New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (725 views) (PDF public 265 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Sep 7; 16(9): 21342-21362.
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Paper type: Journal Article, Research Support, N. I. H. , Extramural , Non-U. S. Gov'T,
Impact factor: 3.257, 5-year impact factor: 3.213
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84941253823&partnerID=40&md5=31fdd8a3c0d1446c51ef33c556456eeb
Keywords: Fab Fragments, Melanoma, Monoclonal Antibody, Nodal, Antigen, Cripto 1, Protein Nodal, Receptor, Smad2 Protein, Smad3 Protein, Unclassified Drug, Antibody Specificity, Antibody Titer, Article, Blood Analysis, Controlled Study, Deglycosylation, Enzyme Linked Immunosorbent Assay, Epitope Mapping, Female, Fluorescence Activated Cell Sorting, Human, Human Cell, Hybridoma, Matrix Assisted Laser Desorption Ionization Time Of Flight Mass Spectrometry, Mouse, Nonhuman, Protein Analysis, Protein Binding, Protein Degradation, Protein Phosphorylation, Solid Phase Synthesis, Surface Plasmon Resonance, Western Blotting, Fab Fragments Monoclonal Antibody Melanoma Nodal Spr, Amino Acid Sequence , Antibodies, Monoclonal Chemistry Pharmacology , Epitope Mapping Methods , Epitopes Chemistry Metabolism , Gpi-Linked Proteins Chemistry Metabolism , Growth Differentiation Factors Chemistry , Immunoglobulin Fab Fragments Chemistry Metabolism , Intercellular Signaling Peptides And Proteins Chemistry Metabolism , Models, Molecular , Molecular Sequence Data , Neoplasm Proteins Chemistry Metabolism , Nodal Protein Antagonists, Inhibitors Chemistry Metabolism , Peptides Chemical Synthesis Chemistry Isolation, Purification Metabolism , Protein Structure, Secondary,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council (IBB-CNR) and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPeB), Universita degli Studi di Napoli "Federico II", Naples 80134, Italy. annalia.foca@gmail.com., Department of Pharmacy, Universita degli Studi di Napoli "Federico II", Naples 80131, Italy. annalia.foca@gmail.com., Bioker Multimedica, Naples 80131, Italy. Luca.Sanguigno@multimedica.it., Institute of Biostructure and Bioimaging, National Research Council (IBB-CNR) and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPeB), Universita degli Studi di Napoli "Federico II", Naples 80134, Italy. giuseppina.foca@gmail.com., Department of Pharmacy, Universita degli Studi di Napoli "Federico II", Naples 80131, Italy. giuseppina.foca@gmail.com., Program in Cancer Biology and Epigenomics, Stanley Manne Children's Research Institute at Ann and Robert H. Lurie Children's Hospital of Chicago, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. LStrizzi@luriechildrens.org., Institute of Biostructure and Bioimaging, National Research Council (IBB-CNR) and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPeB), Universita degli Studi di Napoli "Federico II", Naples 80134, Italy. robertaiannitti@gmail.com., Institute of Biostructure and Bioimaging, National Research Council (IBB-CNR) and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPeB), Universita degli Studi di Napoli "Federico II", Naples 80134, Italy. rosanna.palumbo@cnr.it., Program in Cancer Biology and Epigenomics, Stanley Manne Children's Research Institute at Ann and Robert H. Lurie Children's Hospital of Chicago, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. m-hendrix@northwestern.edu., Department of Molecular Medicine and Medical Biotechnologies, Universita degli Studi di Napoli "Federico II", Naples 80131, Italy. leonardi@unina.it., Ins
References:
Schier, A.F., Nodal signaling in vertebrate development (2003) Annu. Rev. Cell Dev. Biol, 19, pp. 589-62
Shen, M.M., Nodal signaling: Developmental roles and regulation (2007) Development, 134, pp. 1023-1034
Strizzi, L., Hardy, K.M., Kirschmann, D.A., Ahrlund-Richter, L., Hendrix, M.J., Nodal expression and detection in cancer: Experience and challenges (2012) Cancer Res, 72, pp. 1915-1920
Strizzi, L., Postovit, L.M., Margaryan, N.V., Lipavsky, A., Gadiot, J., Blank, C., Seftor, R.E., Hendrix, M.J., Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention (2009) Expert. Rev. Dermatol., 4, pp. 67-78
Lawrence, M.G., Margaryan, N.V., Loessner, D., Collins, A., Kerr, K.M., Turner, M., Seftor, E.A., Postovit, L.M., Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells (2011) Prostate, 71, pp. 1198-1209
Quail, D.F., Siegers, G.M., Jewer, M., Postovit, L.M., Nodal signalling in embryogenesis and tumorigenesis (2013) Int. J. Biochem. Cell Biol., 45, pp. 885-898
