Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials (472 views)
Diseases Of The Esophagus, 2012 Feb; 142(5): 130-136.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 2.057, 5-year impact factor: 2.005
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857113777&partnerID=40&md5=97910941a8218bdc62cf539ac71b35cb
Keywords: Esophageal Cancer, Pooled Analysis, Preoperative Chemoradiotherapy, Cetuximab, Cisplatin, Fluorouracil, Folinic Acid, Oxaliplatin, Paclitaxel, Adult, Article, Cancer Combination Chemotherapy, Cancer Radiotherapy, Cancer Survival, Clinical Effectiveness, Continuous Infusion, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Female, Histopathology, Human, Human Tissue, Major Clinical Study, Multiple Cycle Treatment, Outcome Assessment, Overall Survival, Phase 2 Clinical Trial, Preoperative Treatment, Priority Journal, Radiation Dose, Treatment Response, Antineoplastic Combined Chemotherapy Protocols, Esophageal Neoplasms, Middle Aged, Preoperative Period, Remission Induction, Survival Analysis, Treatment Outcome, Forced Vital Capacity, Letter, Mortality, Reference Value, Risk Assessment, Risk Factor, Total Lung Capacity,
Affiliations:
*** IBB - CNR ***
Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery 'F. Magrassi - A. Lanzara', Second University of Naples School of Medicine, Italy
Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery 'F. Magrassi - A. Lanzara', Second University of Naples School of Medicine, Italy
Division of Radiotherapy, Federico II University of Naples School of Medicine, Naples, Italy
Division of General Surgery, Federico II University of Naples School of Medicine, Naples, Italy
Unit of Respiratory Pathophysiology, Universit Campus Biomedico, Via Alvaro del Portillo, 200, 00128 Rome, Italy
Alberto Sordi Foundation, Rome, Italy
Department of Epidemiology, Roma E. Health Authority, Rome, Italy
Fondazione San Raffaele, Cittadella della Carit, Taranto, Italy
References:
Not available.
Diseases Of The Esophagus, 2012 Feb; 142(5): 130-136.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 2.057, 5-year impact factor: 2.005
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857113777&partnerID=40&md5=97910941a8218bdc62cf539ac71b35cb
Keywords: Esophageal Cancer, Pooled Analysis, Preoperative Chemoradiotherapy, Cetuximab, Cisplatin, Fluorouracil, Folinic Acid, Oxaliplatin, Paclitaxel, Adult, Article, Cancer Combination Chemotherapy, Cancer Radiotherapy, Cancer Survival, Clinical Effectiveness, Continuous Infusion, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Female, Histopathology, Human, Human Tissue, Major Clinical Study, Multiple Cycle Treatment, Outcome Assessment, Overall Survival, Phase 2 Clinical Trial, Preoperative Treatment, Priority Journal, Radiation Dose, Treatment Response, Antineoplastic Combined Chemotherapy Protocols, Esophageal Neoplasms, Middle Aged, Preoperative Period, Remission Induction, Survival Analysis, Treatment Outcome, Forced Vital Capacity, Letter, Mortality, Reference Value, Risk Assessment, Risk Factor, Total Lung Capacity,
Affiliations:
*** IBB - CNR ***
Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery 'F. Magrassi - A. Lanzara', Second University of Naples School of Medicine, Italy
Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery 'F. Magrassi - A. Lanzara', Second University of Naples School of Medicine, Italy
Division of Radiotherapy, Federico II University of Naples School of Medicine, Naples, Italy
Division of General Surgery, Federico II University of Naples School of Medicine, Naples, Italy
Unit of Respiratory Pathophysiology, Universit Campus Biomedico, Via Alvaro del Portillo, 200, 00128 Rome, Italy
Alberto Sordi Foundation, Rome, Italy
Department of Epidemiology, Roma E. Health Authority, Rome, Italy
Fondazione San Raffaele, Cittadella della Carit, Taranto, Italy
References:
Not available.
Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials
This pooled analysis was performed using individual patient data from three phase II trials that included on the whole 113 esophageal cancer treated preoperatively with chemoradiotherapy (CRT), in order to analyze the efficacy and survival outcomes according to the achievement of the pathologic complete response (pCR). Thirty-nine patients were treated with 5-fluorouracil/cisplatin and RT (40Gy), 33 patients received paclitaxel/cisplatin weekly during weeks 1-6 with and RT (46Gy), 41 patients were treated with induction bio-chemotherapy with cetuximab and FOLFOX-4 followed by concomitant cetuximab and RT of 50. 4Gy. One hundred and two out of 113 resected patients were included in the survival analysis. The median overall survival (OS) time for the whole population was 21. 5 months. The 12, 24, and 36 months OS rates were 85. 4, 45. 2, and 33%, respectively. The difference in survival probability between patients with pCR and patients with partial response or stable disease after treatment was significant (P= 0. 0002, hazard ratios = 0. 21, 95% CI 0. 18-0. 60). On multivariate analysis, the pathologic response and histology were the only covariates independently associated with OS (P= 0. 0157 and P= 0. 0212, respectively). In our series, complete responder patients had a significant longer survival probability after treatment when compared to patients with partial response or stable disease. 2011 the Authors. Journal compilation 2011, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus
This pooled analysis was performed using individual patient data from three phase II trials that included on the whole 113 esophageal cancer treated preoperatively with chemoradiotherapy (CRT), in order to analyze the efficacy and survival outcomes according to the achievement of the pathologic complete response (pCR). Thirty-nine patients were treated with 5-fluorouracil/cisplatin and RT (40Gy), 33 patients received paclitaxel/cisplatin weekly during weeks 1-6 with and RT (46Gy), 41 patients were treated with induction bio-chemotherapy with cetuximab and FOLFOX-4 followed by concomitant cetuximab and RT of 50. 4Gy. One hundred and two out of 113 resected patients were included in the survival analysis. The median overall survival (OS) time for the whole population was 21. 5 months. The 12, 24, and 36 months OS rates were 85. 4, 45. 2, and 33%, respectively. The difference in survival probability between patients with pCR and patients with partial response or stable disease after treatment was significant (P= 0. 0002, hazard ratios = 0. 21, 95% CI 0. 18-0. 60). On multivariate analysis, the pathologic response and histology were the only covariates independently associated with OS (P= 0. 0157 and P= 0. 0212, respectively). In our series, complete responder patients had a significant longer survival probability after treatment when compared to patients with partial response or stable disease. 2011 the Authors. Journal compilation 2011, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus
Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials
No results. |
Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials
Other filter: ([btitle,keywords] "Esophageal Cancer" O ...
Buonanno F, Conson M, De Almeida Ribeiro C, Oliviero C, Itta F, Liuzzi R, Pacelli R, Cella L, Clemente S
* Local tumor control and treatment related toxicity after plaque brachytherapy for uveal melanoma: A systematic review and a data pooled analysis (58 views)
Radiother Oncol (ISSN: 0167-8140linking, 1879-0887), 2022 Jan; 166: 15-25.
Impact Factor: 6.28
View Export to BibTeX Export to EndNote
Bonaccorso C, Grasso G, Musso N, Barresi V, Condorelli DF, La Mendola D, Rizzarelli E
* Water soluble glucose derivative of thiocarbohydrazone acts as ionophore with cytotoxic effects on tumor cells (414 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 1873-3344electronic), 2018; 182: 92-102.
Impact Factor: 3.317
View Export to BibTeX Export to EndNote
D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (548 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
View Export to BibTeX Export to EndNote
Orditura M, Galizia G, Di Martino N, Ancona E, Castoro C, Pacelli R, Morgillo F, Rossetti S, Gambardella V, Farella A, Laterza MM, Ruol A, Fabozzi A, Napolitano V, Iovino F, Lieto E, Fei L, Conzo G, Ciardiello F, De Vita F
* Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study (1985 views)
Curr Oncol (ISSN: 1198-0052, 1718-7729electronic, 1198-0052linking), 2014 Jun; 21(3): 125-133.
Impact Factor: 1.785
View Export to BibTeX Export to EndNote
Orditura M, Galizia G, Napolitano V, Martinelli E, Pacelli R, Lieto E, Aurilio G, Vecchione L, Morgillo F, Catalano G, Ciardiello F, Del Genio A, Di Martino N, De Vita F
* Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study (458 views)
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
Impact Factor: 2.39
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (730 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
View Export to BibTeX Export to EndNote
Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (858 views)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
View Export to BibTeX Export to EndNote
Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (452 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Gustavsson T, Sarkar N, Banyasz A, Markovitsi D, Improta R
* Solvent effects on the steady-state absorption and fluorescence spectra of uracil, thymine and 5-fluorouracil (460 views)
Photochem Photobiol (ISSN: 0031-8655), 2007 May; 83(3): 595-599.
Impact Factor: 2.172
View Export to BibTeX Export to EndNote
Santoro F, Barone V, Gustavsson T, Improta R
* Solvent effect on the singlet excited-state lifetimes of nucleic acid bases: A computational study of 5-fluorouracil and uracil in acetonitrile and water (1080 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Dec 20; 128(50): 16312-16322.
