Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (378 views)
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.567, 5-year impact factor: 2.684
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-4444348026&partnerID=40&md5=ea5a05702c8c3d8f29e6946e9932df92
Keywords: Gene Therapy, Microspheres, Peptide Nucleic Acid-Dna Chimeras, Cell Extract, Dimethyldioctadecylammonium Bromide, Double Stranded Dna, Eudragit, Immunoglobulin Enhancer Binding Protein, Phosphorus 32, Solvent, Surfactant, Transcription Factor, Unclassified Drug, Agar Gel Electrophoresis, Article, Binding Affinity, Body Fluid, Chemical Structure, Complex Formation, Controlled Study, Electron Microscopy, Enzymatic Degradation, Evaporation, Ex Vivo Study, Human, Human Cell, Hybrid, Isotope Labeling, Molecule, Particle Size, Pharmacogenomics, Priority Journal, Simulation, Toxicity Testing, Base Sequence, Binding Sites, K562 Cells, Oligodeoxyribonucleotides,
Affiliations:
*** IBB - CNR ***
Dept. of Biochem. and Molec. Biology, University of Ferrara, Ferrara, Italy
Dept. of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy
Dept. Pharmaceutical Chem. Technol., University of Perugia, Perugia, Italy
Inst. of Biostructure and Bioimaging, CNR, Napoli, Italy
Biotechnology Center, University of Ferrara, Ferrara, Italy
References:
Ahn, J.D., Morishita, R., Kaneda, Y., Lee, K.U., Park, J.Y., Jeon, Y.J., Song, H.S., Lee, I.K., Transcription factor decoy for activator protein-1 (AP-1) inhibits high glucose- and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gene expression in cultured human vascular smooth muscle cells (2001) Diabetologia, 44, pp. 713-72
Ball, D.S., Heckman, R., Olenick, S.W., Folander, H.L., Reed III, J., In vitro stability of tris-acryl gelatin microspheres in a multipharmaceutical chemoembolization solution (2003) J Vasc Interv Radiol, 14, pp. 83-88
Borgatti, M., Breda, L., Cortesi, R., Nastruzzi, C., Romanelli, A., Saviano, M., Bianchi, N., Gambari, R., Cationic liposomes as delivery systems for double-stranded peptide nucleic acid (PNA)-DNA chimeras exhibiting decoy activity against nuclear factor-κB transcription factors (2002) Biochem Pharmacol, 64, pp. 609-616
Borgatti, M., Lampronti, I., Romanelli, A., Pedone, C., Saviano, M., Bianchi, N., Mischiati, C., Gambari, R., Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (2003) J Biol Chem, 278, pp. 7500-7509
Borgatti, M., Romanelli, A., Saviano, M., Pedone, C., Lampronti, I., Breda, L., Nastruzzi, C., Gambari, R., Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (2003) Oncol Res, 13, pp. 279-287
Cho-Chung, Y.S., CRE-palindrome oligonucleotide as a transcription factor decoy and an inhibitor of tumor growth (1998) Antisense Nucleic Acid Drug Dev, 8, pp. 167-170
Cho-Chung, Y.S., Park, Y.G., Nesterova, M., Lee, Y.N., Cho, Y.S., CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth (2000) Mol Cell Biochem, 212, pp. 29-34
Demidov, V.V., Potaman, V.N., Frank-Kamenetsk, M.D., Egholm, M., Buchard, O., Sonnichsen, S.H., Nielsen, P.E., Stability of peptide nucleic acids in human serum and cellular extracts (1994) Biochem Pharmacol, 48, pp. 1310-1313
Esposito, E., Cortesi, R., Luca, G., Nastruzzi, C., Pectin-based microspheres: A preformulatory study (2001) Ann NY Acad Sci, 944, pp. 160-179
Esposito, E., Roncarati, R., Cortesi, R., Cervellati, F., Nastruzzi, C., Production of Eudragit microparticles by spray-drying technique: Influence of experimental parameters on morphological and dimensional characteristics (2000) Pharm Dev Technol, 5, pp. 267-278
