Peptides for tumour therapy and diagnosis: current status and future directions (1819 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T, Review,
Impact factor: 4.708, 5-year impact factor: 5.387
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-65649117755&partnerID=40&md5=cdd96a1100d9d9938e34dcf08a217bfa
Keywords: Cck, Integrin, Somatostatin, Structure-Activity Relationships, Tumour Diseases, 4 [[5 (8 Azaspiro[4 5]decan 8 Yl) 4 [(3, 5 Dichlorobenzoyl)amino] 5 Oxopentanoyl]amino] 5 (1 Naphthylamino) 5 Oxopentanoic Acid, Angiopeptin, Arginylglycylaspartic Acid, Cholecystokinin, Cholecystokinin Receptor, Cholecystokinin Receptor Blocking Agent, Cilengitide, Cr 2345, Cr 2767, Depreotide Tc 99m, Integrin Receptor, Itriglumide, Lorglumide, Loxiglumide, Nc 100692 Technetium Tc 99m, Octreotate[3 Tyrosine 1, 10 Tetraazacyclododecane 1, 10 Tetraacetic Acid Lu 177], Octreotide, Octreotide[3 Tyrosine 1, 10 Tetraacetic Acid Y 90], Pasireotide, Pentetreotide In 111, Proglumide, Radiopharmaceutical Agent, Somatostatin Derivative, Somatostatin Receptor, Spiroglumide, Unclassified Drug, Unindexed Drug, Vapreotide, Acromegaly, Antiangiogenic Activity, Breast Cancer, Cancer Chemotherapy, Cancer Diagnosis, Cancer Scintiscanning, Carcinoid, Clinical Trial, Diagnostic Accuracy, Drug Distribution, Drug Megadose, Drug Metabolism, Drug Receptor Binding, Drug Structure, Drug Synthesis, Gastrinoma, Gastrointestinal Tumor, Human, Isotope Labeling, Liver Metastasis, Neuroendocrine Tumor, Nonhuman, Paraganglioma, Protein Expression, Protein Targeting, Review, Single Photon Emission Computer Tomography, Thyroid Medullary Carcinoma, Amino Acid Sequence, Animals, Drug Delivery Systems, Molecular Sequence Data, Neoplasms, Peptides, 4 [[5 (8 Azaspiro [4 5] Decan 8 Yl) 4 [(3, 5 Dichlorobenzoyl) Amino] 5 Oxopentanoyl] Amino] 5 (1 Naphthylamino) 5 Oxopentanoic Acid, Octreotate [3 Tyrosine 1, Octreotide [3 Tyrosine 1,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, University of Naples Federico II, via Mezzocannone 16, 80134, Napoli, Italy.
Institute of Biostructures and Bioimaging, CNR, University of Naples Federico II, via Mezzocannone 16, 80134 Napoli, Italy
References:
Not available.
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T, Review,
Impact factor: 4.708, 5-year impact factor: 5.387
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-65649117755&partnerID=40&md5=cdd96a1100d9d9938e34dcf08a217bfa
Keywords: Cck, Integrin, Somatostatin, Structure-Activity Relationships, Tumour Diseases, 4 [[5 (8 Azaspiro[4 5]decan 8 Yl) 4 [(3, 5 Dichlorobenzoyl)amino] 5 Oxopentanoyl]amino] 5 (1 Naphthylamino) 5 Oxopentanoic Acid, Angiopeptin, Arginylglycylaspartic Acid, Cholecystokinin, Cholecystokinin Receptor, Cholecystokinin Receptor Blocking Agent, Cilengitide, Cr 2345, Cr 2767, Depreotide Tc 99m, Integrin Receptor, Itriglumide, Lorglumide, Loxiglumide, Nc 100692 Technetium Tc 99m, Octreotate[3 Tyrosine 1, 10 Tetraazacyclododecane 1, 10 Tetraacetic Acid Lu 177], Octreotide, Octreotide[3 Tyrosine 1, 10 Tetraacetic Acid Y 90], Pasireotide, Pentetreotide In 111, Proglumide, Radiopharmaceutical Agent, Somatostatin Derivative, Somatostatin Receptor, Spiroglumide, Unclassified Drug, Unindexed Drug, Vapreotide, Acromegaly, Antiangiogenic Activity, Breast Cancer, Cancer Chemotherapy, Cancer Diagnosis, Cancer Scintiscanning, Carcinoid, Clinical Trial, Diagnostic Accuracy, Drug Distribution, Drug Megadose, Drug Metabolism, Drug Receptor Binding, Drug Structure, Drug Synthesis, Gastrinoma, Gastrointestinal Tumor, Human, Isotope Labeling, Liver Metastasis, Neuroendocrine Tumor, Nonhuman, Paraganglioma, Protein Expression, Protein Targeting, Review, Single Photon Emission Computer Tomography, Thyroid Medullary Carcinoma, Amino Acid Sequence, Animals, Drug Delivery Systems, Molecular Sequence Data, Neoplasms, Peptides, 4 [[5 (8 Azaspiro [4 5] Decan 8 Yl) 4 [(3, 5 Dichlorobenzoyl) Amino] 5 Oxopentanoyl] Amino] 5 (1 Naphthylamino) 5 Oxopentanoic Acid, Octreotate [3 Tyrosine 1, Octreotide [3 Tyrosine 1,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, University of Naples Federico II, via Mezzocannone 16, 80134, Napoli, Italy.