Topczewska, J.M., Postovit, L.M., Margaryan, N.V., Sam, A., Hess, A.R., Wheaton, W.W., Nickoloff, B.J., Hendrix, M.J., Embryonic and tumorigenic pathways converge via Nodal signaling: Role in melanoma aggressiveness (2006) Nat. Med, 12, pp. 925-932
Seftor, E.A., Seftor, R.E., Weldon, D.S., Kirsammer, G.T., Margaryan, N.V., Gilgur, A., Hendrix, M.J., Melanoma tumor cell heterogeneity: A molecular approach to study subpopulations expressing the embryonic morphogen nodal (2014) Semin. Oncol, 41, pp. 259-266
Hardy, K.M., Strizzi, L., Margaryan, N.V., Gupta, K., Murphy, G.F., Scolyer, R.A., Hendrix, M.J., Targeting nodal in conjunction with dacarbazine induces synergistic anticancer effects in metastatic melanoma (2015) Mol. Cancer Res, 13, pp. 670-680
Costa, F.F., Seftor, E.A., Bischof, J.M., Kirschmann, D.A., Strizzi, L., Arndt, K., Bonaldo Mde, F., Hendrix, M.J., Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment (2009) Epigenomics, 1, pp. 387-398
Bianco, C., Adkins, H.B., Wechselberger, C., Seno, M., Normanno, N., De Luca, A., Sun, Y., Ebert, A., At al. Cripto-1 activates nodal- and ALK4–dependent and -independent signaling pathways in mammary epithelial Cells (2002) Mol. Cell. Biol, 22, pp. 2586-2597
Reissmann, E., Jörnvall, H., Blokzijl, A., Andersson, O., Chang, C., Minchiotti, G., Persico, M.G., Brivanlou, A.H., The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development (2001) Genes Dev, 15, pp. 2010-2022
Calvanese, L., Sandomenico, A., Caporale, A., Focà, A., Focà, G., D’Auria, G., Falcigno, L., Ruvo, M., Conformational features and binding affinities to Cripto, ALK7 and ALK4 of Nodal synthetic fragments (2015) J. Pept. Sci, 21, pp. 283-293
Aykul, S., Ni, W., Mutatu, W., Martinez-Hackert, E., Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes (2015) Plos ONE, p. 10
De Luca, A., Lamura, L., Strizz, L., Roma, C., D’Antonio, A., Margaryan, N., Pirozzi, G., Mari, E., Expression and functional role of CRIPTO-1 in cutaneous melanoma (2011) Br. J. Cancer, 105, pp. 1030-1038
Quail, D.F., Zhang, G., Findlay, S.D., Hess, D.A., Postovit, L.M., Nodal promotes invasive phenotypes via a mitogen-activated protein kinase-dependent pathway (2014) Oncogene, 33, pp. 461-473
Kirsammer, G., Strizzi, L., Margaryan, N.V., Gilgur, A., Hyser, M., Atkinson, J., Kirschmann, D.A., Hendrix, M.J., Nodal signaling promotes a tumorigenic phenotype in human breast cancer (2014) Semin. Cancer Biol, 29, pp. 40-50
Karimkhani, C., Gonzalez, R., Dellavalle, R.P., A review of novel therapies for melanoma (2014) Am. J. Clin. Dermatol, 15, pp. 323-337
Hao, M., Song, F., Du, X., Wang, G., Yang, Y., Chen, K., Yang, J., Advances in targeted therapy for unresectable melanoma (2015) New Drugs and Combinations. Cancer Lett., 359, pp. 1-8
Spagnolo, F., Ghiorzo, P., Orgiano, L., Pastorino, L., Picasso, V., Tornari, E., Ottaviano, V., Queirolo, P., BRAF-mutant melanoma: Treatment approaches, resistance mechanisms, and diagnostic strategies (2015) Onco Targets Ther, 8, pp. 157-168
Eggermont, A.M., Kirkwood, J.M., Re-evaluating the role of dacarbazine in metastatic melanoma: What have we learned in 30 years (2004) Eur. J. Cancer, 12, pp. 1825-1836
Sullivan, R.J., Flaherty, K.T., Resistance to BRAF-targeted therapy in melanoma (2013) Eur. J. Cancer, 49, pp. 1297-1304
Calvanese, L., Marasco, D., Doti, N., Saporito, A., D’Auria, G., Paolillo, L., Ruvo, M., Falcigno, L., Structural investigations on the Nodal-Cripto binding: A theoretical and experimental approach (2010) Biopolymers, 93, pp. 1011-1021
Strizzi, L., Sandomenico, A., Margayan, N.V., Focà, A., Sanguigno, L., Bodenstine, T.M., Chandler, G.S., Seftor, R., Effect of a novel Nodal-targeting monoclonal antibody in cancer (2015) Oncotarget, , press
Saporito, A., (2005) Chemical Synthesis of Proteins for Biotechnology Applications, , Ph.D. Thesis, Univerisity of Naples “Federico II”, Naples, Italy
De Caestecker, M., The transforming growth factor-beta superfamily of receptors (2004) Cytokine Growth Factor Rev, 15, pp. 1-11
Wilson, D.S., Wu, J., Peluso, P., Nock, S., Improved method for pepsinolysis of mouse IgG(1) molecules to F(ab')(2) fragments (2002) J. Immunol. Methods, 260, pp. 29-36
Yamaguchi, Y., Kim, H., Kato, K., Masuda, K., Shimada, I., Arata, Y., Proteolytic fragmentation with high specificity of mouse immunoglobulin G. Mapping of proteolytic cleavage sites in the hinge region (1995) J. Immunol. Methods, 181, pp. 259-267
