Sniffin' Sticks and olfactory system imaging in patients with Kallmann syndrome (405 views)
Int Forum Allergy Rh (ISSN: 2042-6976), 2015 May 7; 5(9): 855-861.
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Paper type: Journal Article,
Impact factor: 2.35, 5-year impact factor: 2.433
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84928967033&partnerID=40&md5=998afe74debeace2a7156d0e4a949af5
Keywords: Kallmann Syndrome, Sniffin, Sticks, Cortical Thickness, N-Butanol, Odor Discrimination, Odor Identification, Odor Threshold, Olfactory Bulb Volume, Olfactory Sulcus Depth, Adult, Article, Cohort Analysis, Controlled Study, Cortical Thickness (brain), Functional Assessment, Human, Nuclear Magnetic Resonance Imaging, Olfactory Test Kit, Organ Size, Phenotype, Priority Journal, Rhinencephalon, Scoring System, Smelling, Sniffin Stick Test, Adolescent, Child, Middle Aged, Olfaction Disorders, Pathology, Young Adult,
Affiliations:
*** IBB - CNR ***
Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
Department of Advanced Biomedical Sciences-Neuroradiology "Federico II" University Napoli Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Venezia Italy
Department of Statistical Sciences University of Padova Padova Italy
Department of Cardiothoracic Sciences Second University of Napoli Napoli Italy
Institute of Biostructure and Bioimaging, National Research Council, School of Medicine Federico II University Napoli Italy
Department of Medicine (DIMED) University of Padova Padova Italy
References:
Not available.
Int Forum Allergy Rh (ISSN: 2042-6976), 2015 May 7; 5(9): 855-861.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.35, 5-year impact factor: 2.433
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84928967033&partnerID=40&md5=998afe74debeace2a7156d0e4a949af5
Keywords: Kallmann Syndrome, Sniffin, Sticks, Cortical Thickness, N-Butanol, Odor Discrimination, Odor Identification, Odor Threshold, Olfactory Bulb Volume, Olfactory Sulcus Depth, Adult, Article, Cohort Analysis, Controlled Study, Cortical Thickness (brain), Functional Assessment, Human, Nuclear Magnetic Resonance Imaging, Olfactory Test Kit, Organ Size, Phenotype, Priority Journal, Rhinencephalon, Scoring System, Smelling, Sniffin Stick Test, Adolescent, Child, Middle Aged, Olfaction Disorders, Pathology, Young Adult,
Affiliations:
*** IBB - CNR ***
Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
Department of Advanced Biomedical Sciences-Neuroradiology "Federico II" University Napoli Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Venezia Italy
Department of Statistical Sciences University of Padova Padova Italy
Department of Cardiothoracic Sciences Second University of Napoli Napoli Italy
Institute of Biostructure and Bioimaging, National Research Council, School of Medicine Federico II University Napoli Italy
Department of Medicine (DIMED) University of Padova Padova Italy
References:
Not available.
Sniffin' Sticks and olfactory system imaging in patients with Kallmann syndrome
Background: The relationship between olfactory function, rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin' Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical thickness close to the OS, and olfactory phenotype. Methods: Olfaction was assessed administering Sniffin' Sticks®, in 38 KS patients and 17 controls (by means of Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) to study OB volume, sulcus depth, and cortical thickness. Results: Compared to controls, KS patients showed smaller OB volume (p<0.0001), reduced sulcus depth (p<0.0001), and thicker cortex in the region close to the OS (p<0.0001). Anosmic KS patients had smaller OB than controls and hyposmic KS patients; there was no difference between hyposmic KS patients and controls. OB volume correlated with Sniffin' Sticks score (r = 0.64; p < 0.001), OS depth (p<0.0001) and, inversely, with cortical thickness changes (p<0.0001). Sniffin' Sticks showed an inverse correlation with cortical thickness (r = -0.5; p<0.0001) and a trend toward a statistically significant correlation with OS depth. Conclusion: The present study provides further evidence of the strict relationship between olfaction and OB volume. The strong correlation between OB volume and the overlying cortical changes highlights the key role of rhinencephalon in forebrain embryogenesis. © 2015 ARS-AAOA, LLC.
Background: The relationship between olfactory function, rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin' Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical thickness close to the OS, and olfactory phenotype. Methods: Olfaction was assessed administering Sniffin' Sticks®, in 38 KS patients and 17 controls (by means of Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) to study OB volume, sulcus depth, and cortical thickness. Results: Compared to controls, KS patients showed smaller OB volume (p<0.0001), reduced sulcus depth (p<0.0001), and thicker cortex in the region close to the OS (p<0.0001). Anosmic KS patients had smaller OB than controls and hyposmic KS patients; there was no difference between hyposmic KS patients and controls. OB volume correlated with Sniffin' Sticks score (r = 0.64; p < 0.001), OS depth (p<0.0001) and, inversely, with cortical thickness changes (p<0.0001). Sniffin' Sticks showed an inverse correlation with cortical thickness (r = -0.5; p<0.0001) and a trend toward a statistically significant correlation with OS depth. Conclusion: The present study provides further evidence of the strict relationship between olfaction and OB volume. The strong correlation between OB volume and the overlying cortical changes highlights the key role of rhinencephalon in forebrain embryogenesis. © 2015 ARS-AAOA, LLC.
Sniffin' Sticks and olfactory system imaging in patients with Kallmann syndrome
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Sniffin' Sticks and olfactory system imaging in patients with Kallmann syndrome
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Cascino G, Canna A, Monteleone AM, Russo AG, Prinster A, Aiello M, Esposito F, Salle FD, Monteleone P
* Cortical thickness, local gyrification index and fractal dimensionality in people with acute and recovered Anorexia Nervosa and in people with Bulimia Nervosa (93 views)
Psychiatry Res Neuroimaging (ISSN: 0925-4927linking), 2020 May 30; 299: 111069-111069.
Impact Factor: 2.063
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* Cortical thickness, local gyrification index and fractal dimensionality in people with acute and recovered Anorexia Nervosa and in people with Bulimia Nervosa (93 views)
Psychiatry Res Neuroimaging (ISSN: 0925-4927linking), 2020 May 30; 299: 111069-111069.
Impact Factor: 2.063
View Export to BibTeX Export to EndNote
1 Records (1 excluding Abstracts).
Total impact factor: 2.063 (2.063 excluding Abstracts).
Total 5 year impact factor: 0 (0 excluding Abstracts).
Total impact factor: 2.063 (2.063 excluding Abstracts).
Total 5 year impact factor: 0 (0 excluding Abstracts).
405 views. Last view on Monday 07 October 2024, 16:09:00
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