Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (1007 views)
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
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Paper type: Journal Article, Epub,
Impact factor: 3.383, 5-year impact factor: 3.737
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032458223&doi=10.1016%2fj.neuropharm.2017.10.026&partnerID=40&md5=2767897cf0600ed890aecfaa819beac1
Keywords: G-Protein βγ Subunits, Long-Term Depression, Metabotropic Glutamate Receptors, Neurodevelopment, Neuronal Death, Polyphosphoinositide Hydrolysis, Receptor-Receptor Cross-Talk, Synaptic Plasticity, G-Protein Betagamma Subunits, Calcium Ion, Metabotropic Receptor 1, 4 Dihydroxyphenylethylene Glycol, 4 Amino 2 Oxabicyclo[3 1 0]hexane 4, 6 Dicarboxylic Acid, 4 Hydroxy 3 Methoxyphenylethylene Glycol, Amino Acid, Amino Acid Receptor Affecting Agent, Fused Heterocyclic Rings, N Methylaspartic Acid, Adult, Animal Cell, Animal Tissue, Astrocyte, Calcium Mobilization, Cell Viability, Central Nervous System, Controlled Study, Embryo, Female, Human, Human Cell, Long Term Depression, Mouse, Nerve Cell Necrosis, Nerve Cell Plasticity, Nonhuman, Perinatal Period, Prefrontal Cortex, Priority Journal, Protein Expression, Protein Hydrolysis, Protein Protein Interaction, Pyramidal Nerve Cell, Signal Transduction, Wild Type, Analogs And Derivatives, C57bl Mouse, Cell Culture, Cytology, Drug Effect, Gene Expression Regulation, Genetics, Long Term Potentiation, Mammalian Embryo, Metabolism, Newborn, Physiology, Bridged Bicyclo Compounds, Excitatory Amino Acid Agents, Long-Term Potentiation, Methoxyhydroxyphenylglycol, Inbred C57bl, N-Methylaspartate, Phosphatidylinositol Phosphates,
Affiliations:
*** IBB - CNR ***
I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy.
Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232-0697, USA.
Department of Physiology and Pharmacology, University Sapienza of Roma, 00185 Roma, Italy.
PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité, 1141 Paris, France.
Department of Drug Sciences, University of Catania, 95125 Catania, Italy; I.R.C.C.S. Oasi Maria SS, 94018 Troina, Italy.
I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy; Department of Physiology and Pharmacology, University Sapienza of Roma, 00185 Roma, Italy.
Centre for the Developing Brain, Department of Perinatal Health and Imaging, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London SE1 7EH, United Kingdom.
Institute of Biostructure and Bioimaging, National Research Council, 95126 Catania, Italy.
References:
Not available.
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Epub,
Impact factor: 3.383, 5-year impact factor: 3.737
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032458223&doi=10.1016%2fj.neuropharm.2017.10.026&partnerID=40&md5=2767897cf0600ed890aecfaa819beac1
Keywords: G-Protein βγ Subunits, Long-Term Depression, Metabotropic Glutamate Receptors, Neurodevelopment, Neuronal Death, Polyphosphoinositide Hydrolysis, Receptor-Receptor Cross-Talk, Synaptic Plasticity, G-Protein Betagamma Subunits, Calcium Ion, Metabotropic Receptor 1, 4 Dihydroxyphenylethylene Glycol, 4 Amino 2 Oxabicyclo[3 1 0]hexane 4, 6 Dicarboxylic Acid, 4 Hydroxy 3 Methoxyphenylethylene Glycol, Amino Acid, Amino Acid Receptor Affecting Agent, Fused Heterocyclic Rings, N Methylaspartic Acid, Adult, Animal Cell, Animal Tissue, Astrocyte, Calcium Mobilization, Cell Viability, Central Nervous System, Controlled Study, Embryo, Female, Human, Human Cell, Long Term Depression, Mouse, Nerve Cell Necrosis, Nerve Cell Plasticity, Nonhuman, Perinatal Period, Prefrontal Cortex, Priority Journal, Protein Expression, Protein Hydrolysis, Protein Protein Interaction, Pyramidal Nerve Cell, Signal Transduction, Wild Type, Analogs And Derivatives, C57bl Mouse, Cell Culture, Cytology, Drug Effect, Gene Expression Regulation, Genetics, Long Term Potentiation, Mammalian Embryo, Metabolism, Newborn, Physiology, Bridged Bicyclo Compounds, Excitatory Amino Acid Agents, Long-Term Potentiation, Methoxyhydroxyphenylglycol, Inbred C57bl, N-Methylaspartate, Phosphatidylinositol Phosphates,
Affiliations:
*** IBB - CNR ***
I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy.
Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232-0697, USA.