Sondermann, P., Huber, R., Oosthuizen, V., Jacob, U., The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gamma RIII complex (2000) Nature, 406, pp. 267-273
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9 fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res, 35, pp. 161-214
Carter, J.M., Techniques for conjugation of synthetic peptides to carrier molecules (1994) Methods Mol. Biol, 36, pp. 155-191
Bradford, M.M., Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal. Biochem, 72, pp. 248-254
Kohler, G., Milstein, C., Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion (1976) Eur. J. Immunol., 6, pp. 511-519
Johnsson, B., Lofas, S., Lindquist, G., Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors (1991) Anal. Biochem, 198, pp. 268-277
Malchenko, S., Galat, V., Seftor, E.A., Vanin, E.F., Costa, F.F., Seftor, R.E., Soares, M.B., Hendrix, M.J., Cancer hallmarks in induced pluripotent cells: New insights (2010) J. Cell. Physiol, 225, pp. 390-393
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Sep 7; 16(9): 21342-21362.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, N. I. H. , Extramural , Non-U. S. Gov'T,
Impact factor: 3.257, 5-year impact factor: 3.213
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84941253823&partnerID=40&md5=31fdd8a3c0d1446c51ef33c556456eeb
Keywords: Fab Fragments, Melanoma, Monoclonal Antibody, Nodal, Antigen, Cripto 1, Protein Nodal, Receptor, Smad2 Protein, Smad3 Protein, Unclassified Drug, Antibody Specificity, Antibody Titer, Article, Blood Analysis, Controlled Study, Deglycosylation, Enzyme Linked Immunosorbent Assay, Epitope Mapping, Female, Fluorescence Activated Cell Sorting, Human, Human Cell, Hybridoma, Matrix Assisted Laser Desorption Ionization Time Of Flight Mass Spectrometry, Mouse, Nonhuman, Protein Analysis, Protein Binding, Protein Degradation, Protein Phosphorylation, Solid Phase Synthesis, Surface Plasmon Resonance, Western Blotting, Fab Fragments Monoclonal Antibody Melanoma Nodal Spr, Amino Acid Sequence , Antibodies, Monoclonal Chemistry Pharmacology , Epitope Mapping Methods , Epitopes Chemistry Metabolism , Gpi-Linked Proteins Chemistry Metabolism , Growth Differentiation Factors Chemistry , Immunoglobulin Fab Fragments Chemistry Metabolism , Intercellular Signaling Peptides And Proteins Chemistry Metabolism , Models, Molecular , Molecular Sequence Data , Neoplasm Proteins Chemistry Metabolism , Nodal Protein Antagonists, Inhibitors Chemistry Metabolism , Peptides Chemical Synthesis Chemistry Isolation, Purification Metabolism , Protein Structure, Secondary,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council (IBB-CNR) and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPeB), Universita degli Studi di Napoli "Federico II", Naples 80134, Italy. annalia.foca@gmail.com., Department of Pharmacy, Universita degli Studi di Napoli "Federico II", Naples 80131, Italy. annalia.foca@gmail.com., Bioker Multimedica, Naples 80131, Italy. Luca.Sanguigno@multimedica.it., Institute of Biostructure and Bioimaging, National Research Council (IBB-CNR) and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPeB), Universita degli Studi di Napoli "Federico II", Naples 80134, Italy. giuseppina.foca@gmail.com., Department of Pharmacy, Universita degli Studi di Napoli "Federico II", Naples 80131, Italy. giuseppina.foca@gmail.com., Program in Cancer Biology and Epigenomics, Stanley Manne Children's Research Institute at Ann and Robert H. Lurie Children's Hospital of Chicago, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. LStrizzi@luriechildrens.org., Institute of Biostructure and Bioimaging, National Research Council (IBB-CNR) and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPeB), Universita degli Studi di Napoli "Federico II", Naples 80134, Italy. robertaiannitti@gmail.com., Institute of Biostructure and Bioimaging, National Research Council (IBB-CNR) and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPeB), Universita degli Studi di Napoli "Federico II", Naples 80134, Italy. rosanna.palumbo@cnr.it., Program in Cancer Biology and Epigenomics, Stanley Manne Children's Research Institute at Ann and Robert H. Lurie Children's Hospital of Chicago, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. m-hendrix@northwestern.edu., Department of Molecular Medicine and Medical Biotechnologies, Universita degli Studi di Napoli "Federico II", Naples 80131, Italy. leonardi@unina.it., Ins
References:
