Patterns of structural MRI abnormalities in deficit and nondeficit schizophrenia (759 views) (PDF public 227 views)
Schizophr Bull (ISSN: 0586-7614, 1745-1701electronic, 0586-7614linking), 2008 Mar; 34(2): 393-401.
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Paper type: Journal Article, Multicenter Study , Research Support, Non-U. S. Gov'T
Impact factor: 6.592, 5-year impact factor: 6.333
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-40049094653&partnerID=40&md5=fda2f2cf5baf2335f47f33c42b7c07df
Keywords: Cingulate Gyri, Dorsolateral Prefrontal Cortex, Lateral Ventricles, Primary Negative Symptoms, Temporal Lobes, Adult, Article, Brain Size, Controlled Study, Female, Human, Human Relation, Major Clinical Study, Nuclear Magnetic Resonance Imaging, Priority Journal, Schizophrenia, Adolescent, Cognition Disorders, Gyrus Cinguli, Middle Aged, Neuropsychological Tests, Severity Of Illness Index, Brain Anatomy, Histology Pathology , Cognition Disorders Diagnosis , Gyrus Cinguli Pathology , Prefrontal Cortex Pathology , Schizophrenia Diagnosis , Temporal Lobe Pathology
Affiliations:
*** IBB - CNR ***
Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy
Biostructure and Bioimaging Institute, CNR and Diagnostic Imaging, University Federico II, Naples, Italy
Department of Experimental Medicine, University of L'Aquila, Italy
Department of Mental Health, University of Brescia, Italy
References:
Not available.
Schizophr Bull (ISSN: 0586-7614, 1745-1701electronic, 0586-7614linking), 2008 Mar; 34(2): 393-401.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Multicenter Study , Research Support, Non-U. S. Gov'T
Impact factor: 6.592, 5-year impact factor: 6.333
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-40049094653&partnerID=40&md5=fda2f2cf5baf2335f47f33c42b7c07df
Keywords: Cingulate Gyri, Dorsolateral Prefrontal Cortex, Lateral Ventricles, Primary Negative Symptoms, Temporal Lobes, Adult, Article, Brain Size, Controlled Study, Female, Human, Human Relation, Major Clinical Study, Nuclear Magnetic Resonance Imaging, Priority Journal, Schizophrenia, Adolescent, Cognition Disorders, Gyrus Cinguli, Middle Aged, Neuropsychological Tests, Severity Of Illness Index, Brain Anatomy, Histology Pathology , Cognition Disorders Diagnosis , Gyrus Cinguli Pathology , Prefrontal Cortex Pathology , Schizophrenia Diagnosis , Temporal Lobe Pathology
Affiliations:
*** IBB - CNR ***
Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy
Biostructure and Bioimaging Institute, CNR and Diagnostic Imaging, University Federico II, Naples, Italy
Department of Experimental Medicine, University of L'Aquila, Italy
Department of Mental Health, University of Brescia, Italy
References:
Not available.
Patterns of structural MRI abnormalities in deficit and nondeficit schizophrenia
Negative symptoms of schizophrenia have generally been found in association with ventricular enlargement and prefrontal abnormalities. These relationships, however, have not been observed consistently, most probably because negative symptoms are heterogeneous and result from different pathophysiological mechanisms. The concept of deficit schizophrenia (DS) was introduced by Carpenter et al to identify a clinically homogeneous subgroup of patients characterized by the presence of primary and enduring negative symptoms. Findings of brain structural abnormalities reported by magnetic resonance imaging (MRI) studies focusing on DS have been mixed. The present study included 34 patients with DS, 32 with nondeficit schizophrenia (NDS), and 31 healthy comparison subjects, providing the largest set of MRI findings in DS published so far. The Schedule for the Deficit Syndrome was used to categorize patients as DS or NDS patients. The 2 patient groups were matched on age and gender and did not differ on clinical variables, except for higher scores on the negative dimension and more impaired interpersonal relationships in DS than in NDS subjects. Lateral ventricles were larger in NDS than in control subjects but were not enlarged in patients with DS. The cingulate gyri volume was smaller in NDS but not in DS patients as compared with healthy subjects. Both groups had smaller dorsolateral prefrontal cortex and temporal lobes than healthy subjects, but DS patients had significantly less right temporal lobe volume as compared with NDS patients. These findings do not support the hypothesis that DS is the extreme end of a severity continuum within schizophrenia. © The Author 2007. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
Negative symptoms of schizophrenia have generally been found in association with ventricular enlargement and prefrontal abnormalities. These relationships, however, have not been observed consistently, most probably because negative symptoms are heterogeneous and result from different pathophysiological mechanisms. The concept of deficit schizophrenia (DS) was introduced by Carpenter et al to identify a clinically homogeneous subgroup of patients characterized by the presence of primary and enduring negative symptoms. Findings of brain structural abnormalities reported by magnetic resonance imaging (MRI) studies focusing on DS have been mixed. The present study included 34 patients with DS, 32 with nondeficit schizophrenia (NDS), and 31 healthy comparison subjects, providing the largest set of MRI findings in DS published so far. The Schedule for the Deficit Syndrome was used to categorize patients as DS or NDS patients. The 2 patient groups were matched on age and gender and did not differ on clinical variables, except for higher scores on the negative dimension and more impaired interpersonal relationships in DS than in NDS subjects. Lateral ventricles were larger in NDS than in control subjects but were not enlarged in patients with DS. The cingulate gyri volume was smaller in NDS but not in DS patients as compared with healthy subjects. Both groups had smaller dorsolateral prefrontal cortex and temporal lobes than healthy subjects, but DS patients had significantly less right temporal lobe volume as compared with NDS patients. These findings do not support the hypothesis that DS is the extreme end of a severity continuum within schizophrenia. © The Author 2007. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
Patterns of structural MRI abnormalities in deficit and nondeficit schizophrenia
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Patterns of structural MRI abnormalities in deficit and nondeficit schizophrenia
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Impact Factor: 3.383
View Export to BibTeX Export to EndNote
* Functional connectivity of the ventral tegmental area and avolition in subjects with schizophrenia: a resting state functional MRI study (1177 views)
European Neuropsychopharmacology (ISSN: 0924-977x), 2018 Apr; 28(5): 589-602.
Impact Factor: 4.239
View Export to BibTeX Export to EndNote
Volpe U, Mucci A, Quarantelli M, Galderisi S, Maj M
* Dorsolateral prefrontal cortex volume in patients with deficit or nondeficit schizophrenia (842 views) (PDF 258 views)
Prog Neuropsychopharmacol Biol Psychiatry (ISSN: 0278-5846, 0278-5846linking), 2012 Jun 1; 37(2): 264-269.
Impact Factor: 3.552
View Export to BibTeX Export to EndNote
Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (794 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
View Export to BibTeX Export to EndNote
3 Records (3 excluding Abstracts).
Total impact factor: 11.174 (11.174 excluding Abstracts).
Total 5 year impact factor: 11.819 (11.819 excluding Abstracts).
Total impact factor: 11.174 (11.174 excluding Abstracts).
Total 5 year impact factor: 11.819 (11.819 excluding Abstracts).
759 views. Last view on Sunday 26 January 2025, 7:09:15
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