Esposito, E., Sebben, S., Cortesi, R., Menegatti, E., Nastruzzi, C., Preparation and characterization of cationic microspheres for gene delivery (1999) Int J Pharm, 189, pp. 29-41
Furuse, J., Ishii, H., Satake, M., Onaya, H., Nose, H., Mikami, S., Sakai, H., Yoshino, M., Pilot study of transcatheter arterial chemoembolization with degradable starch microspheres in patients with hepatocellular carcinoma (2003) Am J Clin Oncol, 26, pp. 159-164
Gambari, R., Peptide nucleic acids (PNAs): A tool for the development of gene expression modifiers (2001) Curr Pharm des, 7, pp. 1839-1862
Ishibashi, H., Nakagawa, K., Onimaru, M., Castellanous, E.J., Kaneda, Y., Nakashima, Y., Shirasuna, K., Sueishi, K., Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta1, and tissue factor and also cell growth and invasion activities (2000) Cancer Res, 60, pp. 6531-6536
Lebedeva, I., Stein, C.A., Antisense oligonucleotides: Promise and reality (2001) Annu Rev Pharmacol Toxicol, 41, pp. 403-419
Mann, M.J., Dzau, V.J., Therapeutic applications of transcription factor decoy oligonucleotides (2000) J Clin Invest, 106, pp. 1071-1075
Meyer, O., Kirpotin, D., Hong, K., Sternberg, B., Park, J.W., Woodle, M.C., Papahadjopoulos, D., Cationic liposomes coated with polyethylene glycol as carriers for oligonucleotides (1998) J Biol Chem, 273, pp. 15621-15627
Mischiati, C., Borgatti, M., Bianchi, N., Rutigliano, C., Tomassetti, M., Feriotto, G., Gambari, R., Interaction of the human NF-kappaB p52 transcription factor with DNA-PNA hybrids mimicking the NF-kappaB binding sites of the human immunodeficiency virus type 1 promoter (1999) J Biol Chem, 274, pp. 33114-33122
Morishita, R., Aoki, M., Kaneda, Y., Decoy oligodeoxynucleotides as novel cardiovascular drugs for cardiovascular disease (2001) Ann NY Acad Sci, 947, pp. 294-301
Nielsen, P.E., Egholm, M., Berg, R.H., Buchardt, O., Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide (1991) Science, 254, pp. 1497-1500
Penolazzi, L., Lambertini, E., Borgatti, M., Piva, R., Cozzani, M., Giovannini, I., Naccari, R., Gambari, R., Decoy oligodeoxynucleotides targeting NF-kappaB transcription factors: Induction of apoptosis in human primary osteoclasts (2003) Biochem Pharmacol, 66, pp. 1189-1198
Piva, R., Gambari, R., Transcription factor decoy (TFD) in breast cancer research and treatment (2002) Technol Cancer Res Treat, 1, pp. 405-416
Scarfi, S., Giovine, M., Gasparini, A., Damonte, G., Millo, E., Pozzolini, M., Benfatti, U., Modified peptide nucleic acids are internalized in mouse macrophages RAW 264.7 and inhibit inducible nitric oxide synthase (1999) FEBS Lett, 451, pp. 264-268
Shenoy, D.B., D'Souza, R.J., Tiwari, S.B., Udupa, N., Potential applications of polymeric microsphere suspension as subcutaneous depot for insulin (2003) Drug Dev Ind Pharm, 29, pp. 555-563
Thomas, S.M., Zeng, Q., Dyer, K.F., Suscovich, T.J., Kanter, P.M., Whalen, J.D., Watkins, S.F., Grandis, J.R., Tissue distribution of liposome-mediated epidermal growth factor receptor antisense gene therapy (2003) Cancer Gene Ther, 10, pp. 518-528
Van Der Laan, A.C., Meeuwenoord, N.J., Kuyl-Yeheskiely, E., Oosting, R.S., Brands, R., Van Boom, J.H., Solid support synthesis of a PNA-DNA hybrid (1995) Recl Trav Chim Pays Bas, 114, pp. 295-297
Vinayak, R., Van Der Laan, A.C., Brill, R., Otteson, K., Andrus, A., Kuyl-Yeheskiely, E., Van Boom, J.H., Automated chemical synthesis of PNA and PNA-DNA chimera on a nucleic acid synthesizer (1997) Nucleosides Nucleotides, 16, pp. 1653-1656
