Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system(399 views) Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy.
Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232-0697, USA.
Department of Physiology and Pharmacology, University Sapienza of Roma, 00185 Roma, Italy.
PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité, 1141 Paris, France.
Department of Drug Sciences, University of Catania, 95125 Catania, Italy; I.R.C.C.S. Oasi Maria SS, 94018 Troina, Italy.
I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy; Department of Physiology and Pharmacology, University Sapienza of Roma, 00185 Roma, Italy.
Centre for the Developing Brain, Department of Perinatal Health and Imaging, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London SE1 7EH, United Kingdom.
Institute of Biostructure and Bioimaging, National Research Council, 95126 Catania, Italy.
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Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system
mGlu5 receptors are involved in mechanisms of activity-dependent
synaptic plasticity, and are targeted by drugs developed for the
treatment of CNS disorders. We report that mGlu3 receptors, which are
traditionally linked to the control of neurotransmitter release, support
mGlu5 receptor signaling in neurons and largely contribute to the
robust mGlu5 receptor-mediated polyphosphoinositide hydrolysis in the
early postnatal life. In cortical pyramidal neurons, mGlu3 receptor
activation potentiated mGlu5 receptor-mediated somatic Ca
2+
mobilization, and mGlu3 receptor-mediated long-term depression in the
prefrontal cortex required the endogenous activation of mGlu5 receptors.
The interaction between mGlu3 and mGlu5 receptors was also relevant to
mechanisms of neuronal toxicity, with mGlu3 receptors shaping the
influence of mGlu5 receptors on excitotoxic neuronal death. These
findings shed new light into the complex role played by mGlu receptors
in physiology and pathology, and suggest reconsideration of some of the
current dogmas in the mGlu receptor field
Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system
No results.
Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system