Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates(649 views) Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8512-8520.
Keywords: (2 Nitro Imidazol 1 Yl) Acetic Acid, 2 (2 Nitro Imidazol 1 Yl) N (3 Sulfamoylphenyl)acetamide, 2 (2 Nitro Imidazol 1 Yl) N (4 Sulfamoylbenzyl)acetamide, 2 (2 Nitro Imidazol 1 Yl) N (4 Sulfamoylphenyl)acetamide, 2 (2 Nitro Imidazol 1 Yl) N [2 (4 Sulfamoylphenyl)ethyl]acetamide, 2 (2 Nitro Imidazol 1 Yl)ethylamine, Antineoplastic Agent, Carbonate Dehydratase Inhibitor, Carbonate Dehydratase Xii, Doxorubicin, N (3 Sulfamoylphenyl) N [(2 Aminoethyl) 2 Methyl 5 Nitroimidazolyl] Thiourea, N (4 Sulfamoylbenzyl) N [(2 Aminoethyl) 2 Methyl 5 Nitroimidazolyl] Thiourea, N (4 Sulfamoylphenyl) N [(2 Aminoethyl) 2 Methyl 5 Nitroimidazolyl] Thiourea, N (4 Sulfamoylphenylethyl) N [(2 Aminoethyl) 2 Methyl 5 Nitroimidazolyl] Thiourea, N [2 (2 Methyl 5 Nitro Imidazol 1 Yl)ethyl]sulfamide, N [2 (2 Methyl Imidazol 1 Yl)propyl]sulfamide, N [2 (2 Nitro Imidazol 1 Yl)ethyl]sulfamide, N Methanesulfonyl 1 (2 Aminoethyl) 2 Methyl 5 Nitroimidazole, N Methanesulfonyl 2 (2 Nitro Imidazol 1 Yl)ethylamine, N[2 (2 Methyl 5 Nitro Imidazol 1 Yl)ethyl]sulfamate, Nitroimidazole Derivative, Sulfamide Derivative, Sulfonamide, Tert Butyl (2 Nitro Imidazol 1 Yl) Acetate, Unclassified Drug, Acidosis, Animal Cell, Animal Experiment, Animal Model, Article, Chemosensitization, Controlled Study, Enzyme Active Site, Enzyme Activity, Hela Cell, Human, Human Cell, Hypoxia, In Vitro Study, In Vivo Study, Mouse, Nonhuman, Protein Expression, X Ray Crystallography, Anoxia, Antigens, Carbonic Anhydrases, Dose-Response Relationship, Enzyme Inhibitors, Ht29 Cells, Molecular, Molecular Structure, Structure-Activity Relationship, Sulfonic Acids, Amides Chemistry, Neoplasm Metabolism, Carbonic Anhydrases Metabolism, Enzyme Inhibitors Chemical Synthesis Chemistry Pharmacology, Nitroimidazoles Chemistry, Sulfonamides Chemistry, Sulfonic Acids Chemistry, 2 (2 Nitro Imidazol 1 Yl) N (3 Sulfamoylphenyl) Acetamide, 2 (2 Nitro Imidazol 1 Yl) N (4 Sulfamoylbenzyl) Acetamide, 2 (2 Nitro Imidazol 1 Yl) N (4 Sulfamoylphenyl) Acetamide, 2 (2 Nitro Imidazol 1 Yl) N [2 (4 Sulfamoylphenyl) Ethyl] Acetamide, 2 (2 Nitro Imidazol 1 Yl) Ethylamine, N [2 (2 Methyl 5 Nitro Imidazol 1 Yl) Ethyl] Sulfamide, N [2 (2 Methyl Imidazol 1 Yl) Propyl] Sulfamide, N [2 (2 Nitro Imidazol 1 Yl) Ethyl] Sulfamide, N Methanesulfonyl 2 (2 Nitro Imidazol 1 Yl) Ethylamine, N [2 (2 Methyl 5 Nitro Imidazol 1 Yl) Ethyl] Sulfamate,
Affiliations: *** IBB - CNR ***
Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM1-UM2 Baîtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France
Department of Radiation Oncology (MAASTRO Lab), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Universiteitssingel 50/23, 6200 MD, Maastricht, Netherlands
Istituto di Biostrutture e Bioimmagini - CNR, via Mezzocannone 16, 80134 Naples, Italy
Neurofarba Department, Section of Pharmaceutical Sciences, Università Degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy
References: Not available.
Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates