Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis (460 views)
J Bacteriol Journal Of Bacteriology (ISSN: 0021-9193, 1098-5530), 2008 Jul; 190(13): 4749-4753.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.636, 5-year impact factor: 3.748
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-46049101224&partnerID=40&md5=ffa991593ccfb2b9579bb3bdd5452fc1
Keywords: Hemagglutinin, Heparin Binding Protein, Article, Bacterial Virulence, Chemical Analysis, Mycobacterium Tuberculosis, Nonhuman, Priority Journal, Radiation Scattering, Structure Analysis, Bacterial Proteins, Circular Dichroism, Dimerization, Lectins, Models, Molecular, Synchrotrons, X-Rays,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, C.N.R., I-80134, Napoli, Italy
European Molecular Biology Lab., Hamburg, c/o DESY, Notkestrasse 85, 22603 Hamburg, Germany
Dipartimento Delle Scienze Biologiche, Sezione di Biostrutture, Università degli Studi di Napoli Federico II, I-80134, Napoli, Italy
References:
Alfadhli, A., Steel, E., Finlay, L., Bachinger, H.P., Barklis, E., Hantavirus nucleocapsid protein coiled-coil domains (2002) J. Biol. Chem, 277, pp. 27103-2710
Alteri, C.J., Xicohtencatl-Cortes, J., Hess, S., Caballero-Olin, G., Giron, J.A., Friedman, R.L., Mycobacterium tuberculosis produces pili during human infection (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 5145-5150
Berger, P., Schaffitzel, C., Berger, I., Ban, N., Suter, U., Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 12177-12182
Delogu, G., Brennan, M.J., Functional domains present in the mycobacterial hemagglutinin, HBHA (1999) J. Bacteriol, 181, pp. 7464-7469
Gruber, M., Soding, J., Lupas, A.N., Comparative analysis of coiled-coil prediction methods (2006) J. Struct. Biol, 155, pp. 140-145
Hougardy, J. M., K. Schepers, S. Place, A. Drowart, V. Lechevin, V. Vers cheure, A. S. Debrie, T. M. Doherty, J. P. Van Vooren, C. Locht, and F. Mascart. 2007. Heparin-binding-hemagglutinin-induced IFN-gamma release as a diagnostic tool for latent tuberculosis. PLoS One 2:e926Jelesarov, I., Bosshard, H.R., Thermodynamic characterization of the coupled folding and association of heterodimeric coiled coils (leucine zippers) (1996) J. Mol. Biol, 263, pp. 344-358
Kammerer, R.A., Steinmetz, M.O., De novo design of a two-stranded coiled-coil switch peptide (2006) J. Struct. Biol, 155, pp. 146-153
Konarev, P.V., Petoukhov, M.V., Volkov, V.V., Svergun, D.I., ATSAS 2.1, a program package for small-angle scattering data analysis (2006) J. Appl. Crystallogr, 39, pp. 277-286
Konarev, P.V., Volkov, V.V., Sokolova, A.V., Koch, M.H.J., Svergun, D.I., PRIMUS - a Windows-PC based system for small-angle scattering data analysis (2003) J. Appl. Crystallogr, 36, pp. 277-1282
Kozin, M.B., Svergun, D.I., Automated matching of high- and low-resolution structural models (2001) J. Appl. Crystallogr, 34, pp. 33-41
Liu, J., Zheng, Q., Deng, Y., Cheng, C.S., Kallenbach, N.R., Lu, M., A seven-helix coiled coil (2006) Proc. Natl. Acad. Sci. USA, 103, pp. 15457-15462
Locht, C., Hougardy, J.M., Rouanet, C., Place, S., Mascart, F., Heparin-binding hemagglutinin, from an extrapulmonary dissemination factor to a powerful diagnostic and protective antigen against tuberculosis (2006) Tuberculosis (Edinburgh), 86, pp. 303-309
Menozzi, F.D., Bischoff, R., Fort, E., Brennan, M.J., Locht, C., Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 12625-12630
Menozzi, F.D., Reddy, V.M., Cayet, D., Raze, D., Debrie, A.S., Dehouck, M.P., Cecchelli, R., Locht, C., Mycobacterium tuberculosis heparin-binding haemagglutinin adhesin (HBHA) triggers receptor-mediated transcytosis without altering the integrity of tight junctions (2006) Microbes Infect, 8, pp. 1-9
Menozzi, F.D., Rouse, J.H., Alavi, M., Laude-Sharp, M., Muller, J., Bischoff, R., Brennan, M.J., Locht, C., Identification of a heparin-binding hemagglutinin present in mycobacteria (1996) J. Exp. Med, 184, pp. 993-1001
Parra, M., Pickett, T., Delogu, G., Dheenadhayalan, V., Debrie, A.S., Locht, C., Brennan, M.J., The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis (2004) Infect. Immun, 72, pp. 6799-6805
Pethe, K., Alonso, S., Biet, F., Delogu, G., Brennan, M.J., Locht, C., Menozzi, F.D., The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination (2001) Nature, 412, pp. 190-194
Pethe, K., Aumercier, M., Fort, E., Gatot, C., Locht, C., Menozzi, F.D., Characterization of the heparin-binding site of the mycobacterial heparin-binding hemagglutinin adhesin (2000) J. Biol. Chem, 275, pp. 14273-14280
Pethe, K., Bifani, P., Drobecq, H., Sergheraert, C., Debrie, A.S., Locht, C., Menozzi, F.D., Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis (2002) Proc. Natl. Acad. Sci. USA, 99, pp. 10759-10764
Petoukhov, M.V., Svergun, D.I., Joint use of small-angle X-ray and neutron scattering to study biological macromolecules in solution (2006) Eur. Biophys. J, 35, pp. 567-576
Porod, G., General theory (1982) Small-angle X-ray scattering, pp. 17-51. , O. Kratky ed, Academic Press, London, United Kingdom
Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., VVaksman, G., Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism (2006) Mol. Cell, 22, pp. 831-842
Roessle, M.W., Klaering, R., Ristau, U., Robrahn, B., Jahn, D., Gehrmann, T., Konarev, P., Svergun, D., Upgrade of the small-angle X-ray scattering beamline X33 at the European Molecular Biology Laboratory, Hamburg (2007) J. Appl. Crystallogr, 40, pp. s190-s194