Institute of Biostructures and Bioimaging, CNR, University of Naples Federico II, via Mezzocannone 16, 80134 Napoli, Italy
References:
Not available.
Peptides for tumour therapy and diagnosis: current status and future directions
The use of peptides as targeting tools has been validated in different applications. In particular radiolabelled peptides with adequate stability, receptor-binding properties and biokinetic behaviour have been investigated as an important class of radiopharmaceuticals for cancer pathology imaging and therapy. This review focuses on recent progress in design and synthetic modifications of small biologically active peptides used in diagnosis and therapy. In particular, we report the current development and optimization of suitable peptides for targeting three relevant biological receptors (CCK, somatostatin, and integrin receptors) involved in specific tumour diseases.
The use of peptides as targeting tools has been validated in different applications. In particular radiolabelled peptides with adequate stability, receptor-binding properties and biokinetic behaviour have been investigated as an important class of radiopharmaceuticals for cancer pathology imaging and therapy. This review focuses on recent progress in design and synthetic modifications of small biologically active peptides used in diagnosis and therapy. In particular, we report the current development and optimization of suitable peptides for targeting three relevant biological receptors (CCK, somatostatin, and integrin receptors) involved in specific tumour diseases.
Peptides for tumour therapy and diagnosis: current status and future directions
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Peptides for tumour therapy and diagnosis: current status and future directions
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
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* Radiolabeled peptides and their expanding role in clinical imaging and targeted cancer therapy (397 views)
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Impact Factor: 1.807
View Export to BibTeX Export to EndNote
Platella C, Napolitano E, Riccardi C, Musumeci D, Montesarchio D
* Disentangling the Structure-Activity Relationships of Naphthalene Diimides as Anticancer G-Quadruplex-Targeting Drugs (279 views)
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Impact Factor: 7.446
View Export to BibTeX Export to EndNote
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Camera L, Severino R, Faggiano A, Masone S, Mansueto G, Maurea S, Fonti R, Salvatore M
* Contrast enhanced multi-detector CT and MR findings of a well-differentiated pancreatic vipoma (877 views)
World J Radiol (ISSN: 1949-8470, 1949-8470electronic, 1949-8470linking), 2014 Oct 28; 6(10): 840-845.
Impact Factor: 0.567
View Export to BibTeX Export to EndNote
Ramundo V, Del Prete M, Marotta V, Marciello F, Camera L, Napolitano V, de LucaL, Circelli L, Colantuoni V, Di Sarno A, Carratu AC, Di Roseto CDL, Colao A, Faggiano A
* Impact of long-acting octreotide in patients with early-stage MEN1-related duodeno-pancreatic neuroendocrine tumours (894 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265), 2014 Jun; 80(6): 850-855.
Impact Factor: 3.457
View Export to BibTeX Export to EndNote
Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (1408 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
View Export to BibTeX Export to EndNote
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (2719 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
View Export to BibTeX Export to EndNote
Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (810 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Faggiano A, Ramundo V, Del Prete M, Marotta V, Marciello F, Camera L, Napolitano V, de LucaL, Lombardi G, Colao A
* Long-Acting Somatostatin Analogues are Highly Effective in Patients with Early Stage MEN-1-Related Well-Differentiated Neuroendocrine Tumors (418 views)
Neuroendocrinology (ISSN: 0028-3835, 0028-3835linking), 2012; 96: N/D-N/D.
Impact Factor: 3.537
View Export to BibTeX Export to EndNote
Zaccaro L, Garcia-lopez Mt Gonzalez-muniz RG
* TRPV1 modulators: Structure-activity relationships using a rational combinatorial approach (928 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2011 Jun 15; 21(12): 3541-3545.
