A "systems medicine" approach to the study of non-alcoholic fatty liver disease (386 views)
Dig Liver Dis (ISSN: 1590-8658, 1590-8658linking), 2016; 48(3): 333-342.
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Paper type: Journal Article,
Impact factor: 3.061, 5-year impact factor: 2.956
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84960463900&partnerID=40&md5=692ebe96b5589c46583aa71038df818c
Keywords: Fatty Liver, Medicine, Nafld, Personalized, Systems Medicine,
Affiliations:
*** IBB - CNR ***
Section of Gastroenterology, Di.Bi.M.I.S Policlinico Paolo Giaccone Hospital, University of Palermo, Italy
Internal Medicine, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, University of Milan, Italy
Gastroenterology and Hepatology, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza di Torino Hospital, Italy
Section of Endocrinology, Diabetes and Metabolism, University Hospital of Verona, Department of Medicine, Italy
Shrewsbury and Telford NHS Trust, Department of Gastroenterology, Shrewsbury, United Kingdom
Fondazione Italiana Fegato, Bassovizza, Trieste, Italy
General Medicine 2, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Italy
National Research Council (CNR), Institute of Clinical Physiology, Pisa, Italy
Hepato-Gastroenterology, 2nd University of Naples, Italy
Outpatient Liver Clinic and Internal Medicine NOCSAE, USL Modena, Italy
Department of Experimental and Clinical Medicine, University of Florence, Italy
Metabolic Liver Diseases Research Unit, IRCCS Children Hospital Bambino Gesù, Rome, Italy
Pavullo Hospital, Modena, Italy
Hepatology Unit, University Hospital of Pisa, Italy
Istituto Superiore di Sanità, Rome, Italy
Metabolic Medicine, NOCSAE, Baggiovara, Modena, Italy
General Medicine 1, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Italy
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Dig Liver Dis (ISSN: 1590-8658, 1590-8658linking), 2016; 48(3): 333-342.
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Paper type: Journal Article,
Impact factor: 3.061, 5-year impact factor: 2.956
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84960463900&partnerID=40&md5=692ebe96b5589c46583aa71038df818c
Keywords: Fatty Liver, Medicine, Nafld, Personalized, Systems Medicine,
Affiliations:
*** IBB - CNR ***
Section of Gastroenterology, Di.Bi.M.I.S Policlinico Paolo Giaccone Hospital, University of Palermo, Italy
Internal Medicine, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, University of Milan, Italy
Gastroenterology and Hepatology, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza di Torino Hospital, Italy
Section of Endocrinology, Diabetes and Metabolism, University Hospital of Verona, Department of Medicine, Italy
Shrewsbury and Telford NHS Trust, Department of Gastroenterology, Shrewsbury, United Kingdom
Fondazione Italiana Fegato, Bassovizza, Trieste, Italy
General Medicine 2, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Italy
National Research Council (CNR), Institute of Clinical Physiology, Pisa, Italy
Hepato-Gastroenterology, 2nd University of Naples, Italy
Outpatient Liver Clinic and Internal Medicine NOCSAE, USL Modena, Italy
Department of Experimental and Clinical Medicine, University of Florence, Italy
Metabolic Liver Diseases Research Unit, IRCCS Children Hospital Bambino Gesù, Rome, Italy
Pavullo Hospital, Modena, Italy
Hepatology Unit, University Hospital of Pisa, Italy
Istituto Superiore di Sanità, Rome, Italy
Metabolic Medicine, NOCSAE, Baggiovara, Modena, Italy
General Medicine 1, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Italy
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A "systems medicine" approach to the study of non-alcoholic fatty liver disease
The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among different physiological systems. Similarly, translational and clinical research should address the complex interplay between these systems impacting on fatty liver. The clinical needs drive the applications of systems medicine to re-define clinical phenotypes, assessing the multiple nature of disease susceptibility and progression (e.g. the definition of risk, prognosis, diagnosis criteria, and new endpoints of clinical trials). Based on this premise and in light of recent findings, the complex mechanisms involved in the pathology of fatty liver and their impact on the short- and long-term clinical outcomes of cardiovascular, metabolic liver diseases associated with steatosis are presented in this review using a new "systems medicine" approach. A new data set is proposed for studying the impairments of different physiological systems that have an impact on fatty liver in different subsets of subjects and patients. © 2015 Editrice Gastroenterologica Italiana S.r.l.
The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among different physiological systems. Similarly, translational and clinical research should address the complex interplay between these systems impacting on fatty liver. The clinical needs drive the applications of systems medicine to re-define clinical phenotypes, assessing the multiple nature of disease susceptibility and progression (e.g. the definition of risk, prognosis, diagnosis criteria, and new endpoints of clinical trials). Based on this premise and in light of recent findings, the complex mechanisms involved in the pathology of fatty liver and their impact on the short- and long-term clinical outcomes of cardiovascular, metabolic liver diseases associated with steatosis are presented in this review using a new "systems medicine" approach. A new data set is proposed for studying the impairments of different physiological systems that have an impact on fatty liver in different subsets of subjects and patients. © 2015 Editrice Gastroenterologica Italiana S.r.l.
