Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (486 views)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
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Paper type: Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U. S. Gov'T,
Impact factor: 2.019, 5-year impact factor: 4.581
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-3042565671&partnerID=40&md5=66ee82f81e0bb8e68a433ce6d152373e
Keywords: Colonic Fermentation, Fructo-Oligosaccharides, Hyperlypidaemia, Lipid Metabolism, Apolipoprotein A1, Aspartame, Cholesterol, Dextrin, Fructose Oligosaccharide, Glucose, High Density Lipoprotein Cholesterol, Insulin, Low Density Lipoprotein Cholesterol, Maltose, Placebo, Short Chain Fatty Acid, Triacylglycerol, Very Low Density Lipoprotein Cholesterol, Adult, Article, Body Mass, Carbohydrate Diet, Carbohydrate Intake, Cholesterol Blood Level, Clinical Article, Coffee, Controlled Study, Diet Restriction, Fatty Acid Blood Level, Female, Glucose Blood Level, Glucose Metabolism, High Fiber Diet, Human, Hypercholesterolemia, Insulin Blood Level, Insulin Response, Lactobacillus Bifidus, Nutritional Parameters, Postprandial State, Protein Blood Level, Protein Diet, Standard, Statistical Significance, Triacylglycerol Blood Level, Blood Glucose, Cross-Over Studies, Double-Blind Method, Fasting, Volatile, Middle Aged, Postprandial Period, Triglycerides, Blood Glucose Metabolism, Biosynthesis, Pharmacology, Drug Therapy Metabolism, Chemistry Pharmacology,
Affiliations:
*** IBB - CNR ***
Institute of Food Science/Technology, National Reseach Council, Avellino, Italy
Cerestar Research/Development Center, Vilvoorde, Belgium
Nutri-Health, Rueil-Malmaison, France
Dept. of Clin./Experimental Medicine, Med. Sch. of University Federico II, Via S. Pansini 5, Naples 80131, Italy
Dept. of Clin. /Experimental Medicine, Med. Sch. of University Federico II, Via S. Pansini 5, Naples 80131, Italy
References:
Cummings, J.H., Roberfroid, M.B., Anderson, H., A new took at dietary carbohydrate: Chemistry, physiology and health Eur (1997) J. Clin. Nutr., 51, pp. 417-42
Bouhnik, Y., Flourié, B., Riottot, M., Effects of fructo-oligosaccharides ingestion on fecal Bifidobacteria, and selected metabolic indexes of colon carcinogenesis in healthy humans (1996) Nutr. Cancer, 26, pp. 21-29
Bouhnik, Y., Vahedi, K., Achour, L., Short-chain fructo-oligosaccharide administration dose dependently increases fecal Bifidobacteria in healthy humans (1999) J. Nutr., 129, pp. 113-116
Cummings, J.H., Macfarlane, G.T., Englyst, H.N., Prebiotic digestion and fermentation (2001) Am. J. Clin. Nutr., 73, pp. 415S-420S
Todesco, T., Venketshwer Rao, A., Bosello, A., Jenkins, D.J.A., Propionate lowers blood glucose and alters lipid metabolism in healthy subjects (1991) Am. J. Clin. Nutr., 54, pp. 860-865
Wolever, T.M.S., Spadafora, P., Eshuis, H., Interaction between colonic acetate and propionate in humans (1991) Am. J. Clin. Nutr., 53, pp. 681-687
Boillot, J., Alamowitch, C., Berger, A.M., Effects of dietary propionate on hepatic glucose production, whole-body glucose utilization, carbohydrate and lipid metabolism in normal rats (1995) Br. J. Nutr., 73, pp. 241-251
Bornet, F., Alamowitch, C., Slama, G., Short chain fatty acids and metabolic effects in humans (1994) Gum and Stabilisers for Food Industry, pp. 217-229. , Philips GO, Weldlock DJ, Williams TE, editors. 7th ed.. Oxford: Oxford University Press
Yamashita, K., Kawai, K., Itakura, M., Effects of fructo-oligosaccharides on blood glucose and serum lipids in diabetics patients (1984) Nutr. Res., 4, pp. 961-966
Alles, M.S., de Roos, N.M., Bakx, J.C., van de Lisdonk, E., Zock, P.L., Hautvast, J.G.A.J., Consumption of fructo-oligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes (1999) Am. J. Clin. Nutr., 69, pp. 64-69
Davidson, M.H., Maki, K.C., Synecki, C., Torri, S.A., Drennan, R., Evaluation of the influence of dietary inulin on serum lipids in adults with hypercholesterolemia (1998) Nutr. Res., 18, pp. 503-517
Brighenti, F., Casiraghi, M.C., Canzi, E., Ferrari, A., Effects of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers (1999) Eur. J. Clin. Nutr., 53, pp. 726-733
Jackson, K.G., Taylor, G.R.J., Clohessy, A.M., Williams, C.M., The effect of daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women (1999) Br. J. Nutr., 82, pp. 23-30
Letexier, D., Diraison, F., Beylot, M., Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans (2003) Am. J. Clin. Nutr., 77, pp. 559-564
Causey, J.L., Feirtag, J.M., Gallaher, D.D., Tungland, B.C., Slavin, J.L., Effects of dietary inulin on serum lipids, blood glucose and the gastrointestinal environment in hypercholesterolaemic men (2000) Nutr. Res., 20, pp. 191-201
van Vliet, T., A double blind placebo controlled, parallel trial on the effect of oligofructose intake on serum lipids in male volunteeres (1997), Report TNO V 97.874
Zeist: TNOPedersen, A., Sandstrom, B., van Amelsvoort, J.M.M., The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females (1997) Br. J. Nutr., 78, pp. 215-222
Luo, J., Rizkalla, S.W., Alamowitch, C., Chronic consumption of short-chain fructooligosaccharides by health subjects decreased basal hepatic glucose production but had no effect on insulin-stimutated glucose metabolism (1996) Am. J. Clin. Nutr., 63, pp. 939-945
Luo, J., van Yperselle, M., Rizkalla, S.W., Rossi, F., Bornet, F.R.J., Slama, G., Chronic consumption of short-chain fructo-oligosaccharides does not affect basal hepatic glucose production or insulin resistance in type 2 diabetics (2000) J. Nutr., 130, pp. 1572-1577
Drevon, T., Bornet, F., Les fructo-oligosaccharides: Actilight(R) (1992), pp. 313-338. , Multon JL, editor. Le Sucre, les Sucres, les Edulcorants et les Glucides de Charges dans les IAA. Lavoisier: TEC & DOCIstituto nazionale di ricerca per gli alimenti e la nutrizione. Tabelle di composizione degli alimenti (2000), Milan: EDRA Medical Publishing & New MediaSeigler, L., Wu, W.T., Separation of serum high density lipoprotein for cholesterol determination: Ultracentrifugation vs precipitation with sodium phosphotungstate and magnesium chloride (1981) Clin. Chem., 27, pp. 838-841
Marcovina, S.M., Albers, J.J., Henderson, L.O., Hannon, W.H., International Federation of Clinical Chemistry Standardization Project for measurements of Apolipoproteins A-1 and B. III. Comparability of Apolipoprotein A-1 values by use of International Reference Material (1993) Clin. Chem., 39, pp. 773-781
Bailleu, S., Couderc, R., Rossignol, C., Lipoprotein (a) in childhood: Relation with other atherosclerosis risk factors and family history of atherosclerosis (1995) Clin. Chem., 41, pp. 241-245
Remsey, C., Demigne, C., Determination of volatile fatty acids in plasma after ethanolic extraction (1974) Biochemistry, 141, pp. 85-91
Luc, G., Bard, J.M., Arveiler, D., Lipoprotein (a) as a predictor of coronary heart disease: The prime study (2002) Atherosclerosis, 163, pp. 377-384
Delzenne, N., Kok, N., Fiordaliso, M., Deboyser, D., Goethals, F., Roberfroid, M., Dietary fructo-oligosaccharides modify lipid metabolism in rats (1993) Am. J. Clin. Nutr., 57, pp. 820S-825S
Kok, N., Roberfroid, M., Delzenne, N., Dietary oligofructose modifies the impact of fructose on hepatic triacylglycerol metabolism (1996) Metabolism, 45, pp. 1547-1550
Fiordaliso, M., Kok, N., Desager, J.P., Goethals, F., Deboyser, D., Roberfroid, M., Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats (1995) Lipids, 30, pp. 163-167
Agheli, N., Kabir, M., Berni-Canani, S., Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats (1998) J. Nutr., 128, pp. 1283-1288
Lin, Y., Vonk, R.J., Slooff, M.J., Kuipers, F., Smit, M.J., Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes primary culture (1995) Br. J. Nutr., 74, pp. 197-207
Wolever, T.M., Spadafora, P.J., Cunnane, S.C., Pencharz, P.B., Propionate inhibits incorporation of colonic (1,2-13C) acetate into plasma lipids in humans (1995) Am. J. Clin. Nutr., 61, pp. 1241-1247
Cummings, J. H., Roberfroid, M. B., Anderson, H., A new took at dietary carbohydrate: Chemistry, physiology and health Eur (1997) J. Clin. Nutr., 51, pp. 417-42
Cummings, J. H., Macfarlane, G. T., Englyst, H. N., Prebiotic digestion and fermentation (2001) Am. J. Clin. Nutr., 73, pp. 415S-420S
Wolever, T. M. S., Spadafora, P., Eshuis, H., Interaction between colonic acetate and propionate in humans (1991) Am. J. Clin. Nutr., 53, pp. 681-687
Alles, M. S., de Roos, N. M., Bakx, J. C., van de Lisdonk, E., Zock, P. L., Hautvast, J. G. A. J., Consumption of fructo-oligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes (1999) Am. J. Clin. Nutr., 69, pp. 64-69
Davidson, M. H., Maki, K. C., Synecki, C., Torri, S. A., Drennan, R., Evaluation of the influence of dietary inulin on serum lipids in adults with hypercholesterolemia (1998) Nutr. Res., 18, pp. 503-517
Jackson, K. G., Taylor, G. R. J., Clohessy, A. M., Williams, C. M., The effect of daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women (1999) Br. J. Nutr., 82, pp. 23-30
Causey, J. L., Feirtag, J. M., Gallaher, D. D., Tungland, B. C., Slavin, J. L., Effects of dietary inulin on serum lipids, blood glucose and the gastrointestinal environment in hypercholesterolaemic men (2000) Nutr. Res., 20, pp. 191-201
Marcovina, S. M., Albers, J. J., Henderson, L. O., Hannon, W. H., International Federation of Clinical Chemistry Standardization Project for measurements of Apolipoproteins A-1 and B. III. Comparability of Apolipoprotein A-1 values by use of International Reference Material (1993) Clin. Chem., 39, pp. 773-781
Luc, G., Bard, J. M., Arveiler, D., Lipoprotein (a) as a predictor of coronary heart disease: The prime study (2002) Atherosclerosis, 163, pp. 377-384
Lin, Y., Vonk, R. J., Slooff, M. J., Kuipers, F., Smit, M. J., Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes primary culture (1995) Br. J. Nutr., 74, pp. 197-207
Wolever, T. M., Spadafora, P. J., Cunnane, S. C., Pencharz, P. B., Propionate inhibits incorporation of colonic (1, 2-13C) acetate into plasma lipids in humans (1995) Am. J. Clin. Nutr., 61, pp. 1241-1247
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U. S. Gov'T,
Impact factor: 2.019, 5-year impact factor: 4.581
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-3042565671&partnerID=40&md5=66ee82f81e0bb8e68a433ce6d152373e
Keywords: Colonic Fermentation, Fructo-Oligosaccharides, Hyperlypidaemia, Lipid Metabolism, Apolipoprotein A1, Aspartame, Cholesterol, Dextrin, Fructose Oligosaccharide, Glucose, High Density Lipoprotein Cholesterol, Insulin, Low Density Lipoprotein Cholesterol, Maltose, Placebo, Short Chain Fatty Acid, Triacylglycerol, Very Low Density Lipoprotein Cholesterol, Adult, Article, Body Mass, Carbohydrate Diet, Carbohydrate Intake, Cholesterol Blood Level, Clinical Article, Coffee, Controlled Study, Diet Restriction, Fatty Acid Blood Level, Female, Glucose Blood Level, Glucose Metabolism, High Fiber Diet, Human, Hypercholesterolemia, Insulin Blood Level, Insulin Response, Lactobacillus Bifidus, Nutritional Parameters, Postprandial State, Protein Blood Level, Protein Diet, Standard, Statistical Significance, Triacylglycerol Blood Level, Blood Glucose, Cross-Over Studies, Double-Blind Method, Fasting, Volatile, Middle Aged, Postprandial Period, Triglycerides, Blood Glucose Metabolism, Biosynthesis, Pharmacology, Drug Therapy Metabolism, Chemistry Pharmacology,
Affiliations:
*** IBB - CNR ***
Institute of Food Science/Technology, National Reseach Council, Avellino, Italy
Cerestar Research/Development Center, Vilvoorde, Belgium
Nutri-Health, Rueil-Malmaison, France
Dept. of Clin./Experimental Medicine, Med. Sch. of University Federico II, Via S. Pansini 5, Naples 80131, Italy
Dept. of Clin. /Experimental Medicine, Med. Sch. of University Federico II, Via S. Pansini 5, Naples 80131, Italy
References:
Cummings, J.H., Roberfroid, M.B., Anderson, H., A new took at dietary carbohydrate: Chemistry, physiology and health Eur (1997) J. Clin. Nutr., 51, pp. 417-42
Bouhnik, Y., Flourié, B., Riottot, M., Effects of fructo-oligosaccharides ingestion on fecal Bifidobacteria, and selected metabolic indexes of colon carcinogenesis in healthy humans (1996) Nutr. Cancer, 26, pp. 21-29
Bouhnik, Y., Vahedi, K., Achour, L., Short-chain fructo-oligosaccharide administration dose dependently increases fecal Bifidobacteria in healthy humans (1999) J. Nutr., 129, pp. 113-116
Cummings, J.H., Macfarlane, G.T., Englyst, H.N., Prebiotic digestion and fermentation (2001) Am. J. Clin. Nutr., 73, pp. 415S-420S
Todesco, T., Venketshwer Rao, A., Bosello, A., Jenkins, D.J.A., Propionate lowers blood glucose and alters lipid metabolism in healthy subjects (1991) Am. J. Clin. Nutr., 54, pp. 860-865
Wolever, T.M.S., Spadafora, P., Eshuis, H., Interaction between colonic acetate and propionate in humans (1991) Am. J. Clin. Nutr., 53, pp. 681-687
Boillot, J., Alamowitch, C., Berger, A.M., Effects of dietary propionate on hepatic glucose production, whole-body glucose utilization, carbohydrate and lipid metabolism in normal rats (1995) Br. J. Nutr., 73, pp. 241-251
Bornet, F., Alamowitch, C., Slama, G., Short chain fatty acids and metabolic effects in humans (1994) Gum and Stabilisers for Food Industry, pp. 217-229. , Philips GO, Weldlock DJ, Williams TE, editors. 7th ed.. Oxford: Oxford University Press
Yamashita, K., Kawai, K., Itakura, M., Effects of fructo-oligosaccharides on blood glucose and serum lipids in diabetics patients (1984) Nutr. Res., 4, pp. 961-966
Alles, M.S., de Roos, N.M., Bakx, J.C., van de Lisdonk, E., Zock, P.L., Hautvast, J.G.A.J., Consumption of fructo-oligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes (1999) Am. J. Clin. Nutr., 69, pp. 64-69
Davidson, M.H., Maki, K.C., Synecki, C., Torri, S.A., Drennan, R., Evaluation of the influence of dietary inulin on serum lipids in adults with hypercholesterolemia (1998) Nutr. Res., 18, pp. 503-517
Brighenti, F., Casiraghi, M.C., Canzi, E., Ferrari, A., Effects of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers (1999) Eur. J. Clin. Nutr., 53, pp. 726-733
Jackson, K.G., Taylor, G.R.J., Clohessy, A.M., Williams, C.M., The effect of daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women (1999) Br. J. Nutr., 82, pp. 23-30
Letexier, D., Diraison, F., Beylot, M., Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans (2003) Am. J. Clin. Nutr., 77, pp. 559-564
Causey, J.L., Feirtag, J.M., Gallaher, D.D., Tungland, B.C., Slavin, J.L., Effects of dietary inulin on serum lipids, blood glucose and the gastrointestinal environment in hypercholesterolaemic men (2000) Nutr. Res., 20, pp. 191-201
van Vliet, T., A double blind placebo controlled, parallel trial on the effect of oligofructose intake on serum lipids in male volunteeres (1997), Report TNO V 97.874