Impact Factor: 2.554
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (790 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
View Export to BibTeX Export to EndNote
Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
* In-111-pentetreotide scintigraphy: procedure guidelines for tumour imaging (887 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jul; 37(7): 1441-1448.
Impact Factor: 5.036
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (956 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Storto G, Erra P, Pellegrino T, Nardelli A, Milone F, Di Giorgio E, Faggiano A, Castaldi E, Ortosecco G, Speranza A, Klain M, Colao A, Salvatore M, Pace L
* Efficacy and Toxicity of Peptide Receptor Radionuclide Therapy (PRRT) using medium-high activities of Y-90-DOTA-Octreotate (Y-90-DOTATATE) in patients with tumours expressing somatostatin receptors (SSTR) (719 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
Impact Factor: 4.532
View Export to BibTeX Export to EndNote
Pulcrano M, Camera L, Pagano L, Del Vecchio S, Ferone D, Bodei L, Murgia A, Pace L, Storto G, Paganelli G, Colao A, Salvatore M, Lombardi G, Biondi B
* Usefulness of [(111)In-DTPA(0)] octreotide scintigraphy in a family with von Hippel-Lindau disease (577 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2008 Apr; 31(4): 352-359.
Impact Factor: 1.888
View Export to BibTeX Export to EndNote
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (786 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
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Benedetti E, Pedone C, Saviano M
* Structure-activity relationships in peptides: From modelling to rational drug design (1827 views)
Front Drug Des And Discov (ISSN: 1574-0889), 2007; 3(1): 539-558.
Impact Factor: 0
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Vitale RM, Pedone C, De Benedetti PG, Fanelli F
* Structural features of the inactive and active states of the melanin-concentrating hormone receptors: Insights from molecular simulations (816 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Sep 15; 56(3): 430-448.
Impact Factor: 4.429
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (730 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (1251 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
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Camera L, Del Vecchio S, Quarantelli M, Ibello F, Pellegrino T, Salvatore M
* Radiolabeled somatostatin analogs in the diagnosis and staging of neuroendocrine tumors (568 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2003; 26(8Suppl): 60-62.
Impact Factor: 1.621
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Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (703 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (672 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Lastoria S, Vergara E, Palmieri G, Acampa W, Varrella P, Caracò C, Bianco RA, Muto P, Salvatore M
In vivo detection of malignant thymic masses by indium-111-DTPA-D- Phe1-octreotide scintigraphy (654 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Apr; 39(4): 634-639.
Impact Factor: 3.064
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Maurea S, Lastoria S, Caracò C, Klain M, Varrella P, Acampa W, Muto P, Salvatore M
The role of radiolabeled somatostatin analogs in adrenal imaging (788 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 677-680.
Impact Factor: 1.042
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Lastoria S, Muto P, Acampa W, Caraco C, Vergara E, Varrella P, Pezzullo L, Ionna F, Mozzillo N, ListerJames J, Salvatore M
Somatostatin receptor scintigraphy (SRS) with technetium-99m labeled synthetic peptides in melanoma (629 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 May; 37(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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Lastoria S, Maurea S, Vergara E, Acampa W, Varrella P, Klain M, Muto P, Bernardy JD, Salvatore M
Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors (648 views)
Q J Nucl Med (ISSN: 1125-0135, 1124-3937), 1995 Dec; 39(4Suppl1): 145-149.
Impact Factor: 2.125
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Muto P, Lastoria S, Vergara E, Caraco C, Varrella P, Bernardy JD, Acampa W, Salvatore M
Tc-99m labeled somatostatin analogs to image tumors expressing specific receptors (791 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995; 36(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW DISEASES EXPRESSING SOMATOSTATIN RECEPTORS BY IN-111 OCTREOTIDE (453 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW NEOPLASTIC LESIONS EXPRESSING SOMATOSTATIN RECEPTORS USING IN-111 OCTREOTIDE (731 views)
Posters Tomes 1 4proceedings Of The Xvi International Cancer Congress Free Papers And, 1994; N/D: N/D-N/D.
Impact Factor: 0
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31 Records (25 excluding Abstracts).
Total impact factor: 112.406 (93.864 excluding Abstracts).
Total 5 year impact factor: 119.937 (95.691 excluding Abstracts).
Total impact factor: 112.406 (93.864 excluding Abstracts).
Total 5 year impact factor: 119.937 (95.691 excluding Abstracts).
1819 views. Last view on Monday 07 April 2025, 5:04:16
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