A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex (610 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Feb; 70(2): 362-370.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.232, 5-year impact factor: 9.416
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84894210808&partnerID=40&md5=150ded0c90cbfe5575a524b3aefd43e1
Keywords: G-Quadruplex, Locked Nucleic Acids, Thymine Tetrad, Guanine Quadruplex, Oligonucleotide, Article, Chemical Structure, Chemistry, Thermodynamics, X Ray Crystallography, X-Ray, Models, Molecular,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Naples 'Federico II', Complesso Universitario di Monte sant'Angelo, Via Cinthia, I-80126 Napoli, Italy
Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom
Institute of Biostructure and Bioimages, CNR, Via Mezzocannone 16, I-80134 Napoli, Italy
National Institute Biostructures and Biosystems, Inter-University Consortium, Viale Medaglie d'Oro 305, I-00136 Rome, Italy
References:
Battye, T.G.G., Kontogiannis, L., Johnson, O., Powell, H.R., Leslie, A.G.W., (2011) Acta Cryst., D67, pp. 271-28
Beane, R., Gabillet, S., Montaillier, C., Arar, K., Corey, D.R., (2008) Biochemistry, 47, pp. 13147-13149
Beane, R.L., Ram, R., Gabillet, S., Arar, K., Monia, B.P., Corey, D.R., (2007) Biochemistry, 46, pp. 7572-7580
Blanchet, C., Pasi, M., Zakrzewska, K., Lavery, R., (2011) Nucleic Acids Res., 39, pp. W68-W73
Bondensgaard, K., Petersen, M., Singh, S.K., Rajwanshi, V.K., Kumar, R., Wengel, J., Jacobsen, J.P., (2000) Chemistry, 6, pp. 2687-2695
Bonifacio, L., Church, F.C., Jarstfer, M.B., (2008) Int. J. Mol. Sci., 9, pp. 422-433
Braasch, D.A., Corey, D.R., (2001) Chem. Biol., 8, pp. 1-7
Braasch, D.A., Liu, Y., Corey, D.R., (2002) Nucleic Acids Res., 30, pp. 5160-5167
Briones, C., Moreno, M., (2012) Anal. Bioanal. Chem., 402, pp. 3071-3089
Brunet, E., Corgnali, M., Perrouault, L., Roig, V., Asseline, U., Sørensen, M.D., Babu, B.R., Giovannangeli, C., (2005) Nucleic Acids Res., 33, pp. 4223-4234
Brünger, A.T., Adams, P.D., Clore, G.M., De Lano, W.L., Gros, P., Grosse-Kunstleve, R.W., Jiang, J.-S., Warren, G.L., (1998) Acta Cryst., D54, pp. 905-921
Bugaut, A., Balasubramanian, S., (2012) Nucleic Acids Res., 40, pp. 4727-4741
Cáceres, C., Wright, G., Gouyette, C., Parkinson, G., Subirana, J.A., (2004) Nucleic Acids Res., 32, pp. 1097-1102
Campbell, M.A., Wengel, J., (2011) Chem. Soc. Rev., 40, pp. 5680-5689
Cogoi, S., Zorzet, S., Rapozzi, V., Géci, I., Pedersen, E.B., Xodo, L.E., (2013) Nucleic Acids Res., 41, pp. 4049-4064
Collie, G.W., Haider, S.M., Neidle, S., Parkinson, G.N., (2010) Nucleic Acids Res., 38, pp. 5569-5580
Collie, G.W., Parkinson, G.N., Neidle, S., Rosu, F., De Pauw, E., Gabelica, V., (2010) J. Am. Chem. Soc., 132, pp. 9328-9334
Collie, G.W., Sparapani, S., Parkinson, G.N., Neidle, S., (2011) J. Am. Chem. Soc., 133, pp. 2721-2728
Crinelli, R., Bianchi, M., Gentilini, L., Magnani, M., (2002) Nucleic Acids Res., 30, pp. 2435-2443
Deng, J., Xiong, Y., Sundaralingam, M., (2001) Proc. Natl Acad. Sci. USA, 98, pp. 13665-13670
Doessing, H., Vester, B., (2011) Molecules, 16, pp. 4511-4526
Donini, S., Clerici, M., Wengel, J., Vester, B., Peracchi, A., (2007) J. Biol. Chem., 282, pp. 35510-35518
Emsley, P., Cowtan, K., (2004) Acta Cryst., D60, pp. 2126-2132
Endo, M., Sugiyama, H., (2009) Chembiochem, 10, pp. 2420-2443
Evans, P., (2006) Acta Cryst., D62, pp. 72-82
Evans, P.R., Murshudov, G.N., (2013) Acta Cryst., D69, pp. 1204-1214
Fluiter, K., Mook, O.R., Baas, F., (2009) Methods Mol. Biol., 487, pp. 189-203
Förster, C., Zydek, M., Rothkegel, M., Wu, Z., Gallin, C., Gessner, R., Lisdat, F., Fürste, J.P., (2012) Biochem. Biophys. Res. Commun., 419, pp. 60-65
Galeone, A., Mayol, L., Virgilio, A., Virno, A., Randazzo, A., (2008) Mol. Biosys., 4, pp. 426-430
Gupta, N., Fisker, N., Asselin, M.C., Lindholm, M., Rosenbohm, C., Ørum, H., Elmén, J., Straarup, E.M., (2010) PLoS One, 5, pp. e10682
Haider, S., Parkinson, G.N., Neidle, S., (2002) J. Mol. Biol., 320, pp. 189-200
Hazel, P., Parkinson, G.N., Neidle, S., (2006) J. Am. Chem. Soc., 128, pp. 5480-5487
Jakobsen, M.R., Haasnoot, J., Wengel, J., Berkhout, B., Kjems, J., (2007) Retrovirology, 4, p. 29
Jepsen, J.S., Wengel, J., (2004) Curr. Opin. Drug Discov. Devel., 7, pp. 188-194
Kantardjieff, K.A., Rupp, B., (2003) Protein Sci., 12, pp. 1865-1871
Kanwar, J.R., Roy, K., Kanwar, R.K., (2011) Crit. Rev. Biochem. Mol. Biol., 46, pp. 459-477
Kauppinen, S., Vester, B., Wengel, J., (2006) Handb. Exp. Pharmacol., 2006, pp. 405-422
Kaur, H., Babu, B.R., Maiti, S., (2007) Chem. Rev., 107, pp. 4672-4697
Kaur, H., Scaria, V., Maiti, S., (2010) Biochemistry, 49, pp. 9449-9456
Kierzek, E., Pasternak, A., Pasternak, K., Gdaniec, Z., Yildirim, I., Turner, D.H., Kierzek, R., (2009) Biochemistry, 48, pp. 4377-4387
Koshkin, A.A., Nielsen, P., Meldgaard, M., Rajwanshi, V.K., Singh, S.K., Wengel, J., (1998) J. Am. Chem. Soc., 120, pp. 13252-13253
Krissinel, E., Henrick, K., (2004) Acta Cryst., D60, pp. 2256-2268