A "systems medicine" approach to the study of non-alcoholic fatty liver disease
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A "systems medicine" approach to the study of non-alcoholic fatty liver disease
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Di Lascio N, Avigo C, Salvati A, Martini N, Ragucci M, Monti S, Prinster A, Chiappino D, Mancini M, D'Elia D, Ghiadoni L, Bonino F, Brunetto MR, Faita F
* Steato-Score: Non-Invasive Quantitative Assessment of Liver Fat by Ultrasound Imaging (434 views)
Ultrasound Med Biol (ISSN: 0301-5629, 0301-5629linking), 2018; 44(8): 1585-1596.
Impact Factor: 2.494
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Accardo A, Tesauro D, Morelli G
* Peptide-based targeting strategies for simultaneous imaging and therapy with nanovectors (485 views)
Polym J (ISSN: 0032-3896), 2013 May; 45(5): 481-493.
Impact Factor: 1.554
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Zannetti A, Iommelli F, De Rosa V, Nardelli A, Ortosecco G, Del Vecchio S
* Combined Imaging with 18F-FLT PET/CT and 99m-Tc-Hynic-Annexin V SPECT for Personalized Therapy with EGFR Antagonists and Bcl-xL Inhibitors in Non-Small Cell Lung Cancer (394 views)
European Journal Of Cancer (ISSN: 0959-8049), 2012 Nov; 48: N/D-N/D.
Impact Factor: 5.061
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Bozzetto L, Prinster A, Annuzzi G, Costagliola L, Mangione A, Vitelli A, Mazzarella R, Longobardo M, Mancini M, Vigorito C, Riccardi G, Rivellese AA
* Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients (925 views)
Diabetes Care (ISSN: 1935-5548, 0149-5992, 1935-5548electronic), 2012 Jul; 35(7): 1429-1435.
Impact Factor: 7.735
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Bozzetto L, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA, Annuzzi G
* Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (461 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2011 Jan; 41(1): 39-44.
Impact Factor: 3.018
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (445 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Mancini M, Prinster A, Annuzzi G, Liuzzi R, Giacco R, Medagli C, Cremone M, Clemente G, Maurea S, Riccardi G, Rivellese AA, Salvatore M
* Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with (1)H magnetic resonance spectroscopy (441 views)
Metab Clin Exp (ISSN: 1532-8600, 0026-0495), 2009 Dec; 58(12): 1724-1730.
Impact Factor: 2.588
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De Simone G, Supuran CT
* Drug Design of Antiobesity Carbonic Anhydrase Inhibitors (336 views)
Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; 66(DECEMBERSPEC.I): 241-254.
Impact Factor: 1.156
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Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (615 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
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* Nutritional intervention in the management of non-alcoholic fatty liver disease (0 views)
Best Pract Res Clin Gastroenterol (ISSN: 1521-6918linking), 2023 Feb; 62-63: 101830-101830.
Impact Factor:
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Colombatto P, Coco B, Bonino F, Brunetto MR
* Management and Treatment of Patients with Chronic Hepatitis B: Towards Personalized Medicine (13 views)
Viruses (ISSN: 1999-4915linking, 1999-4915electronic), 2022 Mar 28; 14(4): N/D-N/D.
Impact Factor: 5.048
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Rebelos E, Iozzo P, Guzzardi MA, Brunetto MR, Bonino F
* Brain-gut-liver interactions across the spectrum of insulin resistance in metabolic fatty liver disease (37 views)
World J Gastroentero (ISSN: 1007-9327linking, 2219-2840), 2021 Aug 14; 27(30): 4999-5018.
Impact Factor: 3.665
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Abenavoli L, Scarpellini E, Pellicano R, Fagoonee S, Larussa T, Luzza F
* Mediterranean diet and probiotics supplementation to treat non-alcoholic fatty liver disease (37 views)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2020 Dec; 111(6): 526-528.
Impact Factor: 3.031
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Itta F, Liuzzi R, Farella A, Porri G, Pacelli R, Conson M, Oliviero C, Buonanno F, Breve MA, Cennamo G, Clemente S, Cella L
* Personalized treatment planning in eye brachytherapy for ocular melanoma: Dosimetric analysis on ophthalmic structure at risk (37 views)
Phys Med (ISSN: 1120-1797linking), 2020 Aug; 76: 285-293.
Impact Factor: 3.177
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Negri R, Trinchese G, Carbone F, Caprio MG, Stanzione G, Di Scala C, Micillo T, Perna F, Tarotto L, Gelzo M, Cavaliere G, Spagnuolo MI, Corso G, Mattace Raso G, Matarese G, Mollica MP, Greco L, Iorio R
* Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD) (118 views) (PDF 85 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 Jan 4; 9(1): N/D-N/D.
