Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder
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Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder (443 views)

D'Antò V, Michelotti A, Esposito L, Zagari A, Liguori R, Sacchetti L

J Sci Med Sport (ISSN: 1440-2440), 2010; 13(6): 174-179.

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Paper type: Journal Article,

Impact factor: 3.194, 5-year impact factor: 3.834

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77958451506&doi=10.1016%2fj.pio.2010.09.007&partnerID=40&md5=6ade4f3b14b37ed6995e87f6f3e1a473

Keywords: Comt Gene, Disc Displacement Without Reduction, Mutation, Pain Sensitivity, Temporomandibular Joint Disorders, Catechol Methyltransferase, Genomic Dna, Adult, Article, Case Report, Clinical Assessment, Crystallography, Dna Sequence, Female, Gene Expression, Gene Mutation, Human, Jaw Disease, Masticatory Muscle, Myofascial Pain, Nociception, Nuclear Magnetic Resonance Imaging, Pain Assessment, Visual Analog Scale, Adenine, Agents Interacting With Transmitter, Hormone Or Drug Receptors, Arginine, Cytosine, Serine, Codon, Dislocation, Genetics, Joint Characteristics And Functions, Pathology, Physiology, Catechol O-Methyltransferase, Neurotransmitter Agents, Pain Measurement, Range Of Motion, Articular, Temporomandibular Joint Dysfunction Syndrome,

Affiliations:
*** IBB - CNR ***

Department of Oral and Maxillofacial Surgery, University of Naples Federico II, Italy
Institute of biostructure and bioimaging, CNR, Naples, Italy
CEINGE Biotecnologie Avanzate S.C.a R.L, Naples, Italy
Department of Biochemistry and Medical Biotechnology, University of Naples Federico II, Italy


References:
Not available.
Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder

We report a case of temporomandibular disorder patient with disc displacement without reduction, myofascial pain, limited opening and a novel, never described, nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene. COMT is one of the enzymes that metabolizes catecholamines, thereby acting as a key modulator of dopaminergic and adrenergic/noradrenergic neurotransmissions, which play a key role in pain modulation. This novel mutation, p.R58S, changed a codon (58 from arginine to serine) in the COMT protein. The introduction of a serine residue in a highly organised secondary structure, in critical regions of the protein, results in a structural alteration. Therefore, we speculate an influence of the mutation on the high pain sensitivity of the patient. © 2010 Società Italiana di Ortodonzia SIDO.
Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder

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Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder

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8 Records (6 excluding Abstracts).
Total impact factor: 21.037 (19.223 excluding Abstracts).
Total 5 year impact factor: 21.198 (19.379 excluding Abstracts).

Last modified by Marco Comerci on Sunday 12 July 2020, 13:15:01
443 views. Last view on Monday 19 August 2024, 23:27:16