Vos, I.H., Govers, R., Grone, H.J., Kleij, L., Schurink, M., De Weger, R.A., Goldschmeding, R., Rabelink, T.J., NFkappaB decoy oligodeoxynucleotides reduce monocyte infiltration in renal allografts (2000) FASEB J, 14, pp. 815-822
Wang, L.H., Yang, X.Y., Kirken, R.A., Resau, J.H., Farrar, W.L., Targeted disruption of STAT6 DNA binding activity by an oligonucleotide decoy blocks IL-4-driven T(H)2 cell response (2000) Blood, 95, pp. 1249-1257
Wilber, A., Lu, M., Schneider, M.C., Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection (2002) Mol Ther, 6, pp. 35-42
Xu, L., Huang, C.C., Huang, W., Tang, W.H., Rait, A., Yin, Y.Z., Cruz, I., Chang, E.H., Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes (2002) Mol Cancer Ther, 1, pp. 337-346
Yi, S.W., Yune, T.Y., Kim, T.W., Chung, H., Choi, Y.W., Kwon, I.C., Lee, E.B., Jeong, S.Y., A cationic lipid emulsion/DNA complex as a physically stable and serum-resistant gene delivery system (2000) Pharm Res, 17, pp. 314-320
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.567, 5-year impact factor: 2.684
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-4444348026&partnerID=40&md5=ea5a05702c8c3d8f29e6946e9932df92
Keywords: Gene Therapy, Microspheres, Peptide Nucleic Acid-Dna Chimeras, Cell Extract, Dimethyldioctadecylammonium Bromide, Double Stranded Dna, Eudragit, Immunoglobulin Enhancer Binding Protein, Phosphorus 32, Solvent, Surfactant, Transcription Factor, Unclassified Drug, Agar Gel Electrophoresis, Article, Binding Affinity, Body Fluid, Chemical Structure, Complex Formation, Controlled Study, Electron Microscopy, Enzymatic Degradation, Evaporation, Ex Vivo Study, Human, Human Cell, Hybrid, Isotope Labeling, Molecule, Particle Size, Pharmacogenomics, Priority Journal, Simulation, Toxicity Testing, Base Sequence, Binding Sites, K562 Cells, Oligodeoxyribonucleotides,
Affiliations:
*** IBB - CNR ***
Dept. of Biochem. and Molec. Biology, University of Ferrara, Ferrara, Italy
Dept. of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy
Dept. Pharmaceutical Chem. Technol., University of Perugia, Perugia, Italy
Inst. of Biostructure and Bioimaging, CNR, Napoli, Italy
Biotechnology Center, University of Ferrara, Ferrara, Italy
References:
Ahn, J.D., Morishita, R., Kaneda, Y., Lee, K.U., Park, J.Y., Jeon, Y.J., Song, H.S., Lee, I.K., Transcription factor decoy for activator protein-1 (AP-1) inhibits high glucose- and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gene expression in cultured human vascular smooth muscle cells (2001) Diabetologia, 44, pp. 713-72
Ball, D.S., Heckman, R., Olenick, S.W., Folander, H.L., Reed III, J., In vitro stability of tris-acryl gelatin microspheres in a multipharmaceutical chemoembolization solution (2003) J Vasc Interv Radiol, 14, pp. 83-88
Borgatti, M., Breda, L., Cortesi, R., Nastruzzi, C., Romanelli, A., Saviano, M., Bianchi, N., Gambari, R., Cationic liposomes as delivery systems for double-stranded peptide nucleic acid (PNA)-DNA chimeras exhibiting decoy activity against nuclear factor-κB transcription factors (2002) Biochem Pharmacol, 64, pp. 609-616
Borgatti, M., Lampronti, I., Romanelli, A., Pedone, C., Saviano, M., Bianchi, N., Mischiati, C., Gambari, R., Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (2003) J Biol Chem, 278, pp. 7500-7509
Borgatti, M., Romanelli, A., Saviano, M., Pedone, C., Lampronti, I., Breda, L., Nastruzzi, C., Gambari, R., Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (2003) Oncol Res, 13, pp. 279-287
Cho-Chung, Y.S., CRE-palindrome oligonucleotide as a transcription factor decoy and an inhibitor of tumor growth (1998) Antisense Nucleic Acid Drug Dev, 8, pp. 167-170
