Mucosal expression of carcinoembryonic antigen and carbohydrate antigen 19-9 in patients with gastritis and gastric cancer (405 views)
Cancer Detect Prev (ISSN: 0361-090x, 0361-090xlinking), 1999; 23(2): 116-122.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 0.927, 5-year impact factor: 1.822
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0033028934&partnerID=40&md5=a90bfdb9a6939c5c491af2af0b909691
Keywords: Chronic Atrophic Gastritis, Dysplasia, Intestinal Metaplasia, Precancerous Conditions, Tumor Markers, Ca 19-9 Antigen, Carcinoembryonic Antigen, Adult, Aged, Article, Biopsy, Female, Human, Metabolism, Middle Aged, Pathology, Stomach Mucosa, Stomach Tumor, Ca-19-9 Antigen, Gastric Mucosa, Stomach Neoplasms, Biological, Biomarkers,
Affiliations:
Divisione di Oncologia Medica B, Istituto Nazionale Tumori, Fondazione G. Pascale, Via Mariano Semmola, 80131 Napoli, Italy
Ria Laboratory of Nuclear Medicine, National Cancer Institute, Naples, Italy.,
References:
Not available.
Cancer Detect Prev (ISSN: 0361-090x, 0361-090xlinking), 1999; 23(2): 116-122.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 0.927, 5-year impact factor: 1.822
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0033028934&partnerID=40&md5=a90bfdb9a6939c5c491af2af0b909691
Keywords: Chronic Atrophic Gastritis, Dysplasia, Intestinal Metaplasia, Precancerous Conditions, Tumor Markers, Ca 19-9 Antigen, Carcinoembryonic Antigen, Adult, Aged, Article, Biopsy, Female, Human, Metabolism, Middle Aged, Pathology, Stomach Mucosa, Stomach Tumor, Ca-19-9 Antigen, Gastric Mucosa, Stomach Neoplasms, Biological, Biomarkers,
Affiliations:
Divisione di Oncologia Medica B, Istituto Nazionale Tumori, Fondazione G. Pascale, Via Mariano Semmola, 80131 Napoli, Italy
Ria Laboratory of Nuclear Medicine, National Cancer Institute, Naples, Italy.,
References:
Not available.
Mucosal expression of carcinoembryonic antigen and carbohydrate antigen 19-9 in patients with gastritis and gastric cancer
Sixty-eight patients (45 males, 23 females) were studied in order to assess the usefulness of mucosal tissue concentrations of both carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in detecting patients at high risk for gastric cancer. CEA and CA19-9 were assayed on cytosol obtained from multiple endoscopic biopsies of 41 patients with chronic superficial gastritis, 18 with chronic atrophic gastritis, and 9 with gastric cancer. Mucosal tissue concentrations of both CEA and CA19-9 increased from chronic superficial gastritis to chronic atrophic gastritis and to gastric cancer (p = 0.005 and p = 0.002, respectively). Mucosal CEA levels in patients with intestinal metaplasia (IM) were significantly higher than in nonmetaplastic mucosa (p = 0.04). Epithelial dysplasia was associated with higher, though not significant, tissue concentrations of both CEA and CA19-9 when compared with IM. Finally, a correlation between serum levels and tissue concentrations was observed only for CA19-9 (Pearson's correlation coefficient = 0.7). In conclusion, these data indicate that gastric mucosa of patients with chronic atrophic gastritis and intestinal metaplasia express high levels of both CA19-9 and CEA.
Sixty-eight patients (45 males, 23 females) were studied in order to assess the usefulness of mucosal tissue concentrations of both carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in detecting patients at high risk for gastric cancer. CEA and CA19-9 were assayed on cytosol obtained from multiple endoscopic biopsies of 41 patients with chronic superficial gastritis, 18 with chronic atrophic gastritis, and 9 with gastric cancer. Mucosal tissue concentrations of both CEA and CA19-9 increased from chronic superficial gastritis to chronic atrophic gastritis and to gastric cancer (p = 0.005 and p = 0.002, respectively). Mucosal CEA levels in patients with intestinal metaplasia (IM) were significantly higher than in nonmetaplastic mucosa (p = 0.04). Epithelial dysplasia was associated with higher, though not significant, tissue concentrations of both CEA and CA19-9 when compared with IM. Finally, a correlation between serum levels and tissue concentrations was observed only for CA19-9 (Pearson's correlation coefficient = 0.7). In conclusion, these data indicate that gastric mucosa of patients with chronic atrophic gastritis and intestinal metaplasia express high levels of both CA19-9 and CEA.
Mucosal expression of carcinoembryonic antigen and carbohydrate antigen 19-9 in patients with gastritis and gastric cancer
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Mucosal expression of carcinoembryonic antigen and carbohydrate antigen 19-9 in patients with gastritis and gastric cancer
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10 Records (9 excluding Abstracts).
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Total 5 year impact factor: 77.056 (74.57 excluding Abstracts).
Total impact factor: 80.31 (78.203 excluding Abstracts).
Total 5 year impact factor: 77.056 (74.57 excluding Abstracts).
405 views. Last view on Friday 13 September 2024, 14:57:23
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