Steinmetz, M.O., Jelesarov, I., Matousek, W.M., Honnappa, S., Jahnke, W., Missimer, J.H., Frank, S., Kammerer, R.A., Molecular basis of coiled-coil formation (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 7062-7067
Svergun, D.I., Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing (1999) Biophys. J, 76, pp. 2879-2886
Svergun, D.I., Petoukhov, M.V., Koch, M.H.J., Determination of domain structure of proteins from X-ray solution scattering (2001) Biophys. J, 80, pp. 2946-2953
Verbelen, C., Dupres, V., Raze, D., Dewitte, F., Locht, C., Dufrene, Y.F., Single-molecule force spectroscopy of mycobacterial adhesin-adhesin interactions (2007) J. Bacteriol, 189, pp. 8801-8806
Vitagliano, L., Ruggiero, A., Pedone, C., Berisio, R., A molecular dynamics study of pilus subunits: Insights into pilus biogenesis (2007) J. Mol. Biol, 367, pp. 935-941
Wilson, I.A., Skehel, J.J., Wiley, D.C., Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution (1981) Nature, 289, pp. 366-373
Wolf, E., Kim, P.S., Berger, B., MultiCoil: A program for predicting two- and three-stranded coiled coils (1997) Protein Sci, 6, pp. 1179-1189
Alteri, C. J., Xicohtencatl-Cortes, J., Hess, S., Caballero-Olin, G., Giron, J. A., Friedman, R. L., Mycobacterium tuberculosis produces pili during human infection (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 5145-5150
Kammerer, R. A., Steinmetz, M. O., De novo design of a two-stranded coiled-coil switch peptide (2006) J. Struct. Biol, 155, pp. 146-153
Konarev, P. V., Petoukhov, M. V., Volkov, V. V., Svergun, D. I., ATSAS 2. 1, a program package for small-angle scattering data analysis (2006) J. Appl. Crystallogr, 39, pp. 277-286
Konarev, P. V., Volkov, V. V., Sokolova, A. V., Koch, M. H. J., Svergun, D. I., PRIMUS - a Windows-PC based system for small-angle scattering data analysis (2003) J. Appl. Crystallogr, 36, pp. 277-1282
Kozin, M. B., Svergun, D. I., Automated matching of high- and low-resolution structural models (2001) J. Appl. Crystallogr, 34, pp. 33-41
Menozzi, F. D., Bischoff, R., Fort, E., Brennan, M. J., Locht, C., Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 12625-12630
Menozzi, F. D., Reddy, V. M., Cayet, D., Raze, D., Debrie, A. S., Dehouck, M. P., Cecchelli, R., Locht, C., Mycobacterium tuberculosis heparin-binding haemagglutinin adhesin (HBHA) triggers receptor-mediated transcytosis without altering the integrity of tight junctions (2006) Microbes Infect, 8, pp. 1-9
Menozzi, F. D., Rouse, J. H., Alavi, M., Laude-Sharp, M., Muller, J., Bischoff, R., Brennan, M. J., Locht, C., Identification of a heparin-binding hemagglutinin present in mycobacteria (1996) J. Exp. Med, 184, pp. 993-1001
Petoukhov, M. V., Svergun, D. I., Joint use of small-angle X-ray and neutron scattering to study biological macromolecules in solution (2006) Eur. Biophys. J, 35, pp. 567-576
Roessle, M. W., Klaering, R., Ristau, U., Robrahn, B., Jahn, D., Gehrmann, T., Konarev, P., Svergun, D., Upgrade of the small-angle X-ray scattering beamline X33 at the European Molecular Biology Laboratory, Hamburg (2007) J. Appl. Crystallogr, 40, pp. s190-s194
Steinmetz, M. O., Jelesarov, I., Matousek, W. M., Honnappa, S., Jahnke, W., Missimer, J. H., Frank, S., Kammerer, R. A., Molecular basis of coiled-coil formation (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 7062-7067
Svergun, D. I., Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing (1999) Biophys. J, 76, pp. 2879-2886
Svergun, D. I., Petoukhov, M. V., Koch, M. H. J., Determination of domain structure of proteins from X-ray solution scattering (2001) Biophys. J, 80, pp. 2946-2953
Wilson, I. A., Skehel, J. J., Wiley, D. C., Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution (1981) Nature, 289, pp. 366-373
Wolf, E., Kim, P. S., Berger, B., MultiCoil: A program for predicting two- and three-stranded coiled coils (1997) Protein Sci, 6, pp. 1179-1189
J Bacteriol Journal Of Bacteriology (ISSN: 0021-9193, 1098-5530), 2008 Jul; 190(13): 4749-4753.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.636, 5-year impact factor: 3.748
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-46049101224&partnerID=40&md5=ffa991593ccfb2b9579bb3bdd5452fc1
Keywords: Hemagglutinin, Heparin Binding Protein, Article, Bacterial Virulence, Chemical Analysis, Mycobacterium Tuberculosis, Nonhuman, Priority Journal, Radiation Scattering, Structure Analysis, Bacterial Proteins, Circular Dichroism, Dimerization, Lectins, Models, Molecular, Synchrotrons, X-Rays,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, C.N.R., I-80134, Napoli, Italy
European Molecular Biology Lab., Hamburg, c/o DESY, Notkestrasse 85, 22603 Hamburg, Germany
Dipartimento Delle Scienze Biologiche, Sezione di Biostrutture, Università degli Studi di Napoli Federico II, I-80134, Napoli, Italy
References:
Alfadhli, A., Steel, E., Finlay, L., Bachinger, H.P., Barklis, E., Hantavirus nucleocapsid protein coiled-coil domains (2002) J. Biol. Chem, 277, pp. 27103-2710
Alteri, C.J., Xicohtencatl-Cortes, J., Hess, S., Caballero-Olin, G., Giron, J.A., Friedman, R.L., Mycobacterium tuberculosis produces pili during human infection (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 5145-5150
Berger, P., Schaffitzel, C., Berger, I., Ban, N., Suter, U., Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 12177-12182
Delogu, G., Brennan, M.J., Functional domains present in the mycobacterial hemagglutinin, HBHA (1999) J. Bacteriol, 181, pp. 7464-7469
Gruber, M., Soding, J., Lupas, A.N., Comparative analysis of coiled-coil prediction methods (2006) J. Struct. Biol, 155, pp. 140-145
Hougardy, J. M., K. Schepers, S. Place, A. Drowart, V. Lechevin, V. Vers cheure, A. S. Debrie, T. M. Doherty, J. P. Van Vooren, C. Locht, and F. Mascart. 2007. Heparin-binding-hemagglutinin-induced IFN-gamma release as a diagnostic tool for latent tuberculosis. PLoS One 2:e926Jelesarov, I., Bosshard, H.R., Thermodynamic characterization of the coupled folding and association of heterodimeric coiled coils (leucine zippers) (1996) J. Mol. Biol, 263, pp. 344-358
Kammerer, R.A., Steinmetz, M.O., De novo design of a two-stranded coiled-coil switch peptide (2006) J. Struct. Biol, 155, pp. 146-153
Konarev, P.V., Petoukhov, M.V., Volkov, V.V., Svergun, D.I., ATSAS 2.1, a program package for small-angle scattering data analysis (2006) J. Appl. Crystallogr, 39, pp. 277-286
Konarev, P.V., Volkov, V.V., Sokolova, A.V., Koch, M.H.J., Svergun, D.I., PRIMUS - a Windows-PC based system for small-angle scattering data analysis (2003) J. Appl. Crystallogr, 36, pp. 277-1282
Kozin, M.B., Svergun, D.I., Automated matching of high- and low-resolution structural models (2001) J. Appl. Crystallogr, 34, pp. 33-41
Liu, J., Zheng, Q., Deng, Y., Cheng, C.S., Kallenbach, N.R., Lu, M., A seven-helix coiled coil (2006) Proc. Natl. Acad. Sci. USA, 103, pp. 15457-15462
Locht, C., Hougardy, J.M., Rouanet, C., Place, S., Mascart, F., Heparin-binding hemagglutinin, from an extrapulmonary dissemination factor to a powerful diagnostic and protective antigen against tuberculosis (2006) Tuberculosis (Edinburgh), 86, pp. 303-309
Menozzi, F.D., Bischoff, R., Fort, E., Brennan, M.J., Locht, C., Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 12625-12630
Menozzi, F.D., Reddy, V.M., Cayet, D., Raze, D., Debrie, A.S., Dehouck, M.P., Cecchelli, R., Locht, C., Mycobacterium tuberculosis heparin-binding haemagglutinin adhesin (HBHA) triggers receptor-mediated transcytosis without altering the integrity of tight junctions (2006) Microbes Infect, 8, pp. 1-9
Menozzi, F.D., Rouse, J.H., Alavi, M., Laude-Sharp, M., Muller, J., Bischoff, R., Brennan, M.J., Locht, C., Identification of a heparin-binding hemagglutinin present in mycobacteria (1996) J. Exp. Med, 184, pp. 993-1001
Parra, M., Pickett, T., Delogu, G., Dheenadhayalan, V., Debrie, A.S., Locht, C., Brennan, M.J., The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis (2004) Infect. Immun, 72, pp. 6799-6805
Pethe, K., Alonso, S., Biet, F., Delogu, G., Brennan, M.J., Locht, C., Menozzi, F.D., The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination (2001) Nature, 412, pp. 190-194
Pethe, K., Aumercier, M., Fort, E., Gatot, C., Locht, C., Menozzi, F.D., Characterization of the heparin-binding site of the mycobacterial heparin-binding hemagglutinin adhesin (2000) J. Biol. Chem, 275, pp. 14273-14280
Pethe, K., Bifani, P., Drobecq, H., Sergheraert, C., Debrie, A.S., Locht, C., Menozzi, F.D., Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis (2002) Proc. Natl. Acad. Sci. USA, 99, pp. 10759-10764
Petoukhov, M.V., Svergun, D.I., Joint use of small-angle X-ray and neutron scattering to study biological macromolecules in solution (2006) Eur. Biophys. J, 35, pp. 567-576
Porod, G., General theory (1982) Small-angle X-ray scattering, pp. 17-51. , O. Kratky ed, Academic Press, London, United Kingdom
Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., VVaksman, G., Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism (2006) Mol. Cell, 22, pp. 831-842
Roessle, M.W., Klaering, R., Ristau, U., Robrahn, B., Jahn, D., Gehrmann, T., Konarev, P., Svergun, D., Upgrade of the small-angle X-ray scattering beamline X33 at the European Molecular Biology Laboratory, Hamburg (2007) J. Appl. Crystallogr, 40, pp. s190-s194
Steinmetz, M.O., Jelesarov, I., Matousek, W.M., Honnappa, S., Jahnke, W., Missimer, J.H., Frank, S., Kammerer, R.A., Molecular basis of coiled-coil formation (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 7062-7067
Svergun, D.I., Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing (1999) Biophys. J, 76, pp. 2879-2886
Svergun, D.I., Petoukhov, M.V., Koch, M.H.J., Determination of domain structure of proteins from X-ray solution scattering (2001) Biophys. J, 80, pp. 2946-2953
Verbelen, C., Dupres, V., Raze, D., Dewitte, F., Locht, C., Dufrene, Y.F., Single-molecule force spectroscopy of mycobacterial adhesin-adhesin interactions (2007) J. Bacteriol, 189, pp. 8801-8806
Vitagliano, L., Ruggiero, A., Pedone, C., Berisio, R., A molecular dynamics study of pilus subunits: Insights into pilus biogenesis (2007) J. Mol. Biol, 367, pp. 935-941
Wilson, I.A., Skehel, J.J., Wiley, D.C., Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution (1981) Nature, 289, pp. 366-373
Wolf, E., Kim, P.S., Berger, B., MultiCoil: A program for predicting two- and three-stranded coiled coils (1997) Protein Sci, 6, pp. 1179-1189
Alteri, C. J., Xicohtencatl-Cortes, J., Hess, S., Caballero-Olin, G., Giron, J. A., Friedman, R. L., Mycobacterium tuberculosis produces pili during human infection (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 5145-5150
Kammerer, R. A., Steinmetz, M. O., De novo design of a two-stranded coiled-coil switch peptide (2006) J. Struct. Biol, 155, pp. 146-153
Konarev, P. V., Petoukhov, M. V., Volkov, V. V., Svergun, D. I., ATSAS 2. 1, a program package for small-angle scattering data analysis (2006) J. Appl. Crystallogr, 39, pp. 277-286
Konarev, P. V., Volkov, V. V., Sokolova, A. V., Koch, M. H. J., Svergun, D. I., PRIMUS - a Windows-PC based system for small-angle scattering data analysis (2003) J. Appl. Crystallogr, 36, pp. 277-1282
Kozin, M. B., Svergun, D. I., Automated matching of high- and low-resolution structural models (2001) J. Appl. Crystallogr, 34, pp. 33-41
Menozzi, F. D., Bischoff, R., Fort, E., Brennan, M. J., Locht, C., Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 12625-12630
Menozzi, F. D., Reddy, V. M., Cayet, D., Raze, D., Debrie, A. S., Dehouck, M. P., Cecchelli, R., Locht, C., Mycobacterium tuberculosis heparin-binding haemagglutinin adhesin (HBHA) triggers receptor-mediated transcytosis without altering the integrity of tight junctions (2006) Microbes Infect, 8, pp. 1-9
Menozzi, F. D., Rouse, J. H., Alavi, M., Laude-Sharp, M., Muller, J., Bischoff, R., Brennan, M. J., Locht, C., Identification of a heparin-binding hemagglutinin present in mycobacteria (1996) J. Exp. Med, 184, pp. 993-1001
Petoukhov, M. V., Svergun, D. I., Joint use of small-angle X-ray and neutron scattering to study biological macromolecules in solution (2006) Eur. Biophys. J, 35, pp. 567-576
Roessle, M. W., Klaering, R., Ristau, U., Robrahn, B., Jahn, D., Gehrmann, T., Konarev, P., Svergun, D., Upgrade of the small-angle X-ray scattering beamline X33 at the European Molecular Biology Laboratory, Hamburg (2007) J. Appl. Crystallogr, 40, pp. s190-s194
Steinmetz, M. O., Jelesarov, I., Matousek, W. M., Honnappa, S., Jahnke, W., Missimer, J. H., Frank, S., Kammerer, R. A., Molecular basis of coiled-coil formation (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 7062-7067
Svergun, D. I., Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing (1999) Biophys. J, 76, pp. 2879-2886
Svergun, D. I., Petoukhov, M. V., Koch, M. H. J., Determination of domain structure of proteins from X-ray solution scattering (2001) Biophys. J, 80, pp. 2946-2953
Wilson, I. A., Skehel, J. J., Wiley, D. C., Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution (1981) Nature, 289, pp. 366-373
Wolf, E., Kim, P. S., Berger, B., MultiCoil: A program for predicting two- and three-stranded coiled coils (1997) Protein Sci, 6, pp. 1179-1189
Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis
Heparin-binding hemagglutinin (HBHA) is a virulence factor of tuberculosis which is responsible for extrapulmonary dissemination of this disease. A thorough biochemical characterization of HBHA has provided experimental evidence of a coiled-coil nature of HBHA. These data, together with the low-resolution structures of a full-length form and a truncated form of HBHA obtained by small-angle X-ray scattering, have unambiguously indicated that HBHA has a dimeric structure with an elongated shape. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Heparin-binding hemagglutinin (HBHA) is a virulence factor of tuberculosis which is responsible for extrapulmonary dissemination of this disease. A thorough biochemical characterization of HBHA has provided experimental evidence of a coiled-coil nature of HBHA. These data, together with the low-resolution structures of a full-length form and a truncated form of HBHA obtained by small-angle X-ray scattering, have unambiguously indicated that HBHA has a dimeric structure with an elongated shape. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis
| ▼ Structural and functional studies of virulence factors in Mycobacterium tuberculosis infection |
Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis
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Squeglia F, Ruggiero A, Berisio R
* Collagen degradation in tuberculosis pathogenesis: the biochemical consequences of hosting an undesired guest (387 views)
Biochem J (ISSN: 1470-8728electronic, 0264-6021linking, 0264-6021print), 2018 Oct 11; 475(19): 3123-3140.
Impact Factor: 4.897
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Zambrano G, Ruggiero E, Malafronte A, Chino M, Maglio O, Pavone V, Nastri F, Lombardi A
* Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials (242 views)
Int J Mol Sc (ISSN: 1422-0067electronic, 1422-0067linking, 1661-6596), 2018 Sep 24; 19(10): N/D-N/D.
Impact Factor: 3.687
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Squeglia F, Ruggiero A, Berisio R
* Chemistry of Peptidoglycan in Mycobacterium tuberculosis Life Cycle: An off-the-wall Balance of Synthesis and Degradation (103 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2018 Feb 21; 24 (11 ): 2533-2546.
Impact Factor: 5.476
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Squeglia F, Ruggiero A, De Simone A, Berisio R
* A structural overview of mycobacterial adhesins: Key biomarkers for diagnostics and therapeutics (258 views)
Protein Sci (ISSN: 1469-896xelectronic, 0961-8368linking), 2018 Feb; 27(2): 369-380.
Impact Factor: 2.523
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Venuta A, Moret F, Dal Poggetto G, Esposito D, Fraix A, Avitabile C, Ungaro F, Malinconico M, Sortino S, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Shedding light on surface exposition of poly(ethylene glycol) and folate targeting units on nanoparticles of poly(ε-caprolactone) diblock copolymers: Beyond a paradigm (550 views)
Eur J Pharm Sci (ISSN: 0928-0987, 0928-0987linking), 2018 Jan 1; 111: 177-185.