Schier, A.F., Nodal signaling in vertebrate development (2003) Annu. Rev. Cell Dev. Biol, 19, pp. 589-62
Shen, M.M., Nodal signaling: Developmental roles and regulation (2007) Development, 134, pp. 1023-1034
Strizzi, L., Hardy, K.M., Kirschmann, D.A., Ahrlund-Richter, L., Hendrix, M.J., Nodal expression and detection in cancer: Experience and challenges (2012) Cancer Res, 72, pp. 1915-1920
Strizzi, L., Postovit, L.M., Margaryan, N.V., Lipavsky, A., Gadiot, J., Blank, C., Seftor, R.E., Hendrix, M.J., Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention (2009) Expert. Rev. Dermatol., 4, pp. 67-78
Lawrence, M.G., Margaryan, N.V., Loessner, D., Collins, A., Kerr, K.M., Turner, M., Seftor, E.A., Postovit, L.M., Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells (2011) Prostate, 71, pp. 1198-1209
Quail, D.F., Siegers, G.M., Jewer, M., Postovit, L.M., Nodal signalling in embryogenesis and tumorigenesis (2013) Int. J. Biochem. Cell Biol., 45, pp. 885-898
Topczewska, J.M., Postovit, L.M., Margaryan, N.V., Sam, A., Hess, A.R., Wheaton, W.W., Nickoloff, B.J., Hendrix, M.J., Embryonic and tumorigenic pathways converge via Nodal signaling: Role in melanoma aggressiveness (2006) Nat. Med, 12, pp. 925-932
Seftor, E.A., Seftor, R.E., Weldon, D.S., Kirsammer, G.T., Margaryan, N.V., Gilgur, A., Hendrix, M.J., Melanoma tumor cell heterogeneity: A molecular approach to study subpopulations expressing the embryonic morphogen nodal (2014) Semin. Oncol, 41, pp. 259-266
Hardy, K.M., Strizzi, L., Margaryan, N.V., Gupta, K., Murphy, G.F., Scolyer, R.A., Hendrix, M.J., Targeting nodal in conjunction with dacarbazine induces synergistic anticancer effects in metastatic melanoma (2015) Mol. Cancer Res, 13, pp. 670-680
Costa, F.F., Seftor, E.A., Bischof, J.M., Kirschmann, D.A., Strizzi, L., Arndt, K., Bonaldo Mde, F., Hendrix, M.J., Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment (2009) Epigenomics, 1, pp. 387-398
Bianco, C., Adkins, H.B., Wechselberger, C., Seno, M., Normanno, N., De Luca, A., Sun, Y., Ebert, A., At al. Cripto-1 activates nodal- and ALK4–dependent and -independent signaling pathways in mammary epithelial Cells (2002) Mol. Cell. Biol, 22, pp. 2586-2597
Reissmann, E., Jörnvall, H., Blokzijl, A., Andersson, O., Chang, C., Minchiotti, G., Persico, M.G., Brivanlou, A.H., The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development (2001) Genes Dev, 15, pp. 2010-2022
Calvanese, L., Sandomenico, A., Caporale, A., Focà, A., Focà, G., D’Auria, G., Falcigno, L., Ruvo, M., Conformational features and binding affinities to Cripto, ALK7 and ALK4 of Nodal synthetic fragments (2015) J. Pept. Sci, 21, pp. 283-293
Aykul, S., Ni, W., Mutatu, W., Martinez-Hackert, E., Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes (2015) Plos ONE, p. 10
De Luca, A., Lamura, L., Strizz, L., Roma, C., D’Antonio, A., Margaryan, N., Pirozzi, G., Mari, E., Expression and functional role of CRIPTO-1 in cutaneous melanoma (2011) Br. J. Cancer, 105, pp. 1030-1038
Quail, D.F., Zhang, G., Findlay, S.D., Hess, D.A., Postovit, L.M., Nodal promotes invasive phenotypes via a mitogen-activated protein kinase-dependent pathway (2014) Oncogene, 33, pp. 461-473
Kirsammer, G., Strizzi, L., Margaryan, N.V., Gilgur, A., Hyser, M., Atkinson, J., Kirschmann, D.A., Hendrix, M.J., Nodal signaling promotes a tumorigenic phenotype in human breast cancer (2014) Semin. Cancer Biol, 29, pp. 40-50
Karimkhani, C., Gonzalez, R., Dellavalle, R.P., A review of novel therapies for melanoma (2014) Am. J. Clin. Dermatol, 15, pp. 323-337
Hao, M., Song, F., Du, X., Wang, G., Yang, Y., Chen, K., Yang, J., Advances in targeted therapy for unresectable melanoma (2015) New Drugs and Combinations. Cancer Lett., 359, pp. 1-8
Spagnolo, F., Ghiorzo, P., Orgiano, L., Pastorino, L., Picasso, V., Tornari, E., Ottaviano, V., Queirolo, P., BRAF-mutant melanoma: Treatment approaches, resistance mechanisms, and diagnostic strategies (2015) Onco Targets Ther, 8, pp. 157-168
Eggermont, A.M., Kirkwood, J.M., Re-evaluating the role of dacarbazine in metastatic melanoma: What have we learned in 30 years (2004) Eur. J. Cancer, 12, pp. 1825-1836
Sullivan, R.J., Flaherty, K.T., Resistance to BRAF-targeted therapy in melanoma (2013) Eur. J. Cancer, 49, pp. 1297-1304
Calvanese, L., Marasco, D., Doti, N., Saporito, A., D’Auria, G., Paolillo, L., Ruvo, M., Falcigno, L., Structural investigations on the Nodal-Cripto binding: A theoretical and experimental approach (2010) Biopolymers, 93, pp. 1011-1021
