Results of clinical trials with SPEM (340 views)
Nucl Instrum Methods Phys Res Sect A, 2007 Feb 1; 497(1): 46-50.
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Paper type: Journal Article,
Impact factor: 3.221, 5-year impact factor: 4.197
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037457865&partnerID=40&md5=27166fcfffb6e36255ff29a3ba3e9c6e
Keywords: 99 Mtc Sestamibi, Breast Compression, High Resolution Scintimammography, Prone Scintimammography, Spem Camera, Biopsy, Electromagnetic Wave Attenuation, Optical Collimators, Photomultipliers, Signal To Noise Ratio, Tumors, Single Photon Emission Mammography (spem), Breast Cancer, High Resolution Molecular Imaghing, Radionuclides, Light Emission, Medical Imaging, Optical Resolving Power, Photodetectors, Absorptive Collimation, Dual-Head Detectors, Electronic Collimation,
Affiliations:
*** IBB - CNR ***
Section of Nuclear Medicine, c/o Ist. Radiologia Centrale, Univ. of Rome, La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy
National Research Council, ITBM, Pile A. Moro 7, Rome, Italy
ENEA-TEC, CR Casaccia, Rome, Italy
PEM Technologies Inc., 5611 Roosevelt Dr., Bethesda, MA, United States
Harbor UCLA, Medical Center, Torrance, CA, United States
Istituto Superiore di Sanita' and INFN gruppo Sanita, Viale Regina Elena 299, 00161 Rome, Italy
University La Sapienza, Rome, Italy
University Tor Vergata, Rome, Italy
CNR Napoli, Napoli, Italy
Jefferson Lab, Newport News, United States
References:
Not available.
Nucl Instrum Methods Phys Res Sect A, 2007 Feb 1; 497(1): 46-50.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.221, 5-year impact factor: 4.197
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037457865&partnerID=40&md5=27166fcfffb6e36255ff29a3ba3e9c6e
Keywords: 99 Mtc Sestamibi, Breast Compression, High Resolution Scintimammography, Prone Scintimammography, Spem Camera, Biopsy, Electromagnetic Wave Attenuation, Optical Collimators, Photomultipliers, Signal To Noise Ratio, Tumors, Single Photon Emission Mammography (spem), Breast Cancer, High Resolution Molecular Imaghing, Radionuclides, Light Emission, Medical Imaging, Optical Resolving Power, Photodetectors, Absorptive Collimation, Dual-Head Detectors, Electronic Collimation,
Affiliations:
*** IBB - CNR ***
Section of Nuclear Medicine, c/o Ist. Radiologia Centrale, Univ. of Rome, La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy
National Research Council, ITBM, Pile A. Moro 7, Rome, Italy
ENEA-TEC, CR Casaccia, Rome, Italy
PEM Technologies Inc., 5611 Roosevelt Dr., Bethesda, MA, United States
Harbor UCLA, Medical Center, Torrance, CA, United States
Istituto Superiore di Sanita' and INFN gruppo Sanita, Viale Regina Elena 299, 00161 Rome, Italy
University La Sapienza, Rome, Italy
University Tor Vergata, Rome, Italy
CNR Napoli, Napoli, Italy
Jefferson Lab, Newport News, United States
References:
Not available.
Results of clinical trials with SPEM
X-ray mammography represents the principal tool for breast cancer screening, but has several limitations. Due to the low specificity of X-ray mammography, many more biopsies are performed than are necessary. More than 60% of breast biopsies performed because of suspicious X-ray mammograms yield a diagnosis other than cancer. In women with X-ray dense breast tissue, X-ray mammography can miss as many as 20% of cancers. Several studies suggest that combining 99 mTc Sestamibi Scintimammography (SM) with X-ray mammography can increase the accuracy of breast imaging in selected populations. The principal limitation of prone-position scintimammography (PSM) using a standard Anger gamma camera is low sensitivity for subcentimeter cancers (i.e., stages T1a and T1b). Detecting these small cancers is extremely important clinically, since removal of the cancers at these early stages is thought to represent the best opportunity for cure. Our group constructed a high spatial resolution detector specifically dedicated to SM, the Single Photon Emission Mammography (SPEM) camera. Unlike conventional Anger gamma cameras, the SPEM camera incorporates a high spatial resolution position-sensitive photomultiplier tube, coupled to an array of scintillating crystals. The compactness of the SPEM camera allows breast compression to be implemented in a cranio-caudal view, facilitating comparison to X-ray mammograms taken in the same position. Clinical results so obtained have demonstrated increased diagnostic sensitivity in sub-centimeter tumors (80% for SPEM vs 50% with PSM). Factors contributing to this increased sensitivity include improved signal-to-noise ratio (SNR). For sub-centimeter cancers, SPEM SNR values were consistently much higher than those of PSM. Classic detectability studies have demonstrated that an SNR value >5 is required for reliable detection of cancers. For subcentimeter cancers, only the SPEM attained or exceeded this minimum threshold. The results showed that compression, which optimizes resolution by reducing lesion-to-collimator distance, and increases planar image contrast by reducing signal and attenuation from interposed normal breast tissue, plays a fundamental role in the visualization of subcentimeter breast cancers. © 2002 Elsevier Science B.V. All rights reserved.
X-ray mammography represents the principal tool for breast cancer screening, but has several limitations. Due to the low specificity of X-ray mammography, many more biopsies are performed than are necessary. More than 60% of breast biopsies performed because of suspicious X-ray mammograms yield a diagnosis other than cancer. In women with X-ray dense breast tissue, X-ray mammography can miss as many as 20% of cancers. Several studies suggest that combining 99 mTc Sestamibi Scintimammography (SM) with X-ray mammography can increase the accuracy of breast imaging in selected populations. The principal limitation of prone-position scintimammography (PSM) using a standard Anger gamma camera is low sensitivity for subcentimeter cancers (i.e., stages T1a and T1b). Detecting these small cancers is extremely important clinically, since removal of the cancers at these early stages is thought to represent the best opportunity for cure. Our group constructed a high spatial resolution detector specifically dedicated to SM, the Single Photon Emission Mammography (SPEM) camera. Unlike conventional Anger gamma cameras, the SPEM camera incorporates a high spatial resolution position-sensitive photomultiplier tube, coupled to an array of scintillating crystals. The compactness of the SPEM camera allows breast compression to be implemented in a cranio-caudal view, facilitating comparison to X-ray mammograms taken in the same position. Clinical results so obtained have demonstrated increased diagnostic sensitivity in sub-centimeter tumors (80% for SPEM vs 50% with PSM). Factors contributing to this increased sensitivity include improved signal-to-noise ratio (SNR). For sub-centimeter cancers, SPEM SNR values were consistently much higher than those of PSM. Classic detectability studies have demonstrated that an SNR value >5 is required for reliable detection of cancers. For subcentimeter cancers, only the SPEM attained or exceeded this minimum threshold. The results showed that compression, which optimizes resolution by reducing lesion-to-collimator distance, and increases planar image contrast by reducing signal and attenuation from interposed normal breast tissue, plays a fundamental role in the visualization of subcentimeter breast cancers. © 2002 Elsevier Science B.V. All rights reserved.
Results of clinical trials with SPEM
No results. |
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