Department of Physiology and Pharmacology, University Sapienza of Roma, 00185 Roma, Italy.
PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité, 1141 Paris, France.
Department of Drug Sciences, University of Catania, 95125 Catania, Italy; I.R.C.C.S. Oasi Maria SS, 94018 Troina, Italy.
I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy; Department of Physiology and Pharmacology, University Sapienza of Roma, 00185 Roma, Italy.
Centre for the Developing Brain, Department of Perinatal Health and Imaging, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London SE1 7EH, United Kingdom.
Institute of Biostructure and Bioimaging, National Research Council, 95126 Catania, Italy.
References:
Not available.
Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system
mGlu5 receptors are involved in mechanisms of activity-dependent
synaptic plasticity, and are targeted by drugs developed for the
treatment of CNS disorders. We report that mGlu3 receptors, which are
traditionally linked to the control of neurotransmitter release, support
mGlu5 receptor signaling in neurons and largely contribute to the
robust mGlu5 receptor-mediated polyphosphoinositide hydrolysis in the
early postnatal life. In cortical pyramidal neurons, mGlu3 receptor
activation potentiated mGlu5 receptor-mediated somatic Ca 2+
mobilization, and mGlu3 receptor-mediated long-term depression in the
prefrontal cortex required the endogenous activation of mGlu5 receptors.
The interaction between mGlu3 and mGlu5 receptors was also relevant to
mechanisms of neuronal toxicity, with mGlu3 receptors shaping the
influence of mGlu5 receptors on excitotoxic neuronal death. These
findings shed new light into the complex role played by mGlu receptors
in physiology and pathology, and suggest reconsideration of some of the
current dogmas in the mGlu receptor field
mGlu5 receptors are involved in mechanisms of activity-dependent
synaptic plasticity, and are targeted by drugs developed for the
treatment of CNS disorders. We report that mGlu3 receptors, which are
traditionally linked to the control of neurotransmitter release, support
mGlu5 receptor signaling in neurons and largely contribute to the
robust mGlu5 receptor-mediated polyphosphoinositide hydrolysis in the
early postnatal life. In cortical pyramidal neurons, mGlu3 receptor
activation potentiated mGlu5 receptor-mediated somatic Ca 2+
mobilization, and mGlu3 receptor-mediated long-term depression in the
prefrontal cortex required the endogenous activation of mGlu5 receptors.
The interaction between mGlu3 and mGlu5 receptors was also relevant to
mechanisms of neuronal toxicity, with mGlu3 receptors shaping the
influence of mGlu5 receptors on excitotoxic neuronal death. These
findings shed new light into the complex role played by mGlu receptors
in physiology and pathology, and suggest reconsideration of some of the
current dogmas in the mGlu receptor field
Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system
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Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system
Other filter: ([btitle,keywords] "G-Protein βγ Subun ...
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Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (887 views)
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* Reduced Intracranial Volume in Fabry Disease: Evidence of Abnormal Neurodevelopment? (694 views)
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (1072 views)
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (509 views)
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Impact Factor: 5.012
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (3821 views)
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Impact Factor: 5.014
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Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (1170 views)
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Impact Factor: 2.659
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Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (840 views)
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Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (1295 views)
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Impact Factor: 3.383
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
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Impact Factor: 4.852
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* Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia (412 views)
Front Psychiatry (ISSN: 1664-0640linking, 1664-0640electronic), 2019 Feb 14; 10: 49-49.
Impact Factor: 2.857
View Export to BibTeX Export to EndNote
Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (887 views)
Front Mol Neurosci (ISSN: 1662-5099, 1662-5099linking, 1662-5099electronic), 2018 Nov 13; 11: 414-414.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Pontillo G, Cocozza S, Brunetti A, Brescia Morra V, Riccio E, Russo C, Sacca F, Tedeschi E, Pisani A, Quarantelli M
* Reduced Intracranial Volume in Fabry Disease: Evidence of Abnormal Neurodevelopment? (694 views)
Front Neurol (ISSN: 1664-2295linking, 1664-2295print), 2018 Aug 17; 9(AUG): 672-672.
Impact Factor: 3.508
View Export to BibTeX Export to EndNote
Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (1072 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
View Export to BibTeX Export to EndNote
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (509 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
View Export to BibTeX Export to EndNote
Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (3821 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (1170 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (840 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
View Export to BibTeX Export to EndNote
Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (1295 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (695 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
View Export to BibTeX Export to EndNote
10 Records (9 excluding Abstracts).
Total impact factor: 39.76 (34.746 excluding Abstracts).
Total 5 year impact factor: 33.306 (28.015 excluding Abstracts).
Total impact factor: 39.76 (34.746 excluding Abstracts).
Total 5 year impact factor: 33.306 (28.015 excluding Abstracts).
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