Strizzi, L., Sandomenico, A., Margayan, N.V., Focà, A., Sanguigno, L., Bodenstine, T.M., Chandler, G.S., Seftor, R., Effect of a novel Nodal-targeting monoclonal antibody in cancer (2015) Oncotarget, , press
Saporito, A., (2005) Chemical Synthesis of Proteins for Biotechnology Applications, , Ph.D. Thesis, Univerisity of Naples “Federico II”, Naples, Italy
De Caestecker, M., The transforming growth factor-beta superfamily of receptors (2004) Cytokine Growth Factor Rev, 15, pp. 1-11
Wilson, D.S., Wu, J., Peluso, P., Nock, S., Improved method for pepsinolysis of mouse IgG(1) molecules to F(ab')(2) fragments (2002) J. Immunol. Methods, 260, pp. 29-36
Yamaguchi, Y., Kim, H., Kato, K., Masuda, K., Shimada, I., Arata, Y., Proteolytic fragmentation with high specificity of mouse immunoglobulin G. Mapping of proteolytic cleavage sites in the hinge region (1995) J. Immunol. Methods, 181, pp. 259-267
Sondermann, P., Huber, R., Oosthuizen, V., Jacob, U., The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gamma RIII complex (2000) Nature, 406, pp. 267-273
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9 fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res, 35, pp. 161-214
Carter, J.M., Techniques for conjugation of synthetic peptides to carrier molecules (1994) Methods Mol. Biol, 36, pp. 155-191
Bradford, M.M., Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal. Biochem, 72, pp. 248-254
Kohler, G., Milstein, C., Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion (1976) Eur. J. Immunol., 6, pp. 511-519
Johnsson, B., Lofas, S., Lindquist, G., Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors (1991) Anal. Biochem, 198, pp. 268-277
Malchenko, S., Galat, V., Seftor, E.A., Vanin, E.F., Costa, F.F., Seftor, R.E., Soares, M.B., Hendrix, M.J., Cancer hallmarks in induced pluripotent cells: New insights (2010) J. Cell. Physiol, 225, pp. 390-393
New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding
Nodal is a potent embryonic morphogen belonging to the TGF-β superfamily. Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1. Nodal expression is physiologically restricted to embryonic tissues and human embryonic stem cells, is absent in normal cells but re-emerges in several human cancers, including melanoma, breast, and colon cancer. Our aim was to obtain mAbs able to recognize Nodal on a major CBR (Cripto-Binding-Region) site and to block the Cripto-1-mediated signalling. To achieve this, antibodies were raised against hNodal(44–67) and mAbs generated by the hybridoma technology. We have selected one mAb, named 3D1, which strongly associates with full-length rhNodal (KD 1.4 nM) and recognizes the endogenous protein in a panel of human melanoma cell lines by western blot and FACS analyses. 3D1 inhibits the Nodal-Cripto-1 binding and blocks Smad2/3 phosphorylation. Data suggest that inhibition of the Nodal-Cripto-1 axis is a valid therapeutic approach against melanoma and 3D1 is a promising and interesting agent for blocking Nodal-Cripto mediated tumor development. These findings increase the interest for Nodal as both a diagnostic and prognostic marker and as a potential new target for therapeutic intervention. © 2015 by the authors; licensee MDPI, Basel, Switzerland.
Nodal is a potent embryonic morphogen belonging to the TGF-β superfamily. Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1. Nodal expression is physiologically restricted to embryonic tissues and human embryonic stem cells, is absent in normal cells but re-emerges in several human cancers, including melanoma, breast, and colon cancer. Our aim was to obtain mAbs able to recognize Nodal on a major CBR (Cripto-Binding-Region) site and to block the Cripto-1-mediated signalling. To achieve this, antibodies were raised against hNodal(44–67) and mAbs generated by the hybridoma technology. We have selected one mAb, named 3D1, which strongly associates with full-length rhNodal (KD 1.4 nM) and recognizes the endogenous protein in a panel of human melanoma cell lines by western blot and FACS analyses. 3D1 inhibits the Nodal-Cripto-1 binding and blocks Smad2/3 phosphorylation. Data suggest that inhibition of the Nodal-Cripto-1 axis is a valid therapeutic approach against melanoma and 3D1 is a promising and interesting agent for blocking Nodal-Cripto mediated tumor development. These findings increase the interest for Nodal as both a diagnostic and prognostic marker and as a potential new target for therapeutic intervention. © 2015 by the authors; licensee MDPI, Basel, Switzerland.