Impact Factor: 0
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Squeglia F, Ruggiero A, Berisio R
* Chemistry of Peptidoglycan in Mycobacterium tuberculosis life style: an off-the-wall balance of synthesis and degradation (479 views) (PDF 221 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018; 24: 2533-2546.
Impact Factor: 5.317
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Berisio R, Squeglia F, Ruggiero A
* Editorial: Molecular Scenarios Behind Infectious Diseases (315 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2017 Nov 24; 24(36): 3939-3941.
Impact Factor: 3.469
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Squeglia F, Romano M, Ruggiero A, Berisio R
* Molecular players in Tuberculosis drug development: another break in the cell wall (321 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2017 Nov 24; 24(36): 3954-3969.
Impact Factor: 3.469
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Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (462 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
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Ruggiero A, Squeglia F, Romano M, Vitagliano L, De Simone A, Berisio R
* Structure and dynamics of the multi-domain resuscitation promoting factor RpfB from Mycobacterium tuberculosis (359 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2017 May; 35(6): 1322-1330.
Impact Factor: 3.107
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Ruggiero A, Squeglia F, Romano M, Vitagliano L, De Simone A, Berisio R
* The structure of Resuscitation promoting factor B from M. tuberculosis reveals unexpected ubiquitin-like domains (328 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2015 Nov 5; 1860(2): 445-451.
Impact Factor: 4.864
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Romano M, Squeglia F, Berisio R
* Structure and Function of RNase AS, a Novel Virulence Factor from Mycobacterium Tuberculosis (402 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 Apr 17; 22(14): 1745-1756.
Impact Factor: 3.455
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Squeglia F, Ruggiero A, Berisio R
* Exit from mycobacterial dormancy: a structural perspective (396 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 Feb 9; 22(14): 1698-1709.
Impact Factor: 3.455
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Troise AD, Fiore A, Roviello GN, Monti SM, Fogliano V
* Simultaneous quantification of amino acids and Amadori products in foods through ion-pairing liquid chromatography-high-resolution mass spectrometry (1089 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015 Jan; 47(1): 111-124.
Impact Factor: 3.196
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Speciale I, Paciello I, Fazio LL, Sturiale L, Palmigiano A, Lanzetta R, Parrilli M, Garozzo D, Lemaitre B, Bernardini ML, Molinaro A, De Castro C
* Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties (387 views)
Carbohyd Res (ISSN: 0008-6215, 0008-6215linking), 2015; 412: 20-27.
Impact Factor: 1.817
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Ferraro G, Massai L, Messori L, Cinellu MA, Merlino A
* Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme (360 views)
Biometals (ISSN: 0966-0844), 2015; 28(4): 745-754.
Impact Factor: 2.134
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Squeglia F, Ruggiero A, Romano M, Vitagliano L, Berisio R
* Mutational and structural study of RipA, a key enzyme in Mycobacterium tuberculosis cell division: Evidence for the l-to-d inversion of configuration of the catalytic cysteine (455 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Sep; 70(9): 2295-2300.
Impact Factor: 14.1
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Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G
* Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis (468 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Jul; 101(7): 712-719.
Impact Factor: 2.385
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Romano M, Van De Weerd R, Brouwer FCC, Roviello GN, Lacroix R, Sparrius M, Van Den Brink-van Stempvoort G, Maaskant JJ, Van Der Sar AM, Appelmelk BJ, Geurtsen JJ, Berisio R
* Structure and function of RNase AS, a polyadenylate-specific exoribonuclease affecting mycobacterial virulence in vivo (375 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2014 May 6; 22(5): 719-730.
Impact Factor: 5.618
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Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
* Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (464 views)
J Enzym Inhib Med Ch (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2014; 29(4): 500-504.
Impact Factor: 2.332
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Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
* Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis (398 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Sep; 69(Pt9): 1697-1706.
Impact Factor: 7.232
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Squeglia F, Romano M, Ruggiero A, Vitagliano L, De Simone A, Berisio R
* Carbohydrate recognition by RpfB from mycobacterium tuberculosis unveiled by crystallographic and molecular dynamics analyses (471 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2013 Jun 4; 104(11): 2530-2539.
Impact Factor: 3.832
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Correale S, Ruggiero A, Pedone E, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the l, d-transpeptidase LdtMt1 from Mycobacterium tuberculosis (404 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2013 Mar 1; 69(3): 253-256.
Impact Factor: 0.568
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Ruggiero A, Marchant J, Squeglia F, Makarov V, De Simone A, Berisio R
* Molecular determinants of inactivation of the resuscitation promoting factor B from Mycobacterium tuberculosis (408 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2013 Feb 1; 31(2): 195-205.
Impact Factor: 2.983
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Ruggiero A, De Simone P, Smaldone G, Squeglia F, Berisio R
* Bacterial cell division regulation by Ser/Thr kinases: A structural perspective (581 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 756-766.
Impact Factor: 2.326
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Kaprelyants AS, Mukamolova GV, Ruggiero A, Makarov VA, Demina GR, Shleeva MO, Potapov VD, Shramko PA
* Resuscitation-promoting Factors (Rpf): In Search of Inhibitors (496 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1026-1034.
Impact Factor: 1.994
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (535 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Esposito C, Cantisani M, D'Auria G, Falcigno L, Pedone E, Galdiero S, Berisio R
* Mapping key interactions in the dimerization process of HBHA from Mycobacterium tuberculosis, insights into bacterial agglutination (461 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2012 Mar 23; 586(6): 659-667.
Impact Factor: 3.582
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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Esposito C, Marasco D, Delogu G, Pedone E, Berisio R
* Heparin-binding hemagglutinin HBHA from Mycobacterium tuberculosis affects actin polymerisation (346 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2011 Jul 1; 410(2): 339-344.
Impact Factor: 2.484
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Ruggiero A, Squeglia F, Pirone L, Correale S, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis (407 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Jan 1; 67(1): 164-168.
Impact Factor: 0.506
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D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (321 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
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Ruggiero A, Marasco D, Squeglia F, Soldini S, Pedone E, Pedone C, Berisio R
* Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation (419 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2010 Sep 8; 18(9): 1184-1190.
