Sleep disordered breathing and airway disease in primary ciliary dyskinesia(483 views) Santamaria F, Esposito M, Montella S, Cantone E, Mollica C, De Stefano S, Mirra V, Carotenuto M
Department of Translational Medical Sciences, Reproductive and Odontostomatologic Sciences, Unit of Ear, Nose and Throat and Molecular and Cellular Biology and Pathology, Federico II University, Via Sergio Pansini, 5-80131 Naples, Italy
Department of Neurosciences, Reproductive and Odontostomatologic Sciences, Unit of Ear, Nose and Throat and Molecular and Cellular Biology and Pathology, Federico II University, Naples, Italy
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
Clinic of Child and Adolescent Neuropsychiatry, Department of Mental and Physical Health, and Preventive Medicine, Second University of Naples, Naples, Italy
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Knowles, M.R., Daniels, L.A., Davis, S.D., Zariwala, M.A., Leigh, M.W., Primary ciliary dyskinesia: Recent advances in diagnostics, genetics, and characterization of clinical disease (2013) Am. J. Respir. Crit. Care Med., 188, pp. 913-922
Sommer, J.U., Schäfer, K., Omran, H., Olbrich, H., Wallmeier, J., Blum, A., Hörmann, K., Stuck, B.A., ENT manifestations in patients with primary ciliary dyskinesia: Prevalence and significance of otorhinolaryngologic co-morbidities (2011) Eur. Arch. Otorhinolaryngol., 268, pp. 383-388
Kieckhefer, G.M., Lentz, M.J., Tsai, S.Y., Ward, T.M., Parent-child agreement in report of nighttime respiratory symptoms and sleep disruptions and quality (2009) J. Pediatr. Health Care, 23, pp. 315-316
Carson, D.K., Schauer, R.W., Mothers of children with asthma: Perceptions of parenting stress and the mother-child relationship (1992) Psychol. Rep., 71, pp. 1139-1138
Borgström, A., Nerfeldt, P., Friberg, D., Questionnaire OSA-18 has poor validity compared to polysomnography in pediatric obstructive sleep apnea (2013) Int. J. Pediatr. Otorhinolaryngol., 77, pp. 1864-1868
Miller, M.R., Hankinson, J., Brusasco, V., Burgos, F., Casaburi, R., Coates, A., Crapo, R., Gustafsson, P., Standardisation of spirometry (2005) Eur. Respir. J., 26, pp. 319-338
Fokkens, W.J., Lund, V.J., Mullol, J., Bachert, C., Alobid, I., Baroody, F., Cohen, N., Gevaert, P., EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists (2012) Rhinology, 50, pp. 1-12
Lund, V.J., Kennedy, D.W., Quantification for staging sinusitis. The Staging and Therapy Group (1995) Ann. Otol. Rhinol. Laryngol. Suppl., 167, pp. 17-21
Marcus, C.L., Omlin, K.J., Basinki, D.J., Bailey, S.L., Rachal, A.B., Von Pechmann, W.S., Keens, T.G., Ward, S.L., Normal polysomnographic values for children and adolescents (1992) Am. Rev. Respir. Dis., 146, pp. 1235-1239
Goh, D.Y., Galster, P., Marcus, C.L., Sleep architecture and respiratory disturbances in children with obstructive sleep apnea (2000) Am. J. Respir. Crit. Care Med., 162, pp. 682-686
Helbich, T.H., Heinz-Peer, G., Eichler, I., Wunderbaldinger, P., Götz, M., Wojnarowski, C., Brasch, R.C., Herold, C.J., Cystic fibrosis: CT assessment of lung involvement in children and adults (1999) Radiology, 213, pp. 537-544
Hadfield, P.J., Rowe-Jones, J.M., Bush, A., Mackay, I.S., Treatment of otitis media with effusion in children with primary ciliary dyskinesia (1997) Clin. Otolaryngol. Allied Sci., 22, pp. 302-306
Woodson, B.T., Franco, R., Physiology of sleep disordered breathing (2007) Otolaryngol. Clin. North Am., 40, pp. 691-711
Katz, E.S., D'Ambrosio, C.M., Pathophysiology of pediatric obstructive sleep apnea (2008) Proc. Am. Thorac. Soc., 5, pp. 253-262