Zeist: TNOPedersen, A., Sandstrom, B., van Amelsvoort, J.M.M., The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females (1997) Br. J. Nutr., 78, pp. 215-222
Luo, J., Rizkalla, S.W., Alamowitch, C., Chronic consumption of short-chain fructooligosaccharides by health subjects decreased basal hepatic glucose production but had no effect on insulin-stimutated glucose metabolism (1996) Am. J. Clin. Nutr., 63, pp. 939-945
Luo, J., van Yperselle, M., Rizkalla, S.W., Rossi, F., Bornet, F.R.J., Slama, G., Chronic consumption of short-chain fructo-oligosaccharides does not affect basal hepatic glucose production or insulin resistance in type 2 diabetics (2000) J. Nutr., 130, pp. 1572-1577
Drevon, T., Bornet, F., Les fructo-oligosaccharides: Actilight(R) (1992), pp. 313-338. , Multon JL, editor. Le Sucre, les Sucres, les Edulcorants et les Glucides de Charges dans les IAA. Lavoisier: TEC & DOCIstituto nazionale di ricerca per gli alimenti e la nutrizione. Tabelle di composizione degli alimenti (2000), Milan: EDRA Medical Publishing & New MediaSeigler, L., Wu, W.T., Separation of serum high density lipoprotein for cholesterol determination: Ultracentrifugation vs precipitation with sodium phosphotungstate and magnesium chloride (1981) Clin. Chem., 27, pp. 838-841
Marcovina, S.M., Albers, J.J., Henderson, L.O., Hannon, W.H., International Federation of Clinical Chemistry Standardization Project for measurements of Apolipoproteins A-1 and B. III. Comparability of Apolipoprotein A-1 values by use of International Reference Material (1993) Clin. Chem., 39, pp. 773-781
Bailleu, S., Couderc, R., Rossignol, C., Lipoprotein (a) in childhood: Relation with other atherosclerosis risk factors and family history of atherosclerosis (1995) Clin. Chem., 41, pp. 241-245
Remsey, C., Demigne, C., Determination of volatile fatty acids in plasma after ethanolic extraction (1974) Biochemistry, 141, pp. 85-91
Luc, G., Bard, J.M., Arveiler, D., Lipoprotein (a) as a predictor of coronary heart disease: The prime study (2002) Atherosclerosis, 163, pp. 377-384
Delzenne, N., Kok, N., Fiordaliso, M., Deboyser, D., Goethals, F., Roberfroid, M., Dietary fructo-oligosaccharides modify lipid metabolism in rats (1993) Am. J. Clin. Nutr., 57, pp. 820S-825S
Kok, N., Roberfroid, M., Delzenne, N., Dietary oligofructose modifies the impact of fructose on hepatic triacylglycerol metabolism (1996) Metabolism, 45, pp. 1547-1550
Fiordaliso, M., Kok, N., Desager, J.P., Goethals, F., Deboyser, D., Roberfroid, M., Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats (1995) Lipids, 30, pp. 163-167
Agheli, N., Kabir, M., Berni-Canani, S., Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats (1998) J. Nutr., 128, pp. 1283-1288
Lin, Y., Vonk, R.J., Slooff, M.J., Kuipers, F., Smit, M.J., Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes primary culture (1995) Br. J. Nutr., 74, pp. 197-207
Wolever, T.M., Spadafora, P.J., Cunnane, S.C., Pencharz, P.B., Propionate inhibits incorporation of colonic (1,2-13C) acetate into plasma lipids in humans (1995) Am. J. Clin. Nutr., 61, pp. 1241-1247
Cummings, J. H., Roberfroid, M. B., Anderson, H., A new took at dietary carbohydrate: Chemistry, physiology and health Eur (1997) J. Clin. Nutr., 51, pp. 417-42
Cummings, J. H., Macfarlane, G. T., Englyst, H. N., Prebiotic digestion and fermentation (2001) Am. J. Clin. Nutr., 73, pp. 415S-420S
Wolever, T. M. S., Spadafora, P., Eshuis, H., Interaction between colonic acetate and propionate in humans (1991) Am. J. Clin. Nutr., 53, pp. 681-687
Alles, M. S., de Roos, N. M., Bakx, J. C., van de Lisdonk, E., Zock, P. L., Hautvast, J. G. A. J., Consumption of fructo-oligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes (1999) Am. J. Clin. Nutr., 69, pp. 64-69