Impact Factor: 6.337
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Castellano I, Merlino A, Rossi M, La Cara F
* Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity (613 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2010 May; 92(5): 464-474.
Impact Factor: 3.787
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Esposito C, Carullo C, Pedone E, Graziano G, Del Vecchio P, Berisio R
* Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: Implications for bacterial agglutination (494 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 0014-5793linking), 2010 Mar 19; 584(6): 1091-1096.
Impact Factor: 3.601
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Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis (348 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2010 Jan; 17(1): 70-73.
Impact Factor: 1.849
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Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R
* Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis (571 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009 Jan 9; 385(1): 153-162.
Impact Factor: 3.871
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Limauro D, Saviano M, Galdi I, Rossi M, Bartolucci S, Pedone E
* Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites (234 views)
Protein Engineering Design & Selection (ISSN: 1741-0126), 2009 Jan; 22(1): 19-26.
Impact Factor: 2.596
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Banyasz A, Gustavsson T, Keszei E, Improta R, Markovitsi D
* Effect of amino substitution on the excited state dynamics of uracil (330 views)
Photochem Photobiol Sci (ISSN: 1474-905x), 2008 Jul; 7(7): 765-768.
Impact Factor: 2.144
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Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis (387 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2007 Oct 1; 63(10): 870-873.
Impact Factor: 0.645
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Castiglioni E, Abbate S, Longhi G, Gangemi R, Lauceri R, Purrello R
* Absorption flattening as one cause of distortion of circular dichroism spectra of Δ-RuPhen3·H2TPPS complex (303 views)
Chirality (ISSN: 0899-0042), 2007 Sep; 19(8): 642-646.
Impact Factor: 2.436
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Vacatello M, D'Auria G, Falcigno L, Dettin M, Gambaretto R, Di Bello C, Paolillo L
* Conformational Analysis Of Novel Heparin Binding Peptides (618 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2005 Jun; 26(16): 3207-3214.
Impact Factor: 4.698
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Lauceria R, Purrellob R
* Transfer, memory and amplification of chirality in porphyrin aggregates (303 views)
Supramol Chem (ISSN: 1061-0278), 2005; 17(1-2): 61-66.
Impact Factor: 1.715
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Guzzi R, Milardi D, La Rosa C, Grasso D, Verbeet MP, Canters GW, Sportelli L
* The effect of copper/zinc replacement on the folding free energy of wild type and Cys3Ala/Cys26Ala azurin (307 views)
Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2003 Jan 15; 31(4-5): 163-170.
Impact Factor: 1.427
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Monti SM, Ritieni A, Sacchi R, Skog K, Borgen E, Fogliano V
* Characterization of phenolic compounds in virgin olive oil and their effect on the formation of carcinogenic/mutagenic heterocyclic amines in a model system (627 views)
J Agric Food Chem (ISSN: 0021-8561), 2001 Sep; 49(8): 3969-3975.
Impact Factor: 1.576
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (502 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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Gurrieri S, Miceli L, Lanza CM, Tomaselli F, Bonomo RP, Rizzarelli E
Chemical characterization of Sicilian prickly pear (Opuntia ficus indica) and perspectives for the storage of its juice (292 views)
J Agric Food Chem (ISSN: 0021-8561), 2000 Nov; 48(11): 5424-5431.
Impact Factor: 1.56
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Esposito L, Vitagliano L, Sica F, Sorrentino G, Zagari A, Mazzarella L
The ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: Hydration and sterochemical analysis (680 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Mar 31; 297(3): 713-732.
Impact Factor: 5.388
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Monti SM, Borrelli RC, Ritieni A, Fogliano V
A comparison of color formation and Maillard reaction products of a lactose-lysine and lactose-N(α)-acetyllysine model system (469 views)
J Agric Food Chem (ISSN: 0021-8561), 2000; 48(4): 1041-1046.
Impact Factor: 1.56
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* PGRS domain structures: Doomed to sail the mycomembrane (11 views)
Plos Pathog (ISSN: 1553-7366linking), 2022 Sep 1; 18(9): e1010760-N/D.
Impact Factor: 7.5
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Squeglia F, Marasco D, Ruggiero A, Testa G, Esposito L, Berisio R
* Structural and Binding Properties of the Active Cell Wall Hydrolase RipA from M. tuberculosis, a Promising Biosensing Molecule for Early Warning Bacterial Detection (5 views)
Curr Med Chem (ISSN: 0929-8673linking), 2022; 29(24): 4282-4292.
Impact Factor: 4.74
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Kramarska E, Squeglia F, De Maio F, Delogu G, Berisio R
* PE_PGRS33, an Important Virulence Factor of Mycobacterium tuberculosis and Potential Target of Host Humoral Immune Response (19 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2021 Jan 15; 10(1): N/D-N/D.
Impact Factor: 6.6
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De Maio F, Berisio R, Manganelli R, Delogu G
* PE_PGRS proteins of Mycobacterium tuberculosis: A specialized molecular task force at the forefront of host-pathogen interaction (100 views)
Virulence, 2020; N/D: 898-915.
Impact Factor: 5.54
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Calvanese L, Squeglia F, Romano M, D'Auria G, Falcigno L, Berisio R
* Structural and dynamic studies provide insights into specificity and allosteric regulation of Ribonuclease AS, a key enzyme in mycobacterial virulence (216 views) (PDF 10 views)
J Biomol Struct Dyn (ISSN: 0739-1102linking, 1538-0254electronic), 2020; N/D: 1-19.
Impact Factor: 3.11
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Squeglia F, Moreira M, Ruggiero A, Berisio R
* The Cell Wall Hydrolytic NlpC/P60 Endopeptidases in Mycobacterial Cytokinesis: A Structural Perspective (217 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2019 Jun 18; 8(6): N/D-N/D.
Impact Factor: 5.7
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De Maio F, Squeglia F, Goletti D, Delogu G
* The Mycobacterial HBHA Protein: a Promising Biomarker for Tuberculosis (208 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2018 Oct 29; 26(11): 2051-2060.
Impact Factor: 3.519
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Squeglia F, Ruggiero A, Berisio R
* Collagen degradation in tuberculosis pathogenesis: the biochemical consequences of hosting an undesired guest (387 views)
Biochem J (ISSN: 1470-8728electronic, 0264-6021linking, 0264-6021print), 2018 Oct 11; 475(19): 3123-3140.
Impact Factor: 4.897
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Zambrano G, Ruggiero E, Malafronte A, Chino M, Maglio O, Pavone V, Nastri F, Lombardi A
* Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials (242 views)
Int J Mol Sc (ISSN: 1422-0067electronic, 1422-0067linking, 1661-6596), 2018 Sep 24; 19(10): N/D-N/D.
Impact Factor: 3.687
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Squeglia F, Ruggiero A, Berisio R
* Chemistry of Peptidoglycan in Mycobacterium tuberculosis Life Cycle: An off-the-wall Balance of Synthesis and Degradation (103 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2018 Feb 21; 24 (11 ): 2533-2546.
Impact Factor: 5.476
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Squeglia F, Ruggiero A, De Simone A, Berisio R
* A structural overview of mycobacterial adhesins: Key biomarkers for diagnostics and therapeutics (258 views)
Protein Sci (ISSN: 1469-896xelectronic, 0961-8368linking), 2018 Feb; 27(2): 369-380.
Impact Factor: 2.523
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Venuta A, Moret F, Dal Poggetto G, Esposito D, Fraix A, Avitabile C, Ungaro F, Malinconico M, Sortino S, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Shedding light on surface exposition of poly(ethylene glycol) and folate targeting units on nanoparticles of poly(ε-caprolactone) diblock copolymers: Beyond a paradigm (550 views)
Eur J Pharm Sci (ISSN: 0928-0987, 0928-0987linking), 2018 Jan 1; 111: 177-185.
Impact Factor: 0
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Squeglia F, Ruggiero A, Berisio R
* Chemistry of Peptidoglycan in Mycobacterium tuberculosis life style: an off-the-wall balance of synthesis and degradation (479 views) (PDF 221 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018; 24: 2533-2546.
Impact Factor: 5.317
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Berisio R, Squeglia F, Ruggiero A
* Editorial: Molecular Scenarios Behind Infectious Diseases (315 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2017 Nov 24; 24(36): 3939-3941.
Impact Factor: 3.469
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Squeglia F, Romano M, Ruggiero A, Berisio R
* Molecular players in Tuberculosis drug development: another break in the cell wall (321 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2017 Nov 24; 24(36): 3954-3969.
Impact Factor: 3.469
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Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (462 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
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Ruggiero A, Squeglia F, Romano M, Vitagliano L, De Simone A, Berisio R
* Structure and dynamics of the multi-domain resuscitation promoting factor RpfB from Mycobacterium tuberculosis (359 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2017 May; 35(6): 1322-1330.
Impact Factor: 3.107
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Ruggiero A, Squeglia F, Romano M, Vitagliano L, De Simone A, Berisio R
* The structure of Resuscitation promoting factor B from M. tuberculosis reveals unexpected ubiquitin-like domains (328 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2015 Nov 5; 1860(2): 445-451.
Impact Factor: 4.864
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Romano M, Squeglia F, Berisio R
* Structure and Function of RNase AS, a Novel Virulence Factor from Mycobacterium Tuberculosis (402 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 Apr 17; 22(14): 1745-1756.
Impact Factor: 3.455
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Squeglia F, Ruggiero A, Berisio R
* Exit from mycobacterial dormancy: a structural perspective (396 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 Feb 9; 22(14): 1698-1709.
Impact Factor: 3.455
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Troise AD, Fiore A, Roviello GN, Monti SM, Fogliano V
* Simultaneous quantification of amino acids and Amadori products in foods through ion-pairing liquid chromatography-high-resolution mass spectrometry (1089 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015 Jan; 47(1): 111-124.
Impact Factor: 3.196
View Export to BibTeX Export to EndNote
Speciale I, Paciello I, Fazio LL, Sturiale L, Palmigiano A, Lanzetta R, Parrilli M, Garozzo D, Lemaitre B, Bernardini ML, Molinaro A, De Castro C
* Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties (387 views)
Carbohyd Res (ISSN: 0008-6215, 0008-6215linking), 2015; 412: 20-27.
Impact Factor: 1.817
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Ferraro G, Massai L, Messori L, Cinellu MA, Merlino A
* Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme (360 views)
Biometals (ISSN: 0966-0844), 2015; 28(4): 745-754.
Impact Factor: 2.134
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Squeglia F, Ruggiero A, Romano M, Vitagliano L, Berisio R
* Mutational and structural study of RipA, a key enzyme in Mycobacterium tuberculosis cell division: Evidence for the l-to-d inversion of configuration of the catalytic cysteine (455 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Sep; 70(9): 2295-2300.
Impact Factor: 14.1
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Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G
* Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis (468 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Jul; 101(7): 712-719.
Impact Factor: 2.385
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Romano M, Van De Weerd R, Brouwer FCC, Roviello GN, Lacroix R, Sparrius M, Van Den Brink-van Stempvoort G, Maaskant JJ, Van Der Sar AM, Appelmelk BJ, Geurtsen JJ, Berisio R
* Structure and function of RNase AS, a polyadenylate-specific exoribonuclease affecting mycobacterial virulence in vivo (375 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2014 May 6; 22(5): 719-730.
Impact Factor: 5.618
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Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
* Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (464 views)
J Enzym Inhib Med Ch (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2014; 29(4): 500-504.
Impact Factor: 2.332
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Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
* Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis (398 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Sep; 69(Pt9): 1697-1706.
Impact Factor: 7.232
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Squeglia F, Romano M, Ruggiero A, Vitagliano L, De Simone A, Berisio R
* Carbohydrate recognition by RpfB from mycobacterium tuberculosis unveiled by crystallographic and molecular dynamics analyses (471 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2013 Jun 4; 104(11): 2530-2539.