Emilsson, O.I., Janson, C., Benediktsdõttir, B., Júlíusson, S., Gíslason, T., Nocturnal gastroesophageal reflux, lung function and symptoms of obstructive sleep apnea: Results from an epidemiological survey (2012) Respir. Med., 106, pp. 459-466
Ramos, R.T., Salles, C., Gregõrio, P.B., Barros, A.T., Santana, A., Araújo-Filho, J.B., Acosta, A.X., Evaluation of the upper airway in children and adolescents with cystic fibrosis and obstructive sleep apnea syndrome (2009) Int. J. Pediatr. Otorhinolaryngol., 73, pp. 1780-1785
Hudgel, D.W., Martin, R.J., Capehart, M., Johnson, B., Hill, P., Contribution of hypoventilation to sleep oxygen desaturation in chronic obstructive pulmonary disease (1983) J. Appl. Physiol., 55, pp. 669-677
Becker, H.F., Piper, A.J., Flynn, W.E., McNamara, S.G., Grunstein, R.R., Peter, J.H., Sullivan, C.E., Breathing during sleep in patients with nocturnal desaturation (1999) Am. J. Respir. Crit. Care Med., 159, pp. 112-118
Noone, P.G., Leigh, M.W., Sannuti, A., Minnix, S.L., Carson, J.L., Hazucha, M., Zariwala, M.A., Knowles, M.R., Primary ciliary dyskinesia: Diagnostic and phenotypic features (2004) Am. J. Respir. Crit. Care Med., 169, pp. 459-467
Ng, S.S., Chan, T.O., To, K.W., Ngai, J., Tung, A., Ko, F.W., Hui, D.S., Validation of Embletta portable diagnostic system for identifying patients with suspected obstructive sleep apnoea syndrome (OSAS) (2010) Respirology, 15, pp. 336-342
Skinner, M.A., Choudhury, M.S., Homan, S.D., Cowan, J.O., Wilkins, G.T., Taylor, D.R., Accuracy of monitoring for sleep-related breathing disorders in the coronary care unit (2005) Chest, 127, pp. 66-71
Sleep disordered breathing and airway disease in primary ciliary dyskinesia
Background and objective Sleep-disordered breathing (SDB) may develop in primary ciliary dyskinesia (PCD), leading to these diseases worsening one another. Methods Sixteen stable PCD patients (4. 9-17. 2 years) and 42 controls underwent overnight respiratory polysomnography (rPSG) and Sleep Disturbances Scale for Children (SDSC). In PCD we assessed nasal endoscopy, pulmonary function tests and chest high-resolution computed tomography (HRCT). Results Compared with controls, PCD had higher obstructive apnoea (4. 7 vs 0. 2, P < 0. 001), central apnoea (0. 8 vs 0. 2, P < 0. 001), hypopnoea (1. 8 vs 0. 2, P < 0. 001), apnoea-hypopnoea (7. 8 vs 0. 6, P < 0. 001), oxygen desaturation indexes (ODI; 0. 7 vs 0. 2, P = 0. 002), and mean oxygen desaturation (4% vs 1%, P < 0. 001), while mean and nadir oxygen saturation (97. 1% vs 98. 1, P < 0. 001) (93% vs 97. 2%, P < 0. 001) were lower, respectively. In PCD, SDSC was unrelated to rPSG (P > 0. 05), with total score and subscores of disorders in initiating and maintaining sleep, and sleep-wake transition lower than controls. PCD patients had chronic rhinosinusitis (100%) and adenoidal hypertrophy (50%). Total HRCT score was 7 (range 0-14). ODI correlated with functional residual capacity (r = 0. 8, P = 0. 02), total HRCT (r = 0. 6, P = 0. 03) and peribronchial thickening scores (r = 0. 7, P = 0. 02). Oxygen saturation was associated with bronchiectasis severity score (r = -0. 6, P = 0. 02). Conclusions PCD's parents may underestimate SDB. As nocturnal desaturation is associated with lung function and structure abnormalities, SDB may significantly contribute to pulmonary morbidity. 2014 The Authors. Respirology 2014 Asian Pacific Society of Respirology
Sleep disordered breathing and airway disease in primary ciliary dyskinesia
No results.
Sleep disordered breathing and airway disease in primary ciliary dyskinesia