Dietary phytochemicals in chemoprevention of cancer (348 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
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Paper type: Journal Article,
Impact factor: 3.715, 5-year impact factor: 4.239
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Keywords: Cancer, Chemoprevention, Curcumin, Egcg, Genistein, Phytochemicals, Quercetin, Resveratrol, Allyl Isothiocyanate, Allyl Sulfide, Alpha Tocopherol, Anthocyanin, Antineoplastic Agent, Ascorbic Acid, Benzyl Isothiocyanate, Beta Carotene, Caffeic Acid, Calcium, Chlorogenic Acid, Epigallocatechin Gallate, Ferulic Acid, Folic Acid, Iron, Lycopene, Phenethyl Isothiocyanate, Retinol, Rutoside, Selenium, Silymarin, Sulforaphane, Unindexed Drug, Vitamin D, Xanthophyll, Zinc, Aging, Antineoplastic Activity, Antioxidant Activity, Apoptosis, Breast Cancer, Cancer Cell Culture, Cancer Risk, Carcinogenesis, Cardiovascular Disease, Chemoprophylaxis, Clinical Trial, Colon Cancer, Dietary Intake, Down Regulation, Drug Absorption, Drug Dose Regimen, Epidemiological Data, Food Composition, Fruit, Grain, Human, In Vitro Study, In Vivo Study, Incidence, Lung Cancer, Nonhuman, Phytochemistry, Prostate Cancer, Protein Expression, Review, Risk Reduction, Side Effect, Vegetable,
Affiliations:
*** IBB - CNR ***
Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
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Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
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Keywords: Cancer, Chemoprevention, Curcumin, Egcg, Genistein, Phytochemicals, Quercetin, Resveratrol, Allyl Isothiocyanate, Allyl Sulfide, Alpha Tocopherol, Anthocyanin, Antineoplastic Agent, Ascorbic Acid, Benzyl Isothiocyanate, Beta Carotene, Caffeic Acid, Calcium, Chlorogenic Acid, Epigallocatechin Gallate, Ferulic Acid, Folic Acid, Iron, Lycopene, Phenethyl Isothiocyanate, Retinol, Rutoside, Selenium, Silymarin, Sulforaphane, Unindexed Drug, Vitamin D, Xanthophyll, Zinc, Aging, Antineoplastic Activity, Antioxidant Activity, Apoptosis, Breast Cancer, Cancer Cell Culture, Cancer Risk, Carcinogenesis, Cardiovascular Disease, Chemoprophylaxis, Clinical Trial, Colon Cancer, Dietary Intake, Down Regulation, Drug Absorption, Drug Dose Regimen, Epidemiological Data, Food Composition, Fruit, Grain, Human, In Vitro Study, In Vivo Study, Incidence, Lung Cancer, Nonhuman, Phytochemistry, Prostate Cancer, Protein Expression, Review, Risk Reduction, Side Effect, Vegetable,
Affiliations:
*** IBB - CNR ***
Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
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Dietary phytochemicals in chemoprevention of cancer
Regular consumption of fruit and vegetables is associated with reduced risks of cancer, cardiovascular disease and other aging-related diseases. Convincing evidence exists suggesting that an increased fruit, vegetables, and grains consumption is a relatively easy and practical strategy to significantly reduce the incidence of chronic diseases. Cancer chemoprevention intends to interrupt the carcinogenesis process, which includes initiation, promotion and progression of otherwise normal cells to reduce cancer. Despite the failure of β-carotene clinical trial to prevent lung cancer, the development of diet-derived constituents represents one of the major goal in cancer chemoprevention. A key question is whether a purified phytochemical has the same protective effects as does the whole food or mixture of foods in which the phytochemical is present. Putative chemopreventive agents are identified on the basis of epidemiological and in vitro and in vivo studies. All these compounds present tumor-suppressing properties in animal models of carcinogenesis, and they interfere with cellular processes involved in tumor formation, such as suppression of NF-kB and AP1 activation, induction of apoptosis, downregulation of β-catenin expression and activation of ARE/EpRE-dependent gene expression. Phase I clinical trials have been completed only for few of these phytochemicals, and pilot phase II-III trials are planned. In this review, we will begin by describing the different methodological approaches in studying chemopreventive agents, followed by the description of the mechanisms by which these compounds act. Finally, we will review more in details data concerning well-known and promising chemopreventive phytochemicals. © 2005 Bentham Science Publishers Ltd.