Kumar, R., Singh, S.K., Koshkin, A.A., Rajwanshi, V.K., Meldgaard, M., Wengel, J., (1998) Bioorg. Med. Chem. Lett., 8, pp. 2219-2222
Kurreck, J., Wyszko, E., Gillen, C., Erdmann, V.A., (2002) Nucleic Acids Res., 30, pp. 1911-1918
Lam, E.Y., Beraldi, D., Tannahill, D., Balasubramanian, S., (2013) Nature Commun., 4, p. 1796
Lanford, R.E., Hildebrandt-Eriksen, E.S., Petri, A., Persson, R., Lindow, M., Munk, M.E., Kauppinen, S., Ørum, H., (2010) Science, 327, pp. 198-201
Lech, C.J., Heddi, B., Phan, A.T., (2013) Nucleic Acids Res., 41, pp. 2034-2046
Lee, M.P., Parkinson, G.N., Hazel, P., Neidle, S., (2007) J. Am. Chem. Soc., 129, pp. 10106-10107
McCoy, A.J., Grosse-Kunstleve, R.W., Storoni, L.C., Read, R.J., (2005) Acta Cryst., D61, pp. 458-464
Miller, M.C., Buscaglia, R., Chaires, J.B., Lane, A.N., Trent, J.O., (2010) J. Am. Chem. Soc., 132, pp. 17105-17107
Miyoshi, D., Nakao, A., Sugimoto, N., (2002) Biochemistry, 41, pp. 15017-15024
Miyoshi, D., Sugimoto, N., (2008) Biochimie, 90, pp. 1040-1051
Murshudov, G.N., Skubák, P., Lebedev, A.A., Pannu, N.S., Steiner, R.A., Nicholls, R.A., Winn, M.D., Vagin, A.A., (2011) Acta Cryst., D67, pp. 355-367
Nielsen, J.T., Arar, K., Petersen, M., (2006) Nucleic Acids Res., 34, pp. 2006-2014
Obika, S., Nanbu, D., Hari, Y., Andoh, J., Morio, K., Doi, T., Imanishi, T., (1998) Tetrahedron Lett., 39, pp. 5401-5404
Patel, P.K., Hosur, R.V., (1999) Nucleic Acids Res., 27, pp. 2457-2464
Petraccone, L., Erra, E., Randazzo, A., Giancola, C., (2006) Biopolymers, 83, pp. 584-594
Phillips, K., Dauter, Z., Murchie, A.I., Lilley, D.M., Luisi, B., (1997) J. Mol. Biol., 273, pp. 171-182
Pradhan, D., Hansen, L.H., Vester, B., Petersen, M., (2011) Chemistry, 17, pp. 2405-2413
Randazzo, A., Esposito, V., Ohlenschläger, O., Ramachandran, R., Mayola, L., (2004) Nucleic Acids Res., 32, pp. 3083-3092
Russo Krauss, I., Merlino, A., Giancola, C., Randazzo, A., Mazzarella, L., Sica, F., (2011) Nucleic Acids Res., 39, pp. 7858-7867
Schmidt, K.S., Borkowski, S., Kurreck, J., Stephens, A.W., Bald, R., Hecht, M., Friebe, M., Erdmann, V.A., (2004) Nucleic Acids Res., 32, pp. 5757-5765
Straarup, E.M., Fisker, N., Hedtjärn, M., Lindholm, M.W., Rosenbohm, C., Aarup, V., Hansen, H.F., Koch, T., (2010) Nucleic Acids Res., 38, pp. 7100-7111
Sun, Z., Xiang, W., Guo, Y., Chen, Z., Liu, W., Lu, D., (2011) Biochem. Biophys. Res. Commun., 409, pp. 430-435
Vester, B., Hansen, L.H., Lundberg, L.B., Babu, B.R., Sørensen, M.D., Wengel, J., Douthwaite, S., (2006) BMC Mol. Biol., 7, p. 19
Winn, M.D., (2011) Acta Cryst., D67, pp. 235-242
Xu, Y., Ishizuka, T., Kimura, T., Komiyama, M., (2010) J. Am. Chem. Soc., 132, pp. 7231-7233
Zaghloul, E.M., Madsen, A.S., Moreno, P.M., Oprea, I.I., El-Andaloussi, S., Bestas, B., Gupta, P., Smith, C.I., (2011) Nucleic Acids Res., 39, pp. 1142-1154
Zheng, G., Lu, X.-J., Olson, W.K., (2009) Nucleic Acids Res., 37, pp. W240-W246
Battye, T. G. G., Kontogiannis, L., Johnson, O., Powell, H. R., Leslie, A. G. W., (2011) Acta Cryst., D67, pp. 271-28
Beane, R. L., Ram, R., Gabillet, S., Arar, K., Monia, B. P., Corey, D. R., (2007) Biochemistry, 46, pp. 7572-7580
Braasch, D. A., Corey, D. R., (2001) Chem. Biol., 8, pp. 1-7
Braasch, D. A., Liu, Y., Corey, D. R., (2002) Nucleic Acids Res., 30, pp. 5160-5167
Br nger, A. T., Adams, P. D., Clore, G. M., De Lano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. -S., Warren, G. L., (1998) Acta Cryst., D54, pp. 905-921
C ceres, C., Wright, G., Gouyette, C., Parkinson, G., Subirana, J. A., (2004) Nucleic Acids Res., 32, pp. 1097-1102
Campbell, M. A., Wengel, J., (2011) Chem. Soc. Rev., 40, pp. 5680-5689
Collie, G. W., Haider, S. M., Neidle, S., Parkinson, G. N., (2010) Nucleic Acids Res., 38, pp. 5569-5580
Collie, G. W., Parkinson, G. N., Neidle, S., Rosu, F., De Pauw, E., Gabelica, V., (2010) J. Am. Chem. Soc., 132, pp. 9328-9334
Collie, G. W., Sparapani, S., Parkinson, G. N., Neidle, S., (2011) J. Am. Chem. Soc., 133, pp. 2721-2728
Evans, P. R., Murshudov, G. N., (2013) Acta Cryst., D69, pp. 1204-1214
F rster, C., Zydek, M., Rothkegel, M., Wu, Z., Gallin, C., Gessner, R., Lisdat, F., F rste, J. P., (2012) Biochem. Biophys. Res. Commun., 419, pp. 60-65
Jakobsen, M. R., Haasnoot, J., Wengel, J., Berkhout, B., Kjems, J., (2007) Retrovirology, 4, p. 29
Jepsen, J. S., Wengel, J., (2004) Curr. Opin. Drug Discov. Devel., 7, pp. 188-194
Kantardjieff, K. A., Rupp, B., (2003) Protein Sci., 12, pp. 1865-1871
Kanwar, J. R., Roy, K., Kanwar, R. K., (2011) Crit. Rev. Biochem. Mol. Biol., 46, pp. 459-477
Kaur, H., Babu, B. R., Maiti, S., (2007) Chem. Rev., 107, pp. 4672-4697
Koshkin, A. A., Nielsen, P., Meldgaard, M., Rajwanshi, V. K., Singh, S. K., Wengel, J., (1998) J. Am. Chem. Soc., 120, pp. 13252-13253
Lam, E. Y., Beraldi, D., Tannahill, D., Balasubramanian, S., (2013) Nature Commun., 4, p. 1796
Lanford, R. E., Hildebrandt-Eriksen, E. S., Petri, A., Persson, R., Lindow, M., Munk, M. E., Kauppinen, S., rum, H., (2010) Science, 327, pp. 198-201
Lech, C. J., Heddi, B., Phan, A. T., (2013) Nucleic Acids Res., 41, pp. 2034-2046