New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding
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New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding
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Impact Factor: 8.29
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Honarvar H, Calce E, Doti N, Langella E, Orlova A, Buijs J, D’amato V, Bianco R, Saviano M, Tolmachev V, De Luca S
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Impact Factor: 4.259
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Calvanese L, Foca A, Sandomenico A, Foca G, Caporale A, Doti N, Iaccarino E, Leonardi A, D'Auria G, Ruvo M, Falcigno L
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Impact Factor: 2.881
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Berisio R, Squeglia F, Ruggiero A
* Editorial: Molecular Scenarios Behind Infectious Diseases (390 views)
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Impact Factor: 3.469
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Leiria Campo V, Riul TB, Oliveira Bortot L, Martins-teixeira MB, Fiori Marchiori M, Iaccarino E, Ruvo M, Dias-baruffi M, Carvalho I
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Impact Factor: 2.774
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Strizzi L, Sandomenico A, Margaryan NV, Foca A, Sanguigno L, Bodenstine TM, Chandler GS, Reed DW, Gilgur A, Seftor EA, Seftor RE, Khalkhali-ellis Z, Leonardi A, Ruvo M, Hendrix MJ
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Impact Factor: 5.008
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (574 views)
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Impact Factor: 3.455
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Calvanese L, Sandomenico A, Caporale A, Foca A, Foca G, D'Auria G, Falcigno L, Ruvo M
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Impact Factor: 1.951
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
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Impact Factor: 2.066
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
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Impact Factor: 19.358
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Tagliamonte M, Marasco D, Ruggiero A, de Stradis A, Tornesello ML, Totrov M, Buonaguro FM, Buonaguro L
* HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens (468 views)
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Impact Factor: 3.73
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Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
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Impact Factor: 1.461
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Monti SM, Supuran CT, De Simone G
* Carbonic anhydrase IX as a target for designing novel anticancer drugs (590 views)
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Impact Factor: 4.07
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
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Impact Factor: 3.677
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
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Impact Factor: 4.991
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
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Impact Factor: 10.558
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (403 views)
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Impact Factor: 4.293
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (581 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (415 views)
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Impact Factor: 6.069
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (442 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (617 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Cuocolo A, Milcinski M, Bischof Delaloye A
* Syllabus for postgraduate specialisation in Nuclear Medicine: 2006/07 update (427 views)
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Impact Factor: 4.101
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Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (373 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (600 views)
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Impact Factor: 4.041
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Palumbo R, Capasso D, Brescia F, Mita P, Sarti M, Bersani F, Scarfi MR
* Effects on apoptosis and reactive oxygen species formation by Jurkat cells exposed to 50 Hz electromagnetic fields (596 views)
Bioelectromagnetics (ISSN: 0197-8462), 2006 Feb; 27(2): 159-162.
Impact Factor: 1.514
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (501 views)
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Impact Factor: 3.94
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Fonti R, Del Vecchio S, Zannetti A, De Renzo A, Catalano L, Pace L, Rotoli B, Salvatore M
* Functional Imaging Of Multidrug Resistant Phenotype By 99mtc-Mibi Scan In Patients With Multiple Myeloma (462 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004; 19(2): 165-170.
Impact Factor: 1.091
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (536 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (483 views)
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Impact Factor: 3.568
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (399 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
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Impact Factor: 3.72
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Fonti R, Levchenko A, Mehta BM, Zhang J, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (326 views)
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Impact Factor: 1.623
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Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (394 views)
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Impact Factor: 1.623
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Fonti R, Cheung NKV, Bridger GJ, Shen SQ, Finn RD, Abrams RJ, Larson SM
Technetium-99m-Monoclonal Antibody Radio-Labeled Via Hydrazino Nicotinamide Derivative For Imaging Ganglioside Gd2-Positive Tumors (280 views)
Nucl Med Biol, 1999; 26: 681-686.
Impact Factor: 0
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (317 views)
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Impact Factor: 1.045
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Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, Thomas R, D'Aiuto G, Tsuruo T, Salvatore M
Fractional retention of technetium-99m-sestamibi as an index of P- glycoprotein expression in untreated breast cancer patients (1018 views)
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Impact Factor: 3.491
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (283 views)
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Impact Factor: 2.017
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (451 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Latella G, Fonti R, Caprilli R, Marcheggiano A, Magliocca F, Das KM, Gambús G, Sambuy Y
Characterization of the mucins produced by normal human colonocytes in primary culture (281 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1996; 11(2): 76-83.
Impact Factor: 0.732
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (500 views)
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Impact Factor: 8.426
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
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Sofia M, Del Vecchio S, Petrillo A, Mormile M, Salvatore M, Carratù L
Endobronchial deposition of radioactive monoclonal antibody in patients with inoperable non-small-cell carcinoma of the lung [4] (275 views)
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Impact Factor: 2.341
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D'Aiuto G, Del Vecchio S, Mansi L, D'Aprile M, Botti G, Salvatore M
Malignant melanoma of the nipple: A case studied with radiolabeled monoclonal antibody (623 views)
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Impact Factor: 0.408
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (463 views)
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Impact Factor: 2.692
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Del Vecchio S, Camera L, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Clinical studies with B72. 3 in ovarian cancer and probe-guided tumor localization (411 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1991; 18(1): 85-87.
Impact Factor: 1.042
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Del Vecchio S, Mansi L, Petrillo A, Camera L, Sofia M, Marra A, Carratú L, Salvatore M
Endobronchial administration of iodine-131 B72. 3 monoclonal antibody in patients with lung cancer (294 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991; 18(2): 129-132.
Impact Factor: 2.692
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Valenza V, Maussier ML, D'Errico G, Lemmo GF, Frontera D, Ferrante A, Saletnich I, Valli A, Quarantelli M
Cancer of the pancreas and the periampullary region: The usefulness of tumor marker products with the monoclonal antibody technique (292 views)
J Nucl Med Allied Sci (ISSN: 0392-0208), 1990 Oct; 34(4SUPPL.): 131-134.
Impact Factor: 1.91
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Del Vecchio S, Reynolds JC
NONUNIFORM DISTRIBUTION OF RADIOLABELED MONOCLONAL-ANTIBODY IN TUMOR (270 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1990 Jul; 31(7): 1252-1252.
