., The significance of cancer cell expression of the chemokine receptor CXCR4 (2004) Seminars in Cancer Biology, 14 (3), pp. 171-179. , DOI 10.1016/j.semcancer.2003.10.003, PII S1044579X03000981
Scala, S., Ottaiano, A., Ascierto, P.A., Cavalli, M., Simeone, E., Giuliano, P., Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma (2005) Clin Cancer Res, 5, pp. 1835-1841
Ottaiano, A., Franco, R., Aiello Talamanca, A., Liguori, G., Tatangelo, F., Delrio, P., Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients (2006) Clin Cancer Res, 9, pp. 2795-2803
Kim, J., Takeuchi, H., Lam, S.T., Turner, R.R., Wang, H.-J., Kuo, C., Foshag, L., Hoon, D.S.B., Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival (2005) Journal of Clinical Oncology, 23 (12), pp. 2744-2753. , DOI 10.1200/JCO.2005.07.078
Ganju, R.K., Brubaker, S.A., Meyer, J., Dutt, P., Yang, Y., Qin, S., Newman, W., Groopman, J.E., The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways (1998) Journal of Biological Chemistry, 273 (36), pp. 23169-23175. , DOI 10.1074/jbc.273.36.23169
Hamm, H.E., The many faces of G protein signaling (1998) Journal of Biological Chemistry, 273 (2), pp. 669-672. , DOI 10.1074/jbc.273.2.669
Bockaert, J., Fagni, L., Dumuis, A., Marin, P., GPCR interacting proteins (GIP) (2004) Pharmacology and Therapeutics, 103 (3), pp. 203-221. , DOI 10.1016/j.pharmthera.2004.06.004, PII S0163725804001007
Tian, S., Choi, W.T., Liu, D., Pesavento, J., Wang, Y., An, J., Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domains (2005) J Virol, 79, pp. 12667-12673
Brelot, A., Heveker, N., Montes, M., Alizon, M., Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor (2000) Journal of Biological Chemistry, 275 (31), pp. 23736-23744. , DOI 10.1074/jbc.M000776200
Ueda, Y., Neel, N.F., Schutyser, E., Raman, D., Richmond, A., Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells (2006) Cancer Research, 66 (11), pp. 5665-5675. , DOI 10.1158/0008-5472.CAN-05-3579
Roland, J., Murphy, B.J., Ahr, B., Robert-Hebmann, V., Delauzun, V., Nye, K.E., Role of the intracellular domains of CXCR4 in CXCL12-mediated signaling (2003) Blood, 101, pp. 399-406
Teicher, B.A., In vivo tumor response end points (2002) Tumor Models in Cancer Research, pp. 593-616. , Teicher B, editor. Totowa: Humana Press
Wang, J., He, L., Combs, C.A., Roderiquez, G., Norcross, M.A., Dimerization of CXCR4 in living malignant cells: Control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions (2006) Molecular Cancer Therapeutics, 5 (10), pp. 2474-2483. , DOI 10.1158/1535-7163.MCT-05-0261
Labrosse, B., Brelot, A., Heveker, N., Sol, N., Schols, D., De Clercq, E., Alizon, M., Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100 (1998) Journal of Virology, 72 (8), pp. 6381-6388
Zhang, W.B., Navenot, J.M., Haribabu, B., Tamamura, H., Hiramatu, K., Omagari, A., A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists (2002) J Biol Chem, 277, pp. 24515-24521
Hatse, S., Princen, K., Gerlach, L.O., Bridger, G., Henson, G., De Clercq, E., Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100 (2001) Mol Pharmacol, 1, pp. 164-173
Rosenkilde, M.M., Gerlach, L.-O., Hatse, S., Skerlj, R.T., Schols, D., Bridger, G.J., Schwartz, T.W., Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor (2007) Journal of Biological Chemistry, 282 (37), pp. 27354-27365. , http://www.jbc.org/cgi/reprint/282/37/27354, DOI 10.1074/jbc.M704739200
Kawai, T., Choi, U., Cardwell, L., DeRavin, S.S., Naumann, N., Whiting-Theobald, N.L., WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with Cterminus-truncated CXCR4 (2007) Blood, 109, pp. 78-84
Busillo, J.M., Benovic, J.L., Regulation of CXCR4 signaling (2007) Biochimica et Biophysica Acta - Biomembranes, 1768 (4), pp. 952-963. , DOI 10.1016/j.bbamem.2006.11.002, PII S0005273606004214
Schuller, U., Koch, A., Hartmann, W., Garre, M.L., Goodyer, C.G., Cama, A., Subtypespecific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas (2005) Int J Cancer, 1, pp. 82-89
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Miller, R. J., Banisadr, G., Bhattacharyya, B. J., CXCR4 signaling in the regulation of stem cell migration and development (2008) J Neuroimmunol, 198, pp. 31-38
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A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration
The chemokine receptor CXCR4 is widely expressed in human cancers and regulates cell invasion, proliferation and survival. Because mutations in the CXCR4 gene could regulate its function we sequenced the coding region of the CXCR4 gene in 18 human melanoma and 3 human colon carcinoma cell lines. The same somatic point mutation (G574A; V160I) in the fourth transmembrane region of CXCR4 was detected in one colon cancer cell line (PD) and one melanoma cell line (LB). CXCR4 was expressed and functional in both PD and LB cells, PD and LB cells migrated specifically toward the receptor ligand, CXCL12 and P-Erk was specifically induced by CXCL12. To give insight into the function of the mutant CXCR4 receptor, human A431, epidermoid carcinoma cells, were stably transfected with both mutant and wild type CXCR4. In vitro, A431 cells harboring CXCR4(G574A) migrated specifically toward CXCL12 and CXCL12 induced ERK phosphorylation. Interestingly, in vivo studies showed that the growth of A431 tumors harboring CXCR4(G574A) was delayed compared to those harboring WT CXCR4. As expected, treatment with AMD3100, a specific CXCR4 inhibitor, reduced the in vivo growth of CXCR4(G574A) tumor b(G574A) but surprisingly, increased the growth of CXCR4(G574A) A431 cells. This is the first report of a spontaneously occurring, functionally active CXCR4 mutation in human cancer cells. While the mutation impairs cell growth in vivo, the CXCR4 inhibitor, AMD3100, stimulated the growth of cells harboring CXCR4(G574A).