Lee, M. P., Parkinson, G. N., Hazel, P., Neidle, S., (2007) J. Am. Chem. Soc., 129, pp. 10106-10107
McCoy, A. J., Grosse-Kunstleve, R. W., Storoni, L. C., Read, R. J., (2005) Acta Cryst., D61, pp. 458-464
Miller, M. C., Buscaglia, R., Chaires, J. B., Lane, A. N., Trent, J. O., (2010) J. Am. Chem. Soc., 132, pp. 17105-17107
Murshudov, G. N., Skub k, P., Lebedev, A. A., Pannu, N. S., Steiner, R. A., Nicholls, R. A., Winn, M. D., Vagin, A. A., (2011) Acta Cryst., D67, pp. 355-367
Nielsen, J. T., Arar, K., Petersen, M., (2006) Nucleic Acids Res., 34, pp. 2006-2014
Patel, P. K., Hosur, R. V., (1999) Nucleic Acids Res., 27, pp. 2457-2464
Schmidt, K. S., Borkowski, S., Kurreck, J., Stephens, A. W., Bald, R., Hecht, M., Friebe, M., Erdmann, V. A., (2004) Nucleic Acids Res., 32, pp. 5757-5765
Straarup, E. M., Fisker, N., Hedtj rn, M., Lindholm, M. W., Rosenbohm, C., Aarup, V., Hansen, H. F., Koch, T., (2010) Nucleic Acids Res., 38, pp. 7100-7111
Winn, M. D., (2011) Acta Cryst., D67, pp. 235-242
Zaghloul, E. M., Madsen, A. S., Moreno, P. M., Oprea, I. I., El-Andaloussi, S., Bestas, B., Gupta, P., Smith, C. I., (2011) Nucleic Acids Res., 39, pp. 1142-1154
Zheng, G., Lu, X. -J., Olson, W. K., (2009) Nucleic Acids Res., 37, pp. W240-W246
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Feb; 70(2): 362-370.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.232, 5-year impact factor: 9.416
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84894210808&partnerID=40&md5=150ded0c90cbfe5575a524b3aefd43e1
Keywords: G-Quadruplex, Locked Nucleic Acids, Thymine Tetrad, Guanine Quadruplex, Oligonucleotide, Article, Chemical Structure, Chemistry, Thermodynamics, X Ray Crystallography, X-Ray, Models, Molecular,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Naples 'Federico II', Complesso Universitario di Monte sant'Angelo, Via Cinthia, I-80126 Napoli, Italy
Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom
Institute of Biostructure and Bioimages, CNR, Via Mezzocannone 16, I-80134 Napoli, Italy
National Institute Biostructures and Biosystems, Inter-University Consortium, Viale Medaglie d'Oro 305, I-00136 Rome, Italy
References:
Battye, T.G.G., Kontogiannis, L., Johnson, O., Powell, H.R., Leslie, A.G.W., (2011) Acta Cryst., D67, pp. 271-28
Beane, R., Gabillet, S., Montaillier, C., Arar, K., Corey, D.R., (2008) Biochemistry, 47, pp. 13147-13149
Beane, R.L., Ram, R., Gabillet, S., Arar, K., Monia, B.P., Corey, D.R., (2007) Biochemistry, 46, pp. 7572-7580
Blanchet, C., Pasi, M., Zakrzewska, K., Lavery, R., (2011) Nucleic Acids Res., 39, pp. W68-W73
Bondensgaard, K., Petersen, M., Singh, S.K., Rajwanshi, V.K., Kumar, R., Wengel, J., Jacobsen, J.P., (2000) Chemistry, 6, pp. 2687-2695
Bonifacio, L., Church, F.C., Jarstfer, M.B., (2008) Int. J. Mol. Sci., 9, pp. 422-433
Braasch, D.A., Corey, D.R., (2001) Chem. Biol., 8, pp. 1-7
Braasch, D.A., Liu, Y., Corey, D.R., (2002) Nucleic Acids Res., 30, pp. 5160-5167
Briones, C., Moreno, M., (2012) Anal. Bioanal. Chem., 402, pp. 3071-3089
Brunet, E., Corgnali, M., Perrouault, L., Roig, V., Asseline, U., Sørensen, M.D., Babu, B.R., Giovannangeli, C., (2005) Nucleic Acids Res., 33, pp. 4223-4234
Brünger, A.T., Adams, P.D., Clore, G.M., De Lano, W.L., Gros, P., Grosse-Kunstleve, R.W., Jiang, J.-S., Warren, G.L., (1998) Acta Cryst., D54, pp. 905-921
Bugaut, A., Balasubramanian, S., (2012) Nucleic Acids Res., 40, pp. 4727-4741
Cáceres, C., Wright, G., Gouyette, C., Parkinson, G., Subirana, J.A., (2004) Nucleic Acids Res., 32, pp. 1097-1102
Campbell, M.A., Wengel, J., (2011) Chem. Soc. Rev., 40, pp. 5680-5689
Cogoi, S., Zorzet, S., Rapozzi, V., Géci, I., Pedersen, E.B., Xodo, L.E., (2013) Nucleic Acids Res., 41, pp. 4049-4064
Collie, G.W., Haider, S.M., Neidle, S., Parkinson, G.N., (2010) Nucleic Acids Res., 38, pp. 5569-5580
Collie, G.W., Parkinson, G.N., Neidle, S., Rosu, F., De Pauw, E., Gabelica, V., (2010) J. Am. Chem. Soc., 132, pp. 9328-9334
Collie, G.W., Sparapani, S., Parkinson, G.N., Neidle, S., (2011) J. Am. Chem. Soc., 133, pp. 2721-2728
Crinelli, R., Bianchi, M., Gentilini, L., Magnani, M., (2002) Nucleic Acids Res., 30, pp. 2435-2443
Deng, J., Xiong, Y., Sundaralingam, M., (2001) Proc. Natl Acad. Sci. USA, 98, pp. 13665-13670
Doessing, H., Vester, B., (2011) Molecules, 16, pp. 4511-4526
Donini, S., Clerici, M., Wengel, J., Vester, B., Peracchi, A., (2007) J. Biol. Chem., 282, pp. 35510-35518
Emsley, P., Cowtan, K., (2004) Acta Cryst., D60, pp. 2126-2132
Endo, M., Sugiyama, H., (2009) Chembiochem, 10, pp. 2420-2443
Evans, P., (2006) Acta Cryst., D62, pp. 72-82
Evans, P.R., Murshudov, G.N., (2013) Acta Cryst., D69, pp. 1204-1214
Fluiter, K., Mook, O.R., Baas, F., (2009) Methods Mol. Biol., 487, pp. 189-203
Förster, C., Zydek, M., Rothkegel, M., Wu, Z., Gallin, C., Gessner, R., Lisdat, F., Fürste, J.P., (2012) Biochem. Biophys. Res. Commun., 419, pp. 60-65
Galeone, A., Mayol, L., Virgilio, A., Virno, A., Randazzo, A., (2008) Mol. Biosys., 4, pp. 426-430