Impact Factor: 3.491
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Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (316 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
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d'Onofrio G, Menichella G, Zini G, Rumi C, Pierelli L, Quarantelli M, Puggioni PL, Mango G
Lymphocyte subset counting by immunoperoxidase using an automated routine hematologic analyzer (403 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1989 Mar; 74(2): 137-142.
Impact Factor: 2.56
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Reynolds JC, Del Vecchio S, Sakahara H, Lora ME, Carrasquillo JA, Neumann RD, Larson SM
ANTI-MURINE ANTIBODY RESPONSE TO MOUSE MONOCLONAL ANTIBODIES CLINICAL FINDINGS AND IMPLICATIONS (675 views)
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Impact Factor: 1.042
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (301 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC
DETERMINATION OF ANTIGEN CONCENTRATION AND DISTRIBUTION IN HUMAN TUMORS THE QUANTITATIVE AUTORADIOGRAPHIC APPROACH (322 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 143-145.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (350 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (317 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
Impact Factor: 2.692
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Del Vecchio S, Reynolds JC, Blasberg RG, Neumann RD, Carrasquillo JA, Hellström I, Larson SM
Measurement of local Mr 97, 000 and 250, 000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (528 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1988; 48(19): 5475-5481.
Impact Factor: 8.426
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* Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry (17 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2021 Mar 20; 22(6): N/D-N/D.
Impact Factor: 4.556
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Sivaccumar J, Sandomenico A, Vitagliano L, Ruvo M
* Monoclonal Antibodies: A Prospective and Retrospective View (71 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(3): 435-471.
Impact Factor: 4.184
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Camorani S, Passariello M, Agnello L, Esposito S, Collina F, Cantile M, Di Bonito M, Ulasov IV, Fedele M, Zannetti A, De Lorenzo C, Cerchia L
* Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer (111 views) (PDF 48 views)
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Impact Factor: 7.068
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Alterio V, Kellner M, Esposito D, Liesche-starnecker F, Bua S, Supuran CT, Monti SM, Zeidler R, De Simone G
* Biochemical and structural insights into Carbonic Anhydrase XII/Fab6A10 complex (168 views)
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Impact Factor: 5.067
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Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (568 views)
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Impact Factor: 8.29
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Honarvar H, Calce E, Doti N, Langella E, Orlova A, Buijs J, D’amato V, Bianco R, Saviano M, Tolmachev V, De Luca S
* Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe (298 views)
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Impact Factor: 4.259
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Calvanese L, Foca A, Sandomenico A, Foca G, Caporale A, Doti N, Iaccarino E, Leonardi A, D'Auria G, Ruvo M, Falcigno L
* Structural insights into the interaction of a monoclonal antibody and Nodal peptides by STD-NMR spectroscopy (499 views)
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Impact Factor: 2.881
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Berisio R, Squeglia F, Ruggiero A
* Editorial: Molecular Scenarios Behind Infectious Diseases (390 views)
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Impact Factor: 3.469
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Leiria Campo V, Riul TB, Oliveira Bortot L, Martins-teixeira MB, Fiori Marchiori M, Iaccarino E, Ruvo M, Dias-baruffi M, Carvalho I
* A Synthetic MUC1 Glycopeptide Bearing betaGalNAc-Thr as a Tn Antigen Isomer Induces the Production of Antibodies against Tumor Cells (1304 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2017 Mar 16; 18(6): 527-538.
Impact Factor: 2.774
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Strizzi L, Sandomenico A, Margaryan NV, Foca A, Sanguigno L, Bodenstine TM, Chandler GS, Reed DW, Gilgur A, Seftor EA, Seftor RE, Khalkhali-ellis Z, Leonardi A, Ruvo M, Hendrix MJ
* Effects of a novel Nodal-targeting monoclonal antibody in melanoma (393 views) (PDF 211 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic), 2015 Oct 27; 6(33): 34071-34086.
Impact Factor: 5.008
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (574 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Calvanese L, Sandomenico A, Caporale A, Foca A, Foca G, D'Auria G, Falcigno L, Ruvo M
* Conformational features and binding affinities to Cripto, ALK7 and ALK4 of Nodal synthetic fragments (505 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015 Jan 15; 21(4): 283-293.
Impact Factor: 1.951
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
* F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma (547 views)
Eur J Haematol (ISSN: 0902-4441), 2014 May; 92(5): 382-389.
Impact Factor: 2.066
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (2014 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
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Tagliamonte M, Marasco D, Ruggiero A, de Stradis A, Tornesello ML, Totrov M, Buonaguro FM, Buonaguro L
* HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens (468 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Sep 17; 7(8): N/D-N/D.
Impact Factor: 3.73
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Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (385 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Impact Factor: 1.461
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Monti SM, Supuran CT, De Simone G
* Carbonic anhydrase IX as a target for designing novel anticancer drugs (590 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 821-830.
Impact Factor: 4.07
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (756 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (615 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (403 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (581 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (415 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (442 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (617 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Cuocolo A, Milcinski M, Bischof Delaloye A
* Syllabus for postgraduate specialisation in Nuclear Medicine: 2006/07 update (427 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Mar; 34(3): 433-436.
Impact Factor: 4.101
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Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (373 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (600 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Palumbo R, Capasso D, Brescia F, Mita P, Sarti M, Bersani F, Scarfi MR
* Effects on apoptosis and reactive oxygen species formation by Jurkat cells exposed to 50 Hz electromagnetic fields (596 views)
Bioelectromagnetics (ISSN: 0197-8462), 2006 Feb; 27(2): 159-162.