Impact Factor: 7.696
View Export to BibTeX Export to EndNote
Gustavsson T, Sarkar N, Lazzarotto E, Markovitsi D, Barone V, Improta R
* Solvent effect on the singlet excited-state dynamics of 5-fluorouracil in acetonitrile as compared with water (356 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2006 Jul 6; 110(26): 12843-12847.
Impact Factor: 4.115
View Export to BibTeX Export to EndNote
Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (749 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Gustavsson T, Banyasz A, Lazzarotto E, Markovitsi D, Scalmani G, Frisch MJ, Barone V, Improta R
* Singlet excited-state behavior of uracil and thymine in aqueous solution: A combined experimental and computational study of 11 uracil derivatives (876 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jan 18; 128(2): 607-619.
Impact Factor: 7.696
View Export to BibTeX Export to EndNote
d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
* Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (412 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738.
Impact Factor: 4.285
View Export to BibTeX Export to EndNote
Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (289 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
View Export to BibTeX Export to EndNote
* Local tumor control and treatment related toxicity after plaque brachytherapy for uveal melanoma: A systematic review and a data pooled analysis (58 views)
Radiother Oncol (ISSN: 0167-8140linking, 1879-0887), 2022 Jan; 166: 15-25.
Impact Factor: 6.28
View Export to BibTeX Export to EndNote
Bonaccorso C, Grasso G, Musso N, Barresi V, Condorelli DF, La Mendola D, Rizzarelli E
* Water soluble glucose derivative of thiocarbohydrazone acts as ionophore with cytotoxic effects on tumor cells (414 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 1873-3344electronic), 2018; 182: 92-102.
Impact Factor: 3.317
View Export to BibTeX Export to EndNote
D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (548 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
View Export to BibTeX Export to EndNote
Orditura M, Galizia G, Di Martino N, Ancona E, Castoro C, Pacelli R, Morgillo F, Rossetti S, Gambardella V, Farella A, Laterza MM, Ruol A, Fabozzi A, Napolitano V, Iovino F, Lieto E, Fei L, Conzo G, Ciardiello F, De Vita F
* Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study (1985 views)
Curr Oncol (ISSN: 1198-0052, 1718-7729electronic, 1198-0052linking), 2014 Jun; 21(3): 125-133.
Impact Factor: 1.785
View Export to BibTeX Export to EndNote
Orditura M, Galizia G, Napolitano V, Martinelli E, Pacelli R, Lieto E, Aurilio G, Vecchione L, Morgillo F, Catalano G, Ciardiello F, Del Genio A, Di Martino N, De Vita F
* Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study (458 views)
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
Impact Factor: 2.39
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (730 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
View Export to BibTeX Export to EndNote
Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (858 views)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
View Export to BibTeX Export to EndNote
Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (452 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Gustavsson T, Sarkar N, Banyasz A, Markovitsi D, Improta R
* Solvent effects on the steady-state absorption and fluorescence spectra of uracil, thymine and 5-fluorouracil (460 views)
Photochem Photobiol (ISSN: 0031-8655), 2007 May; 83(3): 595-599.
Impact Factor: 2.172
View Export to BibTeX Export to EndNote
Santoro F, Barone V, Gustavsson T, Improta R
* Solvent effect on the singlet excited-state lifetimes of nucleic acid bases: A computational study of 5-fluorouracil and uracil in acetonitrile and water (1080 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Dec 20; 128(50): 16312-16322.
Impact Factor: 7.696
View Export to BibTeX Export to EndNote
Gustavsson T, Sarkar N, Lazzarotto E, Markovitsi D, Barone V, Improta R
* Solvent effect on the singlet excited-state dynamics of 5-fluorouracil in acetonitrile as compared with water (356 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2006 Jul 6; 110(26): 12843-12847.
Impact Factor: 4.115
View Export to BibTeX Export to EndNote
Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (749 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Gustavsson T, Banyasz A, Lazzarotto E, Markovitsi D, Scalmani G, Frisch MJ, Barone V, Improta R
* Singlet excited-state behavior of uracil and thymine in aqueous solution: A combined experimental and computational study of 11 uracil derivatives (876 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jan 18; 128(2): 607-619.
Impact Factor: 7.696
View Export to BibTeX Export to EndNote
d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
* Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (412 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738.
Impact Factor: 4.285
View Export to BibTeX Export to EndNote
Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (289 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
View Export to BibTeX Export to EndNote
15 Records (15 excluding Abstracts).
Total impact factor: 61.249 (61.249 excluding Abstracts).
Total 5 year impact factor: 67.886 (67.886 excluding Abstracts).
Total impact factor: 61.249 (61.249 excluding Abstracts).
Total 5 year impact factor: 67.886 (67.886 excluding Abstracts).
472 views. Last view on Wednesday 11 September 2024, 17:21:20
ibb.cnr.it