Cho-Chung, Y.S., Park, Y.G., Nesterova, M., Lee, Y.N., Cho, Y.S., CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth (2000) Mol Cell Biochem, 212, pp. 29-34
Demidov, V.V., Potaman, V.N., Frank-Kamenetsk, M.D., Egholm, M., Buchard, O., Sonnichsen, S.H., Nielsen, P.E., Stability of peptide nucleic acids in human serum and cellular extracts (1994) Biochem Pharmacol, 48, pp. 1310-1313
Esposito, E., Cortesi, R., Luca, G., Nastruzzi, C., Pectin-based microspheres: A preformulatory study (2001) Ann NY Acad Sci, 944, pp. 160-179
Esposito, E., Roncarati, R., Cortesi, R., Cervellati, F., Nastruzzi, C., Production of Eudragit microparticles by spray-drying technique: Influence of experimental parameters on morphological and dimensional characteristics (2000) Pharm Dev Technol, 5, pp. 267-278
Esposito, E., Sebben, S., Cortesi, R., Menegatti, E., Nastruzzi, C., Preparation and characterization of cationic microspheres for gene delivery (1999) Int J Pharm, 189, pp. 29-41
Furuse, J., Ishii, H., Satake, M., Onaya, H., Nose, H., Mikami, S., Sakai, H., Yoshino, M., Pilot study of transcatheter arterial chemoembolization with degradable starch microspheres in patients with hepatocellular carcinoma (2003) Am J Clin Oncol, 26, pp. 159-164
Gambari, R., Peptide nucleic acids (PNAs): A tool for the development of gene expression modifiers (2001) Curr Pharm des, 7, pp. 1839-1862
Ishibashi, H., Nakagawa, K., Onimaru, M., Castellanous, E.J., Kaneda, Y., Nakashima, Y., Shirasuna, K., Sueishi, K., Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta1, and tissue factor and also cell growth and invasion activities (2000) Cancer Res, 60, pp. 6531-6536
Lebedeva, I., Stein, C.A., Antisense oligonucleotides: Promise and reality (2001) Annu Rev Pharmacol Toxicol, 41, pp. 403-419
Mann, M.J., Dzau, V.J., Therapeutic applications of transcription factor decoy oligonucleotides (2000) J Clin Invest, 106, pp. 1071-1075
Meyer, O., Kirpotin, D., Hong, K., Sternberg, B., Park, J.W., Woodle, M.C., Papahadjopoulos, D., Cationic liposomes coated with polyethylene glycol as carriers for oligonucleotides (1998) J Biol Chem, 273, pp. 15621-15627
Mischiati, C., Borgatti, M., Bianchi, N., Rutigliano, C., Tomassetti, M., Feriotto, G., Gambari, R., Interaction of the human NF-kappaB p52 transcription factor with DNA-PNA hybrids mimicking the NF-kappaB binding sites of the human immunodeficiency virus type 1 promoter (1999) J Biol Chem, 274, pp. 33114-33122
Morishita, R., Aoki, M., Kaneda, Y., Decoy oligodeoxynucleotides as novel cardiovascular drugs for cardiovascular disease (2001) Ann NY Acad Sci, 947, pp. 294-301
Nielsen, P.E., Egholm, M., Berg, R.H., Buchardt, O., Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide (1991) Science, 254, pp. 1497-1500
Penolazzi, L., Lambertini, E., Borgatti, M., Piva, R., Cozzani, M., Giovannini, I., Naccari, R., Gambari, R., Decoy oligodeoxynucleotides targeting NF-kappaB transcription factors: Induction of apoptosis in human primary osteoclasts (2003) Biochem Pharmacol, 66, pp. 1189-1198
Piva, R., Gambari, R., Transcription factor decoy (TFD) in breast cancer research and treatment (2002) Technol Cancer Res Treat, 1, pp. 405-416
Scarfi, S., Giovine, M., Gasparini, A., Damonte, G., Millo, E., Pozzolini, M., Benfatti, U., Modified peptide nucleic acids are internalized in mouse macrophages RAW 264.7 and inhibit inducible nitric oxide synthase (1999) FEBS Lett, 451, pp. 264-268