Impact Factor: 1.514
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (501 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
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Fonti R, Del Vecchio S, Zannetti A, De Renzo A, Catalano L, Pace L, Rotoli B, Salvatore M
* Functional Imaging Of Multidrug Resistant Phenotype By 99mtc-Mibi Scan In Patients With Multiple Myeloma (462 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004; 19(2): 165-170.
Impact Factor: 1.091
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (536 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (483 views)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (399 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Fonti R, Levchenko A, Mehta BM, Zhang J, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (326 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Impact Factor: 1.623
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Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (394 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
Impact Factor: 1.623
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Fonti R, Cheung NKV, Bridger GJ, Shen SQ, Finn RD, Abrams RJ, Larson SM
Technetium-99m-Monoclonal Antibody Radio-Labeled Via Hydrazino Nicotinamide Derivative For Imaging Ganglioside Gd2-Positive Tumors (280 views)
Nucl Med Biol, 1999; 26: 681-686.
Impact Factor: 0
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (317 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, Thomas R, D'Aiuto G, Tsuruo T, Salvatore M
Fractional retention of technetium-99m-sestamibi as an index of P- glycoprotein expression in untreated breast cancer patients (1018 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Sep; 38(9): 1348-1351.
Impact Factor: 3.491
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (283 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (451 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Latella G, Fonti R, Caprilli R, Marcheggiano A, Magliocca F, Das KM, Gambús G, Sambuy Y
Characterization of the mucins produced by normal human colonocytes in primary culture (281 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1996; 11(2): 76-83.
Impact Factor: 0.732
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (500 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
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Sofia M, Del Vecchio S, Petrillo A, Mormile M, Salvatore M, Carratù L
Endobronchial deposition of radioactive monoclonal antibody in patients with inoperable non-small-cell carcinoma of the lung [4] (275 views)
Chest (ISSN: 0012-3692), 1992 Nov; 102(5): 1632-1634.
Impact Factor: 2.341
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D'Aiuto G, Del Vecchio S, Mansi L, D'Aprile M, Botti G, Salvatore M
Malignant melanoma of the nipple: A case studied with radiolabeled monoclonal antibody (623 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 1991 Oct 31; 77(5): 449-451.
Impact Factor: 0.408
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (463 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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Del Vecchio S, Camera L, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Clinical studies with B72. 3 in ovarian cancer and probe-guided tumor localization (411 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1991; 18(1): 85-87.
Impact Factor: 1.042
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Del Vecchio S, Mansi L, Petrillo A, Camera L, Sofia M, Marra A, Carratú L, Salvatore M
Endobronchial administration of iodine-131 B72. 3 monoclonal antibody in patients with lung cancer (294 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991; 18(2): 129-132.
Impact Factor: 2.692
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Valenza V, Maussier ML, D'Errico G, Lemmo GF, Frontera D, Ferrante A, Saletnich I, Valli A, Quarantelli M
Cancer of the pancreas and the periampullary region: The usefulness of tumor marker products with the monoclonal antibody technique (292 views)
J Nucl Med Allied Sci (ISSN: 0392-0208), 1990 Oct; 34(4SUPPL.): 131-134.
Impact Factor: 1.91
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Del Vecchio S, Reynolds JC
NONUNIFORM DISTRIBUTION OF RADIOLABELED MONOCLONAL-ANTIBODY IN TUMOR (270 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1990 Jul; 31(7): 1252-1252.
Impact Factor: 3.491
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Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (316 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
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d'Onofrio G, Menichella G, Zini G, Rumi C, Pierelli L, Quarantelli M, Puggioni PL, Mango G
Lymphocyte subset counting by immunoperoxidase using an automated routine hematologic analyzer (403 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1989 Mar; 74(2): 137-142.
Impact Factor: 2.56
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Reynolds JC, Del Vecchio S, Sakahara H, Lora ME, Carrasquillo JA, Neumann RD, Larson SM
ANTI-MURINE ANTIBODY RESPONSE TO MOUSE MONOCLONAL ANTIBODIES CLINICAL FINDINGS AND IMPLICATIONS (675 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 121-125.
Impact Factor: 1.042
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (301 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC
DETERMINATION OF ANTIGEN CONCENTRATION AND DISTRIBUTION IN HUMAN TUMORS THE QUANTITATIVE AUTORADIOGRAPHIC APPROACH (322 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 143-145.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (350 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (317 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
Impact Factor: 2.692
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Del Vecchio S, Reynolds JC, Blasberg RG, Neumann RD, Carrasquillo JA, Hellström I, Larson SM
Measurement of local Mr 97, 000 and 250, 000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (528 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1988; 48(19): 5475-5481.
Impact Factor: 8.426
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61 Records (56 excluding Abstracts).
Total impact factor: 228.604 (212.971 excluding Abstracts).
Total 5 year impact factor: 245.959 (225.833 excluding Abstracts).
Total impact factor: 228.604 (212.971 excluding Abstracts).
Total 5 year impact factor: 245.959 (225.833 excluding Abstracts).
725 views. Last view on Saturday 03 June 2023, 19:28:36
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