Gupta, N., Fisker, N., Asselin, M.C., Lindholm, M., Rosenbohm, C., Ørum, H., Elmén, J., Straarup, E.M., (2010) PLoS One, 5, pp. e10682
Haider, S., Parkinson, G.N., Neidle, S., (2002) J. Mol. Biol., 320, pp. 189-200
Hazel, P., Parkinson, G.N., Neidle, S., (2006) J. Am. Chem. Soc., 128, pp. 5480-5487
Jakobsen, M.R., Haasnoot, J., Wengel, J., Berkhout, B., Kjems, J., (2007) Retrovirology, 4, p. 29
Jepsen, J.S., Wengel, J., (2004) Curr. Opin. Drug Discov. Devel., 7, pp. 188-194
Kantardjieff, K.A., Rupp, B., (2003) Protein Sci., 12, pp. 1865-1871
Kanwar, J.R., Roy, K., Kanwar, R.K., (2011) Crit. Rev. Biochem. Mol. Biol., 46, pp. 459-477
Kauppinen, S., Vester, B., Wengel, J., (2006) Handb. Exp. Pharmacol., 2006, pp. 405-422
Kaur, H., Babu, B.R., Maiti, S., (2007) Chem. Rev., 107, pp. 4672-4697
Kaur, H., Scaria, V., Maiti, S., (2010) Biochemistry, 49, pp. 9449-9456
Kierzek, E., Pasternak, A., Pasternak, K., Gdaniec, Z., Yildirim, I., Turner, D.H., Kierzek, R., (2009) Biochemistry, 48, pp. 4377-4387
Koshkin, A.A., Nielsen, P., Meldgaard, M., Rajwanshi, V.K., Singh, S.K., Wengel, J., (1998) J. Am. Chem. Soc., 120, pp. 13252-13253
Krissinel, E., Henrick, K., (2004) Acta Cryst., D60, pp. 2256-2268
Kumar, R., Singh, S.K., Koshkin, A.A., Rajwanshi, V.K., Meldgaard, M., Wengel, J., (1998) Bioorg. Med. Chem. Lett., 8, pp. 2219-2222
Kurreck, J., Wyszko, E., Gillen, C., Erdmann, V.A., (2002) Nucleic Acids Res., 30, pp. 1911-1918
Lam, E.Y., Beraldi, D., Tannahill, D., Balasubramanian, S., (2013) Nature Commun., 4, p. 1796
Lanford, R.E., Hildebrandt-Eriksen, E.S., Petri, A., Persson, R., Lindow, M., Munk, M.E., Kauppinen, S., Ørum, H., (2010) Science, 327, pp. 198-201
Lech, C.J., Heddi, B., Phan, A.T., (2013) Nucleic Acids Res., 41, pp. 2034-2046
Lee, M.P., Parkinson, G.N., Hazel, P., Neidle, S., (2007) J. Am. Chem. Soc., 129, pp. 10106-10107
McCoy, A.J., Grosse-Kunstleve, R.W., Storoni, L.C., Read, R.J., (2005) Acta Cryst., D61, pp. 458-464
Miller, M.C., Buscaglia, R., Chaires, J.B., Lane, A.N., Trent, J.O., (2010) J. Am. Chem. Soc., 132, pp. 17105-17107
Miyoshi, D., Nakao, A., Sugimoto, N., (2002) Biochemistry, 41, pp. 15017-15024
Miyoshi, D., Sugimoto, N., (2008) Biochimie, 90, pp. 1040-1051
Murshudov, G.N., Skubák, P., Lebedev, A.A., Pannu, N.S., Steiner, R.A., Nicholls, R.A., Winn, M.D., Vagin, A.A., (2011) Acta Cryst., D67, pp. 355-367
Nielsen, J.T., Arar, K., Petersen, M., (2006) Nucleic Acids Res., 34, pp. 2006-2014
Obika, S., Nanbu, D., Hari, Y., Andoh, J., Morio, K., Doi, T., Imanishi, T., (1998) Tetrahedron Lett., 39, pp. 5401-5404
Patel, P.K., Hosur, R.V., (1999) Nucleic Acids Res., 27, pp. 2457-2464
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A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex
Locked nucleic acids (LNAs) are formed by bicyclic ribonucleotides where the O2' and C4' atoms are linked through a methylene bridge and the sugar is blocked in a 3'-endo conformation. They represent a promising tool for therapeutic and diagnostic applications and are characterized by higher thermal stability and nuclease resistance with respect to their natural counterparts. However, structural descriptions of LNA-containing quadruplexes are rather limited, since few NMR models have been reported in the literature. Here, the first crystallographically derived model of an all-LNA-substituted quadruplex-forming sequence 5'-TGGGT-3' is presented refined at 1.7 angstrom resolution. This high-resolution crystallographic analysis reveals a regular parallel G-quadruplex arrangement terminating in a well defined thymine tetrad at the 3'-end. The detailed picture of the hydration pattern reveals LNA-specific features in the solvent distribution. Interestingly, two closely packed quadruplexes are present in the asymmetric unit. They face one another with their 3'-ends giving rise to a compact higher-order structure. This new assembly suggests a possible way in which sequential quadruplexes can be disposed in the crowded cell environment. Furthermore, as the formation of ordered structures by molecular self-assembly is an effective strategy to obtain nanostructures, this study could open the way to the design of a new class of LNA-based building blocks for nanotechnology.
Locked nucleic acids (LNAs) are formed by bicyclic ribonucleotides where the O2' and C4' atoms are linked through a methylene bridge and the sugar is blocked in a 3'-endo conformation. They represent a promising tool for therapeutic and diagnostic applications and are characterized by higher thermal stability and nuclease resistance with respect to their natural counterparts. However, structural descriptions of LNA-containing quadruplexes are rather limited, since few NMR models have been reported in the literature. Here, the first crystallographically derived model of an all-LNA-substituted quadruplex-forming sequence 5'-TGGGT-3' is presented refined at 1.7 angstrom resolution. This high-resolution crystallographic analysis reveals a regular parallel G-quadruplex arrangement terminating in a well defined thymine tetrad at the 3'-end. The detailed picture of the hydration pattern reveals LNA-specific features in the solvent distribution. Interestingly, two closely packed quadruplexes are present in the asymmetric unit. They face one another with their 3'-ends giving rise to a compact higher-order structure. This new assembly suggests a possible way in which sequential quadruplexes can be disposed in the crowded cell environment. Furthermore, as the formation of ordered structures by molecular self-assembly is an effective strategy to obtain nanostructures, this study could open the way to the design of a new class of LNA-based building blocks for nanotechnology.
