fac-[Re(H2O)3(CO)3]+ Complexed with Histidine and Imidazole in aqueous solution: Speciation, Affinity and Binding Features(392 views) De Tommaso G, Celentano V, Malgieri G, Fattorusso R, Romanelli A, D'Andrea LD, Iuliano M, Isernia C
fac-[Re(H2O)3(CO)3]+ Complexed with Histidine and Imidazole in aqueous solution: Speciation, Affinity and Binding Features
The use of isotopes of transition metal has opened many perspectives in
the development of novel compounds utilizable for therapeutic or
diagnostic purposes. In order to be exploited, though, they must be
stabilized by chelating systems in coordination complexes. The
tricarbonyl complexes of Technetium(I) and Rhenium(I) have assumed
important roles in these fields as they are readily conjugated to
biomolecules to form stable probe useful in the targeting approach. In
this context the amino acid histidine represents a valuable ligand for
bioconjugation. Since little is reported on the chemistry and speciation
of Re(I) and Tc(I) in aqueous solution, here, we analyze the
interaction of fac-[Re(H
2
O)
3
(CO)
3
]
+
with histidine or with the simple imidazole ring by means of
potentiometric and spectroscopic techniques. We describe in details the
equilibria that arise in solution, calculate the constants of each
equilibrium reaction and report coordination properties and atomic
details of the formed complexes. Our data represent a valuable
contribute towards the exploitation in nuclear medicine of histidine
containing biomolecules complexing Tc (I) and Re(I).
fac-[Re(H2O)3(CO)3]+ Complexed with Histidine and Imidazole in aqueous solution: Speciation, Affinity and Binding Features
No results.
fac-[Re(H2O)3(CO)3]+ Complexed with Histidine and Imidazole in aqueous solution: Speciation, Affinity and Binding Features