Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions(317 views) Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Affiliations: Dept. Gen. Surg. Organ Transplant, Med. Sch. of the Univ. Federico II, Naples, Italy
Department of Nuclear Medicine, Med. Sch. of the Univ. Federico II, Naples, Italy
25 Salita Arenella, 80129 Naples, Italy
References: Schulte, W.J., Use of monoclonal antibodies in colorectal cancer: A review (1996) World J Surg, 20, pp. 238-24
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Bertsch, D.J., Burak Jr., W.E., Young, D.C., Radioimmunoguided Surgery system improves survival for patients with recurrent colorectal cancer (1995) Surgery, 118, pp. 634-639
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Schulte, W. J., Use of monoclonal antibodies in colorectal cancer: A review (1996) World J Surg, 20, pp. 238-24
Martin, D. T., Hinkle, G. H., Tuttle, S. E., Intraoperative immunodetection of colorectal tumors with a hand-held radiation detector (1985) Am J Surg, 150, pp. 672-675
Martin Jr., E. W., Tuttle, S. E., Rousseau, M., Radioimmunoguided surgery: Intraoperative use of monoclonal antibody 17-1A in colorectal cancer (1986) Hybridoma, 5 (1 SUPPL.), pp. S97-S108
Arnold, M. W., Young, D. C., Hitchcock, C. L., Radioimmunoguided surgery in primary colorectal carcinoma: An intraoperative prognostic tool and adjuvant to traditional staging (1995) Am J Surg, 170, pp. 315-318
Bertsch, D. J., Burak Jr., W. E., Young, D. C., Radioimmunoguided Surgery system improves survival for patients with recurrent colorectal cancer (1995) Surgery, 118, pp. 634-639
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions
Intraoperative radioimmunodetection is a new staging technique for epithelial neoplasms. After intravenous injection, a radioimmunoconjugate compound (monoclonal antibody and isotope) attaches itself to the antigens expressed on the surface of neoplastic cells, causing them to emit gamma rays. Radioactivity is detected at the presurgical stage by immunoscintigraphy and intraoperatively with a gamma-detecting probe (GDP). In our experience, intraoperative tumor-to-normal-tissue (T/NT) GDP ratio counts ≥3:1 were considered positive radioimmunoguided surgery (RIGS) findings. We studied 52 colorectal cancer patients, 48 with primary lesions and 7 with relapses. Positive RIGS findings were obtained in 33 patients whose lymph node assessments were characterised by eight false positive identifications. In 10 patients, RIGS data yielded a more accurate staging of the disease. Unreliable RIGS findings were recorded in 15 patients: four injected with monoclonal antibody (MAb) B72.3 labeled with Iodine-125; five with MAb anti-carcinoembryonic antigen (CEA) labeled with 99mTechnetium (Tc); two with MAb B72.3 labeled with Indium-111; and three with MAb B72.3 labeled with Iodine-131 plus interferon-beta. In analysis, our experience did not permit definitive evaluation of the method's diagnostic and staging accuracy.
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions
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Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions