Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (402 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
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Paper type: Journal Article,
Impact factor: 1.045, 5-year impact factor: 0
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031731331&partnerID=40&md5=bbd1bb0424eae186a3f9d3fbf8468039
Keywords: Avidin, Biological Response Markers, Biotin, Ca-19-9 Antigen, Carcinoembryonic Antigen, Colonic Neoplasms, Colorectal Neoplasms, Immunohistochemistry, Indiumradioisotopes, Interferon-Beta, Iodine Radioisotopes, Lymph Node Excision, Lymph Nodes Radionuclide Imaging, Monoclonal Antibodies, Radioimmunodetection, Staining, Technetium Compounds, Tissue Polypeptide Antigen, Beta Interferon, Carcinoembryonic Antibody, Indium 111, Iodine 125, Monoclonal Antibody B 72 3, Technetium 99m, Cancer Localization, Cancer Recurrence, Cancer Staging, Colorectal Cancer, Conference Paper, Diagnostic Accuracy, Diagnostic Value, Human, Immunoscintigraphy, Intravenous Drug Administration, Lymph Node Metastasis, Major Clinical Study, Peroperative Care, Priority Journal, Radioimmunology, Radiosurgery, Surgical Technique, Treatment Outcome,
Affiliations:
Dept. Gen. Surg. Organ Transplant, Med. Sch. of the Univ. Federico II, Naples, Italy
Department of Nuclear Medicine, Med. Sch. of the Univ. Federico II, Naples, Italy
25 Salita Arenella, 80129 Naples, Italy
References:
Not available.
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.045, 5-year impact factor: 0
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031731331&partnerID=40&md5=bbd1bb0424eae186a3f9d3fbf8468039
Keywords: Avidin, Biological Response Markers, Biotin, Ca-19-9 Antigen, Carcinoembryonic Antigen, Colonic Neoplasms, Colorectal Neoplasms, Immunohistochemistry, Indiumradioisotopes, Interferon-Beta, Iodine Radioisotopes, Lymph Node Excision, Lymph Nodes Radionuclide Imaging, Monoclonal Antibodies, Radioimmunodetection, Staining, Technetium Compounds, Tissue Polypeptide Antigen, Beta Interferon, Carcinoembryonic Antibody, Indium 111, Iodine 125, Monoclonal Antibody B 72 3, Technetium 99m, Cancer Localization, Cancer Recurrence, Cancer Staging, Colorectal Cancer, Conference Paper, Diagnostic Accuracy, Diagnostic Value, Human, Immunoscintigraphy, Intravenous Drug Administration, Lymph Node Metastasis, Major Clinical Study, Peroperative Care, Priority Journal, Radioimmunology, Radiosurgery, Surgical Technique, Treatment Outcome,
Affiliations:
Dept. Gen. Surg. Organ Transplant, Med. Sch. of the Univ. Federico II, Naples, Italy
Department of Nuclear Medicine, Med. Sch. of the Univ. Federico II, Naples, Italy
25 Salita Arenella, 80129 Naples, Italy
References:
Not available.
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions
Intraoperative radioimmunodetection is a new staging technique for epithelial neoplasms. After intravenous injection, a radioimmunoconjugate compound (monoclonal antibody and isotope) attaches itself to the antigens expressed on the surface of neoplastic cells, causing them to emit gamma rays. Radioactivity is detected at the presurgical stage by immunoscintigraphy and intraoperatively with a gamma-detecting probe (GDP). In our experience, intraoperative tumor-to-normal-tissue (T/NT) GDP ratio counts ≥3:1 were considered positive radioimmunoguided surgery (RIGS) findings. We studied 52 colorectal cancer patients, 48 with primary lesions and 7 with relapses. Positive RIGS findings were obtained in 33 patients whose lymph node assessments were characterised by eight false positive identifications. In 10 patients, RIGS data yielded a more accurate staging of the disease. Unreliable RIGS findings were recorded in 15 patients: four injected with monoclonal antibody (MAb) B72.3 labeled with Iodine-125; five with MAb anti-carcinoembryonic antigen (CEA) labeled with 99mTechnetium (Tc); two with MAb B72.3 labeled with Indium-111; and three with MAb B72.3 labeled with Iodine-131 plus interferon-beta. In analysis, our experience did not permit definitive evaluation of the method's diagnostic and staging accuracy.