Shenoy, D.B., D'Souza, R.J., Tiwari, S.B., Udupa, N., Potential applications of polymeric microsphere suspension as subcutaneous depot for insulin (2003) Drug Dev Ind Pharm, 29, pp. 555-563
Thomas, S.M., Zeng, Q., Dyer, K.F., Suscovich, T.J., Kanter, P.M., Whalen, J.D., Watkins, S.F., Grandis, J.R., Tissue distribution of liposome-mediated epidermal growth factor receptor antisense gene therapy (2003) Cancer Gene Ther, 10, pp. 518-528
Van Der Laan, A.C., Meeuwenoord, N.J., Kuyl-Yeheskiely, E., Oosting, R.S., Brands, R., Van Boom, J.H., Solid support synthesis of a PNA-DNA hybrid (1995) Recl Trav Chim Pays Bas, 114, pp. 295-297
Vinayak, R., Van Der Laan, A.C., Brill, R., Otteson, K., Andrus, A., Kuyl-Yeheskiely, E., Van Boom, J.H., Automated chemical synthesis of PNA and PNA-DNA chimera on a nucleic acid synthesizer (1997) Nucleosides Nucleotides, 16, pp. 1653-1656
Vos, I.H., Govers, R., Grone, H.J., Kleij, L., Schurink, M., De Weger, R.A., Goldschmeding, R., Rabelink, T.J., NFkappaB decoy oligodeoxynucleotides reduce monocyte infiltration in renal allografts (2000) FASEB J, 14, pp. 815-822
Wang, L.H., Yang, X.Y., Kirken, R.A., Resau, J.H., Farrar, W.L., Targeted disruption of STAT6 DNA binding activity by an oligonucleotide decoy blocks IL-4-driven T(H)2 cell response (2000) Blood, 95, pp. 1249-1257
Wilber, A., Lu, M., Schneider, M.C., Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection (2002) Mol Ther, 6, pp. 35-42
Xu, L., Huang, C.C., Huang, W., Tang, W.H., Rait, A., Yin, Y.Z., Cruz, I., Chang, E.H., Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes (2002) Mol Cancer Ther, 1, pp. 337-346
Yi, S.W., Yune, T.Y., Kim, T.W., Chung, H., Choi, Y.W., Kwon, I.C., Lee, E.B., Jeong, S.Y., A cationic lipid emulsion/DNA complex as a physically stable and serum-resistant gene delivery system (2000) Pharm Res, 17, pp. 314-320
Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity
The major aim of this paper was to determine whether cationic microspheres (CM), consisting of the permeable polymer Eudragit(R) RS 100 plus the cationic surfactant dioctadecyl-dimethyl-ammonium bromide (DDAB(18)), could bind to double-stranded peptide nucleic acid PNA-DNA-PNA (PDP) chimeras exhibiting decoy activity against NF-kappaB transcription factors. Microspheres were produced by the 'solvent evaporation method' and centrifugation at 500, 1,000 and 3,000 rpm to obtain different-sized microparticles. Microsphere morphology, size and size distribution were determined by optical and electron microscopy observations. In order to determine their binding activity, double-stranded DNA-based and PDP-based decoy molecules were incubated with different amounts of microparticles in the presence of 100 ng of either P-32-labeled DNA-DNA or DNA-PDP hybrid molecules or cold PDP-PDP hybrids. The complexes were analyzed by agarose gel electrophoresis. The resistance of P-32-labeled DNA-DNA and DNA-PDP molecules in the presence of serum or cellular extracts was evaluated after binding to CM by gel electrophoresis analysis. DDAB18 Eudragit RS 100 microspheres are able to bind to DNA-PDP and PDP-PDP hybrids, to deliver these molecules to target cells and to protect DNA-PDP molecules from enzymatic degradation in simulated biological fluids. In addition, when assayed in ex vivo conditions, DDAB18 Eudragit RS 100 microspheres exhibited low toxicity. The results presented in this paper demonstrate that CM can be considered suitable formulations for pharmacogenomic therapy employing double-stranded PDP chimeras. Copyright (C) 2004 National Science Council, ROC and S. Karger AG, Basel.