A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex
A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex
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Malgieri G, Palmieri M, Esposito S, Maione V, Russo L, Baglivo I, De Paola I, Milardi D, Diana D, Zaccaro L, Pedone PV, Fattorusso R, Isernia C
* Zinc To Cadmium Replacement In The Prokaryotic Zinc-Finger Domain (458 views)
Metallomics (ISSN: 1756-591x, 1756-5901, 1756-591xelectronic), 2013 Dec 18; 6(1): 96-104.
Impact Factor: 3.978
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Pica A, Russo Krauss I, Merlino A, Nagatoishi S, Sugimoto N, Sica F
* Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer (465 views)
Febs Journal (ISSN: 1742-464x), 2013 Dec; 280(24): 6581-6588.
Impact Factor: 3.986
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Russo Krauss I, Merlino A, Vergara A, Sica F
* An overview of biological macromolecule crystallization (1116 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 May 31; 14(6): 11643-11691.
Impact Factor: 2.339
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (444 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Dec; 43(6): 2537-2543.
Impact Factor: 3.914
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (554 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
* G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays (816 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812, 1520-4812electronic), 2012 Mar 21; 23(3): 382-391.
Impact Factor: 4.58
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Improta R, Barone V
* Interplay between "neutral" and "charge-transfer" excimers rules the excited state decay in adenine-rich polynucleotides (499 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2011 Dec 9; 50(50): 12016-12019.
Impact Factor: 13.455
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D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (321 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
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Russo Krauss I, Merlino A, Randazzo A, Mazzarella L, Sica F
* Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer (362 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309, 1532-2335electronic), 2010 Aug 1; 66(Pt8): 961-963.
Impact Factor: 0.563
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (435 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (304 views)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
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D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (412 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
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Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (402 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (401 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Pensato S, Saviano M, Romanelli A
* New peptide nucleic acid analogues: synthesis and applications (606 views)
Expert Opinion On Biological Therapy (ISSN: 1471-2598), 2007 Sep; 7(8): 1219-1232.
Impact Factor: 2.815
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Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
* Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (350 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Impact Factor: 0.723
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (284 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
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Musumeci D, Valente M, Capasso D, Palumbo R, Gorlach M, Schmidtke M, Zell R, Roviello GN, Sapio R, Pedone C, Bucci EM
* A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis (423 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
Impact Factor: 1.801
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Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (512 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (312 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (553 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Menchise V, De Simone G, Tedeschi T, Corradini R, Sforza S, Marchelli R, Capasso D, Saviano M, Pedone C
* Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a D-lysine-based chiral PNA-DNA duplex (553 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2003 Oct 14; 100(21): 12021-12026.
