Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder
CNR Ibb | back to homepage
CNR Ibb | back to homepage

Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder (448 views)

D'Antò V, Michelotti A, Esposito L, Zagari A, Liguori R, Sacchetti L

J Sci Med Sport (ISSN: 1440-2440), 2010; 13(6): 174-179.

Export to BibTeX    Export to EndNote

Paper type: Journal Article,

Impact factor: 3.194, 5-year impact factor: 3.834

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77958451506&doi=10.1016%2fj.pio.2010.09.007&partnerID=40&md5=6ade4f3b14b37ed6995e87f6f3e1a473

Keywords: Comt Gene, Disc Displacement Without Reduction, Mutation, Pain Sensitivity, Temporomandibular Joint Disorders, Catechol Methyltransferase, Genomic Dna, Adult, Article, Case Report, Clinical Assessment, Crystallography, Dna Sequence, Female, Gene Expression, Gene Mutation, Human, Jaw Disease, Masticatory Muscle, Myofascial Pain, Nociception, Nuclear Magnetic Resonance Imaging, Pain Assessment, Visual Analog Scale, Adenine, Agents Interacting With Transmitter, Hormone Or Drug Receptors, Arginine, Cytosine, Serine, Codon, Dislocation, Genetics, Joint Characteristics And Functions, Pathology, Physiology, Catechol O-Methyltransferase, Neurotransmitter Agents, Pain Measurement, Range Of Motion, Articular, Temporomandibular Joint Dysfunction Syndrome,

Affiliations:
*** IBB - CNR ***

Department of Oral and Maxillofacial Surgery, University of Naples Federico II, Italy
Institute of biostructure and bioimaging, CNR, Naples, Italy
CEINGE Biotecnologie Avanzate S.C.a R.L, Naples, Italy
Department of Biochemistry and Medical Biotechnology, University of Naples Federico II, Italy


References:
Not available.
Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder

We report a case of temporomandibular disorder patient with disc displacement without reduction, myofascial pain, limited opening and a novel, never described, nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene. COMT is one of the enzymes that metabolizes catecholamines, thereby acting as a key modulator of dopaminergic and adrenergic/noradrenergic neurotransmissions, which play a key role in pain modulation. This novel mutation, p.R58S, changed a codon (58 from arginine to serine) in the COMT protein. The introduction of a serine residue in a highly organised secondary structure, in critical regions of the protein, results in a structural alteration. Therefore, we speculate an influence of the mutation on the high pain sensitivity of the patient. © 2010 Società Italiana di Ortodonzia SIDO.
Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder

No results.
Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder

Filter those results▼
Query:  [X]
Options:
   Extended  
   IBB affiliation
 
Authors:  [X]
Paper type:  [X]
Start date:  [X]
End date:  [X]
Site:
[Clear form]
Select the year: 
Other filter: ([btitle,keywords] "Disc Displacement Wi ...

Sort by:   date ▼▲   title ▲ ▼   journal ▲ ▼   authors ▲ ▼   I.F. ▲ ▼
Olgiati S, De Rosa A, Quadri M, Criscuolo C, Breedveld GJ, Picillo M, Pappata S, Quarantelli M, Barone P, De Michele G, Bonifati V
* Park20 Caused By Synj1 Homozygous Arg258gln Mutation In A New Italian Family (595 views)
Neurogenetics (ISSN: 1364-6745, 1364-6753, 1364-6745linking), 2014 Aug; 15(3): 183-188.
Impact Factor: 2.884
View    Export to BibTeX    Export to EndNote

Quadri M, Fang M, Picillo M, Olgiati S, Breedveld Gj Graafland J, Wu B, Xu F, Erro R, Amboni M, Pappata S, Quarantelli M, Annesi G, Quattrone A, Chien Hf Barbosa ER, International Parkinsonism Genetics Network Oostra Ba Barone P, Wang J, Bonifati V
* Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism (497 views)
Hum Mutat (ISSN: 1059-7794, 1098-1004, 1098-1004electronic), 2013 Sep; 34(9): 1208-1215.
Impact Factor: 5.122
View    Export to BibTeX    Export to EndNote

D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (680 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
View    Export to BibTeX    Export to EndNote

D'Agata R, Breveglieri G, Zanoli LM, Borgatti M, Spoto G, Gambari R
* Direct Detection of Point Mutations in Nonamplified Human Genomic DNA (891 views)
Analytical Chemistry (ISSN: 0003-2700), 2011 Nov 15; 83(22): 8711-8717.
Impact Factor: 5.856
View    Export to BibTeX    Export to EndNote

D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA (608 views)
Lect Notes Electr Eng, 2010 May 15; 91LNEE: 485-488.
Impact Factor: 0
View    Export to BibTeX    Export to EndNote

D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (644 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
View    Export to BibTeX    Export to EndNote

D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Detection Of Non Amplified Genomic Dna By Advanced Spri Methods (262 views)
Chimica & L Industria, 2010; 7: 140-145.
Impact Factor: 0
View    Export to BibTeX    Export to EndNote

D'Agata R, Breveglieri G, Zanoli L, Borgatti M, Spoto G, Gambari R
* Surface Plasmon Resonance Imaging (SPR-I), peptide nucleic acid (PNA) probes and nanoparticle-enhancement for PCR-free ultrasensitive detection of beta-thalassemia mutations in human genomic DNA (367 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2010; 26: N/D-N/D.
Impact Factor: 1.814
View    Export to BibTeX    Export to EndNote

8 Records (6 excluding Abstracts).
Total impact factor: 21.037 (19.223 excluding Abstracts).
Total 5 year impact factor: 21.198 (19.379 excluding Abstracts).

Last modified by Marco Comerci on Sunday 12 July 2020, 13:15:01
448 views. Last view on Thursday 10 October 2024, 0:12:29