Impact Factor: 3.832
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Correale S, Ruggiero A, Pedone E, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the l, d-transpeptidase LdtMt1 from Mycobacterium tuberculosis (404 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2013 Mar 1; 69(3): 253-256.
Impact Factor: 0.568
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Ruggiero A, Marchant J, Squeglia F, Makarov V, De Simone A, Berisio R
* Molecular determinants of inactivation of the resuscitation promoting factor B from Mycobacterium tuberculosis (408 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2013 Feb 1; 31(2): 195-205.
Impact Factor: 2.983
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Ruggiero A, De Simone P, Smaldone G, Squeglia F, Berisio R
* Bacterial cell division regulation by Ser/Thr kinases: A structural perspective (581 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 756-766.
Impact Factor: 2.326
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Kaprelyants AS, Mukamolova GV, Ruggiero A, Makarov VA, Demina GR, Shleeva MO, Potapov VD, Shramko PA
* Resuscitation-promoting Factors (Rpf): In Search of Inhibitors (496 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1026-1034.
Impact Factor: 1.994
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (535 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Esposito C, Cantisani M, D'Auria G, Falcigno L, Pedone E, Galdiero S, Berisio R
* Mapping key interactions in the dimerization process of HBHA from Mycobacterium tuberculosis, insights into bacterial agglutination (461 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2012 Mar 23; 586(6): 659-667.
Impact Factor: 3.582
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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Esposito C, Marasco D, Delogu G, Pedone E, Berisio R
* Heparin-binding hemagglutinin HBHA from Mycobacterium tuberculosis affects actin polymerisation (346 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2011 Jul 1; 410(2): 339-344.
Impact Factor: 2.484
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Ruggiero A, Squeglia F, Pirone L, Correale S, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis (407 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Jan 1; 67(1): 164-168.
Impact Factor: 0.506
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D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (321 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
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Ruggiero A, Marasco D, Squeglia F, Soldini S, Pedone E, Pedone C, Berisio R
* Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation (419 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2010 Sep 8; 18(9): 1184-1190.
Impact Factor: 6.337
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Castellano I, Merlino A, Rossi M, La Cara F
* Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity (613 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2010 May; 92(5): 464-474.
Impact Factor: 3.787
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Esposito C, Carullo C, Pedone E, Graziano G, Del Vecchio P, Berisio R
* Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: Implications for bacterial agglutination (494 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 0014-5793linking), 2010 Mar 19; 584(6): 1091-1096.
Impact Factor: 3.601
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Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis (348 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2010 Jan; 17(1): 70-73.
Impact Factor: 1.849
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Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R
* Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis (571 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009 Jan 9; 385(1): 153-162.
Impact Factor: 3.871
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Limauro D, Saviano M, Galdi I, Rossi M, Bartolucci S, Pedone E
* Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites (234 views)
Protein Engineering Design & Selection (ISSN: 1741-0126), 2009 Jan; 22(1): 19-26.
Impact Factor: 2.596
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Banyasz A, Gustavsson T, Keszei E, Improta R, Markovitsi D
* Effect of amino substitution on the excited state dynamics of uracil (330 views)
Photochem Photobiol Sci (ISSN: 1474-905x), 2008 Jul; 7(7): 765-768.
Impact Factor: 2.144
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Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis (387 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2007 Oct 1; 63(10): 870-873.
Impact Factor: 0.645
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Castiglioni E, Abbate S, Longhi G, Gangemi R, Lauceri R, Purrello R
* Absorption flattening as one cause of distortion of circular dichroism spectra of Δ-RuPhen3·H2TPPS complex (303 views)
Chirality (ISSN: 0899-0042), 2007 Sep; 19(8): 642-646.
Impact Factor: 2.436
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Vacatello M, D'Auria G, Falcigno L, Dettin M, Gambaretto R, Di Bello C, Paolillo L
* Conformational Analysis Of Novel Heparin Binding Peptides (618 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2005 Jun; 26(16): 3207-3214.
Impact Factor: 4.698
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Lauceria R, Purrellob R
* Transfer, memory and amplification of chirality in porphyrin aggregates (303 views)
Supramol Chem (ISSN: 1061-0278), 2005; 17(1-2): 61-66.
Impact Factor: 1.715
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Guzzi R, Milardi D, La Rosa C, Grasso D, Verbeet MP, Canters GW, Sportelli L
* The effect of copper/zinc replacement on the folding free energy of wild type and Cys3Ala/Cys26Ala azurin (307 views)
Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2003 Jan 15; 31(4-5): 163-170.
Impact Factor: 1.427
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Monti SM, Ritieni A, Sacchi R, Skog K, Borgen E, Fogliano V
* Characterization of phenolic compounds in virgin olive oil and their effect on the formation of carcinogenic/mutagenic heterocyclic amines in a model system (627 views)
J Agric Food Chem (ISSN: 0021-8561), 2001 Sep; 49(8): 3969-3975.
Impact Factor: 1.576
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (502 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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Gurrieri S, Miceli L, Lanza CM, Tomaselli F, Bonomo RP, Rizzarelli E
Chemical characterization of Sicilian prickly pear (Opuntia ficus indica) and perspectives for the storage of its juice (292 views)
J Agric Food Chem (ISSN: 0021-8561), 2000 Nov; 48(11): 5424-5431.
Impact Factor: 1.56
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Esposito L, Vitagliano L, Sica F, Sorrentino G, Zagari A, Mazzarella L
The ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: Hydration and sterochemical analysis (680 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Mar 31; 297(3): 713-732.
Impact Factor: 5.388
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Monti SM, Borrelli RC, Ritieni A, Fogliano V
A comparison of color formation and Maillard reaction products of a lactose-lysine and lactose-N(α)-acetyllysine model system (469 views)
J Agric Food Chem (ISSN: 0021-8561), 2000; 48(4): 1041-1046.
Impact Factor: 1.56
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56 Records (55 excluding Abstracts).
Total impact factor: 203.668 (203.668 excluding Abstracts).
Total 5 year impact factor: 210.573 (210.573 excluding Abstracts).
Total impact factor: 203.668 (203.668 excluding Abstracts).
Total 5 year impact factor: 210.573 (210.573 excluding Abstracts).
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