Impact Factor: 10.272
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (600 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (430 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (435 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (472 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
Impact Factor: 8.46
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De Napoli L, De Luca S, Di Fabio G, Messere A, Montesarchio D, Morelli G, Piccialli G, Tesauro D
A facile solid-phase strategy for the synthesis of oligonucleotide- tetraphenylporphyrin conjugates (417 views)
European Journal Of Organic Chemistry (ISSN: 1434-193x), 2000; (6): 1013-1018.
Impact Factor: 2.15
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Romanelli A, De Napoli L, Messere A, Montesarchio D, Piccialli G, Zaccaro L, Pedone C, Rossi F, Benedetti E
Fully automated synthesis of peptide-oligonucleotide conjugates (355 views)
Peptides For The New Millennium, 2000; N/D: N/D-N/D.
Impact Factor: 2.614
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* Exploring the relationship between G-quadruplex nucleic acids and plants: from plant G-quadruplex function to phytochemical G4 ligands with pharmaceutic potential (8 views)
Pharmaceutics, 2022 Nov 4; N/D: N/D-N/D.
Impact Factor: 6.525
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Greco F, Marzano M, Falanga AP, Terracciano M, Piccialli G, Roviello GN, D , #xerrico S, Borbone N, Oliviero G
* Cytosine-rich oligonucleotides incorporating a non-nucleotide loop: A further step towards the obtainment of physiologically stable i-motif DNA (8 views)
Int J Biol Macromol (ISSN: 0141-8130linking), 2022 Oct 31; 219: 626-636.
Impact Factor: 8.025
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Borbone N, Piccialli I, Falanga AP, Piccialli V, Roviello GN, Oliviero G
* Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era (33 views)
International Journal Of Molecular Sciences, 2022 Jun; 23: 4359-4375.
Impact Factor: 5.924
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Greco F, Musumeci D, Borbone N, Falanga AP, D , #xerrico S, Terracciano M, Piccialli I, Roviello GN, Oliviero G
* Exploring the Parallel G-Quadruplex Nucleic Acid World: A Spectroscopic and Computational Investigation on the Binding of the c-myc Oncogene NHE III1 Region by the Phytochemical Polydatin (25 views)
Molecules (ISSN: 1420-3049linking), 2022 May 7; 27(9): 2997-3006.
Impact Factor: 4.412
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Platella C, Capasso D, Riccardi C, Musumeci D, Dellagreca M, Montesarchio D
* Natural compounds from Juncus plants interacting with telomeric and oncogene G-quadruplex structures as potential anticancer agents (8 views)
Org Biomol Chem (ISSN: 1477-0520linking), 2021 Nov 8; N/D: N/D-N/D.
Impact Factor: 3.876
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Platella C, Gaglione R, Napolitano E, Arciello A, Pirota V, Doria F, Musumeci D, Montesarchio D
* DNA Binding Mode Analysis of a Core-Extended Naphthalene Diimide as a Conformation-Sensitive Fluorescent Probe of G-Quadruplex Structures (10 views)
Int J Mol Sci (ISSN: 1422-0067linking), 2021 Sep 30; 22 (19 ): N/D-N/D.
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Balanikas E, Martinez-fernandez L, Improta R, Podbevšek P, Baldacchino G, Markovitsi D
* The Structural Duality of Nucleobases in Guanine Quadruplexes Controls Their Low-Energy Photoionization (12 views)
J Phys Chem Lett (ISSN: 1948-7185linking, 1948-7185electronic), 2021 Sep 2; 12(34): 8309-8313.
Impact Factor: 6.475
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Mulliri S, Laaksonen A, Spanu P, Farris R, Farci M, Mingoia F, Roviello GN, Mocci F
* Spectroscopic and In Silico Studies on the Interaction of Substituted Pyrazolo[1, 2-a]benzo[1, 2, 3, 4]tetrazine-3-one Derivatives with c-Myc G4-DNA (26 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2021 Jun 2; 22(11): 6028-6028.
Impact Factor: 5.923
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Platella C, Napolitano E, Riccardi C, Musumeci D, Montesarchio D
* Disentangling the Structure-Activity Relationships of Naphthalene Diimides as Anticancer G-Quadruplex-Targeting Drugs (12 views)
J Med Chem (ISSN: 0022-2623linking, 0022-2623print), 2021 Apr 8; 64(7): 3578-3603.
Impact Factor: 7.446
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Green JA, Asha H, Santoro F, Improta R
* Excitonic Model for Strongly Coupled Multichromophoric Systems: The Electronic Circular Dichroism Spectra of Guanine Quadruplexes as Test Cases (82 views)
J Chem Theory Comput (ISSN: 1549-9618linking, 1549-9626electronic), 2021 Jan 12; 17(1): 405-415.
Impact Factor: 5.39
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Riccardi C, Napolitano E, Platella C, Musumeci D, Melone MAB, Montesarchio D
* Anti-VEGF DNA-based aptamers in cancer therapeutics and diagnostics (10 views)
Med Res Rev (ISSN: 0198-6325linking, 1098-1128electronic), 2021 Jan; 41(1): 464-506.
Impact Factor: 9.3
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Riccardi C, Napolitano E, Platella C, Musumeci D, Montesarchio D
* G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects (12 views)
Pharmacol Ther (ISSN: 0163-7258linking), 2021 Jan; 217: 107649-107649.
Impact Factor: 11.127
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Ogloblina AM, Iaccarino N, Capasso D, Di Gaetano S, Garzarella EU, Dolinnaya NG, Yakubovskaya MG, Pagano B, Amato J, Randazzo A
* Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives (61 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Oct 21; 21(20): N/D-N/D.
Impact Factor: 4.556
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Platella C, Raucci U, Rega N, D’atri S, Levati L, Roviello GN, Fuggetta MP, Musumeci D, Montesarchio D
* Shedding light on the interaction of polydatin and resveratrol with G-quadruplex and duplex DNA: a biophysical, computational and biological approach (205 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2020 May 15; 151: 1163-1172.