Intraoperative radioimmunodetection is a new staging technique for epithelial neoplasms. After intravenous injection, a radioimmunoconjugate compound (monoclonal antibody and isotope) attaches itself to the antigens expressed on the surface of neoplastic cells, causing them to emit gamma rays. Radioactivity is detected at the presurgical stage by immunoscintigraphy and intraoperatively with a gamma-detecting probe (GDP). In our experience, intraoperative tumor-to-normal-tissue (T/NT) GDP ratio counts ≥3:1 were considered positive radioimmunoguided surgery (RIGS) findings. We studied 52 colorectal cancer patients, 48 with primary lesions and 7 with relapses. Positive RIGS findings were obtained in 33 patients whose lymph node assessments were characterised by eight false positive identifications. In 10 patients, RIGS data yielded a more accurate staging of the disease. Unreliable RIGS findings were recorded in 15 patients: four injected with monoclonal antibody (MAb) B72.3 labeled with Iodine-125; five with MAb anti-carcinoembryonic antigen (CEA) labeled with 99mTechnetium (Tc); two with MAb B72.3 labeled with Indium-111; and three with MAb B72.3 labeled with Iodine-131 plus interferon-beta. In analysis, our experience did not permit definitive evaluation of the method's diagnostic and staging accuracy.
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions
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Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 3.151
View Export to BibTeX Export to EndNote
Mainenti PP, Iodice D, Segreto S, Storto G, Magliulo M, De Palma GD, Salvatore M, Pace L
* Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging? (504 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2011 Mar 21; 17(11): 1427-1433.
Impact Factor: 2.471
View Export to BibTeX Export to EndNote
Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (632 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
View Export to BibTeX Export to EndNote
Matrone A, Russo M, Mollica C, Lombardi D, Lombardi G, Maurea S, Imbriaco M
* Lymphoepithelial pancreatic cyst: an atypical benign pancreatic mass presenting with a "cheerios-like" appearance (474 views)
Jop (ISSN: 1590-8577, 1590-0857), 2010 Mar 5; 11(2): 170-172.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (568 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
View Export to BibTeX Export to EndNote
Mainenti PP, Salvatore B, Sirignano C, De Falco T, Speranza A, Fiumara G, Ricci F, Evangelista L, Pace L, Salvatore M
* PET/CT colonography in patients with colo-rectal polyps: A feasibility study (551 views)
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Impact Factor: 4.101
View Export to BibTeX Export to EndNote
Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (502 views)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
View Export to BibTeX Export to EndNote
Mainenti PP, Romano M, Imbriaco M, Camera L, Pace L, D'Antonio D, Bucci L, Galloro G, Salvatore M
* Added value of CT colonography after a positive conventional colonoscopy: Impact on treatment strategy (534 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2005 Jan; 30(1): 42-47.
Impact Factor: 1.034
View Export to BibTeX Export to EndNote
Salvatore M, Fonti R
* New frontiers of nuclear medicine (572 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
View Export to BibTeX Export to EndNote
Esposito G, Tempesta A, Galati MG, De Bellis M, Rossi GB, Potena MI, Marone P, Daniele B, Del Vecchio S
Mucosal expression of carcinoembryonic antigen and carbohydrate antigen 19-9 in patients with gastritis and gastric cancer (409 views)
Cancer Detect Prev (ISSN: 0361-090x, 0361-090xlinking), 1999; 23(2): 116-122.
Impact Factor: 0.927
View Export to BibTeX Export to EndNote
Russo GL, Della Pietra V, Mercurio C, Palumbo R, Iacomino G, Russo M, Tosto M, Zappia V
Protective effects of butyric acid in colon cancer (429 views)
Adv Exp Med Biol (ISSN: 0065-2598print, 0065-2598linking), 1999; 472: 131-147.
Impact Factor: 0.446
View Export to BibTeX Export to EndNote
Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (683 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
Valenza V, Maussier ML, D'Errico G, Lemmo GF, Frontera D, Ferrante A, Saletnich I, Valli A, Quarantelli M
Cancer of the pancreas and the periampullary region: The usefulness of tumor marker products with the monoclonal antibody technique (379 views)
J Nucl Med Allied Sci (ISSN: 0392-0208), 1990 Oct; 34(4SUPPL.): 131-134.
Impact Factor: 1.91
View Export to BibTeX Export to EndNote
Steis RG, Carrasquillo JA, Mccabe R, Bookman MA, Reynolds JC, Larson SM, Smith JW, Clark JW, Dailey V, Del Vecchio S
Toxicity, immunogenicity, and tumor radioimmunodetecting ability of two human monoclonal antibodies in patients with metastatic colorectal carcinoma (370 views)
J Clin Oncol (ISSN: 0732-183x, 0732-183xlinking), 1990 Mar; 8(3): 476-490.
Impact Factor: 7.878
View Export to BibTeX Export to EndNote
Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (463 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
View Export to BibTeX Export to EndNote
24 Records (23 excluding Abstracts).
Total impact factor: 70.082 (69.815 excluding Abstracts).
Total 5 year impact factor: 76.277 (75.208 excluding Abstracts).
Total impact factor: 70.082 (69.815 excluding Abstracts).
Total 5 year impact factor: 76.277 (75.208 excluding Abstracts).
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