The major aim of this paper was to determine whether cationic microspheres (CM), consisting of the permeable polymer Eudragit(R) RS 100 plus the cationic surfactant dioctadecyl-dimethyl-ammonium bromide (DDAB(18)), could bind to double-stranded peptide nucleic acid PNA-DNA-PNA (PDP) chimeras exhibiting decoy activity against NF-kappaB transcription factors. Microspheres were produced by the 'solvent evaporation method' and centrifugation at 500, 1,000 and 3,000 rpm to obtain different-sized microparticles. Microsphere morphology, size and size distribution were determined by optical and electron microscopy observations. In order to determine their binding activity, double-stranded DNA-based and PDP-based decoy molecules were incubated with different amounts of microparticles in the presence of 100 ng of either P-32-labeled DNA-DNA or DNA-PDP hybrid molecules or cold PDP-PDP hybrids. The complexes were analyzed by agarose gel electrophoresis. The resistance of P-32-labeled DNA-DNA and DNA-PDP molecules in the presence of serum or cellular extracts was evaluated after binding to CM by gel electrophoresis analysis. DDAB18 Eudragit RS 100 microspheres are able to bind to DNA-PDP and PDP-PDP hybrids, to deliver these molecules to target cells and to protect DNA-PDP molecules from enzymatic degradation in simulated biological fluids. In addition, when assayed in ex vivo conditions, DDAB18 Eudragit RS 100 microspheres exhibited low toxicity. The results presented in this paper demonstrate that CM can be considered suitable formulations for pharmacogenomic therapy employing double-stranded PDP chimeras. Copyright (C) 2004 National Science Council, ROC and S. Karger AG, Basel.
Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity
| ▼ Evaluation of gene expression and test of new therapies by preclinical imaging in murine models |
Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity
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Impact Factor: 6.482
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (430 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (457 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (270 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (435 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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* Specific Recognition of G-Quadruplexes Over Duplex-DNA by a Macromolecular NIR Two-Photon Fluorescent Probe (415 views)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2017 Dec 7; 8(23): 5915-5920.
Impact Factor: 8.709
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (524 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (1162 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (370 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (442 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (401 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (604 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (582 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (439 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (395 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (509 views)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (356 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (600 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (430 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
View Export to BibTeX Export to EndNote
Salvatore M, Fonti R
* New frontiers of nuclear medicine (457 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
View Export to BibTeX Export to EndNote
Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (270 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
View Export to BibTeX Export to EndNote
Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (435 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
View Export to BibTeX Export to EndNote
17 Records (15 excluding Abstracts).
Total impact factor: 78.053 (73.435 excluding Abstracts).
Total 5 year impact factor: 82.135 (76.683 excluding Abstracts).
Total impact factor: 78.053 (73.435 excluding Abstracts).
Total 5 year impact factor: 82.135 (76.683 excluding Abstracts).
378 views. Last view on Tuesday 06 June 2023, 14:28:57
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