Impact Factor: 5.162
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Martínez-fernández L, Esposito L, Improta R
* Studying the excited electronic states of guanine rich DNA quadruplexes by quantum mechanical methods: main achievements and perspectives (70 views)
Photochem Photobiol Sci (ISSN: 1474-905xlinking), 2020 Apr 15; 19(4): 436-444.
Impact Factor: 2.831
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Fik-jaskółka MA, Mkrtchyan AF, Saghyan AS, Palumbo R, Belter A, Hayriyan LA, Simonyan H, Roviello V, Roviello GN
* Spectroscopic and SEM evidences for G4-DNA binding by a synthetic alkyne-containing amino acid with anticancer activity (210 views) (PDF 75 views)
Spectrochim Acta A (ISSN: 1386-1425linking), 2020 Mar 15; 229: 117884-117884.
Impact Factor: 3.232
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Pelliccia S, Amato J, Capasso D, Di Gaetano S, Massarotti A, Piccolo M, Irace C, Tron GC, Pagano B, Randazzo A, Novellino E, Giustiniano M
* Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2, 1-i]purine Derivatives (98 views)
J Med Chem (ISSN: 0022-2623linking, 0022-2623print), 2020 Mar 12; 63(5): 2035-2050.
Impact Factor: 6.205
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Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
* Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)- complexes with an L-alanyl-based ligand (261 views)
J Chem Res (ISSN: 0162-0134linking, 0162-0134print), 2020 Feb; 203: 110868-110868.
Impact Factor: 3.224
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Marzano M, Falanga AP, Marasco D, Borbone N, D , #errico S, Piccialli G, Roviello GN, Oliviero G
* Evaluation of an Analogue of the Marine ε-PLL Peptide as a Ligand of G-quadruplex DNA Structures (164 views) (PDF 61 views)
Mar Drugs (ISSN: 1660-3397linking), 2020 Jan 11; 18(1): 49-60.
Impact Factor: 4.073
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Martinez-fernandez L, Changenet P, Banyasz A, Gustavsson T, Markovitsi D, Improta R
* Comprehensive Study of Guanine Excited State Relaxation and Photoreactivity in G-quadruplexes (60 views)
J Phys Chem Lett (ISSN: 1948-7185linking, 1948-7185electronic), 2019 Nov 7; 10(21): 6873-6877.
Impact Factor: 6.687
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Banyasz A, Balanikas E, Martinez-fernandez L, Baldacchino G, Douki T, Improta R, Markovitsi D
* Radicals Generated in Tetramolecular Guanine Quadruplexes by Photoionization: Spectral and Dynamical Features (67 views)
J Phys Chem B (ISSN: 1520-5207linking, 1520-6106), 2019 Jun 13; 123(23): 4950-4957.
Impact Factor: 3.603
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Marzano M, Falanga AP, D'Errico S, Pinto B, Roviello GN, Piccialli G, Oliviero G, Borbone N
* New G-quadruplex-forming oligodeoxynucleotides incorporating a bifunctional Double-Ended Linker (DEL): effects of DEL size and ODNs orientation on the topology, stability and molecularity of DEL-G-quadruplexes (279 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2019 Feb 12; 24(3): 654-654.
Impact Factor: 3.06
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Camorani S, Fedele M, Zannetti A, Cerchia L
* TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities (345 views) (PDF 123 views)
Pharmaceuticals (ISSN: 1424-8247print, 1424-8247linking), 2018 Nov 13; 11(4): N/D-N/D.
Impact Factor: 4.286
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Martinez-fernandez L, Banyasz A, Markovitsi D, Improta R
* Topology Controls the Electronic Absorption and Delocalization of Electron Holes in Guanine Quadruplexes (425 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Oct 12; 24(57): 15185-15189.
Impact Factor: 5.476
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Martinez Fernandez L, Muñoz-losa A, Esposito L, Improta R
* The optical properties of adenine cation in different oligonucleotides: a PCM/TD‑DFT study (195 views) (PDF 122 views)
Theor Chem Acc (ISSN: 1432-881x), 2018; 137(3): N/D-N/D.
Impact Factor: 1.545
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Deiana M, Mettra B, Martinez-fernandez L, Mazur LM, Pawlik K, Andraud C, Samoc M, Improta R, Monnereau C, Matczyszyn K
* Specific Recognition of G-Quadruplexes Over Duplex-DNA by a Macromolecular NIR Two-Photon Fluorescent Probe (415 views)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2017 Dec 7; 8(23): 5915-5920.
Impact Factor: 8.709
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Piras L, Avitabile C, D'Andrea LD, Saviano M, Romanelli A
* Detection of oligonucleotides by PNA-peptide conjugates recognizing the biarsenical fluorescein complex FlAsH-EDT2 (280 views)
Biochem Bioph Res Co (ISSN: 0006-291x), 2017 Sep 15; N/D: N/D-N/D.
Impact Factor: 2.559
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Banyasz A, Martinez-fernandez L, Balty C, Perron M, Douki T, Improta R, Markovitsi D
* Absorption of Low-Energy UV Radiation by Human Telomere G-Quadruplexes Generates Long-Lived Guanine Radical Cations (184 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2017 Aug 2; 139(30): 10561-10568.
Impact Factor: 14.357
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Platella C, Guida S, Bonmassar L, Aquino A, Bonmassar E, Ravagnan G, Montesarchio D, Roviello GN, Musumeci D, Fuggetta MP
* Antitumour activity of resveratrol on human melanoma cells: a possible mechanism related to its interaction with malignant cell telomerase (290 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2017 Aug 02; 1861(11PtA): 2843-2851.
Impact Factor: 4.28
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D'Urso A, Randazzo R, Rizzo V, Gangemi CMA, Romanucci V, Zarrelli A, Tomaselli G, Milardi D, Borbone N, Purrello R, Piccialli G, Di Fabio G, Oliviero G
* Stabilization vs. destabilization of G-quadruplex superstructures: the role of the porphyrin derivative having spermine arms (284 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2017 Jul 14; 19(26): 17404-17410.