Davidson, M. H., Maki, K. C., Synecki, C., Torri, S. A., Drennan, R., Evaluation of the influence of dietary inulin on serum lipids in adults with hypercholesterolemia (1998) Nutr. Res., 18, pp. 503-517
Jackson, K. G., Taylor, G. R. J., Clohessy, A. M., Williams, C. M., The effect of daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women (1999) Br. J. Nutr., 82, pp. 23-30
Causey, J. L., Feirtag, J. M., Gallaher, D. D., Tungland, B. C., Slavin, J. L., Effects of dietary inulin on serum lipids, blood glucose and the gastrointestinal environment in hypercholesterolaemic men (2000) Nutr. Res., 20, pp. 191-201
Marcovina, S. M., Albers, J. J., Henderson, L. O., Hannon, W. H., International Federation of Clinical Chemistry Standardization Project for measurements of Apolipoproteins A-1 and B. III. Comparability of Apolipoprotein A-1 values by use of International Reference Material (1993) Clin. Chem., 39, pp. 773-781
Luc, G., Bard, J. M., Arveiler, D., Lipoprotein (a) as a predictor of coronary heart disease: The prime study (2002) Atherosclerosis, 163, pp. 377-384
Lin, Y., Vonk, R. J., Slooff, M. J., Kuipers, F., Smit, M. J., Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes primary culture (1995) Br. J. Nutr., 74, pp. 197-207
Wolever, T. M., Spadafora, P. J., Cunnane, S. C., Pencharz, P. B., Propionate inhibits incorporation of colonic (1, 2-13C) acetate into plasma lipids in humans (1995) Am. J. Clin. Nutr., 61, pp. 1241-1247
Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals
Background: The intake of 10 g/day of short-chain-fructo-oligosaccharides (sc-FOS) has been shown to increase significantly bifidus counts and to produce high amounts of short-chain fatty acids (SCFA), presumed to influence glucose and lipid metabolism. Aim: To evaluate the effects of moderate intake of sc-FOS on glucose and lipid metabolism in individuals with mild hypercholesterolaemia. Design: A randomized double-blind sequential cross-over study. Subjects and methods: Thirty subjects of both genders (20 M/10 F), mean age 45.5±9.9 years (M±SD), BMI 26.6±2.2 kg/m2, with plasma cholesterol >5.17 and <7.76 mmol/l and plasma triglycerides <3.45 mmol/l, participated in the study. The study was performed after a wash-out period of 1 month and a run-in period of 1 month to stabilize patients on a standard diet (CHO 50%, fat 30%, protein 20%, fibre 20 g/day) plus placebo (maltodextrine plus aspartame 15 g/day). At the end of run-in, subjects were randomly assigned to receive sc-FOS (Actilight(R)) (10.6 g/day) or placebo (maltodextrine plus aspartame 15 g/day) with tea and/or coffee for a duration of 2 months and thereafter switched to the other treatment for additional 2 months. Plasma glucose, total and lipoprotein (VLDL, LDL, HDL) cholesterol and triglyceride concentrations were measured in the fasting state at the end of run-in and of each treatment period. At the end of the two treatment periods, patients consumed a standard test meal (protein 15%, carbohydrate 34%, fat 51%, kJ 3988) 1 h after the administration of 5.3 g of sc-FOS or placebo; plasma glucose, insulin, free fatty acid (FFA) and triglyceride responses to the test meal were evaluated. Results: No significant difference in fasting parameters was detected between the two treatments. After sc-FOS and placebo plasma cholesterol levels were, respectively, 6.47±0.70 and 6.44±0.78 mmol/l (n.s.) and plasma triglycerides were 1.53±0.71 and 1.56±0.53 mmol/l (n.s.). No significant differences were observed in cholesterol and triglyceride content of VLDL, LDL and HDL and in plasma Apo A1 levels; conversely, fasting plasma Lp(a) concentrations were significantly increased after sc-FOS (37±38 vs. 33±35 mg/dl; P<0.005). Postprandial responses of glucose, FFA and triglycerides were not significantly different between sc-FOS and placebo, while postprandial insulin response (incremental area) was significantly reduced after sc-FOS compared to placebo (14490±7416 vs. 17760±7710 pmol/l × 300 min; P<0.02). Conclusions: A moderate intake of sc-FOS has no major effects on lipid metabolism, both in the fasting and in the postprandial period, in individuals with mild hypercholesterolaemia. A small but significant increase of Lp(a) concentrations was observed with sc-FOS consumption together with a reduction of the postprandial insulin response; however, the clinical relevance of these small effects is unclear. © 2003 Elsevier Ltd. All rights reserved.
Background: The intake of 10 g/day of short-chain-fructo-oligosaccharides (sc-FOS) has been shown to increase significantly bifidus counts and to produce high amounts of short-chain fatty acids (SCFA), presumed to influence glucose and lipid metabolism. Aim: To evaluate the effects of moderate intake of sc-FOS on glucose and lipid metabolism in individuals with mild hypercholesterolaemia. Design: A randomized double-blind sequential cross-over study. Subjects and methods: Thirty subjects of both genders (20 M/10 F), mean age 45.5±9.9 years (M±SD), BMI 26.6±2.2 kg/m2, with plasma cholesterol >5.17 and <7.76 mmol/l and plasma triglycerides <3.45 mmol/l, participated in the study. The study was performed after a wash-out period of 1 month and a run-in period of 1 month to stabilize patients on a standard diet (CHO 50%, fat 30%, protein 20%, fibre 20 g/day) plus placebo (maltodextrine plus aspartame 15 g/day). At the end of run-in, subjects were randomly assigned to receive sc-FOS (Actilight(R)) (10.6 g/day) or placebo (maltodextrine plus aspartame 15 g/day) with tea and/or coffee for a duration of 2 months and thereafter switched to the other treatment for additional 2 months. Plasma glucose, total and lipoprotein (VLDL, LDL, HDL) cholesterol and triglyceride concentrations were measured in the fasting state at the end of run-in and of each treatment period. At the end of the two treatment periods, patients consumed a standard test meal (protein 15%, carbohydrate 34%, fat 51%, kJ 3988) 1 h after the administration of 5.3 g of sc-FOS or placebo; plasma glucose, insulin, free fatty acid (FFA) and triglyceride responses to the test meal were evaluated. Results: No significant difference in fasting parameters was detected between the two treatments. After sc-FOS and placebo plasma cholesterol levels were, respectively, 6.47±0.70 and 6.44±0.78 mmol/l (n.s.) and plasma triglycerides were 1.53±0.71 and 1.56±0.53 mmol/l (n.s.). No significant differences were observed in cholesterol and triglyceride content of VLDL, LDL and HDL and in plasma Apo A1 levels; conversely, fasting plasma Lp(a) concentrations were significantly increased after sc-FOS (37±38 vs. 33±35 mg/dl; P<0.005). Postprandial responses of glucose, FFA and triglycerides were not significantly different between sc-FOS and placebo, while postprandial insulin response (incremental area) was significantly reduced after sc-FOS compared to placebo (14490±7416 vs. 17760±7710 pmol/l × 300 min; P<0.02). Conclusions: A moderate intake of sc-FOS has no major effects on lipid metabolism, both in the fasting and in the postprandial period, in individuals with mild hypercholesterolaemia. A small but significant increase of Lp(a) concentrations was observed with sc-FOS consumption together with a reduction of the postprandial insulin response; however, the clinical relevance of these small effects is unclear. © 2003 Elsevier Ltd. All rights reserved.
Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals
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Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals
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* Acute and chronic improvement in postprandial glucose metabolism by a diet resembling the traditional Mediterranean dietary pattern: Can SCFAs play a role? (52 views)
Clin Nutr (ISSN: 0261-5614linking), 2021 Feb; 40(2): 428-437.
Impact Factor: 6.36
View Export to BibTeX Export to EndNote
Taskinen MR, Soderlund S, Bogl LH, Hakkarainen A, Matikainen N, Pietilainen KH, Rasanen S, Lundbom N, Bjornson E, Eliasson B, Mancina RM, Romeo S, Almeras N, Della Pepa G, Vetrani C, Prinster A, Annuzzi G, Rivellese A, Despres JP, Boren J
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J Intern Med (ISSN: 0954-6820), 2017 May 26; N/D: N/D-N/D.
Impact Factor: 6.754
View Export to BibTeX Export to EndNote
Marcucci G, Cianferotti L, Beck-Peccoz P, Capezzone M, Cetani F, Colao A, Davì MV, Degli Uberti E, Del Prato S, Elisei R, Faggiano A, Ferone D, Foresta C, Fugazzola L, Ghigo E, Giacchetti G, Giorgino F, Lenzi A, Malandrino P, Mannelli M, Marcocci C, Masi L, Pacini F, Opocher G, Radicioni A, Tonacchera M, Vigneri R, Zatelli MC, Brandi ML
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Impact Factor: 1.994
View Export to BibTeX Export to EndNote
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Impact Factor: 1.738
View Export to BibTeX Export to EndNote
Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (447 views)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Impact Factor: 3.891
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, Finamore E, Mansi R, Galdiero M, Morelli G, Tesauro D
* Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (424 views)
Molecular Biosystems (ISSN: 1742-206x), 2012; 8(12): 3166-3177.
Impact Factor: 3.35
View Export to BibTeX Export to EndNote
Giacco R, Clemente G, Cipriano D, Luongo D, Viscovo D, Patti L, Di Marino L, Giacco A, Naviglio D, Bianchi MA, Ciati R, Brighenti F, Rivellese AA, Riccardi G
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Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2010 Mar; 20(3): 186-194.
Impact Factor: 3.438
View Export to BibTeX Export to EndNote
Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (422 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
View Export to BibTeX Export to EndNote
Cigliano L, D'Andrea LD, Maresca B, Serino M, Carlucci A, Salvatore A, Spagnuolo MS, Scigliuolo G, Pedone C, Abrescia P
* Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin (393 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 2008 Nov; 389(11): 1421-1426.
Impact Factor: 3.035
View Export to BibTeX Export to EndNote
Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (482 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
View Export to BibTeX Export to EndNote
Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (440 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
View Export to BibTeX Export to EndNote
Di Gaetano S, Guglielmi F, Arciello A, Mangione P, Monti M, Pagnozzi D, Raimondi S, Giorgetti S, Orru S, Canale C, Pucci P, Dobson CM, Bellotti V, Piccoli R
* Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential (365 views)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x, 0006-291xprint), 2006 Dec 8; 351(1): 223-228.
Impact Factor: 2.855
View Export to BibTeX Export to EndNote
Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (496 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (377 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
View Export to BibTeX Export to EndNote
Greco AM, de Franciscis P, Bozza P, Salvatore M
Thyroid function and lipid metabolism in rats treated with lithium and cholesterol deficient Nath diet (685 views)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Dec 30; 55(24): 2589-2595.
Impact Factor: 0
View Export to BibTeX Export to EndNote
15 Records (15 excluding Abstracts).
Total impact factor: 50.35 (50.35 excluding Abstracts).
Total 5 year impact factor: 50.089 (50.089 excluding Abstracts).
Total impact factor: 50.35 (50.35 excluding Abstracts).
Total 5 year impact factor: 50.089 (50.089 excluding Abstracts).
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