The chemokine receptor CXCR4 is widely expressed in human cancers and regulates cell invasion, proliferation and survival. Because mutations in the CXCR4 gene could regulate its function we sequenced the coding region of the CXCR4 gene in 18 human melanoma and 3 human colon carcinoma cell lines. The same somatic point mutation (G574A; V160I) in the fourth transmembrane region of CXCR4 was detected in one colon cancer cell line (PD) and one melanoma cell line (LB). CXCR4 was expressed and functional in both PD and LB cells, PD and LB cells migrated specifically toward the receptor ligand, CXCL12 and P-Erk was specifically induced by CXCL12. To give insight into the function of the mutant CXCR4 receptor, human A431, epidermoid carcinoma cells, were stably transfected with both mutant and wild type CXCR4. In vitro, A431 cells harboring CXCR4(G574A) migrated specifically toward CXCL12 and CXCL12 induced ERK phosphorylation. Interestingly, in vivo studies showed that the growth of A431 tumors harboring CXCR4(G574A) was delayed compared to those harboring WT CXCR4. As expected, treatment with AMD3100, a specific CXCR4 inhibitor, reduced the in vivo growth of CXCR4(G574A) tumor b(G574A) but surprisingly, increased the growth of CXCR4(G574A) A431 cells. This is the first report of a spontaneously occurring, functionally active CXCR4 mutation in human cancer cells. While the mutation impairs cell growth in vivo, the CXCR4 inhibitor, AMD3100, stimulated the growth of cells harboring CXCR4(G574A).
A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration
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A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (371 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Scala S, Portella L, Napolitano M, Consales C, Polimeno MN, D'Alterio C, Palma G, Arra C, Vitale R, Amodeo P, De Luca S, Monfrecola L, Castello G
* Design, synthesis, and functional characterization of new cyclepeptides inhibitors for C-X-C chemokine receptor-4 (CXCR4) (430 views)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 2010 Apr; 51: N/D-N/D.
Impact Factor: 0
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Matrone A, Russo M, Mollica C, Lombardi D, Lombardi G, Maurea S, Imbriaco M
* Lymphoepithelial pancreatic cyst: an atypical benign pancreatic mass presenting with a "cheerios-like" appearance (315 views)
Jop (ISSN: 1590-8577, 1590-0857), 2010 Mar 5; 11(2): 170-172.
Impact Factor: 0
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Bifulco K, Longanesi-cattani I, Gargiulo L, Maglio O, Cataldi M, De Rosa M, Stoppelli MP, Pavone V, Carriero MV
* An urokinase receptor antagonist that inhibits cell migration by blocking the formyl peptide receptor (380 views)
Febs Lett (ISSN: 0014-5793print, 0014-5793linking, 1873-3468electronic), 2008 Apr 2; 582(7): 1141-1146.
Impact Factor: 3.264
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Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (377 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (438 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (348 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (350 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
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Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (383 views)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
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Nastro P, Sodo M, Dodaro CA, Gargiulo S, Acampa W, Bracale U, Renda A
* Intraoperative radiochromoguided mapping of sentinel lymph node in colon cancer (253 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 Jul; 88(4): 352-353.
Impact Factor: 0.267
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Russo GL, Della Pietra V, Mercurio C, Palumbo R, Iacomino G, Russo M, Tosto M, Zappia V
Protective effects of butyric acid in colon cancer (245 views)
Adv Exp Med Biol (ISSN: 0065-2598print, 0065-2598linking), 1999; 472: 131-147.
Impact Factor: 0.446
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (301 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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28 Records (26 excluding Abstracts).
Total impact factor: 91.52 (87.986 excluding Abstracts).
Total 5 year impact factor: 86.772 (82.757 excluding Abstracts).
Total impact factor: 91.52 (87.986 excluding Abstracts).
Total 5 year impact factor: 86.772 (82.757 excluding Abstracts).
394 views. Last view on Saturday 14 January 2023, 19:03:07
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