Impact Factor: 5.688
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Di Dato F, Spadarella S, Puoti MG, Caprio MG, Pagliardini S, Zuppaldi C, Vallone G, Fecarotta S, Esposito G, Iorio R, Parenti G, Spagnuolo MI
* Daily Fructose Traces Intake and Liver Injury in Children with Hereditary Fructose Intolerance (193 views) (PDF 90 views)
Nutrients (ISSN: 2072-6643linking, 2072-6643electronic), 2019 Oct 07; 11(10): N/D-N/D.
Impact Factor: 4.171
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Klisic A, Abenavoli L, Fagoonee S, Kavaric N, Kocic G, Ninic A
* Older age and HDL-cholesterol as independent predictors of liver fibrosis assessed by BARD score (184 views)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2019 Jun; 110(3): 191-198.
Impact Factor: 2.863
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De Maio F, Squeglia F, Goletti D, Delogu G
* The Mycobacterial HBHA Protein: a Promising Biomarker for Tuberculosis (208 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2018 Oct 29; 26(11): 2051-2060.
Impact Factor: 3.519
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Mancini M, Summers P, Faita F, Brunetto MR, Callea F, De Nicola A, Di Lascio N, Farinati F, Gastaldelli A, Gridelli B, Mirabelli P, Neri E, Salvadori PA, Rebelos E, Tiribelli C, Valenti L, Salvatore M, Bonino F
* Digital liver biopsy: Bio-imaging of fatty liver for translational and clinical research (1981 views) (PDF 138 views)
World J Hepatol (ISSN: 1948-5182print, 1948-5182electronic), 2018 Feb 27; 10(2): 231-245.
Impact Factor: 0.78
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Di Lascio N, Avigo C, Salvati A, Martini N, Ragucci M, Monti S, Prinster A, Chiappino D, Mancini M, D'Elia D, Ghiadoni L, Bonino F, Brunetto MR, Faita F
* Steato-Score: Non-Invasive Quantitative Assessment of Liver Fat by Ultrasound Imaging (434 views)
Ultrasound Med Biol (ISSN: 0301-5629, 0301-5629linking), 2018; 44(8): 1585-1596.
Impact Factor: 2.494
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G
* Peptide-based targeting strategies for simultaneous imaging and therapy with nanovectors (485 views)
Polym J (ISSN: 0032-3896), 2013 May; 45(5): 481-493.
Impact Factor: 1.554
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, De Rosa V, Nardelli A, Ortosecco G, Del Vecchio S
* Combined Imaging with 18F-FLT PET/CT and 99m-Tc-Hynic-Annexin V SPECT for Personalized Therapy with EGFR Antagonists and Bcl-xL Inhibitors in Non-Small Cell Lung Cancer (394 views)
European Journal Of Cancer (ISSN: 0959-8049), 2012 Nov; 48: N/D-N/D.
Impact Factor: 5.061
View Export to BibTeX Export to EndNote
Bozzetto L, Prinster A, Annuzzi G, Costagliola L, Mangione A, Vitelli A, Mazzarella R, Longobardo M, Mancini M, Vigorito C, Riccardi G, Rivellese AA
* Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients (925 views)
Diabetes Care (ISSN: 1935-5548, 0149-5992, 1935-5548electronic), 2012 Jul; 35(7): 1429-1435.
Impact Factor: 7.735
View Export to BibTeX Export to EndNote
Bozzetto L, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA, Annuzzi G
* Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (461 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2011 Jan; 41(1): 39-44.
Impact Factor: 3.018
View Export to BibTeX Export to EndNote
Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (445 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
View Export to BibTeX Export to EndNote
Mancini M, Prinster A, Annuzzi G, Liuzzi R, Giacco R, Medagli C, Cremone M, Clemente G, Maurea S, Riccardi G, Rivellese AA, Salvatore M
* Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with (1)H magnetic resonance spectroscopy (441 views)
Metab Clin Exp (ISSN: 1532-8600, 0026-0495), 2009 Dec; 58(12): 1724-1730.
Impact Factor: 2.588
View Export to BibTeX Export to EndNote
De Simone G, Supuran CT
* Drug Design of Antiobesity Carbonic Anhydrase Inhibitors (336 views)
Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; 66(DECEMBERSPEC.I): 241-254.
Impact Factor: 1.156
View Export to BibTeX Export to EndNote
Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (615 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
View Export to BibTeX Export to EndNote
19 Records (18 excluding Abstracts).
Total impact factor: 58.411 (53.35 excluding Abstracts).
Total 5 year impact factor: 46.678 (41.421 excluding Abstracts).
Total impact factor: 58.411 (53.35 excluding Abstracts).
Total 5 year impact factor: 46.678 (41.421 excluding Abstracts).
386 views. Last view on Wednesday 05 April 2023, 11:15:55
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