Regular consumption of fruit and vegetables is associated with reduced risks of cancer, cardiovascular disease and other aging-related diseases. Convincing evidence exists suggesting that an increased fruit, vegetables, and grains consumption is a relatively easy and practical strategy to significantly reduce the incidence of chronic diseases. Cancer chemoprevention intends to interrupt the carcinogenesis process, which includes initiation, promotion and progression of otherwise normal cells to reduce cancer. Despite the failure of β-carotene clinical trial to prevent lung cancer, the development of diet-derived constituents represents one of the major goal in cancer chemoprevention. A key question is whether a purified phytochemical has the same protective effects as does the whole food or mixture of foods in which the phytochemical is present. Putative chemopreventive agents are identified on the basis of epidemiological and in vitro and in vivo studies. All these compounds present tumor-suppressing properties in animal models of carcinogenesis, and they interfere with cellular processes involved in tumor formation, such as suppression of NF-kB and AP1 activation, induction of apoptosis, downregulation of β-catenin expression and activation of ARE/EpRE-dependent gene expression. Phase I clinical trials have been completed only for few of these phytochemicals, and pilot phase II-III trials are planned. In this review, we will begin by describing the different methodological approaches in studying chemopreventive agents, followed by the description of the mechanisms by which these compounds act. Finally, we will review more in details data concerning well-known and promising chemopreventive phytochemicals. © 2005 Bentham Science Publishers Ltd.
Dietary phytochemicals in chemoprevention of cancer
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Dietary phytochemicals in chemoprevention of cancer
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Ricci A, Roviello GN
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Milardi D
Associazione di derivati di Resveratrolo per la prevenzione e il trattamento di malattie da disordine conformazionale proteico (364 views)
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Lolicato F, Raudino A, Milardi D, La Rosa C
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Sorriento D, Pascale AV, Finelli R, Carillo AL, Annunziata R, Trimarco B, Iaccarino G
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Bera S, De Rosa V, Rachidi W, Diamond AM
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* Exploring the Protective Effect of Food Drugs against Viral Diseases: Interaction of Functional Food Ingredients and SARS-CoV-2, Influenza Virus, and HSV (2 views)
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Impact Factor: 4.647
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Platella C, Guida S, Bonmassar L, Aquino A, Bonmassar E, Ravagnan G, Montesarchio D, Roviello GN, Musumeci D, Fuggetta MP
* Antitumour activity of resveratrol on human melanoma cells: a possible mechanism related to its interaction with malignant cell telomerase (288 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2017 Aug 02; 1861(11PtA): 2843-2851.
Impact Factor: 4.28
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Milardi D
Associazione di derivati di Resveratrolo per la prevenzione e il trattamento di malattie da disordine conformazionale proteico (364 views)
Italian Patent - Brevetto Italiano, 2016 Jul; N/D: 102016000073131-102016000073131.
Impact Factor: 0
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Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
* Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer (295 views)
N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
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Lolicato F, Raudino A, Milardi D, La Rosa C
* Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study (529 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2015; 92: 876-881.
Impact Factor: 3.902
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Sorriento D, Pascale AV, Finelli R, Carillo AL, Annunziata R, Trimarco B, Iaccarino G
* Targeting mitochondria as therapeutic strategy for metabolic disorders (567 views)
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
Impact Factor: 1.219
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Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (503 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (2804 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Sciacca MF, Chillemi R, Sciuto S, Pappalardo M, La Rosa C, Grasso D, Milardi D
* Interactions of two O-phosphorylresveratrol derivatives with model membranes (337 views)
Arch Biochem Biophys (ISSN: 1096-0384, 0003-3986), 2012 May; 521(1-2): 111-116.
Impact Factor: 0
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1028 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (584 views)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Impact Factor: 2.426
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Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (472 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
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23 Records (23 excluding Abstracts).
Total impact factor: 131.944 (131.944 excluding Abstracts).
Total 5 year impact factor: 118.752 (118.752 excluding Abstracts).
Total impact factor: 131.944 (131.944 excluding Abstracts).
Total 5 year impact factor: 118.752 (118.752 excluding Abstracts).
348 views. Last view on Saturday 14 January 2023, 19:37:11
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