Impact Factor: 3.906
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Platella C, Riccardi C, Montesarchio D, Roviello GN, Musumeci D
* G-quadruplex-based aptamers against protein targets in therapy and diagnostics (307 views)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 1872-8006electronic), 2017 May; 1861(5PtB): 1429-1447.
Impact Factor: 3.679
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Esposito V, Pirone L, Mayol L, Pedone E, Virgilio A, Galeone A
* Exploring the binding of d(GGGT)4 to the HIV-1 integrase: An approach to investigate G-quadruplex aptamer/target protein interactions (371 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2016; 127: 19-22.
Impact Factor: 3.112
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Improta R, Santoro F, Blancafort L
* Quantum Mechanical Studies on the Photophysics and the Photochemistry of Nucleic Acids and Nucleobases (1015 views)
Chem Rev (ISSN: 0009-2665), 2016; 116(6): 3540-3593.
Impact Factor: 47.928
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Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (402 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
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Avitabile C, D'Andrea LD, Romanelli A
* Exploring the dark matter of the human genome using oligonucleotide-based molecules (281 views)
Future Med Chem (ISSN: 1756-8919, 1756-8919linking, 1756-8927electronic), 2015; 7(13): 1627-1630.
Impact Factor: 3.345
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Musumeci D, Rozza L, Merlino A, Paduano L, Marzo T, Massai L, Messori L, Montesarchio D
* Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems (568 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(31): 13914-13925.
Impact Factor: 4.177
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Zhang Y, Dood J, Beckstead AA, Li X-B, Nguyen KV, Burrows CJ, Improta R, Kohler B
* Efficient UV-induced charge separation and recombination in an 8-oxoguanine-containing dinucleotide (379 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2014 Sep 12; 111(32): 11612-11617.
Impact Factor: 9.674
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Improta R
* Quantum mechanical calculations unveil the structure and properties of the absorbing and emitting excited electronic states of guanine quadruplex (558 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jun 23; 20(26): 8106-8115.
Impact Factor: 5.731
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Scognamiglio PL, Di Natale C, Leone M, Poletto M, Vitagliano L, Tell G, Marasco D
* G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection (573 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2014 Jun; 1840(6): 2050-2059.
Impact Factor: 5.353
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Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (559 views)
Pharmacol Ther (ISSN: 0163-7258, 0163-7258linking), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
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Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (365 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 960-966.
Impact Factor: 2.793
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Malgieri G, Palmieri M, Esposito S, Maione V, Russo L, Baglivo I, De Paola I, Milardi D, Diana D, Zaccaro L, Pedone PV, Fattorusso R, Isernia C
* Zinc To Cadmium Replacement In The Prokaryotic Zinc-Finger Domain (458 views)
Metallomics (ISSN: 1756-591x, 1756-5901, 1756-591xelectronic), 2013 Dec 18; 6(1): 96-104.
Impact Factor: 3.978
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Pica A, Russo Krauss I, Merlino A, Nagatoishi S, Sugimoto N, Sica F
* Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer (465 views)
Febs Journal (ISSN: 1742-464x), 2013 Dec; 280(24): 6581-6588.
Impact Factor: 3.986
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Russo Krauss I, Merlino A, Vergara A, Sica F
* An overview of biological macromolecule crystallization (1116 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 May 31; 14(6): 11643-11691.
Impact Factor: 2.339
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (444 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Dec; 43(6): 2537-2543.
Impact Factor: 3.914
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (554 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
* G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays (816 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812, 1520-4812electronic), 2012 Mar 21; 23(3): 382-391.
Impact Factor: 4.58
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Improta R, Barone V
* Interplay between "neutral" and "charge-transfer" excimers rules the excited state decay in adenine-rich polynucleotides (499 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2011 Dec 9; 50(50): 12016-12019.
Impact Factor: 13.455
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D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (321 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
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Russo Krauss I, Merlino A, Randazzo A, Mazzarella L, Sica F
* Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer (362 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309, 1532-2335electronic), 2010 Aug 1; 66(Pt8): 961-963.
Impact Factor: 0.563
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (435 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (304 views)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
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D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (412 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
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Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (402 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (401 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Pensato S, Saviano M, Romanelli A
* New peptide nucleic acid analogues: synthesis and applications (606 views)
Expert Opinion On Biological Therapy (ISSN: 1471-2598), 2007 Sep; 7(8): 1219-1232.
Impact Factor: 2.815
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Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
* Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (350 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Impact Factor: 0.723
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (284 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
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Musumeci D, Valente M, Capasso D, Palumbo R, Gorlach M, Schmidtke M, Zell R, Roviello GN, Sapio R, Pedone C, Bucci EM
* A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis (423 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
Impact Factor: 1.801
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Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (512 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (312 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (553 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Menchise V, De Simone G, Tedeschi T, Corradini R, Sforza S, Marchelli R, Capasso D, Saviano M, Pedone C
* Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a D-lysine-based chiral PNA-DNA duplex (553 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2003 Oct 14; 100(21): 12021-12026.
Impact Factor: 10.272
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (600 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (430 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (435 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (472 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
Impact Factor: 8.46
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De Napoli L, De Luca S, Di Fabio G, Messere A, Montesarchio D, Morelli G, Piccialli G, Tesauro D
A facile solid-phase strategy for the synthesis of oligonucleotide- tetraphenylporphyrin conjugates (417 views)
European Journal Of Organic Chemistry (ISSN: 1434-193x), 2000; (6): 1013-1018.
Impact Factor: 2.15
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Romanelli A, De Napoli L, Messere A, Montesarchio D, Piccialli G, Zaccaro L, Pedone C, Rossi F, Benedetti E
Fully automated synthesis of peptide-oligonucleotide conjugates (355 views)
Peptides For The New Millennium, 2000; N/D: N/D-N/D.
Impact Factor: 2.614
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70 Records (66 excluding Abstracts).
Total impact factor: 358.806 (351.95 excluding Abstracts).
Total 5 year impact factor: 334.935 (327.094 excluding Abstracts).
Total impact factor: 358.806 (351.95 excluding Abstracts).
Total 5 year impact factor: 334.935 (327.094 excluding Abstracts).
610 views. Last view on Thursday 18 May 2023, 15:41:19
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